期刊
ONCOIMMUNOLOGY
卷 1, 期 5, 页码 746-748出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.19535
关键词
miR-30d; GALNT; GalNAc-Ts; glycosylation; immunosuppression; miRNA; melanoma; metastasis
资金
- PHS HHS Funding Source: Medline
Glycosylation is a key process impacting on many aspects of cellular interactions. We recently reported that a miRNA cluster controls glycosylation by directly targeting N-acetylgalactosamine transferases (GALNTs), resulting in increased tumor invasion and immunosuppression. Here we further discuss how defective glycosylation or GALNTs dysregulation may contribute to tumor progression
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