Review
Geriatrics & Gerontology
Valentina Gnoni, Stefano Zoccolella, Alessia Giugno, Daniele Urso, Ludovica Tamburrino, Marco Filardi, Giancarlo Logroscino
Summary: This review summarizes studies on sleep disorders in amyotrophic lateral sclerosis (ALS) published between 2000 and 2023, and examines the potential mechanisms by which hypothalamic dysfunctions contribute to ALS-related sleep disturbances. Gaining a deeper understanding of the relationship between hypothalamic dysfunction and sleep disturbances in ALS can enhance the management of ALS and alleviate the burden on patients and their families.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Environmental Sciences
Renjie Hu, Wenhui Zhang, Ran Li, Li Qin, Rucheng Chen, Lu Zhang, Weijia Gu, Qinghua Sun, Cuiqing Liu
Summary: New evidence suggests that exposure to ambient PM2.5 is associated with metabolic syndrome, with potential impact on the hypothalamic-pituitary-adrenal axis and disruption of circadian rhythms. The study found that PM2.5 exposure significantly affected the expression of clock genes in the hypothalamus and adrenal gland, leading to disturbances in metabolic homeostasis. This research provides insights into the mechanisms through which ambient PM2.5 exposure may contribute to metabolic disorders.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Clinical Neurology
Andrea Carmine Belin, Mads Christian Barloese
Summary: Cluster headache displays unique rhythmic patterns, suggesting a distinct pathophysiology from migraine. The heritability of the disorder is linked to chronobiological systems, while genetic markers of circadian rhythm genes have been implicated in cluster headache.
Article
Physiology
Jingjing Lin, Xinyue Sun, Xiaofeng Dai, Shaoying Zhang, Xueling Zhang, Qiaosong Wang, Qirong Zheng, Minfang Huang, Yuanyuan He, Rongjin Lin
Summary: This study aimed to investigate the effects of circadian rhythm inversion on proteins, metabolites, and related mechanisms in the hypothalamus of pregnant rats during the whole pregnancy cycle. The results showed that circadian rhythm inversion can affect the number and average weight of offspring in pregnant rats and lead to significant changes in the expression of proteins and metabolites. The integrated analysis between proteins and metabolites found that certain key proteins were closely associated with carbon metabolism and glycerophospholipid metabolism, while differential metabolites were enriched in ATP-binding cassette transporters.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
K. Palus-Chramiec, A. M. Sanetra, M. H. Lewandowski
Summary: This study investigated the effects of time-of-day and high-fat diet on the neuronal networks and sensitivity to metabolic information in the hypothalamus. The results showed that even a short period of high-fat diet consumption can disrupt the neuronal network and alter the sensitivity to incoming information. Prolonged high-fat diet consumption increased the responsiveness to metabolic cues.
Article
Anatomy & Morphology
Rong-Jun Ni, Yu-Mian Shu, Peng-Hao Luo, Jiang-Ning Zhou
Summary: The study reveals that the suprachiasmatic nucleus in tree shrews has distinct neuroanatomical characteristics from rostral to caudal, and it receives inputs from various brain regions, providing further insights into the neural organization and physiological processes of circadian rhythms.
Review
Neurosciences
Nikolas Bergum, Casey-Tyler Berezin, Jozsef Vigh
Summary: Chronic opioid use is associated with sleep disturbances, but the mechanism is unclear. Animal studies suggest that opioids disrupt the circadian rhythms by affecting retinal cells responsible for light detection. Therefore, ipRGCs may be a potential therapeutic target for opioid-related sleep problems.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Behavioral Sciences
Pawan Kumar Jha, Hanan Bouaouda, Andries Kalsbeek, Etienne Challet
Summary: The master clock in the SCN uses environmental light to synchronize circadian rhythms, while behavioral arousal disrupts the circadian system and alters molecular functions of pacemaker cells, affecting nocturnal and diurnal animals differently. Further research is needed to understand circadian impairments associated with shift work and trans-meridian travel in both nocturnal and diurnal animal models.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Tomoko Yamagata, Martin C. Kahn, Jose Prius-Mengual, Elise Meijer, Merima Sabanovic, Mathilde C. C. Guillaumin, Vincent van der Vinne, Yi-Ge Huang, Laura E. McKillop, Aarti Jagannath, Stuart N. Peirson, Edward O. Mann, Russell G. Foster, Vladyslav V. Vyazovskiy
Summary: The inhibitory neurons in the lateral preoptic area (LPO) of the hypothalamus play a role in regulating arousal levels, impacting both the quality of sleep and the accumulation of sleep pressure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Fuyuki Asano, Staci J. Kim, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Nodoka Asama, Kanako Iwasaki, Miyo Kakizaki, Seiya Mizuno, Michihiro Mieda, Fumihiro Sugiyama, Satoru Takahashi, Shoi Shi, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa
Summary: Deficiency of SIK3 in GABAergic neurons or NMS-producing neurons delays the arousal peak phase, while a gain-of-function mutant allele of Sik3 in GABAergic neurons advances the activity onset. Furthermore, HDAC4 deficiency shortens the circadian cycle.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Marlene Cervantes, Robert G. Lewis, Maria Agnese Della-Fazia, Emiliana Borrelli, Paolo Sassone-Corsi
Summary: The circadian clock and metabolism are closely linked, relying on interactions between organ systems for proper timing. Substance use disrupts communication between organs and alters rhythmic activities. This study finds that alterations in dopamine signaling in the brain can affect circadian metabolism in peripheral organs. Drugs like cocaine that increase dopamine levels disrupt circadian metabolic profiles in the liver, especially when dopamine D2 receptors are lost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Calvin V. Lieu, Neruja Loganathan, Denise D. Belsham
Summary: The hypothalamus plays a crucial role in maintaining body homeostasis by integrating various signals, including hormones, nutrients, and signaling molecules. Distinct neuronal subpopulations in the hypothalamus regulate functions such as energy balance, reproduction, and circadian rhythms. Changes at the hypothalamic level caused by factors like excessive saturated fatty acid consumption can lead to metabolic diseases, and microRNAs are emerging as potential tools in diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Mitsuhiro Yoshimura, Becky Conway-Campbell, Yoichi Ueta
Summary: Arginine vasopressin (AVP) has attracted attention for its central and peripheral functions, particularly in controlling feeding behavior and energy balance. It has become a promising target for treating obesity and related metabolic disorders, though the underlying mechanisms for AVP regulation of these central processes remain largely unknown.
Article
Biochemistry & Molecular Biology
Aissatou Bailo Diallo, Soraya Mezouar, Asma Boumaza, Oksana Fiammingo, Benjamin Coiffard, Pierre Pontarotti, Benoit Desnues, Jean-Louis Mege
Summary: A study has found the expression of circadian rhythm molecular clock genes in Escherichia coli, which could potentially lead to new perspectives in antibacterial treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Victoria A. Acosta-Rodriguez, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi
Summary: Dietary restriction, along with drug interventions targeting nutrient-sensing gene pathways, influences energy intake and circadian rhythms to promote a healthy lifespan and mitigate negative effects of a mismatch between internal and external rhythms on organismal health.
NATURE COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Gabriela M. Bosque Ortiz, Gustavo M. Santana, Marcelo O. Dietrich
Summary: Genomic imprinting affects the behavior of mammalian offspring, with the loss of the paternally inherited gene Magel2 leading to decreased separation-induced vocalizations in mouse pups at a specific age. Additionally, dams show altered behavior towards Magel2 deficient offspring, retrieiving wildtype control pups first and faster, indicating impaired maternal behavior at a certain stage of postnatal development.
GENES BRAIN AND BEHAVIOR
(2022)
Review
Cell Biology
Filipa Rijo-Ferreira, Joseph S. Takahashi
Summary: Many organisms have evolved timekeeping mechanisms to optimize cellular functions and anticipate environmental changes. Recent research has focused on the interactions between hosts and microbes, with a specific emphasis on how circadian clocks modulate these interactions.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Onur Iyilikci, Marcelo R. Zimmer, Marcelo O. Dietrich
Summary: This review discusses the role of neurons regulating energy metabolism in the relationship between infants and mothers during the perinatal period. Specifically, Agrp neurons in the hypothalamus are highlighted for their significant role in energy regulation. The differences in the function of Agrp neurons between neonates and adults are emphasized, with the former motivating offspring to seek proximity to the caregiver and the latter motivating animals to eat.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Martin Wellman, Radek Budin, Barbara Woodside, Alfonso Abizaid
Summary: Lactating rats undergo hormonal and brain signal changes that promote hyperphagia and milk production. This study found that despite lower plasma ghrelin levels, lactating rats have increased sensitivity to ghrelin's orexigenic effects, which is associated with lactational hyperphagia.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Editorial Material
Neurosciences
Onur Iyilikci, Marcelo O. Dietrich
Summary: This research demonstrates that nest building in pregnant females relies on the activity of peptidergic neurons in the Edinger-Westphal nucleus.
Article
Multidisciplinary Sciences
Victoria Acosta-Rodriguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Mary Wight-Carter, Carla B. Green, Joseph S. Takahashi
Summary: Research shows that the interval of fasting and circadian alignment of feeding are important factors in extending lifespan under CR; nighttime CR can alleviate inflammation and metabolic pathway damage caused by aging; circadian interventions promote longevity.
Review
Biochemistry & Molecular Biology
Emil Sjulstok Rasmussen, Joseph S. Takahashi, Carla B. Green
Summary: The circadian clock is an intracellular timekeeping device that regulates daily rhythms in the body through a core transcription/translation negative feedback loop and additional interlocking feedback loops. Pharmacological manipulation of the clock may be beneficial for treating various diseases such as jet lag, shift work and sleep disorders, metabolic diseases, and cancer.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bernardo Stutz, Michael J. Waterson, Matija Sestan-Pesa, Marcelo O. Dietrich, Mario Skarica, Nenad Sestan, Bence Racz, Aletta Magyar, Peter Sotonyi, Zhong-Wu Liu, Xiao-Bing Gao, Ferenc Matyas, Milan Stoiljkovic, Tamas L. Horvath
Summary: This study reveals the important role of hypothalamic AgRP neurons in the control of neuronal pathways that regulate higher-order brain functions during development and adulthood. Impairment or inhibition of AgRP neurons leads to changes in the medial prefrontal cortex, affecting network activity, sensorimotor gating, and ambulatory behavior. These effects are transduced via dopaminergic neurons and may also involve medial thalamic neurons.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Pin Xu, Kazuhiro Shimomura, Changhoon Lee, Xiaofei Gao, Eleanor H. Simpson, Guocun Huang, Chryshanthi M. Joseph, Vivek Kumar, Woo-Ping Ge, Karen S. Pawlowski, Mitchell D. Frye, Said Kourrich, Eric R. Kandel, Joseph S. Takahashi
Summary: Through in vivo mutagenesis screening, researchers identified a mutation in the Kcnc3 gene that leads to spatial learning deficits. Further investigation revealed that this mutation results in the loss of function in voltage-gated potassium channels, affecting conductance.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Ayeila Z. B. Daneshmend, Jayme Stewart, Dana A. Jarkas, Sabina Franklyn, Robert L. Gabrys, Zachary R. Patterson, Alfonso Abizaid, Kim G. C. Hellemans, Robyn J. McQuaid
Summary: Cannabis use is associated with suicidal ideation and suicide attempts among university students, with trait impulsiveness mediating this relationship and previous trauma experiences moderating the association.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Shuzhang Yang, Shin Yamazaki, Kimberly H. Cox, Yi-Lin Huang, Evan W. Miller, Joseph S. Takahashi
Summary: This study reports the discovery of temperature-sensitive ultradian rhythms in mammalian fibroblasts, which are independent of the cell cycle and circadian clock. These ultradian rhythms are synchronized through cellular coupling and metabolic feedback mechanisms, and play a role in balancing energy demands in cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Peter Sguigna, Sabeen Toranian, Lauren M. Tardo, Kyle M. Blackburn, Lindsay A. Horton, Darrel Conger, Ethan Meltzer, R. Nick Hogan, Morgan C. McCreary, Phyllis C. Zee, Joseph S. Takahashi, Benjamin M. Greenberg
Summary: This study investigated the prevalence and causes of excessive daytime sleepiness (EDS) in multiple sclerosis (MS) patients. After excluding patients with sleep disorders, it was found that EDS was not associated with age, sex, disease severity, or optic nerve damage, but was associated with visual dysfunction.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Veterinary Sciences
Ikuo Miura, Yoshiaki Kikkawa, Shumpei P. Yasuda, Akiko Shinogi, Daiki Usuda, Vivek Kumar, Joseph S. Takahashi, Masaru Tamura, Hiroshi Masuya, Shigeharu Wakana
Summary: The study investigated single nucleotide polymorphisms (SNPs) available for genetic mapping in substrains of C57BL/6 and BALB/c mice, providing important insights and methods for genetic mapping.
EXPERIMENTAL ANIMALS
(2022)
Meeting Abstract
Geriatrics & Gerontology
Victoria Acosta-Rodriguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Carla Green, Joseph Takahashi
INNOVATION IN AGING
(2021)
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)