Article
Cell Biology
Jan Zbinden, Paolo Sassu, Enzo Mastinu, Eric J. Earley, Maria Munoz-Novoa, Rickard Branemark, Max Ortiz-Catalan
Summary: This study demonstrates that by creating electro-neuromuscular constructs using distributed nerve transfers and implanted electrodes, the control capability of limb prostheses can be enhanced. The results show that this method allows for gradual increase in myoelectric signal strength, enabling individuals with above-elbow amputations to control wrist and finger prosthetic joints flexibly. This study is of great significance for improving the functionality of limb prostheses.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Anesthesiology
Elizabeth Roth, Allison Linehan, Dorothee Weihrauch, Cheryl Stucky, Quinn Hogan, Gwendolyn Hoben
Summary: Targeted muscle reinnervation (TMR) is an effective clinical intervention for preventing or reducing amputation-related pain, especially when performed immediately after injury. However, the effectiveness of TMR significantly decreases when applied several weeks after injury. A preclinical model was developed to study the mechanisms of pain relief in TMR of amputated nerves.
Article
Surgery
Norbert Venantius Kang, Alexander Woollard, Dominika Antonina Michno, Yazan Al-Ajam, Jaclyn Tan, Esther Hansen
Summary: It is crucial for surgeons and patients to fully understand the course and outcomes of this novel surgery prior to undertaking treatment.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Neurosciences
Jordan A. Borrell, Arun Karumattu Manattu, Christopher Copeland, Kaitlin Fraser, Andrew D'Ovidio, Zach Granatowicz, Alex C. Lesiak, Sean C. Figy, Jorge M. Zuniga
Summary: Targeted muscle reinnervation (TMR) surgery aims to reduce phantom limb pain by reconnecting amputated nerves to nearby motor nerve branches. This study created a phantom limb therapy protocol for a TMR surgery patient, which resulted in improved cortical efficiency of the sensorimotor network. The findings suggest that phantom limb therapy can accelerate the decoupling process, leading to reduced fatigue and improved limb synchronization for amputees.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Oncology
Thien Huong N. Huynh, Davis R. Kuruvilla, Matthew D. Nester, Guston Zervoudakis, G. Douglas Letson, David M. Joyce, Odion T. Binitie, Alexander L. Lazarides
Summary: This review summarizes current findings on limb amputation in the context of cancer, highlighting improvements in functional outcomes with rotationplasty, osseointegration, targeted muscle reinnervation (TMR), and regenerative peripheral nerve interfaces (RPNI) compared to traditional amputation. Limb-sparing surgeries are the mainstay for musculoskeletal malignancies, but amputation can be useful as a palliative technique or primary treatment for complex cancers. Rotationplasty and osseointegration have been valuable limb-sparing techniques, and TMR and RPNI have shown promise in improving control over myoelectric prostheses for patients requiring amputations.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Health Care Sciences & Services
Martin Aman, Bahram Biglari, Mirjam Thielen, Arne H. Boecker, Annette Stolle, Daniel Schwarz, Emre Gazyakan, Ulrich Kneser, Leila Harhaus
Summary: Complex regional pain syndrome (CRPS) can lead to a devastating condition where some patients may request amputation due to non-response to existing therapies. This article proposes an advanced algorithm for amputation indications in CRPS patients, combining various factors such as psychiatric assessment, diagnostic hybrid prosthetic fitting, and surgical procedures.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Agnes Sturma, Laura A. Hruby, Anna Boesendorfer, Clemens Gstoettner, Dario Farina, Oskar C. Aszmann
Summary: Targeted Muscle Reinnervation (TMR) improves the biological control interface for myoelectric prostheses after above-elbow amputation by surgically re-routing nerves, yielding a high number of independent myoelectric control signals. Selective patient assessment and specific rehabilitation therapy are necessary, both before and after surgery, focusing on muscle functions, pain control, balance, and range of motion.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Engineering, Biomedical
Andrew Sawers, Stefania Fatone
Summary: The purpose of this study was to test whether there were differences in hip strength between the residual and intact limbs of lower limb prosthesis users. The results suggest that the intact limb is weaker compared to the residual limb, which may be due to methodological choices or biomechanical demands on the residual limb hip muscles. Further research is needed to confirm, expand upon, and elucidate the findings, as well as clarify the contributions of intact and residual limb hip muscles to walking and balance in lower limb prosthesis users.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Alexander Gardetto, Eva-Maria Baur, Cosima Prahm, Vinzenz Smekal, Johannes Jeschke, Gerfried Peternell, Michael T. Pedrini, Jonas Kolbenschlag
Summary: Targeted sensory reinnervation (TSR) involves surgical rewiring of sensory nerves to reduce phantom limb pain and restore a more normal body image. When combined with special prosthetic devices, TSR can also improve gait and balance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
Seoyoung Choi, Wonwoo Cho, Keehoon Kim
Summary: Adding a wrist rotation module to prosthetic hand designs for partial hand amputees can restore natural upper limb movement patterns, reduce compensatory movements, and prevent secondary musculoskeletal damage, thereby enhancing overall functionality and quality of life.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Surgery
Hugh M. Herr, Tyler R. Clites, Shriya Srinivasan, Simon G. Talbot, Gregory A. Dumanian, Paul S. Cederna, Matthew J. Carty
Summary: The article proposes an approach to limb amputation based on the availability of native tissues, aiming to maximize function, reduce neuropathic pain, restore perception and proprioception, and mitigate atrophy. It suggests reframing the execution of amputation procedures as a form of limb reconstruction, leveraging both time-tested reconstructive techniques and cutting-edge surgical procedures.
Article
Surgery
Ian L. Valerio, Michael Larsen, Kyle R. Eberlin
Summary: Targeted muscle reinnervation is a modern technique that can reduce neuropathic pain in amputees, and utilizing spare parts reconstruction can address limitations in certain amputations. The combination of spare parts reconstruction and targeted muscle reinnervation may lead to fewer occurrences of neuroma and phantom limb pain.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Critical Care Medicine
Major Kirstie E. Forbes, Will Cobb, Major Johann Jeevaratnam, Ian King, Tania Cubison
Summary: This retrospective study investigated the impact of pathology and reason for revision surgery on surgical and rehabilitation outcomes for patients undergoing stump revision. Good outcomes were associated with defined anatomical abnormalities such as bone pathology or neuromas, while revisions for soft tissue pathology had poorer results. Careful patient selection and consideration of surgical techniques are crucial for successful revision amputation surgery.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Orthopedics
Konstantin D. Bergmeister, Stefan Salminger, Oskar C. Aszmann
Summary: TMR surgery has advanced prosthetic control by increasing control signals and treating neuromas simultaneously. Patient selection is crucial for success, as the procedure has a high success rate and can lead to significant improvement in control post-rehabilitation.
Article
Biophysics
David P. Henson, Caitlin Edgar, Ziyun Ding, Biranavan Sivapuratharasu, Peter Le Feuvre, Mary E. Finnegan, Rebecca Quest, Alison H. McGregor, Anthony M. J. Bull
Summary: This study aimed to quantify muscle parameters of individuals with limb loss using high resolution MRI and compare them to matched control subjects. The results show that unilateral amputees experience muscle volume loss in the residual limb with compensation dominated by the intact limb, while bilateral amputees exhibit significant volume increases or decreases in specific muscles.
JOURNAL OF BIOMECHANICS
(2021)
Article
Engineering, Biomedical
Lauren H. Smith, Todd A. Kuiken, Levi J. Hargrove
JOURNAL OF NEURAL ENGINEERING
(2015)
Article
Engineering, Biomedical
Lauren H. Smith, Todd A. Kuiken, Levi J. Hargrove
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2016)
Article
Engineering, Biomedical
Lauren H. Smith, Todd A. Kuiken, Levi J. Hargrove
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2016)
Article
Engineering, Biomedical
Rebecca A. Bercich, Zhi Wang, Henry Mei, Lauren H. Hammer, Kevin L. Seburn, Levi J. Hargrove, Pedro P. Irazoqui
JOURNAL OF NEURAL ENGINEERING
(2016)
Article
Engineering, Biomedical
Aaron J. Young, Lauren H. Smith, Elliott J. Rouse, Levi J. Hargrove
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2013)
Article
Engineering, Biomedical
Yao Li, Lauren H. Smith, Levi J. Hargrove, Douglas J. Weber, Gerald E. Loeb
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2013)
Article
Engineering, Biomedical
Dennis C. Tkach, Aaron J. Young, Lauren H. Smith, Elliott J. Rouse, Levi J. Hargrove
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2014)
Article
Engineering, Biomedical
Lauren H. Smith, Todd A. Kuiken, Levi J. Hargrove
JOURNAL OF NEURAL ENGINEERING
(2014)
Article
Engineering, Biomedical
Aaron J. Young, Lauren H. Smith, Elliott J. Rouse, Levi J. Hargrove
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2014)
Article
Neurosciences
Daniel D. Cummins, Ryan B. Kochanski, Roee Gilron, Nicole C. Swann, Simon Little, Lauren H. Hammer, Philip A. Starr
Summary: This study compared the sensing capabilities of the first-generation Medtronic PC + S and second-generation Percept PC neurostimulators in a single patient with Parkinson's disease. The results showed that the Percept PC had improved ability to sense local field potential signals during active stimulation compared to the PC + S, which was limited by artifact interference. The advancement in implantable neurostimulator technology between the first and second generation devices demonstrates the potential for further exploration into the neurophysiology of movement disorders and the clinical implementation of adaptive algorithms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Lauren H. Hammer, Ryan B. Kochanski, Philip A. Starr, Simon Little
Summary: This study provides a detailed description of the signal recording properties of the Medtronic Percept device in real-world settings and evaluates the impact of different artifacts on neural signal spectral properties using offline artifact removal techniques. The results demonstrate that template subtraction can successfully remove multiple artifacts, but the presence of unrejected artifacts may affect online power estimates and potentially impact the performance of adaptive DBS algorithms.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2022)
Proceedings Paper
Engineering, Biomedical
Lauren H. Smith, Todd A. Kuiken, Levi J. Hargrove
2015 7TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2015)
Proceedings Paper
Engineering, Biomedical
Lauren H. Smith, Todd A. Kuiken, Levi J. Hargrove
2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2015)
Proceedings Paper
Engineering, Biomedical
Kimberly A. Ingraham, Lauren H. Smith, Ann M. Simon, Levi J. Hargrove
2015 37TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2015)
