Article
Nanoscience & Nanotechnology
Ao Chen, Fan Yang, Jing Kuang, Yuan Xiong, Bo-Bin Mi, Ying Zhou, Jing-Jing Hu, Shu-Jun Song, Tao Wan, Zhong-Zhong Wan, Hong-Yang Huang, Xin-Run Li, Wen Song, Wen-Xiu Qiu
Summary: A nanoplatform was constructed to reverse tumor acidosis and hypoxia through alkali and oxygen generation triggered by tumor acidosis, polarizing tumor-associated macrophages to anti-tumor M1 phenotype macrophages and enhancing tumor immune response. Furthermore, under regional light irradiation, reactive oxygen species produced by photosensitizers in the nanoplatform could increase the immunogenicity of tumors, transitioning tumors from immunosuppressive cold tumors to immunogenic hot tumors and amplifying the effect of immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Immunology
Zicong He, Shuixing Zhang
Summary: TAMs are crucial immune cells in tumors, and their functional transformation from M1 to M2 as tumors progress plays a key role in immunosuppression and tumor promotion processes. Understanding the mechanism of TAM functional transformation in the hypoxic environment is essential for developing novel tumor immunotherapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Alireza Najafi, Maryam Keykhaee, Hossein Khorramdelazad, Mohammad Yahya Karimi, Leila Nejatbakhsh Samimi, Nazanin Aghamohamadi, Milad Karimi, Reza Falak, Mehdi Khoobi
Summary: The tumor microenvironment (TME) plays a critical role in tumor progression and resistance to treatment. Tumor-associated macrophages (TAMs) and hypoxia are important factors in the TME. Catalase and catalase-mimicking compounds can reduce hypoxia and promote TAM polarization, showing potential in cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Plant Sciences
Qiu-Ping Liu, Yu-Ying Chen, Pei An, Khalid Rahman, Xin Luan, Hong Zhang
Summary: Macrophages in the tumor microenvironment (TME) can polarize into M2 type, which promotes tumor development. This review summarizes the effects of TME on macrophage polarization and the reversal of M2 polarization by natural products, providing directions for tumor therapy.
Review
Biochemistry & Molecular Biology
Ava J. Boutilier, Sherine F. Elsawa
Summary: The M1/M2 macrophage paradigm is crucial in tumor progression, where M1 macrophages have anti-tumor effects and M2 macrophages contribute to tumor development through various mechanisms. The tumor microenvironment plays a role in influencing macrophage polarization and activation, which is essential for understanding the pro-tumor effects of tumor-associated macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Immunology
Angela DeRosa, Avigdor Leftin
Summary: Macrophages play important roles in systemic iron metabolism and immune response. Infiltration and polarization of macrophages in the tumor microenvironment are associated with cancer prognosis, with distinct iron and immune phenotypes observed in tumor associated macrophages in most cancers. Functional connections between dysfunctional iron metabolism and tumor immune response are emerging, providing new insights for immunometabolic precision therapy approaches.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Shilin Wang, Guohong Liu, Yirong Li, Yunbao Pan
Summary: Macrophages are crucial cells in the innate immune system and can differentiate into two distinct subtypes, affecting tumor progression. Tumor-associated macrophages have the phenotype and function of M2 macrophages and meet cell growth requirements through metabolic reprogramming. Understanding pro-tumor and antitumor metabolic switches in TAM is essential for understanding immune escape mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Huogang Wang, Mingo M. H. Yung, Hextan Y. S. Ngan, Karen K. L. Chan, David W. Chan
Summary: Metastasis, driven by tumor-associated macrophages (TAMs), is a key factor in most cancer deaths, with TAMs playing a crucial role in influencing tumor metastasis and treatment outcomes by polarizing metabolism patterns. Tumor cell-driven TAMs in the tumor microenvironment promote tumor metastasis and are associated with poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Jiabao Ling, Yanzhou Chang, Zhongwen Yuan, Qi Chen, Lizhen He, Tianfeng Chen
Summary: This study proposes a feasible therapeutic strategy for depleting lactate and reconstructing an immunosuppressive tumor microenvironment using Se-containing nanosheets, which can restore the potent tumor-killing activity of macrophages, thereby amplifying the effects of TAM-based antitumor immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yumin Zhang, Zujian Feng, Jinjian Liu, Hui Li, Qi Su, Jiamin Zhang, Pingsheng Huang, Weiwei Wang, Jianfeng Liu
Summary: This study aimed to overcome radioresistance in tumors by regulating the polarization of tumor-associated macrophages (TAMs) using a toll-like receptor agonist TLR7/8a conjugated with a radiosensitive peptide hydrogel (Smac-TLR7/8 hydrogel). The results showed that the Smac-TLR7/8 hydrogel effectively polarized TAMs into an anti-tumor M1 phenotype upon gamma-ray radiation. The repolarization of TAMs promoted tumor necrosis factor secretion, activated the anti-tumor immune response, and inhibited tumor growth. Furthermore, TAMs repolarization enhanced the efficacy of PD1-blockade by increasing tumor infiltrating lymphocytes (TILs) and decreasing Treg cells in solid tumors.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Jing Huang, Zhenlin Gu, Yingying Xu, Lei Jiang, Weiguo Zhu, Wanwei Wang
Summary: The study found that CHI3L1 is overexpressed in esophageal cancer tissues and positively correlated with tumor size, as well as with increased expression of macrophage signature genes in the tumor tissues. Additionally, CHI3L1 overexpression may promote macrophage recruitment in esophageal tumor tissues.
Review
Biochemistry & Molecular Biology
Radu Pirlog, Andrei Cismaru, Andreea Nutu, Ioana Berindan-Neagoe
Summary: Lung cancer, particularly non-small cell lung cancer, is primarily caused by tobacco smoke which leads to progressive damage in the respiratory tract. The interactions between tumor cells, tumor microenvironment, and cancerized field involve molecular messages exchanged through various molecules like proteins, ncRNAs, and miRNAs. Understanding these interactions can provide insights into tumor regulatory mechanisms and potentially enhance therapy approaches for lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Shiyao Xu, Yan Xiong, Beibei Fu, Dong Guo, Zhou Sha, Xiaoyuan Lin, Haibo Wu
Summary: Cancer and microbial infections are major global health challenges, with bacteria playing a potential role in cancer development. This review summarizes the variety and specificity of bacterial species found in various cancers and explores the relationship between bacteria and macrophages in cancer, seeking evidence for bacterial-induced macrophage polarization. Additionally, the potential roles of metabolites, cytokines, and microRNAs in the regulation of the tumor microenvironment by bacterially activated macrophages are briefly discussed. Understanding the complex interactions between bacteria and macrophages in cancer will lead to new therapeutic approaches for both inflammatory diseases and cancer.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Jiashu Han, Luochu Dong, Mengwei Wu, Fei Ma
Summary: Immunotherapy has revolutionized tumor treatment, but many patients still do not respond due to the immunosuppressive tumor microenvironment. Tumor-associated macrophages (TAMs) play a crucial role in shaping this microenvironment and interacting with intratumoral T cells. However, the heterogeneity and plasticity of TAMs make it challenging to target specific factors and develop effective therapies.
FRONTIERS IN IMMUNOLOGY
(2023)