Review
Microbiology
Neil A. R. Cow, Megan D. Lenardon
Summary: The fungal cell wall is crucial for the growth and survival of fungi and is targeted by antifungal drugs and the immune system. The inner wall of most fungi is made up of chitin and beta-glucans, while the outer wall is composed of a variety of polymers and glycosylated proteins. Understanding the organization of fungal cell walls can lead to the development of diagnostics and drugs for combating fungal infections.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Physiology
Phillipp Hartmann, Sonja Lang, Suling Zeng, Yi Duan, Xinlian Zhang, Yanhan Wang, Marina Bondareva, Andrey Kruglov, Derrick E. Fouts, Peter Starkel, Bernd Schnabl
Summary: The study revealed dynamic changes in the intestinal fungal microbiome in patients with alcohol use disorder (AUD), and demonstrated that improved liver health after alcohol abstinence in AUD patients was associated with lower abundances of specific fungal genera and species, as well as changes in serum anti-fungal IgG levels. These findings suggest that intestinal fungi could be a potential therapeutic target to improve the outcome of patients with ALD.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Microbiology
Thomas J. Williams, Luis E. Gonzales-Huerta, Darius Armstrong-James
Summary: Fungal infections are a significant health concern with high mortality rates despite available antifungal treatments, prompting further research into fungal pathogenic mechanisms. Researchers discuss the induction of programmed cell death by microbes and how fungi manipulate these pathways.
Article
Biotechnology & Applied Microbiology
Tingan Zhou, Shiyu Yu, Huibin Xu, Huiling Liu, Yijian Rao
Summary: Low production of fungal natural products (NPs) remains a critical factor in their large-scale applications. This study found that exogenous beta-glucanase treatment can stimulate fungal cell wall integrity, thereby improving the production of fungal NPs.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xue-jiao Yin, Shou-kun Ji, Chun-hui Duan, Pei-zhi Tian, Si-si Ju, Hui Yan, Ying-jie Zhang, Yue-qin Liu
Summary: This study investigated the dynamics of fungal communities in the rumen and rectum of lambs and found that the composition, diversity, and abundance of gastrointestinal fungal communities were influenced by the age of the lambs. The study also discovered significant differences in fungal communities between the rumen and rectum.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Multidisciplinary Sciences
Liyanage D. Fernando, Yordanis Perez-Llano, Malitha C. Dickwella Widanage, Anand Jacob, Liliana Martinez-Avila, Andrew S. Lipton, Nina Gunde-Cimerman, Jean-Paul Latge, Ramon Alberto Batista-Garcia, Tuo Wang
Summary: Halophilic fungi adapt to survive in hypersaline environments by altering their cell wall structures, which provide a mechanism to withstand external stress. These molecular principles can be utilized to optimize the use of halophilic strains in biotechnology applications.
NATURE COMMUNICATIONS
(2023)
Review
Microbiology
Adley C. H. Mok, Christopher H. Mody, Shu Shun Li
Summary: This review explores mechanisms of fungal host defense by the immune system, highlighting both similarities and differences in granule morphology, content, release process, etc. among different immune cells, aiming to facilitate further research in this area.
Article
Genetics & Heredity
Ci Fu, Aaliyah Davy, Simeon Holmes, Sheng Sun, Vikas Yadav, Asiya Gusa, Marco A. Coelho, Joseph Heitman
Summary: This study reveals the genetic regulatory circuitry governing ploidy duplication during C. deneoformans unisexual reproduction, showing that cyclin and cyclin-dependent kinase regulator genes function together to orchestrate ploidy transition. The generation of a ploidy reporter also uncovered segmental aneuploidy in addition to diploidization, illustrating diverse mechanisms of genome plasticity in C. deneoformans.
Article
Multidisciplinary Sciences
Zhiming Zhang, Yuhong Gao, Wenjuan Zhao, Zhuo Wei, Xiaozhen Liu, Hanyao Zhang
Summary: This study analyzed the fungal population composition and diversity in the natural fermentation process of 'Hongyang' kiwifruit wine at different time points. The results showed that Aureobasidium pullulans was the dominant species in the early fermentation stage, while Pichia became dominant as fermentation proceeded. Pichia kluyveri played an important role in the later stages of fermentation by producing aromatic compounds. This research provides a theoretical basis for studying fungal diversity and changes during kiwifruit fermentation.
Article
Genetics & Heredity
Adriana M. Rico-Ramirez, A. Pedro Goncalves, N. Louise Glass
Summary: This review discusses regulated cell death in fungi, including apoptotic-like, necroptosis-like, and pyroptosis-like death, as well as the role of NLR proteins in fungal cell death. It also describes recent data on meiotic drive elements involved in spore killing and the molecular basis of allorecognition-related cell death during cell fusion of genetically dissimilar cells. The importance of fungal regulated cell death in developing strategies to avoid resistance and tolerance to antifungal agents is also discussed.
FUNGAL GENETICS AND BIOLOGY
(2022)
Review
Cell Biology
Giorgio Camilli, Mariana Blagojevic, Julian R. Naglik, Jonathan P. Richardson
Summary: Fungal diseases have a significant impact on human health. Recent research has focused on understanding the molecular mechanisms behind fungal pathogenicity and host responses, particularly in programmed cell death pathways during fungal infections. Manipulation of host cell death by pathogens is a key survival strategy that affects immunity towards pathogenic fungi.
TRENDS IN CELL BIOLOGY
(2021)
Article
Veterinary Sciences
Yanfang Lan, Yaonan Li, Gang Yu, Zhengyi Zhang, Irfan Irshad
Summary: The gut fungal community in diarrheic horses showed significant changes in alpha and beta diversity, as well as taxonomic compositions. Several differential fungal phyla and genera were identified, with decreased abundances during diarrhea. The study highlights the important role of gut fungal community in equine health and provides insights into the characterization of gut microbial dysbiosis in diarrhea.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Lara Luquez-Caravaca, Minami Ogawa, Rewa Rai, Nitin Nitin, Juan Moreno, Teresa Garcia-Martinez, Juan Carlos Mauricio, Juan Carlos Jimenez-Uceda, Jaime Moreno-Garcia
Summary: In this study, a novel method for immobilizing yeast cells in filamentous fungal pellets was explored, which showed significant improvements in productivity, cell retention, and fermentation control compared to a previous technique. Although the sensory properties of the produced wine did not differ significantly from those produced conventionally, certain differences were positively evaluated by the sensory panel. The immobilization technique offers potential for various industrial applications beyond winemaking.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mayura Veerana, Hyun-Chul Kim, Sarmistha Mitra, Bishwa Chandra Adhikari, Gyungsoon Park, Seong Huh, Sung-Jin Kim, Youngmee Kim
Summary: Three-dimensional copper metal organic frameworks with different ligands were synthesized and found to exhibit antifungal effects and induce apoptosis-like death of fungi, possibly due to elevated intracellular reactive species levels.
Review
Microbiology
Petra Vande Zande, Xin Zhou, Anna Selmecki
Summary: Fungal species have dynamic genomes and exhibit genomic plasticity in response to stress. This has phenotypic consequences that affect fitness and drug resistance. Understanding the rates, mechanisms, and impact of genomic changes in fungi is important for addressing the challenges in human health caused by fungal pathogens and antifungal drug resistance.
ANNUAL REVIEW OF MICROBIOLOGY
(2023)
Review
Mycology
Edward Dearberg, Nathan Smith
Summary: This article discusses the application of photogrammetry in the field of mycology, highlighting the initial tests using dried fungal material and the improvements in methodology.
FUNGAL BIOLOGY REVIEWS
(2024)
