Article
Oncology
Noritaka Komune, Ryosuke Kuga, Takahiro Hongo, Daisuke Kuga, Kuniaki Sato, Takashi Nakagawa
Summary: This study retrospectively reviewed 40 surgical cases of en bloc temporal bone resection for external auditory canal squamous cell carcinoma (EAC-SCC). The results showed that positive-margin resection was observed in 22.5% of cases and was associated with poor prognosis and increased risk of postoperative recurrence. Therefore, additional treatment measures should be considered for EAC-SCC patients with positive-margin resection to reduce the risk of recurrence.
Article
Otorhinolaryngology
Bingbin Xie, Meiqun Wang, Shaorong Zhang, Yuehui Liu
Summary: This study investigates optimal approaches for appropriate removal of the parotid gland in the management of squamous cell carcinoma (SCC) of the external auditory canal. The study found that total parotidectomy should be mandatory for all advanced-staged patients, while management decisions for early stages depend on the infiltration or erosion of the anterior wall of the EAC.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Medicine, General & Internal
Naoto Osu, Atsushi Musha, Hikaru Yumisaki, Kohei Okada, Nobuteru Kubo, Naoko Okano, Yukihiko Takayasu, Masato Shino, Osamu Nikkuni, Shota Ida, Hidemasa Kawamura, Kazuaki Chikamatsu, Tatsuya Ohno
Summary: This study suggests that radiotherapy is effective for T1-3 EAC squamous cell carcinoma, while chemoradiotherapy can be an alternative treatment for T1-3 cases. However, the efficacy of chemoradiotherapy is inadequate for T4 cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Diego Cazzador, Leonardo Franz, Giulia Tealdo, Andrea Luigi Camillo Carobbio, Maria Ferraro, Antonio Mazzoni, Gino Marioni, Elisabetta Zanoletti
Summary: This study conducted a systematic review of SCC of the EAC literature and identified risk factors for OS and DSS. The study found that locally advanced tumors were associated with poor prognosis, with a high rate of local recurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Noritaka Komune, Daisuke Kuga, Koichi Miki, Takashi Nakagawa
Summary: Surgical patterns for advanced squamous cell carcinoma of the external auditory canal involve four categories, with extended LTBR offering versatility based on tumor extension. En bloc resection increases technical difficulty due to limited exposure of the petrous segment of the internal carotid artery. Accurate preoperative evaluation and consideration are crucial for achieving negative margin resection.
Article
Medicine, Research & Experimental
Omer J. Ungar, Felipe Santos, Joseph B. Nadol, Gilad Horowitz, Dan M. Fliss, William C. Faquin, Ophir Handzel
Summary: The study described the invasion patterns of advanced-stage external auditory canal squamous cell carcinoma, finding that tumors tend to spread along preexisting TB air-tract routes and well-aerated TB may facilitate extension to the petrous apex.
Article
Medicine, Research & Experimental
Kiyoto Shiga, Ken-ichi Nibu, Yasushi Fujimoto, Takahiro Asakage, Akihiro Homma, Hiroki Mitani, Takenori Ogawa, Kenji Okami, Shigeyuki Murono, Shigeru Hirano, Tsutomu Ueda, Nobuhiro Hanai, Kiyoaki Tsukahara, Ichiro Ota, Seiichi Yoshimoto, Takeshi Shinozaki, Shigemichi Iwae, Katsunori Katagiri, Daisuke Saito, Naomi Kiyota, Makoto Tahara, Fumiaki Takahashi, Ryuichi Hayashi
Summary: This study retrospectively analyzed the outcomes of 181 patients with advanced cancer of the external auditory canal who underwent chemoradiotherapy, with a focus on 74 patients who showed a 5-year survival rate of 54.6%. Results indicate favorable clinical outcomes for chemoradiotherapy in advanced EAC cancer, especially with the modified TPF regimen.
Article
Otorhinolaryngology
Jae Won Chang, Seulgi Lee, Jeon Mi Lee, In Seok Moon, Young-Sang Cho, Yang-Sun Cho, Jin Woong Choi
Summary: In patients with early-stage squamous cell carcinoma of the external auditory canal, tumors located in the anterior wall and cartilaginous portion show a higher rate of occult parotid involvement, suggesting the need for elective parotidectomy in these cases.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Rocio Garcia-Marin, Virginia N. Cabal, Carmen Fernandez-Cedron Bermejo, Cristina Riobello, Laura Suarez-Fernandez, Helena Codina-Martinez, Ainhoa Navarro-Garcia, Sara Lucila Lorenzo-Guerra, Jorge Garcia-Martinez, Blanca Vivanco, Fernando Lopez, Jose Luis Llorente, Mario A. Hermsen
Summary: This study reports a stable cell line CAE606 derived from a squamous cell carcinoma of the external auditory canal, which has specific genetic features and can be used for preclinical testing of new therapeutic agents for EAC SCC.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Gregory J. Basura, Joshua D. Smith, Susan Ellsperman, Apurva Bhangale, John Chad Brenner
Summary: Squamous cell carcinomas (SCC) of the external auditory canal (EAC) may have unique genomic alterations that explain their aggressive behavior and differentiate them from cutaneous SCCs of other sites. Recurrent alterations in TP53, EGFR, FGFR, PIK3CA, telomerase reverse transcriptase amplification, and DNA methyltransferase 1 were found in primary EAC SCCs, suggesting potential targets for precision medicine approaches.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2021)
Review
Oncology
Shixun Zhong, Wenqi Zuo
Summary: Malignant tumors of the external auditory canal are rare and challenging to diagnose and treat due to their rarity and the complex anatomy of the temporal bone.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Shih-Lung Chen, Chi-Ju Yeh, Kai-Chieh Chan
Summary: SDC is a rare aggressive tumor that often invades major and minor salivary glands. The first report of SDC in the EAC highlights the importance of careful evaluation of subcutaneous lesions in the EAC to avoid misdiagnosis.
Article
Oncology
Shinya Morita, Satoshi Kano, Kanako C. Hatanaka, Yutaka Hatanaka, Takayoshi Suzuki, Atsushi Fukuda, Kimiko Hoshino, Keishi Fujiwara, Yuji Nakamaru, Akihiro Homma
Summary: This study suggested that TP53 mutations have potential as a biomarker for identifying individuals at high risk of developing tumors and predicting survival outcome in EACSCC. IHC staining for p53 may serve as a useful screening tool for detecting TP53 mutations in patients with EACSCC.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Dong You, Zhao Ma, Jing Liu, Xiao Song, Wei Dong
Summary: MES in the external auditory canal is a rare sweat gland tumor, with only a few cases reported to date.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Isabelle J. H. Jang, Jiun Fong Thong, Constance E. H. Teo, Kiattisa Sommat
Summary: This study investigated the prognostic factors and treatment outcomes in patients with external auditory canal squamous cell carcinoma (EAC SCC). The results showed that previous radiotherapy, facial nerve palsy, and posterior pattern of disease invasion were independent prognostic factors for poorer survival in patients with EAC SCC.