期刊
ONCOIMMUNOLOGY
卷 1, 期 8, 页码 1417-1419出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.21097
关键词
oncolytic viruses; parvoviruses; immune response
Oncolytic virotherapy represents a recent approach to anticancer therapy. Rodent autonomous parvoviruses (PVs) represent naturally oncolytic viruses that are non-pathogenic for humans but possess and extended tropism, being capable of infecting transformed cells of both rodent and human origin. Recent work from our group demonstrate that PVs can act as direct lytic agents and adjuvants, stimulating antitumor immune responses against glioma and pancreatic ductal adenocarcinoma (PDAC).
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