Review
Radiology, Nuclear Medicine & Medical Imaging
Elze R. R. Timmers, Marrit R. R. Klamer, Ramesh S. S. Marapin, Adriaan A. A. Lammertsma, Bauke M. M. de Jong, Rudi A. J. O. Dierckx, Marina A. J. Tijssen
Summary: This study provides a comprehensive literature overview on alterations in regional cerebral glucose metabolism in conditions associated with hyperkinetic movement disorders and ataxia, using [F-18]FDG PET. The study included studies on tremors, tics, dystonia, ataxia, chorea, myoclonus, functional movement disorders, or mixed movement disorders due to autoimmune or metabolic causes. The results showed that glucose metabolism changes were found in various brain regions in all movement disorders, and clinical characteristics often correlated with glucose metabolism.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Neuroimaging
Ramesh S. Marapin, Harm J. van der Horn, A. M. Madelein van der Stouwe, Jelle R. Dalenberg, Bauke M. de Jong, Marina A. J. Tijssen
Summary: This article provides a comprehensive review of resting-state brain connectivity alterations in patients with hyperkinetic movement disorders (HMD) using rs-fMRI. The study identifies various types of connectivity abnormalities in different HMD phenotypes and highlights the involvement of specific brain regions. The findings contribute to a better understanding of the neural connectivity profiles in HMD.
NEUROIMAGE-CLINICAL
(2023)
Review
Psychology, Multidisciplinary
Parisa Gazerani
Summary: Nightmares typically occur during REM sleep and are associated with physical symptoms and emotions. Nightmare disorders require professional medical treatment, and nightmares in migraine may negatively impact mental and physical health.
BEHAVIORAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mariana Lapo Pais, Joao Martins, Miguel Castelo-Branco, Joana Goncalves
Summary: Tryptophan is an essential amino acid that plays a role in neuropsychiatric diseases. Women have a higher susceptibility to serotonin alterations due to changes in tryptophan levels, leading to a female sex bias in neuropsychiatric diseases. Further research is needed on the impact of diet and sex steroids on tryptophan metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Guenter F. Pilz, Frank Weber, Werner G. Mueller, Juergen R. Schaefer
Summary: Patients often struggle for years without a valid diagnosis, causing pain and high costs. By using statistics and algebra in healthcare, doctors can receive more valuable inputs to improve diagnosis efficiency and save money in healthcare systems.
Article
Neurosciences
Laura Prieto-Arenas, Ignacio Diaz, M. Carmen Arenas
Summary: This study analyzes the literature to determine the presence of gender differences in the development of psychotic, depressive, and anxious symptoms associated with cannabis use. The review reveals that there are gender differences in psychiatric symptoms linked to cannabis use, but the direction of these differences is not always clear. Further research is needed to understand the causal relationship between cannabis use and the development of psychiatric symptoms, as well as the gender differences observed.
Review
Clinical Neurology
Ricardo Sukiennik, Josemar Marchezan, Francisco Scornavacca
Summary: Brazil, as a continental country with a population of over 210 million, shares similarities with other low and middle income countries. The distribution of wealth in Brazil is highly concentrated, with the southern and southeastern regions being wealthier, while there are also areas of immense poverty. This leads to significant disparities in the healthcare system, with university hospitals and facilities equipped with sophisticated tools and trained doctors, but access to quality healthcare is often difficult. This results in challenges in the medical community, such as a higher average age of autism diagnosis and a shortage of professionals trained in ASD diagnosis, as well as a lack of resources translated into Portuguese.
FRONTIERS IN NEUROLOGY
(2022)
Article
Behavioral Sciences
Veronica Menghi, Francesca Bisulli, Francesco Cardinale, Luca Vignatelli, Corrado Zenesini, Roberto Mai, Paola Proserpio, Stefano Francione, Ivana Sartori, Paolo Tinuper, Lino Nobili
Summary: The study identified predisposing factors for hyperkinetic seizure occurrence in patients with drug-resistant focal epilepsy who underwent surgery, highlighting the role of sleep-related epilepsy, type II focal cortical dysplasia, and frontal epileptogenic zone as predictors. Age was also found to have an effect on hyperkinetic manifestations.
EPILEPSY & BEHAVIOR
(2022)
Review
Clinical Neurology
Giulia Paparella, Alfonso Fasano, Mark Hallett, Alfredo Berardelli, Matteo Bologna
Summary: Bradykinesia is a common motor abnormality observed in various neurological diseases not primarily characterized by parkinsonism. The underlying pathophysiology of bradykinesia in these conditions may be related to dysfunction of brain networks. It is suggested that a more accurate and widely used definition of bradykinesia is needed in the context of movement disorders and other neurological conditions.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Christiane Gasperi, Alexander Hapfelmeier, Tanja Daltrozzo, Antonius Schneider, Ewan Donnachie, Bernhard Hemmer
Summary: The study found that patients with multiple sclerosis often experience various diseases and symptoms in the 5 years before diagnosis, with many symptoms suggestive of demyelinating events or other neurological diagnoses.
Article
Clinical Neurology
Christiane Gasperi, Alexander Hapfelmeier, Tanja Daltrozzo, Antonius Schneider, Ewan Donnachie, Bernhard Hemmer
Summary: The study found that patients with multiple sclerosis (MS) were more likely to have certain diseases and symptoms recorded in the 5 years before diagnosis compared to patients without autoimmune diseases. These findings point towards a potential link between symptoms prior to MS diagnosis and the ongoing disease progression.
Review
Neurosciences
Gaetano Rizzo, Davide Martino, Laura Avanzino, Alessio Avenanti, Carmelo Mario Vicario
Summary: A systematic review analyzed 50 published studies and found that hyperkinetic movement disorders, including Huntington disease, Tourette syndrome, dystonia, and essential tremor, have a negative impact on social cognition, particularly in theory of mind, social perception, and empathy. Impairments were observed in the recognition of negative emotions, and empathy disorders were found in individuals with Huntington's Disease and Tourette syndrome. These findings suggest the involvement of subcortical structures responsible for movement disorders in deficits related to social cognition.
SOCIAL NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Dax Volle
Summary: With the growing geriatric population in the United States, the prevalence of dementia is also expected to increase. Planning and managing end of life care for dementia patients are important but often neglected aspects of dementia care. This review aims to explore the reasons behind this disparity, shift the focus toward a palliative approach to dementia care, and provide information on disease trajectory and advanced care planning for patients with dementia.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Review
Clinical Neurology
Aurelie Meneret, Beatrice Garcin, Solene Frismand, Annie Lannuzel, Louise-Laure Mariani, Emmanuel Roze
Summary: Hyperkinetic movement disorders are characterized by abnormal involuntary movements, with causes ranging from autoimmune disorders to genetic diseases. The difficulty in diagnosing these disorders can lead to delayed treatment and potentially serious consequences.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Belen Perez-Duenas, Kathleen Gorman, Anna Marce-Grau, Juan D. Ortigoza-Escobar, Alfons Macaya, Federica R. Danti, Katy Barwick, Apostolos Papandreou, Joanne Ng, Esther Meyer, Shekeeb S. Mohammad, Martin Smith, Francesco Muntoni, Pinki Munot, Johanna Uusimaa, Paivi Vieira, Eammon Sheridan, Renzo Guerrini, Jan Cobben, Sanem Yilmaz, Elisa De Grandis, Russell C. Dale, Roser Pons, Kathryn J. Peall, Vincenzo Leuzzi, Manju A. Kurian
Summary: This study delineates the genetic landscape and key clinical characteristics of complex, early-onset, monogenic hyperkinetic movement disorders, highlighting the importance of comprehensive analysis in guiding physicians for genetic investigation, early diagnosis, precision treatment, and genetic counseling.
MOVEMENT DISORDERS
(2022)