期刊
ONCOIMMUNOLOGY
卷 1, 期 5, 页码 780-782出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.19731
关键词
myeloid-derived suppressor cells; tumor-associated macrophages; CpG ODN; toll like receptor; immunotherapy; tumor microenvironment; myeloid derived suppressor cells; CpG oligonucleotides; TLR9; immunotherapy; tumor microenvironment
CpG oligonucleotides stimulate via TLR9 and enhance anti-tumor immunity, an effect attributed to the activation of NK and CD8+ T cells. Our recent work demonstrates that CpG ODN also induce monocytic myeloid-derived suppressor cells to mature into M1 macrophages, further aiding tumor elimination. This provides insight into the mechanism through which CpG promote tumor regression.
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