期刊
ONCOIMMUNOLOGY
卷 1, 期 4, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.19366
关键词
NK cells; PCNA; NCR; NKp44; ITIM; inhibitory ligand
资金
- NCI NIH HHS [R01 CA083859] Funding Source: Medline
We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.
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