Review
Biochemistry & Molecular Biology
Panka Pinter, Alan Alpar
Summary: The focus of this study is on changes in the extracellular matrix in neurodegenerative disorders. The composition of the extracellular matrix is critical for neuronal function, and changes in its assembly can trigger or reflect dysfunction in the brain/spinal cord. The study summarizes the phenotypic appearance, biochemical characteristics, and major enzymes involved in regulating and remodeling the extracellular matrix in disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Antonios Douros, Christina Santella, Sophie Dell'Aniello, Laurent Azoulay, Christel Renoux, Samy Suissa, Paul Brassard
Summary: The study found that infectious disease burden was associated with an increased risk of Alzheimer's disease (AD), with the risk gradually increasing with longer time since first infection. However, the risk did not increase with cumulative number of infections.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
John L. Robinson, Sharon X. Xie, Daniel R. Baer, EunRan Suh, Vivianna M. Van Deerlin, Nicholas J. Loh, David J. Irwin, Corey T. McMillan, David A. Wolk, Alice Chen-Plotkin, Daniel Weintraub, Theresa Schuck, Virginia M. Y. Lee, John Q. Trojanowski, Edward B. Lee
Summary: In this retrospective study, the incidence of 10 pathologies in neurodegenerative disease (ND) and normal aging was examined, with up to seven pathologies observed concurrently resulting in 161 different combinations. The presence of multiple additive pathologies was associated with factors such as longer disease duration, clinical dementia, older age, and APOE e4 status.
Article
Multidisciplinary Sciences
Ping-Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Jay Penney, Ravikiran M. Raju, Ute Geigenmuller, M. Catarina Silva, Diane E. Lucente, James F. Gusella, Bradford C. Dickerson, Anjanet Loon, Margaret X. Yu, Michael Bula, Melody Yu, Stephen J. Haggarty, Li-Hue Tsai
Summary: In this study, a 12-amino-acid-long peptide fragment derived from Cdk5 (Cdk5i) was identified. The Cdk5i showed high binding affinity toward the Cdk5/p25 complex and reduced Cdk5/p25 kinase activity, offering therapeutic potential for neurodegenerative diseases associated with Cdk5 hyperactivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Environmental Sciences
Shichen Wu, Junkai Xie, Han Zhao, Oscar Sanchez, Xihui Zhao, Jennifer L. Freeman, Chongli Yuan
Summary: GenX, a safer alternative to PFOA, has raised safety concerns due to its association with various organ damages. This study systematically assessed the molecular neurotoxicity of low-dose GenX exposure, revealing persistent changes in nuclear morphology, chromatin arrangements, and neuronal characteristics, suggesting GenX as a potential neurotoxin and risk factor for Parkinson's disease.
Article
Biochemistry & Molecular Biology
Keren Zohar, Elyad Lezmi, Tsiona Eliyahu, Michal Linial
Summary: The compound ladostigil has been shown to alleviate cell damage induced by oxidation, inhibit microglial activation, and improve learning deficits under conditions of chronic oxidative stress in the aging brain.
Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Physiology
Camilla Ferrari, Sandro Sorbi
Summary: The history of Alzheimer's disease dates back to 1907, but it wasn't until the end of the century that the components of pathological hallmarks and genetic subtypes were identified, leading to the first pathogenic hypothesis. Advances in biomarkers and technology have shifted the concept of AD from a static view to a biological entity that can manifest in various ways. Research shows that AD is heterogeneous in terms of amyloid composition, tau distribution, clinical symptoms, and genetic background, making it difficult to explain with a single pathological process.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Jacob Connolly, Bella Khatib-Shahidi, Abdulsahib Albehadili, Iman Tassavvor, Meghana Ranabothu, Noha Eid, Prabhatchandra Dube, Samer J. Khouri, Deepak Malhotra, Steven T. Haller, David J. Kennedy
Summary: Paraoxonase enzymes are an important redox system that protect cells against oxidative stress. The PON enzymes family, consisting of PON-1, PON-2, and PON-3, play a role in preventing cardiovascular disease and are associated with neurological disorders and neurodegenerative diseases. This review summarizes the evidence on the role of PONs in these diseases and their ability to modify risk factors for neurological disorders, focusing on Alzheimer's disease, Parkinson's disease, and other neurodegenerative and neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Construction & Building Technology
Mehdi Amouei Torkmahalleh, Motahareh Naseri, Sholpan Nurzhan, Raikhangul Gabdrashova, Zhibek Bekezhankyzy, Aidana Gimnkhan, Milad Malekipirbazari, Mojtaba Jouzizadeh, Mahsa Tabesh, Hamta Farrokhi, Hossein Mehri-Dehnavi, Reza Khanbabaie, Sahar Sadeghi, Ali Alizadeh Khatir, Sergei Sabanov, Giorgio Buonanno, Philip K. Hopke, Flemming Cassee, Byron Crape
Summary: This study assessed the effects of exposure to high concentrations of cooking aerosol on brain activity and found that during exposure, the brain's fast-wave band decreased and the ratio of slow-wave band to fast-wave band increased, similar to observations in neurodegenerative diseases and Alzheimer's disease. However, the brain tended to return to its normal condition within 30 minutes after exposure.
Review
Biochemistry & Molecular Biology
Yapei Jiang, Naihan Xu
Summary: Neurodegenerative diseases are a major global health problem, and identifying molecular markers related to neurodegenerative processes is urgently important. Defects in autophagy, the process of removing aggregate-prone proteins in neurons, are often associated with the development of neurodegenerative diseases. Aberrant regulation of long non-coding RNAs (lncRNAs) also plays a role in neurological disorders. This review summarizes the recent progress in studying lncRNAs and autophagy in the context of neurodegenerative disorders, particularly Alzheimer's disease (AD) and Parkinson's disease (PD), providing guidance for future research in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lukasz Brylinski, Katarzyna Kostelecka, Filip Wolinski, Piotr Duda, Joanna Gora, Michal Granat, Jolanta Flieger, Grzegorz Teresinski, Grzegorz Buszewicz, Ryszard Sitarz, Jacek Baj
Summary: Aluminium (Al) is widely present in the Earth's crust and its role in the pathogenesis of neurological diseases is still debated. This review examines Al toxicokinetics and its involvement in several diseases, including Alzheimer's disease, autism spectrum disorder, alcohol use disorder, multiple sclerosis, Parkinson's disease, and dialysis encephalopathy. The literature suggests excessive Al accumulation in the central nervous system in these diseases, as well as epidemiological links between Al exposure and increased disease prevalence. Al also shows potential as a disease marker and the use of Al chelators has beneficial effects in some cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xianwei Chen, Guoqiang Sun, E. Tian, Mingzi Zhang, Hayk Davtyan, Thomas G. Beach, Eric M. Reiman, Mathew Blurton-Jones, David M. Holtzman, Yanhong Shi
Summary: This study established a human brain organoid-based sAD model using hiPSC-derived 3D brain organoids to mimic the serum exposure consequence of blood-brain barrier breakdown in AD patients. The model successfully recapitulated AD-like pathologies and could serve as a powerful platform for mechanistic study and therapeutic development in the future.
Review
Pharmacology & Pharmacy
Mangaldeep Dey, Rakesh Kumar Singh
Summary: Aluminium, one of the most widely distributed elements on Earth, has no critical biological functions in the human body, but its excessive exposure has attracted significant attention due to its potential neurotoxic effects. This review discusses the neuroinflammatory and neurodegenerative events in the brain caused by aluminium exposure, including oxidative stress, apoptosis, inflammatory events, calcium dyshomeostasis, A beta deposition, and neurofibrillary tangle formation. Protective measures for preventing aluminium-induced neuronal dysregulations are also highlighted.
PHARMACOLOGICAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Emma Shardlow, Cassandra Rao, Roman Sattarov, Ling Wu, Paul E. Fraser, Christopher Exley
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Article
Pathology
Javier Asin, Jessica Molin, Marta Perez, Pedro Pinczowski, Marina Gimeno, Nuria Navascues, Ana Muniesa, Ignacio de Blas, Delia Lacasta, Antonio Fernandez, Lorena de Pablo, Matthew Mold, Christopher Exley, Damian de Andres, Ramses Reina, Lluis Lujan
VETERINARY PATHOLOGY
(2019)
Letter
Anesthesiology
C. Exley
Article
Environmental Sciences
Christopher Exley, Gea Guerriero, Xabier Lopez
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Environmental Sciences
Matthew Mold, Jason Cottle, Andrew King, Christopher Exley
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Toxicology
Karine P. Reichert, Maria Rosa C. Schetinger, Micheli M. Pillat, Nathieli B. Bottari, Tais V. Palma, Jessie M. Gutierres, Henning Ulrich, Cinthia M. Andrade, Christopher Exley, Vera M. M. Morsch
ARCHIVES OF TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Gea Guerriero, Rupesh Deshmukh, Humira Sonah, Kjell Sergeant, Jean-Francois Hausman, Esther Lentzen, Nathalie Valle, Khawar Sohail Siddiqui, Christopher Exley
Letter
Biochemistry & Molecular Biology
Christopher Exley
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Chemistry, Physical
Christopher Exley, Gea Guerriero, Xabier Lopez
Article
Water Resources
C. Linhart, D. Davidson, S. Pathmanathan, T. Kamaladas, C. Exley
EXPOSURE AND HEALTH
(2020)
Review
Cell Biology
Gea Guerriero, Ian Stokes, Nathalie Valle, Jean-Francois Hausman, Christopher Exley
Article
Biochemistry & Molecular Biology
Emma Shardlow, Caroline Linhart, Sameerah Connor, Erin Softely, Christopher Exley
Summary: The study measured the aluminium content of thirteen infant vaccines, finding that only three vaccines contained the amount indicated by the manufacturer. Six vaccines had a greater quantity of aluminium, while four vaccines had a lower quantity. The data raised questions about the significance of aluminium content in vaccines and highlighted areas of limited information. Monitoring the aluminium content in vaccines is crucial for ensuring both efficacy and safety, given the known toxicity of aluminium in humans.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emma Shardlow, Bakhtbilland Khan, Christopher Exley
Summary: This study investigated the impact of different metal ions on the aggregatory behavior and size of A beta(1-42) under simulated physiological conditions. The results showed that Al3+ ions stabilized smaller, toxic intermediates while excess Cu2+ facilitated the formation of larger, more inert species. This suggests a complex relationship between metal ions and the toxicity of A beta(1-42).
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Caroline Silveira Martinez, Jose Antonio Uranga-Ocio, Franck Maciel Pecanha, Dalton Valentim Vassallo, Christopher Exley, Marta Miguel-Castro, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can protect rats from the effects of long-term exposure to high and low levels of aluminum in the diet on reproductive function. The supplementation of EWH can reduce inflammation and oxidative stress in the reproductive organs, and maintain normal sperm production and quality.
Article
Multidisciplinary Sciences
Christopher Exley, Matthew J. Mold