Article
Biochemistry & Molecular Biology
Javier Botella, Nicholas A. Jamnick, Cesare Granata, Amanda J. Genders, Enrico Perri, Tamim Jabar, Andrew Garnham, Michael Lazarou, David J. Bishop
Summary: Autophagy is an important mechanism for cells to degrade old or dysfunctional proteins and organelles. The effects of exercise on autophagosome content markers differ between rodents and humans. The decrease in LC3B-II protein levels induced by exercise in humans does not reflect a decreased autophagy flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Sport Sciences
Javier Botella, Christopher S. Shaw, David J. Bishop
Summary: This article examines the differences in autophagy gene expression profiles between human and mouse skeletal muscle and how they may explain the divergent exercise-induced autophagy responses. It also summarizes transcriptomic and phosphoproteomic datasets to identify potential targets for autophagy regulation following exercise in humans. Recommendations are provided for using ex vivo autophagy flux assays to further understand the impact of exercise on autophagy regulation in humans.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ikumi Ohsawa, Fuminori Kawano
Summary: This study showed that exercise training activates histone turnover in skeletal muscle fibers, leading to nucleosome loosening and enhanced gene responses to exercise.
Article
Biochemistry & Molecular Biology
Corey M. Summers, Rudy J. Valentine
Summary: Short bouts of heat can induce a hormetic stress response, but prolonged or excessive exposure may have detrimental effects. This study suggests that 2 hours of heat exposure leads to cell stress and accumulation of autophagasomes in skeletal muscle.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Physiology
Qianghua Xia, Xubo Huang, Jieru Huang, Yongfeng Zheng, Michael E. March, Jin Li, Yongjie Wei
Summary: Skeletal muscle is rich in tissue composition, and autophagy plays a crucial role in energy generation, consumption, and substance turnover processes within it. Autophagy activity is tightly regulated by various signaling pathways and can lead to pathological cascades under abnormal conditions, interacting with other pathways.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Fisheries
Ping Wu, Lin Chen, Jia Cheng, Yaxiong Pan, Xin Zhu, Wuying Chu, Jianshe Zhang
Summary: This study investigated the effects of starvation and diet after starvation on the autophagy of adult Chinese perch muscle. The results showed that after 3 days of starvation, the autophagy marker protein LC3 and the number of autophagosomes remained unchanged. However, after 7 days of starvation, the number of autophagosomes increased along with a decrease in antioxidant molecules and the accumulation of ROS. Refeeding after starvation effectively reduced ROS levels, restored antioxidant enzyme activity, decreased autophagy, and improved feed efficiency.
JOURNAL OF FISH BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ana P. Pinto, Alisson L. da Rocha, Giovana R. Teixeira, Rafael L. Rovina, Allice S. C. Veras, Fabiani Frantz, Jose R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Joe Quadrilatero, Adelino S. R. da Silva
Summary: Excessive downhill running leads to hepatic fat accumulation, and is associated with increased levels of mTORC1 and insulin signaling. Rapamycin administration can inhibit mTORC1, but does not upregulate autophagy flux.
Review
Physiology
Cenyi Wang, Jiling Liang, Yuanyuan Ren, Jielun Huang, Baoming Jin, Guodong Wang, Ning Chen
Summary: Exercise can prevent and delay skeletal muscle aging by regulating the expression of autophagy-related proteins. Long-term aerobic exercise and resistance exercise can increase autophagy in aging skeletal muscle, while short-term high-intensity exercise may induce excessive autophagy and short-term low-intensity exercise may not reach the threshold for exercise-induced autophagy, resulting in no significant effect on delaying muscle aging.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Joshua C. Drake, Rebecca J. Wilson, Di Cui, Yuntian Guan, Mondira Kundu, Mei Zhang, Zhen Yan
Summary: This study compared the roles of Ulk1 and Ulk2 in skeletal muscle insulin action following exercise training, and found that Ulk1 is essential for exercise training-induced improvement in insulin action in skeletal muscle.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gokce Ceren Kuscu, Cevik Gurel, Aylin Buhur, Fatih Oltulu, Levent Akman, Timur Kose, Nefise Ulku Karabay Yavasoglu, Altug Yavasoglu
Summary: This study demonstrated that tamoxifen citrate and clomiphene citrate can induce autophagy in the ovaries of patients with PCOS, suggesting that autophagy may be a promising target for understanding the pathophysiology of this disease and developing more effective and safe treatment protocols for PCOS-related anovulation.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pharmacology & Pharmacy
Ping Wang, Chun Guang Li, Xian Zhou, Di Cui, Ting Ouyang, Weikai Chen, Shuzhe Ding
Summary: The study investigated the activation of AMPK and autophagy in mice gastrocnemius muscle after a single bout of exhaustive treadmill exercise. The results showed that AMPK content and activity significantly increased at 0, 6, and 12 hours after the exercise, and the expressions of autophagy markers changed at different time points in the recovery period. Positive correlations were observed between the expressions of LC3II/LC3I ratio and pAMPK(Thr172) or AMPK, and a negative correlation was found between the expressions of p62 and AMPK or pAMPK(Thr172). These findings suggest that acute exercise enhances AMPK-related autophagy activation, which may regulate cellular energy metabolism during exercise.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Orthopedics
Paola Contreras-Munoz, Joan Ramon Torrella, Vanessa Venegas, Xavier Serres, Laura Vidal, Ingrid Vila, Ilmari Lahtinen, Gines Viscor, Vicente Martinez-Ibanez, Jose Luis Peiro, Tero A. H. Jarvinen, Gil Rodas, Mario Marotta
Summary: In this study, the effects of muscle precursor cells (MPCs) on muscle healing in a small animal model were evaluated. The results showed that single intramuscular administration of MPCs improved histological outcome and force recovery of the injured skeletal muscle in a rat injury model that imitates sports-related muscle injuries. Additionally, the combination of cell therapy with an early active rehabilitation protocol in rats showed a synergistic effect, suggesting novel therapeutic strategies for the treatment of human skeletal muscle injuries.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Geriatrics & Gerontology
Yuan-Li Chen, Yi-Cheng Ma, Jie Tang, Dan Zhang, Qiu Zhao, Jian-Jun Liu, Hong-Shu Tang, Jin-Yu Zhang, Guang-Hui He, Chi-Hui Zhong, Yu-Tong Wu, Heng-Ruo Wen, Lan-Qing Ma, Cheng-Gang Zou
Summary: This study found that activation of the adiponectin receptor PAQR-1/AdipoR1 plays a crucial role in the lifespan extension during exercise, and exercise improves skeletal muscle quality in aged mice, which is dependent on the presence of AdipoR1. The anti-ageing effects of exercise are mediated through the activation of AMPK signaling, FOXO signaling, and autophagy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Md. Ataur Rahman, Yoonjeong Cho, Ghilsoo Nam, Hyewhon Rhim
Summary: Oxyresveratrol affects the function of astrocytes by promoting autophagy signaling and inhibiting APP production. Co-treatment with chloroquine significantly enhances autophagic flux, and the regulation of autophagy substrates and pathways by Oxyresveratrol depends on the PI3 kinase pathway.
Article
Medicine, Research & Experimental
Zhipeng Huang, Qinglong Wang, Tao Zhang, Yinsheng Fu, Wenbo Wang
Summary: This study showed that sPL can enhance the healing of glucocorticoid-induced osteonecrosis of the femoral head by increasing autophagy of osteoblasts and inhibiting apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Junya Sango, Taichi Kakihana, Masahiko Takahashi, Yoshinori Katsuragi, Sergei Anisimov, Masaaki Komatsu, Masahiro Fujii
Summary: Nrf2 is an antioxidant transcriptional activator that plays a role in various human disorders. This study shows that the protein USP10 reduces dopamine-induced ROS production and apoptosis in neuronal cells by stimulating the antioxidant activity of Nrf2. USP10 is a key regulator of Nrf2 antioxidant activity in neuronal cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Neurosciences
Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomita
Summary: This study explores the changes in autophagy signaling in the prefrontal cortex (PFC) under repeated social defeat (RSD) and their potential involvement in behavioral changes induced by stress. The results suggest that enhanced autophagy may alleviate stress-induced depression, and microglial autophagy plays a role in stress-induced behavioral changes.
Article
Biochemistry & Molecular Biology
Akiko Suzuki, Chihiro Iwaya, Kenichi Ogata, Hiroki Yoshioka, Junbo Shim, Isei Tanida, Masaaki Komatsu, Norihiro Tada, Junichi Iwata
Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by immune cell infiltration of the exocrine glands. Deficiency in enzymes involved in the ubiquitin modification pathway leads to a Sjogren's syndrome-like phenotype, and activation of GATE16 is crucial for exocytosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Letter
Gastroenterology & Hepatology
Wen-Xing Ding, Hong-Min Ni, Satoshi Waguri, Masaaki Komatsu
JOURNAL OF HEPATOLOGY
(2022)
Article
Cell Biology
Maiko Ono, Masaaki Komatsu, Bin Ji, Yuhei Takado, Masafumi Shimojo, Takeharu Minamihisamatsu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Ichio Aoki, Nicholas M. Kanaan, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
Summary: In this study, evidence is provided that p62 exerts a protective role against neuronal death and neuroinflammation induced by abnormal tau accumulation. By eliminating neurotoxic tau species, p62 may act as a potential therapeutic target for the treatment of tauopathies.
Article
Cell Biology
Sang-Won Park, Pureum Jeon, Akinori Yamasaki, Hye Eun Lee, Haneul Choi, Ji Young Mun, Yong-Woo Jun, Ju-Hui Park, Seung-Hwan Lee, Soo-Kyeong Lee, You-Kyung Lee, Hyun Kyu Song, Michael Lazarou, Dong-Hyong Cho, Masaaki Komatsu, Nobuo N. Noda, Deok-Jin Jang, Jin-A Lee
Summary: This study identified the selective interactions of various membrane-anchored mATG8 proteins in mammals and developed tools to regulate the autophagy of disease-related protein aggregates. This has significant implications for understanding the functional roles of mATG8 proteins on autophagic membranes in autophagy research.
Article
Biochemistry & Molecular Biology
Yukiko Sasazawa, Sanae Souma, Norihiko Furuya, Yoshiki Miura, Saiko Kazuno, Soichiro Kakuta, Ayami Suzuki, Ryota Hashimoto, Hiroko Hirawake-Mogi, Yuki Date, Masaya Imoto, Takashi Ueno, Tetsushi Kataura, Viktor Korolchuk, Taiji Tsunemi, Nobutaka Hattori, Shinji Saiki
Summary: This study found that acrolein enhances autophagy by promoting lysosomal clustering around the microtubule organising centre. JIP4 phosphorylation tightly regulates this system in response to Ca2+ fluxes. This research is important for understanding the regulation of autophagy and lysosomal distribution.
Correction
Cell Biology
Shuhei Nakamura, Saki Shigeyama, Satoshi Minami, Takayuki Shima, Shiori Akayama, Tomoki Matsuda, Alessandra Esposito, Gennaro Napolitano, Akiko Kuma, Tomoko Namba-Hamano, Jun Nakamura, Kenichi Yamamoto, Miwa Sasai, Ayaka Tokumura, Mika Miyamoto, Yukako Oe, Toshiharu Fujita, Seigo Terawaki, Atsushi Takahashi, Maho Hamasaki, Masahiro Yamamoto, Yukinori Okada, Masaaki Komatsu, Takeharu Nagai, Yoshitsugu Takabatake, Haoxing Xu, Yoshitaka Isaka, Andrea Ballabio, Tamotsu Yoshimori
NATURE CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Masaaki Komatsu
Summary: In this review, the author discusses the history of p62 research in relation to autophagy and provides an overview of the formation, degradation, and physiological functions of the p62 body, including efficient degradation of ubiquitinated proteins and involvement in antioxidant stress response.
Editorial Material
Cell Biology
Reo Kurusu, Hideaki Morishita, Masaaki Komatsu
Summary: SQSTM1/p62 bodies are phase-separated condensates that play a crucial role in intracellular quality control and stress responses. A recent study discovered a novel substrate for selective autophagy called vault, which directly binds to NBR1 and is degraded by selective autophagy dependent on the phase separation of SQSTM1/p62. This process, named vault-phagy, is related to nonalcoholic steatohepatitis (NASH)-derived hepatocellular carcinoma.
Article
Multidisciplinary Sciences
Ryosuke Ishimura, Sota Ito, Gaoxin Mao, Satoko Komatsu-Hirota, Toshifumi Inada, Nobuo N. Noda, Masaaki Komatsu
Summary: Research has shown that UFM1 plays a role in processes such as endoplasmic reticulum-associated protein degradation, ribosome-associated protein quality control, and ER-phagy, and the UFM1 E3 complex is involved in both ufmylation and ER-RQC.
Article
Microbiology
Michitaka Suzuki, Tomoko Funakoshi, Keigo Kumagai, Masaaki Komatsu, Satoshi Waguri
Summary: Chlamydia trachomatis infection can be regulated by autophagy-related (ATG) genes. Depletion of ATG9A suppressed C. trachomatis growth in HeLa cells, and this growth was restored by re-expressing ATG9A or an ATG9A mutant. The depletion of lipid transfer proteins ATG2A/B did not significantly alter the growth, highlighting the non-autophagic function of ATG9A in supporting C. trachomatis infection. Re-expression of a mutant lacking an N-terminal adapter protein-binding domain did not rescue C. trachomatis growth, emphasizing the importance of this domain. These findings suggest that the proper trafficking of ATG9A assists C. trachomatis growth in the inclusion.
MICROBIOLOGY SPECTRUM
(2023)
Review
Biochemistry & Molecular Biology
Reo Kurusu, Hideaki Morishita, Masaaki Komatsu
Summary: Cellular zoning and the formation of membraneless organelles play crucial roles in regulating biochemical reactions inside cells, with p62 bodies maintaining cellular homeostasis through selective autophagy and activating the anti-oxidative stress response.
JOURNAL OF BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Ge Peng, Saya Tsukamoto, Risa Ikutama, Hai Le Thanh Nguyen, Yoshie Umehara, Juan V. Trujillo-Paez, Hainan Yue, Miho Takahashi, Takasuke Ogawa, Ryoma Kishi, Mitsutoshi Tominaga, Kenji Takamori, Jiro Kitaura, Shun Kageyama, Masaaki Komatsu, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda, Francois Niyonsaba
Summary: A study found that autophagy in keratinocytes is restrained in patients with atopic dermatitis (AD) and mouse models of AD. Human β-defensin-3 (hBD-3) alleviates the impairment of the tight junction barrier through activation of keratinocyte autophagy, and reduces skin inflammation. This suggests that autophagy contributes to the pathogenesis of AD, and hBD-3 could be used therapeutically.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Shun-Suke Sakai, Atsushi Hasegawa, Ryosuke Ishimura, Naoki Tamura, Shun Kageyama, Satoko Komatsu-Hirota, Manabu Abe, Yiwei Ling, Shujiro Okuda, Manabu Funayama, Mika Kikkawa, Yoshiki Miura, Kenji Sakimura, Ichiei Narita, Satoshi Waguri, Ritsuko Shimizu, Masaaki Komatsu
Summary: A study found that the copy number duplication of ATG2B and GSKIP genes is associated with myeloproliferative neoplasm (MPN). Mice lacking both Atg2b and Gskip genes showed decreased hematopoiesis, leading to fetal death and anemia. The number of hematopoietic stem cells (HSCs), especially long-term HSCs, was significantly decreased due to increased cell death. The results demonstrate the synergistic effect of Atg2b and Gskip in maintaining the pool size of HSCs.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)