Article
Microbiology
Kavinda Tissera, Myeong-A Kim, Jing Lai, Sacheera Angulmaduwa, Aeryun Kim, D. Scott Merrell, Ji-Hye Kim, Hanfu Su, Jeong-Heon Cha
Summary: The CagA protein of H. pylori shows geographic-dependent variation in EPIYA motifs, with East-Asian isolates carrying ABD type and Western isolates carrying ABC type. Some Western isolates exhibit multi-copy EPIYA-C motifs which are associated with disease severity. In a study of Korean clinical isolates, some East-Asian isolates were found to carry Western ABC-type CagA, indicating possible intraspecies diversity in East-Asian H. pylori.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Yuanhai You, Kaisa Thorell, Lihua He, Koji Yahara, Yoshio Yamaoka, Jeong-Heon Cha, Kazunari Murakami, Yukako Katsura, Ichizo Kobayashi, Daniel Falush, Jianzhong Zhang
Summary: The East Asian region, including China, Japan and Korea, has high gastric cancer death rates. The population structure of Helicobacter pylori in this region is unknown. This study analyzed H. pylori genomes from different areas in these countries and discovered genetic differences associated with gastric cancer risk. These findings have important implications for understanding the variation in gastric cancer incidence between geographical areas in East Asia.
MICROBIAL GENOMICS
(2022)
Article
Food Science & Technology
Aina Ichihara, Hinako Ojima, Kazuyoshi Gotoh, Osamu Matsushita, Susumu Take, Hiroyuki Okada, Akari Watanabe, Kenji Yokota
Summary: This study aimed to explore the association between different antibody reactivities and bacterial genome organization. High-reactive strains showed high gene homology, while inversion around the vacA gene was found in the genome of poorly responsive antigen strains.
Article
Public, Environmental & Occupational Health
Saori Horiuchi, Ryuichi Nakano, Akiyo Nakano, Naokuni Hishiya, Kenji Uno, Yuki Suzuki, Naoki Kakuta, Risako Kakuta, Kohsuke Tsubaki, Noriko Jojima, Hisakazu Yano
Summary: The study revealed low prevalence of H. pylori and cagA-positive strains among residents, with a potential correlation between contact with dogs and glmM gene positivity. Further investigation targeting community-dwelling healthy people and their living environments is required for H. pylori infection control.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Miftahussurur, Ricky Indra Alfaray, Kartika Afrida Fauzia, Astri Dewayani, Dalla Doohan, Langgeng Agung Waskito, Yudith Annisa Ayu Rezkitha, Didik Huswo Utomo, Gde Somayana, Ari Fahrial Syam, Masrul Lubis, Junko Akada, Takashi Matsumoto, Yoshio Yamaoka
Summary: In this study, the expression of genes encoding proinflammatory cytokines in gastric biopsy specimens was analyzed to understand the low incidence of intestinal metaplasia in Indonesia. The characteristics of East-Asian-type CagA in Indonesia were also investigated. The findings suggest that both the low inflammatory response of the host and the lower virulence of CagA play a role in the low incidence of intestinal metaplasia in Indonesia.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Infectious Diseases
Tomomi Kobatake, Keiki Ogino, Hiroyuki Sakae, Kazuyoshi Gotoh, Akari Watanabe, Osamu Matsushita, Hiroyuki Okada, Kenji Yokota
Summary: The study found that disulfiram has bactericidal effects on Helicobacter pylori at low concentrations, suggesting it can serve as a supplement to current H. pylori eradication drugs.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Medicine, General & Internal
Soichiro Abiko, Yoji Hirayama, Junji Otaki, Yoshimi Harada, Kohei Kawakami, Takahiro Toi, Tomoko Takamiya, Takashi Kawai
Summary: This study aimed to understand the recent prevalence and time trends of Helicobacter pylori infection rates in the Japanese population. The results showed a consistent decline in infection rates among 35-year-old male and female Japanese workers over the past 11 years, with joinpoints observed around the age of 50, suggesting a sustained decreasing trend in H. pylori infection rates in Japan.
Article
Surgery
Dudaka Anusha, Amaranathan Anandhi, Subair Mohsina, Gubbi Shamanna Sreenath, Jharna Mandal, Vikram Kate
Summary: This study found no direct association between Helicobacter pylori infection and colorectal cancer, but noted a correlation between CagA strains and well-differentiated adenocarcinoma in Helicobacter pylori-infected patients.
INDIAN JOURNAL OF SURGERY
(2022)
Article
Medicine, Research & Experimental
Zong-Bao Yan, Jin-Yu Zhang, Yi-Pin Lv, Wen-Qing Tian, Zhi-Guo Shan, Fang-Yuan Mao, Yu-Gang Liu, Wan-Yan Chen, Pan Wang, Yun Yang, Ping Cheng, Liu-Sheng Peng, Ya-Ling Liao, Geng-Yu Yue, Xiao-Lin Xu, Yong-Liang Zhao, Mu-Han Lu, Yuan Zhuang
Summary: The study found that REDD1 is increased in the gastric mucosa of H. pylori-infected patients and mice. H. pylori induced GECs to express REDD1 via the phosphorylated cagA, activating the MAPKp38 pathway. In Redd1-/- mice, gastric inflammation, MHCII+ monocyte infiltration, IL-23, and IL-17A were all attenuated.
Article
Endocrinology & Metabolism
Jun Xie, Jinyun Wang, Rong Zeng, Yong Xie
Summary: The available evidence regarding the relationship between lipid profile and Helicobacter pylori infection is limited and conflicting. A cross-sectional study using NHANES data found that there is a positive association between H. pylori seropositivity and triglyceride levels, especially in females.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Sebastian Diechler, Bianca E. Chichirau, Gernot Posselt, Dionyssios N. Sgouras, Silja Wessler
Summary: Research has shown that the diverse structure of CagA regulates B cell physiology, while B cell survival is independent of CagA.
Article
Gastroenterology & Hepatology
Sungil Jang, Lori M. Hansen, Hanfu Su, Jay Solnick, Jeong-Heon Cha
Summary: This study found that the number of cagA copies in Helicobacter pylori is higher in mice with less intense immune response and lower in mice with more intense immune response. Additionally, cagY recombination is also associated with H. pylori virulence.
Article
Geriatrics & Gerontology
Yifan Shan, Wenjing Zhao, Wen Hao, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi
Summary: Engaging in social-related, learning, and personal activities at increased or continued regular frequency was found to be associated with lower likelihood of developing depressive symptoms. Participation in personal activities at increased or continued regular frequency was also linked to lower likelihood of persistent depressive symptoms for those with depressive symptoms at baseline. Regularly engaging in a combination of these activities was inversely associated with the occurrence and persistence of depressive symptoms.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Oncology
Yasush Adachi, Masanori Nojima, Mitsuru Mori, Toshiyuki Kubo, Noriyuki Akutsu, Yasushi Sasaki, Hiroshi Nakase, Yingsong Lin, Youichi Kurozawa, Kenji Wakai, Akiko Tamakoshi
Summary: This study analyzed the association between serum sFas levels and the incidence of liver cancer. The results showed that high levels of sFas were associated with an increased risk of liver cancer. These findings suggest that sFas may serve as a biomarker for assessing liver cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Peripheral Vascular Disease
Kaori Kitaoka, Katsuyuki Miura, Naoyuki Takashima, Aya Kadota, Akiko Harada, Yasuyuki Nakamura, Yoshikuni Kita, Yuichiro Yano, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Yoko Kubo, Sadao Suzuki, Takeshi Nishiyama, Shiroh Tanoue, Chihaya Koriyama, Kiyonori Kuriki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Yuichiro Nishida, Chisato Shimanoe, Etsuko Ozaki, Daisuke Matsui, Hiroaki Ikezaki, Jun Otonari, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Kenji Wakai, Keitaro Matsuo
Summary: This study investigated the association between dietary patterns and serum LDL cholesterol in a large population in Japan. The results showed that certain recent dietary patterns were associated with serum LDL cholesterol levels.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Public, Environmental & Occupational Health
Mako Nagayoshi, Asahi Hishida, Tomonori Shimizu, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Jun Otonari, Hiroaki Ikezaki, Megumi Hara, Yuichiro Nishida, Isao Oze, Yuriko N. Koyanagi, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Sakurako Katsuura-Kamanos, Kokichi Arisawa, Masahiro Nakatochi, Yukihide Momozawa, Kenji Takeuchi, Kenji Wakai, J-MICC Study group
Summary: This study found that higher BMI in the Japanese population is causally associated with various cardiometabolic traits including high blood pressure, triglycerides, uric acid, low high-density-lipoprotein cholesterol, and eGFR. However, there was no significant association between genetic risk scores for BMI and individual-level cardiometabolic traits.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Takeshi Watanabe, Kokichi Arisawa, Tien Van Nguyen, Masashi Ishizu, Sakurako Katsuura-Kamano, Asahi Hishida, Takashi Tamura, Yasufumi Kato, Rieko Okada, Rie Ibusuki, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kenji Wakai, Keitaro Matsuo
Summary: This cross-sectional study investigated the relationship between coffee consumption and metabolic phenotypes, and found that high coffee consumption was associated with a lower prevalence of metabolically unhealthy phenotypes in both normal weight and obese individuals. Specifically, filtered/instant coffee consumption showed an inverse association with the prevalence of metabolically unhealthy phenotypes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, Ippei Shimoshikiryo, Daisaku Nishimoto, Keiichi Shimatani, Toshiro Takezaki, Hiroaki Ikezaki, Masayuki Murata, Megumi Hara, Yuichiro Nishida, Takashi Tamura, Asahi Hishida, Mako Nagayoshi, Rieko Okada, Keitaro Matsuo, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Takahiro Otani, Sadao Suzuki, Teruhide Koyama, Etsuko Ozaki, Kiyonori Kuriki, Naoyuki Takashima, Naoko Miyagawa, Kokichi Arisawa, Sakurako Katsuura-Kamano, Yukihide Momozawa, Michiaki Kubo, Kenji Takeuchi, Kenji Wakai
Summary: The study evaluated the population-based impact of smoking, drinking, and genetic factors on low HDL-C levels using data from the J-MICC Study. The findings showed that smoking, drinking, and certain genetic variants were associated with HDL-C levels, but there was no significant gene-environment interaction. The population-based impact of the genetic factor CETP rs3764261 was higher than that of smoking and lower than that of drinking.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Chisato Shimanoe, Kayoko Koga, Takuma Furukawa, Yasuki Higaki, Koichi Shinchi, Hiroaki Ikezaki, Masayuki Murata, Kenji Takeuchi, Takashi Tamura, Asahi Hishida, Mineko Tsukamoto, Yuka Kadomatsu, Keitaro Matsuo, Isao Oze, Haruo Mikami, Miho Kusakabe, Toshiro Takezaki, Rie Ibusuki, Sadao Suzuki, Hiroko Nakagawa-Senda, Daisuke Matsui, Teruhide Koyama, Kiyonori Kuriki, Naoyuki Takashima, Yasuyuki Nakamura, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai
Summary: Insufficient moderate-to-vigorous physical activity and longer sedentary behavior are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD). The study also found that replacing sedentary time with physical activity can benefit kidney function, especially in men.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Mako Nagayoshi, Kenji Takeuchi, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Takashi Tamura, Asahi Hishida, Jun Otonari, Hiroaki Ikezaki, Yuichiro Nishida, Chisato Shimanoe, Yuriko N. Koyanagi, Keitaro Matsuo, Haruo Mikami, Miho Kusakabe, Daisaku Nishimoto, Keiichi Shibuya, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Kokichi Arisawa, Sakurako Katsuura-Kamano, Kenji Wakai
Summary: In Japanese adults, stress-coping strategies are related to all-cause mortality. Three coping strategies (emotional expression, emotional support-seeking, and disengagement) were associated with lower mortality in women. Emotional expression, problem-solving, and positive reappraisal were associated with lower mortality in men, but the relationship depended on the follow-up period. There was evidence of sex differences in the relationship between emotional support-seeking and all-cause mortality.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Takashi Tamura, Kenji Wakai, Yasufumi Kato, Yudai Tamada, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Asahi Hishida, Nahomi Imaeda, Chiho Goto, Hiroaki Ikezaki, Jun Otonari, Megumi Hara, Keitaro Tanaka, Yohko Nakamura, Miho Kusakabe, Rie Ibusuki, Chihaya Koriyama, Isao Oze, Hidemi Ito, Sadao Suzuki, Hiroko Nakagawa-Senda, Etsuko Ozaki, Daisuke Matsui, Kiyonori Kuriki, Keiko Kondo, Naoyuki Takashima, Takeshi Watanabe, Sakurako Katsuura-Kamano, Keitaro Matsuo
Summary: This study aimed to examine the associations between carbohydrate and fat intakes and mortality risk. The results showed that low carbohydrate intake was associated with increased all-cause mortality risk in men, while high carbohydrate intake was associated with increased all-cause mortality risk in women. Additionally, high fat intake was potentially associated with lower mortality risk in women with relatively high carbohydrate intake.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Akiko Hanyuda, Atsushi Goto, Ryoko Katagiri, Yuriko N. Koyanagi, Masahiro Nakatochi, Yoichi Sutoh, Shiori Nakano, Isao Oze, Hidemi Ito, Taiki Yamaji, Norie Sawada, Masao Iwagami, Aya Kadota, Teruhide Koyama, Sakurako Katsuura-Kamano, Hiroaki Ikezaki, Keitaro Tanaka, Toshiro Takezaki, Issei Imoto, Midori Suzuki, Yukihide Momozawa, Kenji Takeuchi, Akira Narita, Atsushi Hozawa, Kengo Kinoshita, Atsushi Shimizu, Kozo Tanno, Keitaro Matsuo, Shoichiro Tsugane, Kenji Wakai, Makoto Sasaki, Masayuki Yamamoto, Motoki Iwasaki
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Yukihiro Sugimoto, Yuriko N. Koyanagi, Yukino Kawakatsu, Isao Oze, Yukari Taniyama, Yumiko Kasugai, Tsutomu Tanaka, Tetsuya Abe, Masahiro Tajika, Yasuhiro Shimizu, Hidemi Ito, Kenji Wakai, Keitaro Matsuo
Summary: Alcohol is metabolized to acetaldehyde and acetate through the actions of alcohol dehydrogenase and aldehyde dehydrogenase. The ADH1B rs1229984 polymorphism is associated with drinking habits and the risk of esophageal cancer. Mediation analysis showed that this genetic variant increases the risk of esophageal cancer by affecting alcohol metabolism and drinking intensity.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)