Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Huan-Yu Gong, Peng-Cheng Zhou, Hao-Ye Zhang, Li-Min Chen, Yang-Mei Zhou, Zhen-Guo Liu
Summary: A regulatory protein called GLIS2 is significantly reduced in fibrotic liver tissues compared to healthy tissues. Decreased levels of GLIS2 result in a transformation of hepatic stellate cells and lead to the development of fibrosis. Boosting GLIS2 activity could prevent fibrosis by maintaining hepatic stellate cells in a less active state.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Beatriz Ballester, Javier Milara, Paula Montero, Julio Cortijo
Summary: The study reveals the overexpression of MUC16 in lung tissue of IPF patients and its collaboration with the TGF-beta 1 pathway to induce fibrotic processes. Repression of MUC16 expression can inhibit fibrotic processes, suggesting that targeting MUC16 may be a potential drug target for human IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation is a common clinically significant arrhythmia with four fundamental pathophysiological mechanisms, with TGF-beta playing a key role. Studies have shown that TGF-beta 1 is involved in the development and propagation of atrial fibrillation.
Article
Gastroenterology & Hepatology
Ming-Yu Zhou, Ming-Liang Cheng, Tao Huang, Rui-Han Hu, Gao-Liang Zou, Hong Li, Bao-Fang Zhang, Juan-Juan Zhu, Yong-Mei Liu, Yang Liu, Xue-Ke Zhao
Summary: The study found that TGF-beta 1 induces GLUT1 expression in HSCs and is involved in the development of liver fibrosis. Experimental results showed that GLUT1 inhibition can reduce the degree of liver fibrosis. The mechanisms of action of GLUT1, TGF-beta 1, and aerobic glycolysis in the process of HSC activation during liver fibrosis were explored through various experimental approaches.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Laura J. Kitto, Neil C. Henderson
Summary: Mesenchymal cells play a key role during liver regeneration, with recent single-cell genomics approaches revealing spatial and functional zonation of the hepatic mesenchyme in homeostasis and following liver injury. The use of preclinical models helps to precisely identify highly targeted, pro-regenerative therapies for patients with liver disease.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Cell Biology
Parth Trivedi, Shuang Wang, Scott L. Friedman
Summary: Hepatic stellate cells play a crucial role in regulating physiological and pathological responses in the liver, particularly in chronic liver injury. They drive hepatic fibrosis and are involved in inflammation and cancer by adapting metabolic pathways to meet increased energy demands.
Article
Immunology
Ruoyu Wang, Dong Zhang, Dan Tang, Kewei Sun, Jianping Peng, Wenfang Zhu, Sihan Yin, Yunan Wu
Summary: Amygdalin effectively suppressed the activation of hepatic stellate cells induced by TGF-beta 1 by modulating proliferation, fibrogenesis, and inflammation signaling pathways in vitro, leading to improvement in liver fibrosis and damage in a CCl4-stimulated rat model in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Florian P. Reiter, Liangtao Ye, Andrea Ofner, Tobias S. Schiergens, Andreas Ziesch, Lydia Brandl, Najib Ben Khaled, Simon Hohenester, Ralf Wimmer, Renate Artmann, Yulong He, Serene M. L. Lee, Doris Mayr, Changhua Zhang, Alexander L. Gerbes, Julia Mayerle, Gerald Denk, Enrico N. De Toni
Summary: The study identified p70S6K as a checkpoint of fibrogenesis in vitro and in vivo, suggesting that it could be a potential target for the treatment of liver fibrosis. Furthermore, the pharmacological inhibition of p70S6K by CEP-1347 showed promising results in reducing fibrosis development in mice models.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mengchao Yan, Ye Xie, Jia Yao, Xun Li
Summary: This study investigates the correlation between alpha-SMA expression and collagen secretion in liver fibrosis, proposing a dual-mode transition model for myofibroblasts in fibrotic liver. The model reasonably explains collagen deposition and expansion in the initial stage of liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Wei Liang, Yingnan Zhang, Liang Zhou, Xiaoqin Lu, Margaret E. Finn, Wei Wang, Hui Shao, Douglas C. Dean, Lijun Zhang, Yongqing Liu
Summary: The study found that Zeb1 forms a positive regulatory loop with Tgfb to regulate early corneal inflammation by controlling immune cell viability and mobility, and later promotes corneal wound healing through activation of various signaling pathways.
Article
Chemistry, Medicinal
Yuecheng Jiang, Xin Lin, Yan Mao, Jianqiu Zhao, Guihua Zhang, Jiali Yu, Rong Dong, Yan Zha
Summary: The study found that acteoside (ACT) can inhibit renal fibrosis in unilateral ureteral obstruction (UUO) rats, probably by inhibiting the beta-catenin/CTGF signaling pathway.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Agriculture, Dairy & Animal Science
T. Xing, Z. R. Zhao, X. Zhao, X. L. Xu, L. Zhang, F. Gao
Summary: Wooden breast myopathy in broiler chickens induces severe fibrosis in the pectoralis major muscle by enhancing extracellular matrix deposition, collagen cross-linking, and dysregulating TGF-beta signaling and the MMP and TIMP system.