期刊
ONCOIMMUNOLOGY
卷 1, 期 9, 页码 1658-1660出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.22032
关键词
dendritic cell; immunosurveillance; immunotherapy; multiple myeloma; T cell; T cell clones; Th17; Treg; trogocytosis
Trogocytosis, which results in the acquisition of myeloma cell-derived membrane proteins by T cells, and hence generates novel regulatory T cells, adds to the growing list of immune defects of multiple myeloma patients. The increasing complexity of the cancer-associated immune defects must be attentively considered for attempting to improve the so-far unsatisfactory rates of clinical responses to immunotherapy in patients affected by multiple myeloma and other malignancies.
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