Article
Clinical Neurology
Florian Wolf, Mareike Eschweiler, Annette Rademacher, Philipp Zimmer
Summary: Multimodal agility-based exercise training (MAT) is a valuable framework for improving cardiovascular, neuromuscular, and cognitive function. However, current exercise recommendations for persons with Multiple Sclerosis (pwMS) are difficult to implement and lack effective and engaging training methods. Therefore, it is recommended to investigate multimodal exercise interventions, such as MAT, and compare them to unimodal approaches.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Clinical Neurology
Rodrigo Vitorio, Mahmoud El-Gohary, Sean Pearson, Patricia Carlson-Kuhta, Graham Harker, Fay B. Horak, Jodi Lapidus, Mike Studer, Martina Mancini
Summary: This study aims to evaluate the effectiveness of a wearable inertial sensor feedback system, Mobility Rehab, in gait training for older adults. The research is a single-center, pragmatic clinical trial involving 200 elderly patients with gait disturbances undergoing either standard physical therapy or therapist-assisted feedback therapy for 6 weeks.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Natalia Mariano Barboza, Martina Mancini, Suhaila Mahmoud Smaili, Fay B. Horak, Patricia Carlson-Kuhta, Rosie Morris, Laurie A. King
Summary: This study compared different aspects of gait and balance between individuals with Parkinson's disease who have normal cognition and those with impaired cognition. The results showed that dynamic balance during gait was more impaired in individuals with impaired cognition. No differences were found in other balance domains.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Mohan Ganesan, Demetrios Skias, Alexander S. Aruin
Summary: The study found that balance, gait, and mobility in individuals with MS could be improved after 4 weeks of visual cue guided multi-direction stepping training. This training method could be significant in helping MS patients achieve greater independence in mobility.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Fatih Soke, Fatma Aydin, Selda Karakoc, Cagri Gulsen, Mustafa Ertugrul Yasa, Nursena Ersoy, Elvan Ozcan Gulsen, Canan Yucesan
Summary: Backward walking training (BWT) combined with conventional walking training (CWT) has positive effects on balance, gait, and functional mobility in patients with multiple sclerosis (MS).
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medicine, General & Internal
Qurat ul Ain, Muhammad Imran, Ayesha Bashir, Arshad Nawaz Malik
Summary: The study aimed to investigate the effects of progressive resistance training on gait and mobility in stroke patients, and found significant improvements in gait dynamic index, six-meter walk test, and five times sit-to-stand test after nine weeks of intervention.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2021)
Article
Oncology
Jennifer Blackwood, Kateri Rybicki
Summary: This study found that in older breast cancer survivors, performance on the TUG and TUG-Cognitive can predict the risk of falls, while gait speed measures have poor predictive ability.
INTEGRATIVE CANCER THERAPIES
(2021)
Article
Orthopedics
Jennifer A. Nelson, Elizabeth R. Boyer
Summary: The study found that balance and endurance are the most important factors limiting walking ability in individuals with cerebral palsy, followed by weakness, safety concerns, mental ability, and pain. The extent of limitation caused by these factors varies across different GMFCS levels, and there are weak associations between age and pain, mental ability, safety, and balance.
Review
Rehabilitation
Mariana Volpini, Mariana Aquino, Ana Carolina Holanda, Elizabeth Emygdio, Janaine Polese
Summary: The systematic review showed that RAGT can significantly improve walking distance and have clinical effects on gait speed and functionality for children with CP, with effects maintained in both short and long term.
DISABILITY AND REHABILITATION
(2022)
Review
Orthopedics
Augustine Joshua Devasahayam, Kyle Farwell, Bohyung Lim, Abigail Morton, Natalie Fleming, David Jagroop, Raabeae Aryan, Tyler Mitchell Saumur, Avril Mansfield
Summary: The study found that objective reactive balance training (RBT) can effectively reduce the likelihood of falls in daily life for individuals at increased risk of falls. However, more adverse events were reported in the RBT group compared to the control group.
Article
Biophysics
Caroline Massot, Nicolas Decoufour, Mathias Blandeau, Franck Barbier, Cecile Donze, Emilie Simoneau, Sebastien Leteneur
Summary: Tandem gait is commonly used to evaluate balance in chronic diseases like MS. In this study, two indexes were proposed to measure limb and trunk movements during tandem gait in early-stage MS patients. The results showed that MS patients had higher speed and step length during tandem gait compared to healthy participants. The contribution indexes of upper limbs were decreased and the inefficiency index was higher in MS patients. These indexes can be used as physical markers to evaluate balance deterioration and rehabilitation efficiency in early-stage MS.
JOURNAL OF BIOMECHANICS
(2023)
Article
Multidisciplinary Sciences
Yu Imaoka, Andri Flury, Laura Hauri, Eling D. de Bruin
Summary: Postural sway and eye movements can serve as potential biomarkers for dementia screening. Comprehensive assessment of these two movements can improve the understanding of complex syndrome for more accurate screening. This study evaluated the effects of comprehensive assessment in healthy older adults using a novel concurrent assessment system.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Andrew S. Monaghan, Patrick G. Monaghan, Sutton B. Richmond, Jamie A. Roper, Brett W. Fling
Summary: This study investigated the effect of shoe cushioning on gait and balance in females with MS. The results suggest that extra cushioning in shoes can improve gait characteristics, reduce sway, and enhance balance performance in this population.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Geriatrics & Gerontology
Peggy M. Cawthon, Sheena M. Patel, Stephen B. Kritchevsky, Anne B. Newman, Adam Santanasto, Douglas P. Kiel, Thomas G. Travison, Nancy Lane, Steven R. Cummings, Eric S. Orwoll, Kate A. Duchowny, Timothy Kwok, Vasant Hirani, John Schousboe, Magnus K. Karlsson, Dan Mellstrom, Claes Ohlsson, Osten Ljunggren, Qian-Li Xue, Michelle Shardell, Joanne M. Jordan, Karol M. Pencina, Roger A. Fielding, Jay Magaziner, Rosaly Correa-de-Araujo, Shalender Bhasin, Todd M. Manini
Summary: This study demonstrates that walking speed cut-points of approximately 0.60 m/s and 0.75 m/s can effectively discriminate individuals with self-reported mobility limitation from those without, with minimal need for reclassification.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hsiang-Tsen Kuo, Nai-Chen Yeh, Yea-Ru Yang, Wen-Chi Hsu, Ying-Yi Liao, Ray-Yau Wang
Summary: This study aimed to determine the effects of cognitive and motor dual task walking training on dual task walking performance and brain changes in older people with MCI. The results showed that both cognitive and motor dual task training improved dual task walking and caused activation changes in specific brain areas.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Elisa Gervasoni, Ettore Beghi, Chiara Corrini, Riccardo Parelli, Elisa Bianchi, Fabiola Giovanna Mestanza Mattos, Johanna Jonsdottir, Angelo Montesano, Davide Cattaneo
Summary: This study examined the validity and reliability of two patient-reported fall prevention strategy scales in people with neurological disorders. The results showed that both scales were effective in assessing fall prevention strategies and providing individual behavior information.
JOURNAL OF GERIATRIC PHYSICAL THERAPY
(2023)
Article
Clinical Neurology
Rita Bertoni, Davide Cattaneo, Cristina Grosso, Francesca Baglio, Johanna Jonsdottir
Summary: This study examined the alterations in bilateral gross and fine manual dexterity in persons with multiple sclerosis (PwMS) and found that most patients exhibited abnormalities in their manual dexterity. The abnormalities in gross manual dexterity were more prevalent and pronounced with increasing disability levels. The prevalence of bilateral alterations in gross manual dexterity was higher than that of fine manual dexterity in all types of multiple sclerosis considered.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Claudio Solaro, Rachele Di Giovanni, Erica Grange, Giampaolo Brichetto, Margit Mueller, Andrea Tacchino, Rita Bertoni, Francesco Patti, Angelo Pappalardo, Luca Prosperini, Letizia Castelli, Rosalba Rosato, Davide Cattaneo, Davide Marengo
Summary: The study aims to evaluate the associations between Manual Ability Measure-36 (MAM-36) and objective measures, including the Nine Hole Peg Test (9-HPT), Box and Block Test (BBT), and Hand Grip Strength (HGS) in people with multiple sclerosis (PwMS). The study found small correlations between MAM-36 and these objective measures, with different correlations seen in different subgroups. Combining 9-HPT and HGS can enhance the assessment of upper limb function in daily activities.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Rita Bertoni, Fabiola Giovanna Mestanza Mattos, Micaela Porta, Federico Arippa, Eleonora Cocco, Massimiliano Pau, Davide Cattaneo
Summary: The study investigated the feasibility and effects of an immersive commercial virtual reality system for upper limb bilateral rehabilitation in people with multiple sclerosis. The results showed improvement in gross manual dexterity in the less affected limb but did not translate into modifications in terms of self-reported ability or other outcomes.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Niels Bergsland, Michael G. Dwyer, Dejan Jakimovski, Eleonora Tavazzi, Ralph H. B. Benedict, Bianca Weinstock-Guttman, Robert Zivadinov
Summary: This study found a correlation between increased volume and inflammation of the choroid plexus (CP) and clinical disability progression in patients with multiple sclerosis (MS).
Article
Chemistry, Analytical
Ilaria Carpinella, Denise Anastasi, Elisa Gervasoni, Rachele Di Giovanni, Andrea Tacchino, Giampaolo Brichetto, Paolo Confalonieri, Marco Rovaris, Claudio Solaro, Maurizio Ferrarin, Davide Cattaneo
Summary: In this study, an instrumented modified Romberg test (ImRomberg) was used to assess the balance of early-stage multiple sclerosis (MS) patients. By extracting two key parameters that are descriptive of different aspects of balance, significant correlations with clinical scales were found. The results showed that the proposed approach, when integrated with the clinical tandem gait test, could identify balance impairments in early-stage MS patients with higher sensitivity compared to traditional tests. This approach could help identify patients who could benefit from preventive rehabilitation interventions.
Article
Clinical Neurology
Monica Guglielmetti, Giuseppe Grosso, Cinzia Ferraris, Roberto Bergamaschi, Eleonora Tavazzi, Alessandro La Malfa, H. Al-Qahtani Wahidah, Anna Tagliabue
Summary: This study investigated the potential association between consumption of ultra-processed foods (UPFs) and the severity of multiple sclerosis (MS) in Italian patients. The results showed that higher UPF consumption was associated with more severe MS. These findings provide preliminary evidence for exploring the relationship between diet and the progression of MS.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Alberto Loro, Margherita Beatrice Borg, Marco Battaglia, Angelo Paolo Amico, Roberto Antenucci, Paolo Benanti, Michele Bertoni, Luciano Bissolotti, Paolo Boldrini, Donatella Bonaiuti, Thomas Bowman, Marianna Capecci, Enrico Castelli, Loredana Cavalli, Nicoletta Cinone, Lucia Cosenza, Rita Di Censo, Giuseppina Di Stefano, Francesco Draicchio, Vincenzo Falabella, Mirko Filippetti, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Marco Invernizzi, Johanna Jonsdottir, Carmelo Lentino, Perla Massai, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Sandra Morelli, Giovanni Morone, Antonio Nardone, Daniele Panzeri, Maurizio Petrarca, Federico Posteraro, Andrea Santamato, Lorenza Scotti, Michele Senatore, Stefania Spina, Elisa Taglione, Giuseppe Turchetti, Valentina Varalta, Alessandro Picelli, Alessio Baricich
Summary: This study aims to determine the efficacy of robotic gait training (RAGT) on the balance of post-stroke survivors. The results show that RAGT is equally effective as traditional therapy, and the combination of the two may lead to better outcomes. Therefore, future experimentation should focus on robot-assisted balance training.
Article
Clinical Neurology
Johanna Jonsdottir, Carme Santoyo-Medina, Turhan Kahraman, Alon Kalron, Kamila Rasova, Lousin Moumdjian, Susan Coote, Andrea Tacchino, Erica Grange, Tori Smedal, Ellen Christin Arntzen, Yvonne Learmonth, Ludovico Pedulla, Gillian Quinn, Daphne Kos
Summary: The COVID-19 pandemic has led to reorganization or reduction of neurorehabilitation services for people with multiple sclerosis. This study explored the changes in the organizational framework and technology usage in physiotherapy services for these patients. A survey completed by 215 physiotherapists showed a significant reduction in the number, duration, and perceived effectiveness of rehabilitation sessions during the pandemic, while the use of remote technologies did not change. Therefore, providing guidelines and training in telehealth technologies in professional education becomes crucial.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Johanna Jonsdottir, Fabiola Giovanna Mestanza Mattos, Alessandro Torchio, Chiara Corrini, Davide Cattaneo
Summary: This cross-sectional study investigates the value of including stabilometric measures of sway with clinical measures of balance in models for identification of faller chronic stroke survivors, and the relations between variables. The results show that a model combining BBS, BI, and SwayML is best at accurately identifying faller status in persons in the chronic phase post stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Michela Goffredo, Chiara Pagliari, Andrea Turolla, Cristina Tassorelli, Sonia Di Tella, Sara Federico, Sanaz Pournajaf, Johanna Jonsdottir, Roberto De Icco, Leonardo Pellicciari, Rocco Salvatore Calabro, Francesca Baglio, Marco Franceschini
Summary: This study aimed to expand the research on the impact of telerehabilitation on quality of life to a larger sample of neurological patients, including those with Parkinson's Disease. The results showed that telerehabilitation positively affected static and dynamic balance and gait in people with Parkinson's Disease and Multiple Sclerosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Giacomo Greco, Elena Colombo, Matteo Gastaldi, Lara Ahmad, Eleonora Tavazzi, Roberto Bergamaschi, Eleonora Rigoni
Summary: Optic neuritis (ON) is a common cause of vision loss in young adults, and atypical forms are characterized by unusual features and negative AQP4 and MOG antibodies. A broad differential diagnosis is needed for AQP4 and MOG-seronegative ON to promptly identify and provide appropriate management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Virginia Bandini, Ilaria Carpinella, Alberto Marzegan, Johanna Jonsdottir, Carlo Albino Frigo, Laura Avanzino, Elisa Pelosin, Maurizio Ferrarin, Tiziana Lencioni
Summary: Persons post-stroke often experience excessive muscle co-contraction, causing compromised arm functions in daily activities. This study aims to investigate whether the surface electromyography (sEMG)-based co-contraction index (CCI) can be a clinical tool for assessing and monitoring motor performance in stroke patients. Results showed that stroke patients exhibited higher muscle co-contraction compared to healthy subjects. After robot therapy, stroke patients showed improved motor control compared to usual care therapy. The sEMG-based CCI could be a valuable tool in clinical practice.
Review
Virology
Eleonora Tavazzi, Anna Pichiecchio, Elena Colombo, Eleonora Rigoni, Carlo Asteggiano, Elisa Vegezzi, Francesco Masi, Giacomo Greco, Stefano Bastianello, Roberto Bergamaschi
Summary: The recent SARS-CoV-2 pandemic and related vaccines have prompted the investigation of the potential relationship between viral infections or vaccinations and dysimmune CNS disorders. This study focuses on 12 cases of multiple sclerosis/myelitis onset or reactivation after exposure to SARS-CoV-2 infection/vaccines, as well as a review of published case reports and case series. The findings suggest a temporal association between viral/vaccine exposure and symptoms onset, indicating a possible role of SARS-CoV-2 infection/vaccines in unmasking dysimmune CNS disorders.
Article
Biology
Valeria Cavalloro, Francesca Soddu, Sandro Baroni, Francesco Saverio Robustelli della Cuna, Eleonora Tavazzi, Emanuela Martino, Simona Collina
Summary: This study investigates the traditional preparations and botanical ingredients of anesthetic recipes in medieval manuscripts. The results are of particular interest for future biological investigations.
