Article
Nutrition & Dietetics
Aida Lahmar, Aline Mathey, Virginie Aires, Dorra Elgueder, Anne Vejux, Rihab Khlifi, Fairouz Sioud, Leila Chekir-Ghedira, Dominique Delmas
Summary: The study highlights the potential of Pituranthos chloranthus and Teucrium ramosissimum Desf. essential oils as chemopreventive and chemosensitizing agents against uterine sarcoma cell lines. The combination of these oils with doxorubicin induces synergistic effects that increase cell death in resistant cells and decrease resistance to the chemotherapy drug. This is achieved through modulation of the cell cycle, induction of apoptosis, and a decrease in P-gp expression and activity.
Article
Cell Biology
Vinaya Phatak, Yannick von Grabowiecki, Justyna Janus, Leah Officer, Caron Behan, Lydia Aschauer, Lucia Pinon, Hannah Mackay, Sara Zanivan, Jim C. Norman, Michael Kelly, John Le Quesne, Patricia A. J. Muller
Summary: Mutant p53 protein can facilitate the cell membrane recycling of P-gp through RCP, leading to chemoresistance. Cells without RCP or mutant p53 show increased sensitivity to cisplatin and etoposide.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Sruthi Sritharan, Sampurna Guha, Snoopy Hazarika, Nageswaran Sivalingam
Summary: Cancer is a challenging disease with a significant mortality rate worldwide. The current treatment involving chemotherapy has adverse effects and the development of resistance limits its effectiveness. Research efforts are now focused on finding agents that can sensitize resistant cancer cells to chemotherapy to improve clinical efficiency.
Article
Gastroenterology & Hepatology
Hongyan Gou, Hao Su, Dehua Liu, Chi Chun Wong, Haiyun Shang, Yi Fang, Xianyi Zeng, Huarong Chen, Yan Li, Ziheng Huang, Miao Fan, Chunxian Wei, Xin Wang, Xiang Zhang, Xiaoxing Li, Jun Yu
Summary: The study demonstrates that Pien Tze Huang (PZH) can prevent colorectal cancer by modulating gut microbiota and metabolites, improving gut barrier function, and suppressing oncogenic and pro-inflammatory pathways.
Article
Nutrition & Dietetics
Sergio Crovella, Allal Ouhtit, Shaikh Mizanoor Rahman, Md Mizanur Rahman
Summary: Drug resistance is a major challenge in cancer treatment, but researchers are exploring the use of natural molecules like docosahexaenoic acid (DHA) to enhance the effectiveness of chemotherapy. DHA has shown promise in enhancing the cytotoxicity of anti-cancer drugs, but more research is needed to understand its detailed mechanism of action.
Article
Oncology
Elina Khatoon, Kishore Banik, Choudhary Harsha, Bethsebie Lalduhsaki Sailo, Krishan Kumar Thakur, Amrita Devi Khwairakpam, Rajesh Vikkurthi, Thengujam Babita Devi, Subash C. Gupta, Ajaikumar B. Kunnumakkara
Summary: Despite advances in cancer treatment, drug resistance remains a major challenge. Phytochemicals have emerged as potential chemosensitizing agents due to their multitargeted properties and low toxicity.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pradhapsingh Bharathiraja, David S. P. Cardoso, N. Rajendra Prasad, Silva Mulhovo, Deepa S. Lakra, Maria-Jose U. Ferreira
Summary: This study found that derivatives of N-alkylated monoterpene indole alkaloids, particularly N-(para-bromobenzyl) (NBBT), can reverse P-gp-mediated multidrug resistance in cancer cells. NBBT exhibited the highest P-gp inhibitory activity and reduced P-gp overexpression by inhibiting the nuclear translocation of the nuclear factor kappa B p-50 subunit. Additionally, NBBT showed synergistic effects with doxorubicin, decreasing the cellular migration and increasing apoptotic incidence in drug-resistant cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Applied
Deepa Swati Lakra, B. Pradhapsingh, N. Deepika, T. Dhanalakshmi, G. Kanimozhi, Rajendra N. Prasad
Summary: This study evaluated the chemosensitizing property of Andro in P-gp overexpressing multidrug-resistant (MDR) colchicine-selected KBCh(R) 8-5 cells. Molecular docking studies showed Andro exhibits higher binding interaction with P-gp than other studied transporters. Furthermore, Andro downregulates P-gp overexpression via NF-kappa B signaling in MDR cell lines and enhances the therapeutic effect of PTX in drug-resistant cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Cell Biology
Ming-Kun Chen, Jun-Hao Zhou, Peng Wang, Yun-lin Ye, Yang Liu, Jia-Wei Zhou, Zi-Jian Chen, Jian-Kun Yang, De-Ying Liao, Zhi-Jian Liang, Xiao Xie, Qi-Zhao Zhou, Kang-Yi Xue, Wen-Bin Guo, Ming Xia, Ji-Ming Bao, Cheng Yang, Hai-Feng Duan, Hong-Yi Wang, Zhi-Peng Huang, Zi-Ke Qin, Cun-Dong Liu
Summary: Elevated BMI1 expression in bladder cancer is associated with chemoresistance to cisplatin and gemcitabine, leading to tumor relapse and progression. Mechanistically, BMI1 interacts with p53 to repress miR-3682-3p expression and induce ABCB1 gene overexpression, contributing to chemoresistance in bladder cancer. Targeting P-glycoprotein through miR-3682-3p mimics or inhibitors can reverse chemoresistance in bladder cancer cells.
Article
Food Science & Technology
Carla Cifuentes-Collari, Rodrigo Valenzuela-Baez, Jose Luis Guil-Guerrero, Casimir C. Akoh, Miguel Angel Rincon-Cervera
Summary: This study synthesized 1,3-diacylglycerols containing stearidonic acid, gamma-linolenic acid, and alpha-linolenic acid through lipase-mediated catalysis, and investigated their potential as functional ingredients in foods for weight and obesity management.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Oncology
Nair Hariprasad Haritha, Akbar Nawab, Vinod Vijayakurup, Nikhil Ponnoor Anto, Vijayasteltar B. Liju, Vijai V. Alex, Areekkara Nisthul Amrutha, Sreekumar U. Aiswarya, Mundanattu Swetha, Balachandran S. Vinod, Sankar Sundaram, Maria Guijarro, Thomas Herlevich, Archana Krishna, Nesteena K. Nestory, Smitha Bava, Chittalakkottu Sadasivan, Maria Zajac-Kaye, Ruby John Anto
Summary: A study found that curcumin enhances the sensitivity of breast cancer cells to 5-fluorouracil chemotherapy, particularly in triple-negative breast cancer, providing a new strategy for the treatment of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Mariana Nunes, Patricia M. A. Silva, Ricardo Coelho, Carla Pinto, Albina Resende, Hassan Bousbaa, Gabriela M. Almeida, Sara Ricardo
Summary: Debulking surgery followed by chemotherapy is the standard treatment for high-grade serous carcinoma, but most patients eventually develop chemoresistance leading to poor survival rates. Researchers established two high-grade serous carcinoma cell lines with intrinsic resistance to Carboplatin and induced resistance to Paclitaxel, providing a valuable tool for studying drug resistance mechanisms and testing new therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Chung-Pu Wu, Cheng-Yu Hung, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu, Suresh Ambudkar
Summary: In this study, we investigate the role of P-glycoprotein (P-gp) in the reduced sensitivity of cancer cells to the anaplastic lymphoma kinase (ALK) inhibitor ensartinib. Our results demonstrate that P-gp overexpression decreases the intracellular accumulation and cytotoxic activity of ensartinib in cancer cells. These findings highlight the importance of understanding the mechanisms of ensartinib resistance mediated by P-gp.
Article
Pharmacology & Pharmacy
Charlotte Smith Bonde, Louis Bornancin, Yi Lu, Henrik Toft Simonsen, Maria Martinez-Valladares, Miguel Pena-Espinoza, Helena Mejer, Andrew R. Williams, Stig Milan Thamsborg
Summary: The study shows that seaweed can provide bioactive compounds with anti-parasitic activity, with Saccharina latissima and Laminaria digitata showing particularly high anti-parasitic activity. Fatty acids may play an important role in controlling intestinal helminth infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Aranka Brockmueller, Anjana Sajeev, Lenka Koklesova, Samson Mathews Samuel, Peter Kubatka, Dietrich Busselberg, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: Despite medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy can lead to side effects and drug resistance, highlighting the need for natural compounds that can sensitize cancer cells to overcome resistance. Resveratrol, a natural polyphenolic compound, has been shown to enhance the effectiveness of chemotherapy by modulating multiple pathways in CRC cells.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Shailendra Singh, Chandrabose Karthikeyan, Narayana Subbiah Hari Narayana Moorthy
Summary: Fatty acid synthase (FASN), an important enzyme in fatty acid biosynthesis, is upregulated in various cancer cells. This study identified a series of compounds with FASN inhibitory activity and found that the topological properties of the molecules played a key role in activity classification. The presence of heteroatoms and hydrogen bond acceptor groups also actively contributed to the inhibitory activities.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Chemistry, Multidisciplinary
Mariam Abou-Dahech, Sai H. S. Boddu, Rinda Devi Bachu, R. Jayachandra Babu, Moyad Shahwan, Moawia M. Al-Tabakha, Amit K. Tiwari
Summary: Ultraviolet light from the sun can cause long-term skin damage and cancer. The use of sunscreen products with UV filters is recommended to prevent sun exposure-related harm. However, there are growing concerns about the safety of sunscreens for humans and the environment. Research has shown that UV filters like oxybenzone can have harmful effects on the hormone systems of aquatic animals and humans. Animal models are currently being used to study the mechanisms and cellular effects of these products. The lack of non-clinical safety assessment data has led to controversy surrounding the reported findings on the potential toxicities of UV filters.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Behavioral Sciences
Alaa M. Hammad, Asma'a Naser, Haneen Amawi, F. Scott Hall, Amit K. Tiwari, Bahaa Al-Trad
Summary: Substance abuse is a global problem with significant consequences. Pregabalin, a medication commonly used for neuropathic pain, has raised concerns for its potential abuse and misuse. This study found that pregabalin can produce rewarding effects and alter glutamate homeostasis, indicating its abuse liability. The findings suggest that the abuse potential of pregabalin should be further examined, and the mechanisms underlying its effects are similar to other drugs of abuse.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Chanchal Kiran Thakur, Chandrabose Karthikeyan, Mariam Sami Abou-Dahech, Moawia Mohd A. M. Altabakha, Moayad Jamal Saeed Al Shahwan, Charles R. R. Ashby Jr, Amit K. Tiwari, R. Jayachandra Babu, Narayana Subbiah Hari Narayana Moorthy
Summary: Microwave-assisted synthetic methods are commonly used for the surface modification and functionalization of multi-walled carbon nanotubes (MWCNTs) in diverse drug delivery applications. Microwave-induced functionalization of MWCNTs offers high efficiency and shorter reaction time compared to conventional techniques. Microwave methods are simple, fast, and effective for the covalent and noncovalent conjugation of MWCNTs with various biomolecules and polymers. This review focuses on the synthesis and drug delivery applications of microwave irradiation techniques (MITs) for the functionalization of MWCNTs using amino acids, vitamins, proteins, epoxy moieties, metal nanoparticles, and polymers.
Article
Chemistry, Medicinal
Inass A. Ahmed, Saly Hafiz, Sabrina van Ginkel, Satyanarayana R. Pondugula, Azza S. Abdelhaffez, Hayam G. Sayyed, Ebtihal A. Abd El-Aziz, Mahmoud M. Mansour
Summary: This study evaluated the synergistic effects of four natural compounds (calebin A, 3'-hydroxypterostilbene, hispolon, and tetrahydrocurcumin) on docetaxel (DTX) for the treatment of metastatic castration-resistant prostate cancer. The results showed that these compounds significantly enhanced the toxicity of DTX to androgen-resistant prostate cancer cells.
NATURAL PRODUCT COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Chandrasekhar Garapati, Sai HS. Boddu, Shery Jacob, Ketan M. Ranch, Chirag Patel, R. Jayachandra Babu, Amit K. Tiwari, Haya Yasin
Summary: Resistance to antimicrobial drugs is a growing healthcare problem. Photodynamic therapy, using photosensitizers activated by light, shows effectiveness against microbial cells. Nanocarrier systems can enhance the internalization of photosensitizers into microbial cells, improving therapeutic efficiency. This review highlights the principles of photodynamic therapy and emphasizes the use of nanosystems for antimicrobial photodynamic therapy.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Ahmed Al Saqr, Manjusha Annaji, Ishwor Poudel, Mohammed F. Aldawsari, Hamad Alrbyawi, Nur Mita, Muralikrishnan Dhanasekaran, Sai H. S. Boddu, Rabin Neupane, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study aimed to develop a microemulsion formulation for topical delivery of Diacetyl Boldine (DAB) and evaluate its cytotoxicity against melanoma cell line (B16BL6) in vitro. The results showed that the microemulsion formulation exhibited significantly higher skin retention levels than the DAB solution in MCT oil. Additionally, the microemulsion formulations showed substantially higher cytotoxicity toward B16BL6 cell lines than the control formulation.
Review
Chemistry, Medicinal
Qi Wang, Keerthi Atluri, Amit K. Tiwari, R. Jayachandra Babu
Summary: Various formulations of polymeric micelles are being investigated as potential nanomedicines for cancer treatment. They target specific tissues and have prolonged circulation in the body. This review focuses on the different polymeric materials available for micelle synthesis and the ways they can be tailored to be responsive to different stimuli. It also discusses clinical trends, drug delivery applications, and challenges in this field.
Article
Medicine, Research & Experimental
Saba Omer, Suhrud Pathak, Rishi Nadar, Dylan Bowen, Maninder Sandey, Muralikrishnan Dhanasekaran, Satyanarayana Pondugula, Mohammed Mansour, Dawn Boothe
Summary: The study demonstrated the anti-lymphoma pharmacodynamic actions of endocannabinoids on canine and human NHL cells, validated the expression of CB1 and CB2 receptors in canine NHL cells, and showed differential effects on B-cell lymphoma cells compared to T-cell lymphoma cells. The endocannabinoids altered markers of oxidative stress, inflammation, and mitochondrial function in canine NHL cells without affecting apoptotic markers.
Article
Medicine, Research & Experimental
Keyi Liu, Surekha Kadannagari, Jack Deruiter, Suhrud Pathak, Kodye L. Abbott, Julia M. Salamat, Satyanarayana R. Pondugula, Benson T. Akingbemi, Muralikrishnan Dhanasekaran
Summary: The current literature suggests that BPS, a substitute for BPA, may have negative effects on liver function. However, this study found that acute exposure to BPS had minimal impact on hepatocellular functions in newborn rats, and even showed hepatoprotective effects.
Review
Chemistry, Multidisciplinary
Monu Kumar Shukla, Arpana Parihar, Chandrabose Karthikeyan, Deepak Kumar, Raju Khan
Summary: This review discusses the potential of multifunctional graphene quantum dots (GQDs) as a platform for receptor targeting, drug delivery, and bioimaging in pancreatic cancer. GQDs have the ability to selectively target pancreatic cancer cells and serve as drug delivery vehicles for controlled and targeted release of therapeutics. Additionally, GQDs show promise as imaging agents for pancreatic cancer detection and monitoring.
Review
Oncology
Rinda Devi Bachu, Mariam Abou-Dahech, Swapnaa Balaji, Sai H. S. Boddu, Samson Amos, Vishal Singh, R. Jayachandra Babu, Amit K. Tiwari
Summary: Biologics play an important role in cancer treatment, but their high costs limit accessibility for many patients. The development of biosimilars aims to lower costs and provide new cancer therapies, but lack of knowledge and potential immunogenicity create uncertainties for healthcare professionals and patients.
Correction
Chemistry, Multidisciplinary
Radha Rani Mehra, Anindya Basu, Ryann M. Christman, Jeena Harjit, Anil K. Mishra, Amit K. Tiwari, Anita DuttKonar
Summary: This is a correction for the article titled "Mechanoresponsive, proteolytically stable and biocompatible supergelators from ultra short enantiomeric peptides with sustained drug release propensity" by Radha Rani Mehra et al., published in New J. Chem., 2020, 44, 6346-6354, https://doi.org/10.1039/D0NJ00102C.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)