Review
Immunology
Dipranjan Laha, Robert Grant, Prachi Mishra, Naris Nilubol
Summary: The tumor microenvironment is a complex system consisting of various cells and structures. Tumor necrosis factor-alpha plays a crucial role in the TME, affecting the interaction between tumor cells and immune cells, with significant implications for immune response, tumorigenesis, invasion, and metastasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi
Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Gwenael Page, Marion Tardieu, Jean-Luc Gennisson, Laurent Besret, Philippe Garteiser, Bernard E. Van Beers
Summary: The biomechanical properties of tumors, including viscoelasticity and pressure, are associated with tumor severity. MR elastography shows potential for non-invasive assessment of tumor viscoelasticity, while the study suggests that compression rate could serve as a non-invasive biomarker for tumor solid stress. The findings highlight the importance of studying tumor biomechanical features for a better understanding of tumor behavior.
Article
Oncology
Fen Xi, Yuyi Feng, Qiaoli Chen, Liping Chen, Jianhua Liu
Summary: This study used microbubbles ultrasonic cavitation to regulate interstitial fluid pressure (IFP) in tumors and evaluate the effects of sonodynamic therapy (SDT). The results showed that microbubbles ultrasonic cavitation increased the accumulation of sonosensitizers in tumor tissues and improved the therapeutic effects of SDT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Peter A. R. Bork, Antonio Ladron-de-Guevara, Anneline H. Christensen, Kaare H. Jensen, Maiken Nedergaard, Tomas Bohr
Summary: The glymphatic system, a cerebrospinal fluid transport system in the brain, has been associated with waste clearance, neurodegenerative diseases, and acute neurological disorders. While valves are important in other low-pressure fluid pathways to ensure flow direction, no valves have been found in the glymphatic system. This study proposes that astrocyte endfeet may act as valves using an elastic mechanism.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Computer Science, Information Systems
Md Tauhidul Islam, Songyuan Tang, Ennio Tasciotti, Raffaella Righetti
Summary: Interstitial fluid pressure, interstitial fluid velocity and related parameters play a crucial role in cancer diagnosis, prognosis and treatment. Non-invasive techniques have been developed to estimate these mechanopathological parameters in cancers in vivo. The new ultrasound poroelastography methods were able to accurately estimate fluid pressure, fluid velocity and fluid flow inside tumors under external compression, with validation through finite element and ultrasound simulations.
Article
Multidisciplinary Sciences
Batuhan Koyuncu, Ahmet Melek, Defne Yilmaz, Mert Tuzer, Mehmet Burcin Unlu
Summary: Angiogenesis plays a crucial role in the inefficiency of drug delivery in solid tumors. Antiangiogenic treatment and the combination of antiangiogenic agents and chemotherapy drugs have shown promising effects in enhancing drug delivery. However, finding the optimal scheduling and dosages for the combination therapy remains challenging. This study proposes a deep learning model to predict tumor microenvironment maps and evaluate the effects of ongoing treatment, providing insights for determining the optimal starting time and dosages of cytotoxic drug treatment.
SCIENTIFIC REPORTS
(2022)
Article
Peripheral Vascular Disease
Zhi-He Jin
Summary: This study explores the characteristics of interstitial fluid flow in a solid tumor with partial fluid leakage at the tumor surface under oscillatory microvascular pressure. Results show that partial fluid leakage reduces pore pressure drop and fluid velocity near the surface, while both pore pressure and fluid velocity decrease significantly with an increase in vascular frequency. The amplitude of pore pressure may reach that of vascular pressure under steady state conditions.
MICROVASCULAR RESEARCH
(2021)
Article
Multidisciplinary Sciences
Stephane Urcun, Pierre-Yves Rohan, Wafa Skalli, Pierre Nassoy, Stephane P. A. Bordas, Giuseppe Sciume
Summary: The study reveals that considering the triphasic nature of spheroids can provide a new perspective for analyzing pressure in Cellular Capsule Technology experiments. Experimentally retrieved pressure cannot directly reflect the pressure sustained by tumor cells and therefore cannot be used to quantify the critical pressure for stress-induced phenotype switch.
Article
Chemistry, Multidisciplinary
Pengbo He, Guo Chen, Mengling Huang, Lili Jing, Wen Wu, Hao-Chung Kuo, Chang-Ching Tu, Sung-Liang Chen
Summary: In this study, biocompatible and biodegradable germanium nanoparticles with high photothermal stability and strong absorption for NIR-II PA imaging were developed. The excellent biocompatibility and versatile imaging capabilities of the GeNPs were demonstrated through in vitro and in vivo experiments. The biodegradation of GeNPs was observed not only in normal tissue but also in tumors, making them a promising candidate for clinical NIR-II PA imaging applications.
Article
Oncology
Kathleen M. Mahoney, Petra Ross-Macdonald, Long Yuan, Linan Song, Eliseo Veras, Megan Wind-Rotolo, David F. McDermott, F. Stephen Hodi, Toni K. Choueiri, Gordon J. Freeman
Summary: This study investigated the levels of soluble PD-L1 (sPD-L1) before and during nivolumab treatment in metastatic clear cell renal cell carcinoma (RCC) and melanoma patients. The results showed that sPD-L1 levels were associated with worse prognosis and clinical factors. Additionally, changes in sPD-L1 levels during treatment were linked to treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Chenchen Wu, Zhiyu Wang, Xiaobo Wang, Jiahui Zou, Zimei Wu, Jianping Liu, Wenli Zhang
Summary: The challenge of insufficient drug accumulation in tumors for nanochemotherapy can be addressed by synchronously regulating the size and shape of nanocarriers and tumoral IFP. A dual-functional polymer-polypeptide was synthesized to construct nanopomegranate-like nanovectors with tunable size/shape switch and controlled release of IFP alleviator. The nanovectors exhibited optimal tumor penetration and enhanced chemotherapy, showing potential for combined chemotherapy to improve tumor penetration.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Environmental
Cong Cong, Cheng Rao, Zhenhe Ma, Yi Yuan, Desong Wang, Xuwu Zhang, Yuchu He, Hongming Lou, Dawei Gao
Summary: A novel nanomedicine was designed as nano-lymphatic vessels, coupled with piezo-photocatalysis, to enhance intratumoral delivery. This strategy reduces high lymphatic interstitial fluid pressure (TIFP) and improves the accumulation of nanomedicine within tumors. Additionally, the photocatalytic reaction also enhances the antitumor efficacy of the nanomedicine.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biology
Mutaz Dwairy, J. N. Reddy, Raffaella Righetti
Summary: The uncontrolled proliferation of cancer cells leads to tumor growth, which is opposed by compressive forces from the surrounding tissue. These forces promote tumor metastasis, invasion, and affect drug delivery. A two-dimensional biomechanical model based on the biphasic assumption of the solid matrix and fluid phase is developed in this study. Heterogeneous vasculature and nonuniform blood perfusion are also considered. The findings show differences in the tissue's response to stress between linear and nonlinear models, while the interstitial fluid pressure distribution is independent of the model used.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Clinical Neurology
Steffen Halbgebauer, Patrick Oeckl, Petra Steinacker, Deniz Yilmazer-Hanke, Sarah Anderl-Straub, Christine von Arnim, Lutz Froelich, Luis Aragao Gomes, Lucrezia Hausner, Andre Huss, Holger Jahn, Jochen Weishaupt, Albert C. Ludolph, Dietmar R. Thal, Markus Otto
Summary: A novel ELISA was established to evaluate beta-synuclein as a potential marker for Alzheimer's disease. The study found increased levels of beta-synuclein in the CSF of some patients, supporting its potential use as a marker of synaptic degeneration. Furthermore, beta-synuclein was localized in glutamatergic synapses, with its expression reduced in AD patients' brain tissue.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
