期刊
ONCOIMMUNOLOGY
卷 1, 期 6, 页码 940-942出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.20305
关键词
Toll-like receptor; Nod-like receptor; flagellin; pattern recognition receptor; vaccination; immunotherapy; inflammasome; T cell response; adaptive immunity; innate immunity
The use of innate immune receptor agonists in cancer therapies has suffered from many drawbacks. Our recent observations suggest that some of these hurdles can be overcome by introducing flagellin into tumor cells to promote tumor antigen presentation by dendritic cells (DCs) and simultaneously trigger two types of pattern recognition receptors (PRRs).
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