Article
Immunology
Wanjing Cen, Felix Umrath, Antonio Jose Salgado, Siegmar Reinert, Dorothea Alexander
Summary: The secretomes derived from osteogenically induced jaw periosteum-derived mesenchymal stem cells (JPCs) have inhibitory effects on the maturation of monocyte-derived dendritic cells (MoDCs), as they reduce the formation of MoDC clusters and down-regulate the expression of CD80, CD86, and CD197 on MoDCs. The secretomes also enhance the uptake capacity of MoDCs and promote the expansion of regulatory T cells. Furthermore, the secretomes affect the gene expression of MoDCs, up-regulating CD209, HLA-DRA, CSF3, IL10, and IL8, and down-regulating IFN gamma and IL12B.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Eimear Mylod, Ashanty M. Melo, Noel E. Donlon, Maria Davern, Anshul Bhardwaj, John Reynolds, Joanne Lysaght, Melissa J. Conroy
Summary: Esophagogastric adenocarcinomas (EAC) are obesity-associated malignancies characterized by severe immune dysregulation and inflammation. The study reveals that NK cell frequencies decrease in EAC tumor with increasing visceral obesity in patients. Fractalkine plays a key role in NK cell chemotaxis to omentum, but has a lesser role in NK cell homing to tumor in EAC.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dongli Cai, Fang Wang, Changgang Wang, Liping Jin
Summary: The study revealed that in ovarian cancer, the expression of B7S1 (VTCN1) was increased, which may lead to dysfunction of CD8(+) tumor-infiltrating lymphocytes and could be targeted for cancer immunotherapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Immunology
Ivan Ramirez De Oleo, Vera Kim, Yemil Atisha-Fregoso, Andrew J. Shih, Kyungwoo Lee, Betty Diamond, Sun Jung Kim
Summary: Since the discovery of age-associated or autoimmune-associated B cells (ABCs), there has been increasing interest in understanding their role in autoimmunity. ABCs have distinct functional properties compared to follicular B cells and have a unique transcriptomic profile focused on metabolism, cytokine signaling, and antigen uptake and processing. Treatment with metformin can suppress antigen presentation by ABCs and decrease differentiation of T follicular helper (Tfh) cells. This study highlights the fundamental connection between metabolism and function in ABCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia Franzoni, Lorena Mura, Elisabetta Razzuoli, Chiara Grazia De Ciucis, Floriana Fruscione, Filippo Dell'Anno, Susanna Zinellu, Tania Carta, Antonio G. G. Anfossi, Silvia Dei Giudici, Simon P. P. Graham, Annalisa Oggiano
Summary: Swine are gaining attention as a valuable biomedical model due to their immunological similarities with humans, but the polarization of porcine macrophages has not been well-studied. In this study, we investigated how porcine monocyte-derived macrophages respond to different activation stimuli. Our results show that IFN-gamma and LPS induce a proinflammatory phenotype, while IL-4, IL-10, TGF-beta, and dexamethasone trigger distinct M2-related phenotypes. These findings contribute to our understanding of porcine macrophage plasticity and reveal some unique characteristics in this species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Seiji Mabuchi, Tomoyuki Sasano, Naoko Komura
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in ovarian cancer, with increased frequencies associated with poor prognosis. Depletion of MDSCs can significantly inhibit tumor growth and enhance the efficacy of existing anticancer therapies.
Article
Geriatrics & Gerontology
Yu Cao, Yang Fan, Fangyuan Li, Yu Hao, Yaxian Kong, Chen Chen, Xing Hao, Dannuo Han, Guoli Li, Zengtao Wang, Chuan Song, Junyan Han, Hui Zeng
Summary: Circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
Article
Immunology
Tamar Smit, Paul R. Ormel, Jacqueline A. Sluijs, Lianne A. Hulshof, Jinte Middeldorp, Lot D. de Witte, Elly M. Hol, Vanessa Donega
Summary: Dysregulation of microglial function is involved in Alzheimer's disease pathogenesis, with changes in immune and inflammatory pathways linked to genetic risk factors. Aβ oligomers may induce a protective response rather than an inflammatory profile in vitro.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Louis Hinkle, Yongbin Liu, Chaoyang Meng, Zhe Chen, Junhua Mai, Licheng Zhang, Yitian Xu, Ping-Ying Pan, Shu-Hsia Chen, Haifa Shen
Summary: The sympathetic nervous system plays a role in regulating immune cell function, particularly in tumor growth and antitumor immunity. Combining propranolol with a peptide cancer vaccine showed promising results in treating melanoma in mice by enhancing DC maturation and reducing the presence of myeloid-derived suppressor cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Justin Thomas, Molly A. Torok, Kriti Agrawal, Timothy Pfau, Trang T. Vu, Justin Lyberger, Hsiaochi Chang, Alyssa Marie M. Castillo, Min Chen, Bryan Remaily, Kyeongmin Kim, Zhiliang Xie, Mary E. Dillhoff, Samuel K. Kulp, Gregory K. Behbehani, Zobeida Cruz-Monserrate, Latha P. Ganesan, Dwight H. Owen, Mitch A. Phelps, Christopher C. Coss, Thomas A. Mace
Summary: The neonatal Fc receptor (FcRn) is responsible for recycling antibodies and albumin in the body. However, little is known about its expression in circulating immune cells. In this study, FcRn expression was found to be elevated in immune cells of pancreatic ductal adenocarcinoma (PDAC) patients and mice with PDAC. These findings may contribute to understanding the mechanisms behind poor efficacy of antibody immunotherapies in PDAC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Allison Mathiesen, Bronson Haynes, Ryan Huyck, Michael Brown, Anca Dobrian
Summary: Metastatic prostate cancer is associated with obesity and systemic chronic inflammation. Adipose tissue inflammation leads to dysfunctional endothelial cells and the production of extracellular vesicles (EV), which can affect malignant cells in distant tissues. In this study, EVs from obese adipose tissue and inflamed endothelial cells were found to impact the phenotypic plasticity of prostate cancer cells, with reduced invasion and increased proliferation. These functional changes were attributed to the miRNA cargo of the EVs and were TWIST1-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Beatrice Aramini, Valentina Masciale, Anna Valeria Samarelli, Alessandra Dubini, Michele Gaudio, Franco Stella, Uliano Morandi, Massimo Dominici, Sara De Biasi, Lara Gibellini, Andrea Cossarizza
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), is a major global health concern with high mortality rates. Despite the introduction of new therapies, this disease remains difficult to cure and control. Advancements in single-cell technologies have allowed researchers to better understand the characteristics and functions of immune cells in the tumor microenvironment (TME), leading to the discovery of predictive biomarkers and the development of new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bo Ding, Zheng Ye, Han Yin, Xin-Yi Hong, Song-Wei Feng, Jing-Yun Xu, Yang Shen
Summary: This study reveals the regulatory role of tumor exosomes on cancer-associated fibroblast (CAF) in ovarian cancer, showing that ovarian cancer-derived exosomes can promote the proliferation and migration of CAF through the H19/miR-29c-3p/LOXL2-COL1A1 pathway, leading to tumor growth. This finding provides a theoretical basis for the development of therapeutic regimens targeting fibroblasts in ovarian cancer.
Article
Biology
Ausra Mongirdiene, Julius Liobikas
Summary: Chronic heart failure (CHF) is a long-term condition where the heart has difficulty pumping blood enriched in oxygen and required nutrients to the body's tissues. Inflammation is a key factor in promoting CHF, and monocytes, a group of cells in the blood and tissues, play a role in both pro- and anti-inflammatory processes. This review aims to summarize current studies on the function of different monocyte subsets in CHF, particularly in patients with preserved or reduced left ventricle ejection fractions, and their relationship to inflammatory markers.
Article
Hematology
Sophie L. Gibbings, Kelsey C. Haist, Heidi Nick, S. Courtney Frasch, Teagan H. Glass, Brian Vestal, Thomas Danhorn, Kara J. Mould, Peter M. Henson, Donna L. Bratton
Summary: Loss of NADPH oxidase activity in chronic granulomatous disease (CGD) leads to altered phagocyte responses and exaggerated inflammation. The absence of Nox2 in monocyte-derived macrophages (MoMacs) results in impaired maturation and persistent recruitment during zymosan-induced peritonitis in CGD mice.
Article
Biochemistry & Molecular Biology
Sally Demirdjian, Kristin Schutz, Matthew J. Wargo, Joseph S. Lam, Brent Berwin
MOLECULAR IMMUNOLOGY
(2017)
Article
Toxicology
Eileen M. Martinez, Alison L. Young, Yash R. Patankar, Brent L. Berwin, Li Wang, Katharine M. von Herrmann, Jaclyn M. Weier, Matthew C. Havrda
TOXICOLOGICAL SCIENCES
(2017)
Article
Physiology
Roxanna Barnaby, Katja Koeppen, Amanda Nymon, Thomas H. Hampton, Brent Berwin, Alix Ashare, Bruce A. Stanton
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Article
Physiology
Iviana M. Torres, Yash R. Patankar, Brent Berwin
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Article
Immunology
Sally Demirdjian, Daniel Hopkins, Hector Sanchez, Michael Libre, Scott A. Gerber, Brent Berwin
INFECTION AND IMMUNITY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hafsa Khurshid, Yipeng Shi, Brent L. Berwin, John B. Weaver
Review
Toxicology
Faith L. Anderson, Madeleine M. Coffey, Brent L. Berwin, Matthew C. Havrda
TOXICOLOGICAL SCIENCES
(2018)
Article
Oncology
Ivy Wilkinson-Ryan, Melissa M. Pham, Petra Sergent, Laura J. Tafe, Brent L. Berwin
TRANSLATIONAL ONCOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Sally Demirdjian, Hector Sanchez, Daniel Hopkins, Brent Berwin
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Immunology
Sladjana Skopelja-Gardner, Jomkuan Theprungsirikul, Kimberley A. Lewis, John H. Hammond, Kyrsten M. Carlson, Haley F. Hazlett, Amanda Nymon, Dao Nguyen, Brent L. Berwin, Deborah A. Hogan, William F. C. Rigby
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Sally Demirdjian, Daniel Hopkins, Nadia Cumbal, Craig T. Lefort, Brent Berwin
INFECTION AND IMMUNITY
(2020)
Article
Engineering, Biomedical
John B. Weaver, Dylan B. Ness, Jennifer Fields, Dhrubo Jyoti, Scott W. Gordon-Wylie, Brent L. Berwin, Sohail Mirza, Steven N. Fiering
PHYSICS IN MEDICINE AND BIOLOGY
(2020)
Article
Microbiology
Hector Sanchez, George A. A. O'Toole, Brent Berwin
Summary: This study investigates the glycans used by P. aeruginosa PAO1 cells to bind to phagocytic cells and characterizes the suite of such molecules that can facilitate host cell binding by this microbe using a glycan array. The findings provide a better understanding of P. aeruginosa-glycan interactions and offer a valuable dataset for future studies in this area.
MICROBIOLOGY SPECTRUM
(2023)
Article
Cell Biology
Arjun Balakrishnan, Rajendra Karki, Brent Berwin, Masahiro Yamamoto, Thirumala-Devi Kanneganti
CELL DEATH DISCOVERY
(2018)
Article
Physiology
Iviana M. Torres, Sally Demirdjian, Jennifer Vargas, Britton C. Goodale, Brent Berwin
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)