Article
Immunology
Masaya Yokoyama, Motoko Y. Kimura, Toshihiro Ito, Koji Hayashizaki, Yukihiro Endo, Yangsong Wang, Ryoji Yagi, Tomoo Nakagawa, Naoya Kato, Hisahiro Matsubara, Toshinori Nakayama
Summary: This study found that Myl9/12 were highly expressed in patients with inflammatory bowel disease and mice with DSS-induced colitis. Administration of anti-Myl9/12 Ab alleviated inflammation and prolonged survival, indicating Myl9/12 may be a new therapeutic target for patients with IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Gavin W. Sewell, Arthur Kaser
Summary: The cytokine interleukin-23 (IL-23), mainly produced by macrophages and dendritic cells in response to microbial stimulation, plays a critical role in chronic intestinal inflammation. IL-23 has been found to be associated with disease protection through genetic variations, and therapeutic targeting of the shared p40 subunit of IL-12/IL-23 has shown success in treating inflammatory bowel disease (IBD). Recent phase 2 studies have shown promise in targeting the specific p19 subunit of IL-23. However, the exact pathways downstream of IL-23 in mucosal inflammation in the gut are still debated.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Immunology
Jonathan W. Wallace, David A. Constant, Timothy J. Nice
Summary: IFN-lambda plays a complex and diverse role in IBD, promoting colonic epithelial tissue healing while potentially exacerbating small intestinal epithelial cell death. Additionally, IFN-lambda acts through non-epithelial cell types to protect against excessive inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
John P. Thomas, Dezso Modos, Simon M. Rushbrook, Nick Powell, Tamas Korcsmaros
Summary: This review examines the interaction between bile acid metabolites and intestinal inflammation in inflammatory bowel disease (IBD), highlighting their role in regulation of the inflammatory milieu through pathways such as autophagy, apoptosis, and the inflammasome pathway. The study also discusses the potential of novel experimental and bioinformatics approaches to further advance our understanding of the role of bile acids in IBD and inform therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Montserrat Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel disease is a global disease with challenges in understanding its complex pathogenesis and progression, leading to limited progress in diagnosis and treatment. Future studies are needed to comprehensively characterize the disease biology for early detection and monitoring of clinical outcomes.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Gastroenterology & Hepatology
Maria Manuela Estevinho, Paula Leao Moreira, Isabel Silva, Joao Laranjeira Correia, Mafalda Santiago, Fernando Magro
Summary: This review summarizes the definitions of early Crohn's disease (CD) and ulcerative colitis (UC), analyzes the underlying immunological mechanisms, and evaluates the impact of recognizing and treating early inflammatory bowel disease (IBD) on patients' prognosis. The treatment of early CD appears to be crucial for the management of CD patients, impacting short-, medium-, and long-term outcomes. However, evidence for the early treatment of UC is limited and inconclusive.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Korta, Julia Kula, Krzysztof Gomulka
Summary: Interleukin-23 (IL-23) is a proinflammatory cytokine that plays a role in tissue damage. It interacts with both the innate and adaptive immune systems, and the IL-23/Th17 axis appears to be involved in the development of chronic intestinal inflammation. Despite the incomplete understanding of the etiology and pathophysiology of inflammatory bowel disease (IBD), research on IL-23 shows potential for clinical applications as therapeutic targets in IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mayte Buchbender, Jakob Fehlhofer, Peter Proff, Tobias Moest, Jutta Ries, Matthias Hannig, Markus F. Neurath, Madline Gund, Raja Atreya, Marco Kesting
Summary: This study analyzed the expression of cytokines in biofilm samples from patients with IBD and compared them to healthy patients. The results showed different expression levels of IL-10 and MMP-7 in plaque samples from IBD patients. Despite a significant increase in bleeding on probing, it was concluded that there was no clinical impairment of periodontal tissue in IBD patients.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Gastroenterology & Hepatology
Sari M. Herman, Karver Zaborniak, Charles N. Bernstein
Summary: Inflammatory bowel diseases (IBD) are immune dysregulation disorders that are influenced by genetic predisposition and environmental factors. The role of aeroallergens in the pathogenesis of IBD has not been thoroughly investigated and requires further research.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Developmental Biology
Vikrant Rahi, Puneet Kumar
Summary: ADHD is a heterogeneous neuropsychiatric disorder characterized by symptoms of hyperactivity, attention deficit, and impulsiveness, which can significantly impact academic, occupational, and social functioning. Currently, there are limited effective medications available to completely eliminate ADHD symptoms, making it essential to understand the neurochemical and genetic alterations that contribute to the progression of the disorder. Animal models serve as a valuable tool for studying the pathological mechanisms involved in disease progression and have good predictive validity for the development of new therapeutic interventions.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Abdul Kadir, Jasdeep Singh, Vikrant Rahi, Puneet Kumar
Summary: Berberine, with its antioxidant properties, has been widely used to treat various brain disorders. This study found that berberine can improve behavioral changes caused by Huntington's disease and tardive dyskinesia, and enhance antioxidant capacity.
NEUROCHEMICAL RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Divya Soni, Puneet Kumar
Summary: Movement disorders are neurological conditions that cause involuntary motor movements. Excessive ROS generation, mitochondrial dysfunction, neuroinflammation, and neurotransmitter imbalance contribute to the development of motor dysfunction. The Nrf2/HO-1 antioxidant pathway and GSK-3 beta play important roles in neuroprotection against movement disorders.
PHARMACOLOGICAL REPORTS
(2022)
Review
Cell Biology
Shubham Upadhayay, Rishav Gupta, Surbhi Singh, Maroti Mundkar, Gursewak Singh, Puneet Kumar
Summary: The G-protein-coupled estrogen receptor-1 (GPER) is an extranuclear estrogen receptor that regulates cell migration, proliferation, and apoptosis in different parts of the brain. It is activated by estrogen and plays a role in maintaining cellular homeostasis and influencing neurogenesis. Research suggests that GPER has the potential to slow down the progression of neurodegenerative disorders.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Heena Khan, Annu Bangar, Amarjot Kaur Grewal, Puneet Bansal, Thakur Gurjeet Singh
Summary: Caspases play a crucial role in neuronal disorders and neurodegenerative diseases, and the development of caspase inhibitors as therapeutic agents is being actively studied. However, no drug targeting caspase inhibition is currently available in the market.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maroti Mundkar, Anjali Bijalwan, Divya Soni, Puneet Kumar
Summary: Moringa oleifera, a traditional Indian herb, has potential therapeutic effects in various neurological disorders due to its phytoconstituents. It has neuroprotective effects in neurodegenerative diseases and can be used in the treatment of brain disorders. Further research on specific signaling pathways and the use of moringa as a nutraceutical may contribute to understanding its mechanism of action and boosting the economies of moringa-growing countries.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Immunology
Shubham Upadhayay, Richmond Arthur, Divya Soni, Poonam Yadav, UmaShanker Navik, Randhir Singh, Thakur Gurjeet Singh, Puneet Kumar
Summary: Monkeypox is a zoonotic disease similar to smallpox, transmitted through direct contact with infected animals or individuals with infectious sores, scabs, or body fluids. There is currently no definitive treatment, but antiviral medication can be used to alleviate symptoms and reverse skin lesions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Richmond Arthur, Umashanker Navik, Puneet Kumar
Summary: Artemisinins and their derivatives can be repurposed as neuroprotective agents by modulating the PI3K/Akt pathway to inhibit oxidative stress, neuroinflammation, and apoptosis in neurodegenerative disorders.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Neurosciences
Vikrant Rahi, Parladh Ram, Puneet Kumar
Summary: This study evaluates the neuroprotective effect of filgrastim in rat models of movement disorders. The results demonstrate that filgrastim treatment significantly reduces motor impairment and oxidative stress. Therefore, filgrastim may be a novel candidate for the treatment of TD and HD.
NEUROTOXICITY RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Mandeep Kumar, T. P. Nhung Nguyen, Jasleen Kaur, Thakur Gurjeet Singh, Divya Soni, Randhir Singh, Puneet Kumar
Summary: Artificial intelligence (AI) is a machine science that imitates human behavior and intelligent data analysis using specialized algorithms, deep learning, and machine learning. It provides an automated and reliable tool for accurately and rapidly making decisions in the digital world where a vast amount of medical data is generated daily. AI has been widely applied in various fields in pharmaceutical science, particularly in pharmacological research, aiding in the analysis of preclinical and clinical trial data, drug discovery/manufacturing, disease diagnosis, personalized treatment, clinical trial research, radiotherapy, surgical robotics, electronic health records, and epidemic outbreak prediction. Additionally, AI is instrumental in evaluating biomarkers and diseases. This review explains the models and processes of machine learning and discusses their role in pharmacological science, illustrating the relevance and potential of AI with deep learning and machine learning in pharmacological research.
PHARMACOLOGICAL REPORTS
(2023)
Article
Pharmacology & Pharmacy
Rishav Gupta, Divya Soni, Shubham Upadhayay, Maanvi Dhureja, Puneet Kumar
Summary: Epilepsy is a disease characterized by excessive excitatory neuronal firing and motor, psychomotor, and sensory impairments. Current therapies fall short in producing satisfactory outcomes due to the complexity of the disease, inadequate diagnosis, and the rise of drug-resistant epilepsy. This study investigated the potential of repurposing the drug "noscapine" for the management of epilepsy and its associated complications. The results showed that noscapine pretreatment attenuated the behavioral and biochemical changes induced by prolonged PTZ treatment in mice, suggesting its potential as a new antiepileptic agent.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Amandeep Kaur, Navneet Singh, Harmanpreet Kaur, Violina Kakoty, Deep Shikha Sharma, Rubiya Khursheed, Molakpogu Ravindra Babu, Vancha Harish, Gaurav Gupta, Monica Gulati, Puneet Kumar, Harish Dureja, Nahed S. Alharthi, Farhan R. Khan, Zia Ur Rehman, Mohammed Ageeli Hakami, Mrunali Patel, Rashmin Patel, Milad Zandi, Sukriti Vishwas, Kamal Dua, Sachin Kumar Singh
Summary: Neurodegenerative diseases (NDs) pose a burden on human lives and economies, and traditional treatment approaches are ineffective in the long term. Dendrimers offer promise as nanocarriers for drug delivery, providing a non-invasive approach for treating NDs. However, limitations in elimination and cytotoxicity need to be addressed.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Narhari Gangaram Yedke, Divya Soni, Puneet Kumar
Summary: This study aimed to investigate the neuroprotective effect of the BCG vaccine on the rotenone-induced Parkinson's disease model. Rats were injected with rotenone and the BCG vaccine, and behavioral assessments and biochemical analysis were performed. The results showed that the BCG vaccine significantly improved motor deficits, restored biochemical levels, normalized neurotransmitter levels, and reduced inflammatory cytokines in the striatum. These findings suggest that the BCG vaccine has neuroprotective properties and could be used for other neurological disorders, including PD.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Maanvi Dhureja, Richmond Arthur, Divya Soni, Shubham Upadhayay, Pooja Temgire, Puneet Kumar
Summary: Recent neuroscience breakthroughs have revealed the important role of calcium channels, particularly RyR and SERCA, in neural functions and their dysregulation in neurodegenerative disorders.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Narhari Gangaram Yedke, Shubham Upadhayay, Randhir Singh, Sumit Jamwal, Sheikh F. Ahmad, Puneet Kumar
Summary: The study aimed to confirm the neuroprotective effect of the BCG vaccine on haloperidol-induced tardive dyskinesia (TD)-like symptoms in rats. The results showed that the BCG vaccine reversed orofacial dyskinesia and improved motor function. Additionally, it increased the levels of antioxidant enzymes, reduced oxidative stress and apoptotic markers, and restored neurotransmitter levels.