期刊
ONCOIMMUNOLOGY
卷 1, 期 1, 页码 38-47出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.1.1.18312
关键词
NK cells; tumors; chemotherapy
资金
- INSERM
- la Fondation pour la Recherche Medicale (FRM)
- la Societe Francaise de Dermatologie (SFD)
- la Ligue Nationale contre le Cancer (Comite Ile de France)
- Canceropole IdF
- Ligue Nationale contre le Cancer
- FRM
The recent findings on NK activation indicate that these cells are important antitumor effectors. NK cells participate in the graft-vs.-leukemia effect to control the relapse in leukemic patients transplanted with allogeneic hematopoietic stem cells. In various tumors, correlation between NK cell infiltrates and prognosis were reported. However, tumor-infiltrating NK cells are yet poorly characterized. We here summarize our results and the recent studies of the literature on tumor-infiltrating NK cells, and discuss the impact of these novel insights into NK cell responses against tumors for the design of NK cell-based therapies.
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