Article
Chemistry, Multidisciplinary
Lluis Rodas, Sonia Martinez, Aina Riera-Sampol, Hannah J. Moir, Pedro Tauler
Summary: Both caffeine and 5-CQA have limited anti-inflammatory effects in vitro. These effects are observed with high physiological concentrations for caffeine, while supraphysiological concentrations are needed for 5-CQA.
APPLIED SCIENCES-BASEL
(2022)
Review
Behavioral Sciences
Manit Srisurapanont, Sirijit Suttajit, Natapong Kosachunhanun, Surinporn Likhitsathian, Chawisa Suradom, Benchalak Maneeton
Summary: This network meta-analysis compared the short-term treatment effects of different antidepressants on depression severity and HbA1c in depressed patients with type 2 diabetes mellitus. The results showed that escitalopram ranked first in reducing depression severity and HbA1c, followed by agomelatine.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Genetics & Heredity
Umesh K. Shandilya, Ankita Sharma, Ran Xu, Maria Malane M. Muniz, Niel A. Karrow
Summary: This study used a co-culture model to investigate the impact of Fusarium mycotoxins on the inflammatory response in bovine epithelial cells. The results showed that certain cytokines were significantly induced after mycotoxin treatment, and gene expression analysis revealed enrichment in processes related to inflammation, apoptosis, and Wnt signaling.
Article
Biochemistry & Molecular Biology
Arlinda Ljoki, Tanzila Aslam, Tina Friis, Ragnhild G. Ohm, Gunnar Houen
Summary: In this study, a co-culture assay with human umbilical vein endothelial cells (HUVECs) and normal human dermal fibroblasts (NHDFs) was used to investigate the effects of selected angiogenesis inhibitors on the differentiation and network formation of HUVECs in vitro. The results showed that neutralizing VEGF and inhibiting VEGFR2 resulted in the formation of HUVEC clusters, while other inhibitors of the VEGF signaling pathways did not have this effect. Additionally, glucocorticoid receptor activation was found to be linked to angiogenesis and HUVEC differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Rob Simmons, Des AR. Tutt, Gizem Guven-Ates, Wing Yee Kwong, R. Labrecque, Federico Randi, Kevin D. Sinclair
Summary: The production of cattle embryos in vitro requires maturation of oocytes in vitro before fertilization. Progesterone support during ovarian stimulation can improve the success of in vitro production. This study investigated the effects of increased peripheral progesterone concentrations during ovarian stimulation cycles.
Article
Immunology
Marthe Jontvedt Jorgensen, Kristin G. Nore, Hans Christian D. Aass, Emilie Layre, Jerome Nigou, Rasmus Mortensen, Kjetil Tasken, Dag Kvale, Synne Jenum, Kristian Tonby, Anne Ma Dyrhol-Riise
Summary: The study shows that COX-2 inhibitors may reduce excess inflammation in TB patients via the LOX pathway and modulate phosphorylation patterns in monocytes. Further investigation on the immunomodulatory effects of adjunctive COX-2 inhibitors in TB is needed before recommending it as a HDT strategy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Grazia Maria Virzi, Maria Mattiotti, Anna Clementi, Sabrina Milan Manani, Giovanni Giorgio Battaglia, Claudio Ronco, Monica Zanella
Summary: This study aims to evaluate the eryptosis rate in healthy red blood cells (RBCs) treated with different concentrations of cytokines and uremic toxins, comparable to the plasmatic level of chronic kidney disease (CKD) patients. The results show that these cytokines and toxins have a harmful effect on the morphology and viability of RBCs, accelerating the occurrence of eryptosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Abraham G. Eappen, Tao Li, Meghan Marquette, Sumana Chakravarty, Natasha Kc, Gigliola Zanghi, Benjamin U. Hoffman, Hashani Hettiarachchi, Asha Patil, Yonas Abebe, Christiane Tran, Alemtaye A. Yossef, Ian McWilliams, Robert D. Morrison, Ayyappan Rathakrishnan, Ehud Inbar, Ahmed S. Aly, Patricia De la Vega, Maria Belmonte, Martha Sedegah, Tint Wai, Joseph J. Campo, Harley King, Stefan H. Kappe, MingLin Li, Peter F. Billingsley, B. Kim Lee Sim, Stephen L. Hoffman
Summary: This study successfully produced hundreds of millions of mosquito-free Plasmodium falciparum sporozoites (iPfSPZ) and demonstrated their ability to develop into mature stages in human cells, completing the entire life cycle of the parasite.
Article
Integrative & Complementary Medicine
Chien Yi Koay, Anna Pick Kiong Ling, Ying Pei Wong, Rhun Yian Koh, Sobri Hussein
Summary: The methanol extract of P. ginseng root culture did not demonstrate significant anti-inflammatory effects on NO and IL-6 levels, but it may have potential anti-neuroinflammatory and pro-neuroinflammatory properties by downregulating TNF-alpha and IL-10 levels respectively.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Inha Lee, So Hyun Ahn, Hye In Kim, Hye Won Baek, Yun Jeong Park, Heeyon Kim, Aminah Ibrahim Aljassim, Whan Shin, Chungsoon Ryu, Jeongmi Yoon, Jae Hoon Lee, Bo Hyon Yun, Seok Kyo Seo, Joo Hyun Park, Young Sik Choi, SiHyun Cho, Byung Seok Lee
Summary: Specific cytokines in human embryo culture media can be used to predict embryo quality and IVF outcomes. CCL15, CCL27, and CXCL-12 were found to be significantly elevated in the top-quality embryo group.
Review
Pharmacology & Pharmacy
Ye Peng, Shifeng Chu, Yantao Yang, Zhao Zhang, Zongran Pang, Naihong Chen
Summary: Cell cultures are widely used in pharmaceutical, medical, and biological sciences. Neuronal and glial cell models are important tools for researching neurological disorders, with current studies on neuroinflammation contributing to understanding blood-brain barrier damage. Immortalized cell lines of the central nervous system are being used to study anti-inflammatory potential in neurological disorders, with 2D and 3D co-culture models being discussed for their different advantages and limitations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paulina Kazimierczak, Malgorzata Koziol, Agata Przekora
Summary: The newly developed biomaterial showed high biocompatibility and influenced macrophage polarization and osteoblast differentiation, playing an immunomodulatory role. The study demonstrated a low risk of inflammatory response and induced macrophage polarization into the osteogenic phenotype M2, making it a promising bone scaffold for regenerative medicine applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Nadia Fattahi, Ali Ramazani, Mehrdad Hamidi, Maliheh Parsa, Kobra Rostamizadeh, Hamid Rashidzadeh
Summary: The study successfully enhanced the brain penetration of MTX using synthesized lipophilic MTX prodrugs, without increasing drug toxicity, and significantly increasing the uptake clearance of MTX by brain parenchyma.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Geremew Tasew, Endalamaw Gadisa, Adugna Abera, Menberework Chanyalew, Markos Abebe, Rawleigh Howe, Uwe Ritter, Abraham Aseffa, Tamas Laskay
Summary: Research has shown that in visceral leishmaniasis (VL) patients, blood leukocytes have a diminished ability to respond to Leishmania, leading to severe disease progression and increased susceptibility to secondary infections.
Review
Immunology
Norihiro Watanabe, Feiyan Mo, Mary Kathryn McKenna
Summary: CAR T cell therapy has shown promising success in cancer treatment, with ex vivo culture conditions being a crucial factor in impacting CAR T cell functionality.
FRONTIERS IN IMMUNOLOGY
(2022)