Article
Engineering, Electrical & Electronic
Huan Zhou, Xiao-Yu Peng, Yangjiuzhou Gou, Desheng Pei, Xi Zhang, Julia Li Zhong
Summary: Strong terahertz waves can induce morphology changes in living cells, and in this study, we found that melanoma cells showed obvious changes after exposure to strong THz waves, but no changes were observed when the increase in temperature was suppressed by reducing the repetition rate.
JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES
(2022)
Article
Engineering, Biomedical
Abraham Ittycheri, Zachary W. Lipsky, Tracy A. Hookway, Guy K. German
Summary: This study investigates the effects of UV-induced photoageing on the mechanical properties of skin. It is found that the relative difference in elastic modulus, fracture stress, and toughness increases with increased UV irradiation. These changes are significant at UVA dosage of 1200 J/cm2 and for samples aligned with the collagen orientation at UVB dosage of 1200 J/cm2. However, statistical differences in samples perpendicular to the collagen orientation emerge only at UVB dosage of 1600 J/cm2.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Lucia Hoppanova, Juliana Dylikova, Dusan Kovacik, Veronika Medvecka, Pavol Durina, Svetlana Krystofova, Daniela Hudecova, Barbora Kalinakova
Summary: This study investigated the effect of non-thermal plasma (NTP) on Aspergillus parasiticus. The results showed that NTP treatment significantly increased the production of aflatoxins by the fungus shortly after exposure. NTP also had a rapid devitalizing effect on the fungus. At the molecular level, NTP caused disruptions in the cell surface and oxidation of biological components in Aspergillus parasiticus.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Physics, Applied
Yuxuan Wei, Jiaming Le, Li Huang, Chuanshan Tian
Summary: This work presents a convenient approach to generate strong broadband terahertz (THz) pulses with a tunable center frequency using low-cost crystalline quartz. The THz conversion efficiency in quartz reaches 0.05%, comparable to LiNbO3 at room temperature, while providing a much broader THz spectral range. This not only addresses the urgent need for a light source in nonlinear THz spectroscopy beyond 2 THz but also offers an alternative route in selecting nonlinear optical crystals for frequency conversion.
APPLIED PHYSICS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Svetlana Bannikova, Tamara Khlebodarova, Asya Vasilieva, Irina Mescheryakova, Alla Bryanskaya, Elizaveta Shedko, Vasily Popik, Tatiana Goryachkovskaya, Sergey Peltek
Summary: Studying the effects of terahertz radiation on the proteome of temperature-sensitive organisms is challenging, but extremophilic bacteria provide insights into direct effects. The study found that terahertz radiation can induce protein expression changes and impact multiple metabolic systems and stress defense in cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Mechanics
Pawel Hlosta, Marcin Nita, Dorota Powala, Waldemar Swiderski
Summary: Terahertz (THz) technology has attracted more interest in recent years due to its unique properties for non-destructive evaluation (NDE). Materials like dielectrics are transparent to THz waves, while conducting materials like metals are opaque. The potential application of THz radiation in detecting defects in composite pyrotechnic materials is being explored.
COMPOSITE STRUCTURES
(2022)
Review
Chemistry, Physical
F. N. Jumaah, N. N. Mobarak, N. H. Hassan, S. A. M. Noor, S. N. S. Nasir, N. A. Ludin, K. H. Badri, A. Ahmad, Elisabeth R. D. Ito, M. Yoshizawa-Fujita, M. S. Su'ait
Summary: In this review, a brief discussion on non-crystalline and crystalline quaternary ammonium substances, such as ionic liquids (ILs), ionic liquid crystals (ILCs), and ionic plastic crystals (IPCs), was carried out based on their analog structures and thermal properties. The classification of organic salts was proposed based on their chemical properties and physical properties, and the general information of ILs, ILCs, and IPCs was summarized. The paper provides comprehensive classification information about these ions.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biotechnology & Applied Microbiology
Ma Shaoqing, Li Zhiwei, Gong Shixiang, Lu Chengbiao, Li Xiaoli, Li Yingwei
Summary: This study investigates the effects of terahertz waves on the structure of neurons through modeling and experimentation. The results indicate that the frequency and power of terahertz waves are the main factors influencing field strength and temperature in neurons, and there is a positive correlation between them. Appropriate reductions in radiation power can mitigate the rise in temperature in the neurons, and the use of pulsed waves and short bursts of cumulative radiation is effective. Short-duration cumulative radiation with specific parameters does not cause neuronal death and can promote neuronal growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Sudha Yadav, Manju Kumari, Debabrata Nayak, N. Kiran, N. Vijayan, Mukesh Jewariya
Summary: This study focused on the terahertz-based characterization of an efficient organic nonlinear optical single crystal of L-alanine. The crystal was grown using the slow evaporation solution growth method and its structure was analyzed using various techniques. The optical behavior and thermal stability of the crystal were studied, and its nonlinear behavior was analyzed using different measurements. The results showed significant variations in absorption coefficient and refractive index at terahertz frequencies.
Article
Chemistry, Multidisciplinary
Adrian Sanchez-Fernandez, Medina Basic, Jenny Xiang, Sylvain Prevost, Andrew J. Jackson, Cedric Dicko
Summary: This study demonstrates that the hydration of deep eutectic solvents (DESs), a type of solvent used for preserving labile biomolecules, has a significant impact on the behavior, conformation, and stability of proteins. The behavior of two proteins, bovine serum albumin and lysozyme, and an antibody, immunoglobulin G, in DESs with different hydration levels was investigated. The results showed that the proteins exhibited a re-entrant behavior with solvent hydration, with a dome-shaped transition observed at very low and high hydration levels. The hydration also influenced protein folding and stability. The study highlights the importance of quantifying the hydration of DESs in understanding protein behavior and provides new insights into protein folding and stability in hydrated DESs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Energy & Fuels
Masanori Kaneko, Shunsuke Nozawa, Koichi Yamashita
Summary: In this study, the structural changes in the electronically excited state of tungsten oxide were discussed using first-principles calculations. It was found that the interaction between carriers and phonons led to local lattice distortion and the formation of bipolaron states, which enhanced the internal quantum yields in photocatalysis.
FRONTIERS IN ENERGY RESEARCH
(2022)
Article
Materials Science, Ceramics
Mengting Guo, Shikai Wang, Tongyao Zhao, Chongyun Shao, Suya Feng, Chunlei Yu, Jinjun Ren, Lili Hu
Summary: The study explored the relationship among the thermal history, refractive index (RI), and structures of Yb3+/Al3+/P5+/F--co-doped silica glass, and revealed the intrinsic connection between these factors through advanced experimental techniques. Additionally, the influence of thermal history on the beam quality of Yb3+-doped large-mode-area photonic crystal fiber (LMA PCF) was investigated, with results indicating significant improvement in beam quality with proper thermal annealing. Overall, the findings offer valuable insights for the precise manipulation of the numerical aperture of Yb3+-doped active fiber.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2021)
Article
Chemistry, Physical
Jiawei Chang, He Wang, Zhen Lei, Wanyi Du, Yuanyuan Huang, Yixuan Zhou, Lipeng Zhu, Xinlong Xu
Summary: The study demonstrated coherent elliptical polarized THz radiation from WSe2 under linearly polarized fs laser excitation, with the ellipticity and major axis direction of the THz wave efficiently controlled through the amplitudes and phases of the two coherent orthogonal THz wave components.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Review
Food Science & Technology
Rahul Islam Barbhuiya, Poonam Singha, Sushil Kumar Singh
Summary: Non-thermal food processing technologies provide a viable alternative to traditional thermal processing, meeting the demand for high-quality, convenient, and minimally processed foods. These technologies can alter food structure, affecting properties such as rheology, flavor, texture, and appearance, by changing protein structures and lipid oxidation processes to create novel food textures.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Physics, Applied
K. J. Kihlstrom, K. C. Reddy, S. Elghazoly, T. E. Sharma, A. E. Koshelev, U. Welp, Y. Hao, R. Divan, M. Tsujimoto, K. Kadowaki, W. -K. Kwok, T. M. Benseman
Summary: Mesa-shaped structures of high-Tc superconductor Bi2Sr2CaCu2O8+delta; can emit coherent radiation in the terahertz gap range, and the emission power depends on the operating temperature. In this study, we achieved the generation of 130 μW of coherent power at 0.456 THz from a mesa of Bi2Sr2CaCu2O8+delta; doped with 0.16 holes per Cu atom, at a bath temperature of 77.4 K. The emission is related to the excitation of cavity modes, and the power decreases with increasing mesa temperature.
PHYSICAL REVIEW APPLIED
(2023)
Article
Chemistry, Physical
Ran Friedman
Summary: The use of actinides for medical, scientific and technological purposes is gaining importance. Understanding their interactions with biomolecules and designing agents with high affinities require accurate reference values for actinide hydration. This study developed a set of ionic radii that enables calculations of binding energies for actinides and biomolecules.
Article
Engineering, Chemical
Marlene Bonmann, Diana Carolina Guio-Perez, Tomas Bryllert, David Pallares, Martin Seemann, Filip Johnsson, Jan Stake
Summary: This paper presents the development and validation of a sub-millimeter wave range-Doppler radar for non-intrusive sensing of solids concentrations in gas-solids systems. The radar system offers the ability to penetrate opaque materials, measure local solids velocity, and provide reflected radar power with high spatial resolution. The experimental results demonstrate that the radar system provides reliable measurements of solids concentrations with high accuracy.
ADVANCED POWDER TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Anis Moradikouchi, Anders Sparen, Olof Svensson, Staffan Folestad, Jan Stake, Helena Rodilla
Summary: In this study, the feasibility of using terahertz spectroscopy combined with multivariate analysis for the quantification of API concentration and tablet density in pharmaceutical tablets was explored. The results showed that terahertz spectroscopy can accurately measure tablet density and has lower scattering effects compared to Raman and NIR spectroscopy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Thales Souza Freire, Ignez Caracelli, Julio Zukerman-Schpector, Ran Friedman
Summary: Gilteritinib is effective in treatment of acute myeloid leukaemia (AML) by inhibiting the FLT3/ITD mutated protein. However, tumour cells develop resistance to gilteritinib due to mutations in the drug target. We used a computer-aided approach to understand the resistance mechanism and found that the mutations F691L and D698N lead to higher activation energy barrier, making mutant enzymes more active. This suggests that tyrosine kinases contribute to resistance against type 1 and type 2 kinase inhibitors.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Engineering, Electrical & Electronic
Juan Cabello-Sanchez, Vladimir Drakinskiy, Jan Stake, Helena Rodilla
Summary: Planar Goubau lines show promise for terahertz (THz) applications, but existing filters lack clear design procedures. In this study, we propose a design for a bandpass/bandstop filter by periodically loading the line with capacitively-coupled lambda/2 resonators. The filter's working principle is explained using a transmission-line model. We fabricated and tested a passband filter centered at 0.9 THz on a 10-µm silicon-membrane substrate, demonstrating good agreement between measurements and simulations.
IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eva-Maria Krammer, Clarisse Bridot, Sonia Serna, Begona Echeverria, Shubham Semwal, Benoit Roubinet, Kim van Noort, Ruud H. P. Wilbers, Gleb Bourenkov, Jerome de Ruyck, Ludovic Landemarre, Niels Reichardt, Julie Bouckaert
Summary: The FimH type-1 fimbrial adhesin allows pathogenic Escherichia coli to adhere to glycoproteins in human bladder and intestinal tract linings. Oligomannose-3 and oligomannose-5 have the highest affinity for FimH. Our findings provide important structural insights for the design of multivalent FimH antagonists that bind with positive cooperativity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Optics
R. Voigt, M. Wienold, D. Jayasankar, V. Drakinskiy, J. Stake, P. Sobis, L. Schrottke, X. Lu, H. T. Grahn, H-W Huebers
Summary: We demonstrate the frequency stabilization of a terahertz quantum-cascade laser (QCL) using the Lamb dip of a D2O rotational transition absorption line. A Schottky diode harmonic mixer is used to generate a downconverted QCL signal, which is measured by a spectrum analyzer and shows a full width at half maximum of 350 kHz limited by high-frequency noise beyond the stabilization loop bandwidth.
Article
Instruments & Instrumentation
Tilman Donath, Dubravka Sisak Jung, Max Burian, Valeria Radicci, Pietro Zambon, Andrew N. Fitch, Catherine Dejoie, Bingbing Zhang, Marie Ruat, Michael Hanfland, Cameron M. Kewish, Grant A. van Riessen, Denys Naumenko, Heinz Amenitsch, Gleb Bourenkov, Gerard Bricogne, Ashwin Chari, Clemens Schulze-Briese
Summary: This paper facilitates the optimal use of EIGER2 detectors by providing theory and practical advice on their design, technical specifications, operating modes, and new acquisition features. It also presents examples of their implementation and application at several synchrotron sources, demonstrating their advantages in high-throughput data collection, X-ray diffraction, and optical experiments.
JOURNAL OF SYNCHROTRON RADIATION
(2023)
Article
Physics, Applied
S. Majdi, V. Djurberg, M. Asad, A. Aitkulova, N. Suntornwipat, J. Stake, J. Isberg
Summary: In this study, the researchers successfully fabricated graphene-diamond heterostructures by transferring graphene to an ultra-pure single-crystalline diamond substrate. Hall-effect measurements were conducted to investigate the charge transport properties in these devices. Enhanced hole mobility of 2750 cm(2) V-1 s(-1) was observed at room temperature when using diamond with reduced nitrogen impurity concentration, and the upper limit for mobility was determined by electrostatically varying the carrier concentration. These results are promising for enabling room-temperature applications of carbon-carbon devices.
APPLIED PHYSICS LETTERS
(2023)
Article
Energy & Fuels
Diana Carolina Guio-Perez, Marlene Bonmann, Tomas Bryllert, Martin Seemann, Jan Stake, Filip Johnsson, David Pallares
Summary: The aim of this work is to demonstrate the value of radar technology for studying experimentally the solids flows in gas-solids fluidized beds. The work presents original results regarding the solids concentration and velocity acquired in a non-intrusive manner from a cold flow model. The radar technique applied in this work is a promising technique for detailed characterization of the solids flow in fluidized beds, offering high spatial and temporal resolutions, allowing the determination of both solids velocity and concentration, and having a reasonably high penetration depth.
Article
Biochemistry & Molecular Biology
Kirill Kovalev, Fedor Tsybrov, Alexey Alekseev, Vitaly Shevchenko, Dmytro Soloviov, Sergey Siletsky, Gleb Bourenkov, Michael Agthe, Marina Nikolova, David von Stetten, Roman Astashkin, Sergey Bukhdruker, Igor Chizhov, Antoine Royant, Alexander Kuzmin, Ivan Gushchin, Riccardo Rosselli, Francisco Rodriguez-Valera, Nikolay Ilyinskiy, Andrey Rogachev, Valentin Borshchevskiy, Thomas R. Schneider, Ernst Bamberg, Valentin Gordeliy
Summary: By studying a bacterial inward proton-pumping rhodopsin, researchers have uncovered its molecular mechanism and revealed how proton wires mediate ion selectivity and proton transport through cell membrane. Proton transport is essential for cell life and understanding the mechanisms behind it is a challenge. The study presents a comprehensive function-structure analysis of a light-driven bacterial inward proton pump, providing insights into proton translocation and the use of synchrotron source for rhodopsin studies. The results also have implications for optogenetics.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Tomas Bryllert, Marlene Bonmann, Jan Stake
Summary: This work presents a 340-GHz frequency-modulated continuous-wave (FMCW) pulse-Doppler radar based on a transceiver module with high output power and wide bandwidth. The radar system demonstrates high sensitivity and resolution in detecting and mapping both single particles and particle clouds at a 5-m distance. The ability to monitor particle dynamics is valuable in various industrial applications.
IEEE TRANSACTIONS ON TERAHERTZ SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Maja Jensen, Venkataragavan Chandrasekaran, Maria-Jose Garcia-Bonete, Shuxiang Li, Atsarina Larasati Anindya, Karin Andersson, Malin C. Erlandsson, Nina Y. Oparina, Bjorn M. Burmann, Ulrika Brath, Anna R. Panchenko, Maria Bokarewa, Gergely Katona
Summary: This study explores the role of survivin in the epigenetic regulation of gene transcription through its interaction with the PRC2. The findings show that survivin inhibits the function of PRC2 by preventing H3K27 trimethylation. The study also reveals the interaction between survivin and PRC2 subunit EZH2, which potentially inhibits EZH2's methylation activity.