Article
Pediatrics
Thierry Debillon, Loic Sentilhes, Gilles Kayem, Marie Chevallier, Jennifer Zeitlin, Olivier Baud, Antoine Vilotitch, Veronique Pierrat, Isabelle Guellec, Pierre Yves Ancel, Nathalie Bednarek, Anne Ego
Summary: In newborns with hypoxic-ischemic encephalopathy (HIE), early neurological and biological examinations were found to be associated with unfavorable outcomes, including death and abnormal MRI results, despite the widespread use of hypothermia treatment (HT).
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Y. W. Wu, B. A. Comstock, F. F. Gonzalez, D. E. Mayock, A. M. Goodman, N. L. Maitre, T. Chang, K. P. Van Meurs, A. L. Lampland, E. Bendel-Stenzel, A. M. Mathur, T-W Wu, D. Riley, U. Mietzsch, L. Chalak, J. Flibotte, J-H Weitkamp, K. A. Ahmad, T. D. Yanowitz, M. Baserga, B. B. Poindexter, E. E. Rogers, J. R. Lowe, K. C. K. Kuban, T. M. O'Shea, J. L. Wisnowski, R. C. McKinstry, S. Bluml, S. Bonifacio, K. L. Benninger, R. Rao, C. D. Smyser, G. M. Sokol, S. Merhar, M. D. Schreiber, H. C. Glass, P. J. Heagerty, S. E. Juul
Summary: The administration of erythropoietin to newborns undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy did not result in a lower risk of death or neurodevelopmental impairment than placebo and was associated with a higher rate of serious adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Katarina Esih, Katja Goricar, Zvonka Rener-Primec, Vita Dolzan, Aneta Soltirovska-Salamon
Summary: Genetic variability in inflammation- and antioxidant-related pathways may influence the response to hypoxic-ischemic brain injury in newborns, with certain polymorphisms being associated with specific brain injury patterns identified by MRI.
Review
Biotechnology & Applied Microbiology
Girish Kumar Rasineni, Nalinikanta Panigrahy, Subha Narayan Rath, Madhurarekha Chinnaboina, Ramesh Konanki, Dinesh Kumar Chirla, Srinivas Madduri
Summary: Perinatal asphyxia and neonatal encephalopathy contribute to neonatal mortality, and a combination of clinical data, neuroimaging, and biochemical parameters is a strategy for improved diagnosis and prognosis. Omics technologies may help identify biomarkers associated with brain injuries and predict disease severity.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Licia Lugli, Elisabetta Garetti, Bianca Maria Goffredo, Francesco Candia, Sara Crestani, Caterina Spada, Isotta Guidotti, Luca Bedetti, Francesca Miselli, Elisa Muttini Della Casa, Maria Federica Roversi, Raffaele Simeoli, Sara Cairoli, Daniele Merazzi, Paola Lago, Lorenzo Iughetti, Alberto Berardi
Summary: This study aims to evaluate the pharmacokinetic characteristics of fentanyl in full-term newborns with hypoxic-ischemic encephalopathy (HIE) who have undergone therapeutic hypothermia (TH). By measuring fentanyl plasma concentrations, the study aims to optimize the dosing regimen of fentanyl during TH.
Article
Biochemistry & Molecular Biology
Katarina Esih, Katja Goricar, Aneta Soltirovska-Salamon, Vita Dolzan, Zvonka Rener-Primec
Summary: The study revealed that genetic variability in antioxidant and inflammatory pathways may be associated with epilepsy development in newborns treated with therapeutic hypothermia after HIE. Interaction between specific genetic polymorphisms could influence the risk of epilepsy in these newborns.
Article
Nutrition & Dietetics
Rebekah Nixon, Ting Hin Richard Ip, Benjamin Jenkins, Ping K. Yip, Paul Clarke, Vennila Ponnusamy, Adina T. Michael-Titus, Albert Koulman, Divyen K. Shah
Summary: The study revealed that peripheral blood lipidomic signature of newborns with hypoxic-ischemic encephalopathy (HIE) can be significantly impacted, with different severities of HIE leading to changes in lipid species in the blood. These findings may guide research in nutrition-based intervention strategies to enhance neuroprotection after HIE.
Article
Pediatrics
Alexandra Bower, Perrine Lorain, Gilles Kayem, Marc Dommergues, Laurence Foix-L'Helias, Isabelle Guellec
Summary: The study found that newborns with pathological foetal acidemia but without moderate or severe HIE may have metabolic disorders, require organ support, hospitalization, and blood sampling for detecting biological anomalies. Prospective studies are needed to establish consensus guidelines for managing this vulnerable population.
Article
Pediatrics
Lucia Lanciotti, Rossella Sica, Laura Penta, Francesca Parisi, Alberto Argentiero, Maurizio Radicioni, Giuseppe Di Cara, Francesca Di Genova, Alberto Verrotti, Stefania Troiani, Susanna Maria Roberta Esposito
Summary: The aim of this study is to evaluate whether minipuberty occurs in patients with hypoxic ischemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH). The results showed that minipuberty occurred in the case group patients, with no significant differences reported from the control group and with hormonal serum levels comparable to healthy infants of the control group.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Gian Pietro Sechi, Flaminia Bardanzellu, Maria Cristina Pintus, Maria Margherita Sechi, Maria Antonietta Marcialis, Vassilios Fanos
Summary: This review discusses the potential therapeutic role of thiamine and its derivatives in the management of neonatal hypoxic-ischemic encephalopathy (HIE), highlighting its antioxidant properties and ability to rescue mitochondrial function. It suggests a synergistic effect between thiamine treatment and therapeutic hypothermia.
Article
Obstetrics & Gynecology
Alessandro Presacco, Venkata C. Chirumamilla, Gilbert Vezina, Ruoying Li, Adre Du Plessis, An N. Massaro, Rathinaswamy B. Govindan
Summary: The objective of this study was to assess the use of continuous heart rate variability as a predictor of brain injury severity in newborns with moderate to severe hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. The results showed that heart rate variability can predict the severity of brain injury in these newborns.
JOURNAL OF PERINATOLOGY
(2023)
Review
Pediatrics
Suresh Victor, Eridan Rocha-Ferreira, Ahad Rahim, Henrik Hagberg, David Edwards
Summary: Around 0.75 million babies suffer from HIE each year, leading to neurodevelopmental impairment. Therapeutic hypothermia is effective but improvements are needed. Challenges for the next decade include better animal models, industry support, and well-designed clinical trials to enhance treatment outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Anja Troha Gergeli, Andreja Skofljanec, David Neubauer, Darja Paro Panjan, Jana Kodric, Damjan Osredkar
Summary: This study evaluated the predictive value of commonly used diagnostic methods in newborns with HIE for short-term and long-term neurodevelopmental outcome. The results showed that MRI performed in the first week after HIE had a higher accuracy in predicting long-term neurological outcome, while EEG and ATNA performed in the second or third week postnatally also had good predictive value.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Mari Merce Cascant-Vilaplana, Angel Sanchez-Illana, Jose David Pineiro-Ramos, Roberto Llorens-Salvador, Guillermo Quintas, Camille Oger, Jean-Marie Galano, Claire Vigor, Thierry Durand, Julia Kuligowski, Maximo Vento
Summary: This study investigates the role of oxidative stress and inflammation in neonatal hypoxic-ischemic encephalopathy, identifying an increase in oxidative stress biomarkers over time and a decrease in prostaglandin levels. MRI findings reveal correlations between oxidative stress levels and brain lesion patterns, while gender does not significantly impact biomarker concentrations. Monitoring noninvasive lipid peroxidation biomarkers may aid in diagnosis and predicting outcomes for HIE patients.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Editorial Material
Biochemistry & Molecular Biology
GianPietro Sechi, M. Margherita Sechi
Summary: In neonatal hypoxic-ischemic encephalopathy (HIE), therapeutic hypothermia (TH) is the standard care in developed countries, but it may not be beneficial or suitable in developing nations. Moreover, hypothermic neuroprotection is often incomplete, with infants still experiencing death or significant neurological issues. Therefore, there is a need to find innovative neuroprotective compounds for HIE, such as ketone bodies and thiamine, which may provide additional neuroprotection in conjunction with TH and improve treatment strategies in low-middle-income countries.
ACS CHEMICAL NEUROSCIENCE
(2023)