Article
Oncology
Chenyue Zhang, Chenxing Zhang, Haiyong Wang
Summary: Immune checkpoint inhibitors (ICIs) have advanced cancer treatment, but only a few patients benefit from them while the majority do not. This review summarizes different mechanisms of ICI resistance and provides corresponding strategies to overcome this resistance.
Review
Biochemistry & Molecular Biology
Ying Sun, Xiaoli Ma, Hao Hu
Summary: Cascade technology based on nanotechnology has achieved good therapeutic effects in cancer treatment, providing controllability, specificity, and effectiveness in treatment. It can trigger cascade reactions under specific tumor conditions to enhance drug efficacy and reduce side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Bikash Chandra Jena, Lipsa Rout, Ankita Dey, Mahitosh Mandal
Summary: Autophagy plays a crucial role in cancer cells, particularly in cancer-associated fibroblasts, where it not only provides nutrients and protection but also promotes cancer progression. Targeting autophagy in CAFs has become a significant focus in cancer treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yi Xiao, Dihua Yu
Summary: This article summarizes the current progress in targeting the tumor microenvironment in both drug development and clinical trials, emphasizing the challenges in intervening in the tumor microenvironment and discussing strategies to maximize therapeutic benefits. New technologies and approaches to better understand the tumor microenvironment are explored in this context.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Oncology
Sabrina Rizzolio, Silvia Giordano, Simona Corso
Summary: In the last two decades, targeted drugs have revolutionized clinical oncology. However, primary and acquired resistance to these therapies has become a significant limitation, with cancer-associated fibroblasts (CAFs) playing a crucial role. CAFs not only contribute to tumor stroma structure, but also release various molecules that impact tumor properties, including response to drug treatment. The role of CAFs in resistance to targeted therapies, particularly molecular therapies, has been overlooked.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Naji Kharouf, Thomas W. Flanagan, Sofie-Yasmin Hassan, Hosam Shalaby, Marla Khabaz, Sarah-Lilly Hassan, Mosaad Megahed, Youssef Haikel, Simeon Santourlidis, Mohamed Hassan
Summary: As a solid tumor, melanoma is composed of tumor cells, supporting stroma, extracellular matrix, and soluble molecules forming the tumor microenvironment. The tumor microenvironment plays a central role in tumor progression and treatment resistance, making it a potential target for melanoma treatment.
Article
Biochemistry & Molecular Biology
Sakthi Lenin, Elise Ponthier, Kaitlin G. Scheer, Erica C. F. Yeo, Melinda N. Tea, Lisa M. Ebert, Mariana Oksdath Mansilla, Santosh Poonnoose, Ulrich Baumgartner, Bryan W. Day, Rebecca J. Ormsby, Stuart M. Pitson, Guillermo A. Gomez
Summary: This study conducted a systematic review on the molecular mechanisms driving glioblastoma progression, identifying 65 drugs/inhibitors for screening their efficacy on patient-derived glioma stem cells. Costunolide, a TERT inhibitor, was found effective in reducing cell viability in both primary and pre-treated tumor models. This novel workflow could lead to personalized and effective treatment for recurrent glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Daiyong Deng, Riya Patel, Cheng-Yao Chiang, Pingping Hou
Summary: Pancreatic cancer has a poor prognosis and lacks a cure. The unique features of the pancreatic tumor microenvironment contribute to its tumorigenesis, metastasis, and therapy resistance. Recent studies highlight the importance of understanding the role of cells in the tumor microenvironment in combating pancreatic cancer. Molecular insights will aid in the development of novel therapies.
Review
Biochemistry & Molecular Biology
Bikash Chandra Jena, Mahitosh Mandal
Summary: The tumor microenvironment (TME) is a complex network of cellular organization supporting tumor growth through intercellular communication, with a pivotal role in the development of anti-cancer drug resistance. Exosomes have emerged as key players in mediating bidirectional interplay between tumor and TME, promoting drug resistance and challenging therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Pharmacology & Pharmacy
Jae Young So, Joyce Ohm, Stan Lipkowitz, Li Yang
Summary: This review discusses current therapies, studies in treatment resistance and relapse, including recent single-cell sequencing data, for triple-negative breast cancer (TNBC). It also examines changes in the transcriptome and epigenome of TNBC, mechanisms regulating the immune microenvironment, and provides new perspectives on patient stratification and treatment options.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Oncology
Lars M. Schiffmann, Christiane J. Bruns, Thomas Schmidt
Summary: Anti-angiogenic therapies have not met expectations in clinical trials, as patients develop resistance. Understanding resistance mechanisms is crucial for improving treatment efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Miok Kim, Yong Ki Min, Jinho Jang, Hyejin Park, Semin Lee, Chang Hoon Lee
Summary: This study reveals the distinct immune modulation effects of CD73 inhibition compared to PD-1 blockade, suggesting that AB680 may serve as a novel anticancer immunotherapy for CRC with potential synergistic effects when combined with PD-1 blockers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Yinmin Zhao, Jiahui Liu, Mengting He, Qi Dong, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The construction of a smart therapeutic nanoplatform consisting of TiO2@Pt/GOx (TPG) allows for efficient sonodynamic therapy (SDT) and starvation therapy (ST), which lead to systemic tumor suppression and hypoxia alleviation in the tumor microenvironment. The optimized energy structure of TPG enables rapid generation of singlet oxygen and hydroxyl radicals. The accumulation of reactive oxygen species and glucose depletion facilitated by TPG result in oxidative damage and energy exhaustion of cancer cells, amplified by Pt-catalyzed oxygen self-supply. The combinatorial therapy also triggers immunogenetic cell death and subsequent suppression of distant tumors and metastasis through antitumor immunity.
Review
Oncology
Tian Yun, Zhenzhu Liu, Jianbo Wang, Rui Wang, Liang Zhu, Zheng Zhu, Xuejian Wang
Summary: This paper describes the mechanism of ferroptosis in tumor therapy and immunotherapy, as well as the application and benefits of nanotechnology in the combination of tumor immunotherapy and ferroptosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Yibing Chen, Huan Jin, Yucen Song, Ting Huang, Jun Cao, Qing Tang, Zhengzhi Zou
Summary: Tumor-associated macrophages play a significant role in tumor progression and treatment resistance in solid tumors, leading to the development of promising immunotherapeutic strategies targeting macrophages. Targeting TAMs in combination with conventional therapies has shown to be effective in treating solid tumors. Challenges, obstacles in clinical trials, and future perspectives for TAMs-targeting therapies in various cancers are also discussed in this review.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Cao Fang, Yibin Kang
Summary: Metastasis is the leading cause of death in malignant solid tumors, with bone being frequently affected in cancer metastasis. The development of bone metastasis involves cellular and molecular changes that enable cancer cells to adapt to different environments. Understanding these mechanisms is crucial for the development of effective therapies.
Article
Oncology
Minhong Shen, Shanshan Xie, Michelle Rowicki, Sven Michel, Yong Wei, Xiang Hang, Liling Wan, Xin Lu, Min Yuan, John F. Jin, Frank Jaschinski, Tianhua Zhou, Richard Klar, Yibin Kang
Summary: The study found that MTDH promotes the progression of colorectal and lung cancers by facilitating Wnt activation and inducing T-cell exhaustion. Treatment with MTDH antisense oligonucleotides effectively suppresses MTDH expression and significantly attenuates the progression and metastasis of these cancers.
Article
Medicine, Research & Experimental
Kai Song, Xiaofeng Cai, Yunzhou Dong, Hao Wu, Yong Wei, Uma T. Shankavaram, Kui Cui, Yang Lee, Bo Zhu, Sudarshan Bhattacharjee, Beibei Wang, Kun Zhang, Aiyun Wen, Scott Wong, Lili Yu, Lijun Xia, Alana L. Welm, Diane R. Bielenberg, Kevin A. Camphausen, Yibin Kang, Hong Chen
Summary: ER-negative breast cancer exhibits elevated NF-kappa B activity, and here it is shown that epsin proteins play a pivotal role in promoting breast cancer by promoting NEMO linear ubiquitination and sustaining NF-kappa B signaling. The heightened levels of epsins in ER-negative breast cancer are associated with poor relapse-free survival, and targeting epsins may represent a strategy to restrain NF-kappa B signaling and provide a new perspective into ER-negative breast cancer treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Oncology
Fenfang Chen, Yujiao Han, Yibin Kang
Summary: The bone marrow provides a unique microenvironment for tumor cell colonization and growth. The interactions between tumor cells and bone niches play a critical role in controlling tumor cell initiation, dormancy, and progression. Targeting these interactions may lead to potential therapeutic approaches for the clinical treatment of bone metastasis.
BRITISH JOURNAL OF CANCER
(2021)
Editorial Material
Cell Biology
Yibin Kang, Charlotte Kuperwasser
Summary: Selective pressure and signals from the tissue microenvironment play a crucial role in driving metastasis and determining the survival of metastatic tumor cells at distant organs. By utilizing CRISPR-mediated evolving barcode technology, researchers are able to elucidate the impact of the bone microenvironment on the evolution of breast cancer metastasis.
DEVELOPMENTAL CELL
(2021)
Editorial Material
Oncology
Eunmi Lee, Yibin Kang
Summary: The combination of single-cell lineage tracing and RNA sequencing has opened up unprecedented opportunities for prospectively exploring metastatic dynamics. In a pancreatic cancer model, Simeonov et al. developed the macsGESTALT lineage recording system, revealing that hybrid EMT states and S100 expression are associated with increased metastatic abilities.
Editorial Material
Oncology
Cao Fang, Yibin Kang
Summary: Loss of E-cadherin is not only linked to cancer metastasis, but also influences cell signaling events and cellular plasticity. This study highlighted the importance of E-cadherin as a global regulator in driving EMT and the metastatic phenotype, inspiring further research in the field.
Editorial Material
Cell Biology
Yong Tang, Yibin Kang
Summary: The study found that the microbial metabolite TMAO enhances CD8(+) T cell-mediated antitumor immunity in triple-negative breast cancer (TNBC) by inducing pyroptosis in tumor cells, thus improving the efficacy of immunotherapy.
Article
Cell Biology
Jingjing Meng, Yi-zhou Jiang, Shen Zhao, Yuwei Tao, Tengjiang Zhang, Xuxiang Wang, Yuan Zhang, Keyong Sun, Min Yuan, Jin Chen, Yong Wei, Xun Lan, Mo Chen, Charles J. David, Zhijie Chang, Xiaohuan Guo, Deng Pan, Meng Chen, Zhi-Ming Shao, Yibin Kang, Hanqiu Zheng
Summary: This study reveals that Jagged1, derived from tumors, plays a crucial role in regulating the immune microenvironment of breast cancer. Jagged1 promotes tumorigenesis and facilitates the recruitment of macrophages into the tumor microenvironment by activating the Notch pathway. Educated macrophages then interact with tumor-infiltrating T cells to inhibit their proliferation and tumoricidal activity. The high expression of Jagged1 in triple-negative breast cancer patients is associated with increased macrophage infiltration and decreased T cell activity. Co-administration of an ICI PD-1 antibody with a Notch inhibitor effectively inhibits tumor growth in breast cancer models, suggesting potential therapeutic targets.
Review
Oncology
Minhong Shen, Yibin Kang
Summary: The traditional approach to cancer therapeutics targets driver oncogenes, but this method has limitations such as toxicity to normal tissue and treatment resistance. However, a new class of genes called 'cancer fitness genes' have been identified, which play crucial roles in metastasis. These genes help tumor cells adapt to changing microenvironments, facilitating tumor progression and metastasis. They have therapeutic potential as targeting them is less likely to harm noncancerous tissues.
Article
Chemistry, Medicinal
Hailing Chen, Meimiao Zhan, Jianbo Liu, Zhihong Liu, Minhong Shen, Fenfang Yang, Yibin Kang, Feng Yin, Zigang Li
Summary: This study developed a novel class of stabilized peptide inhibitors to disrupt the interaction between MTDH and SND1, showing promising potential as a breast cancer treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Ivan Perez-Nunez, Catalina Rozalen, Jose Angel Palomeque, Irene Sangrador, Mariona Dalmau, Laura Comerma, Anna Hernandez-Prat, David Casadevall, Silvia Menendez, Daniel Dan Liu, Minhong Shen, Jordi Berenguer, Irene Rius Ruiz, Raul Pena, Jose Carlos Montanes, M. Mar Alba, Sarah Bonnin, Julia Ponomarenko, Roger R. Gomis, Juan Miguel Cejalvo, Sonia Servitja, Diego M. Marzese, Lluis Morey, Leonie Voorwerk, Joaquin Arribas, Begona Bermejo, Marleen Kok, Lajos Pusztai, Yibin Kang, Joan Albanell, Toni Celia-Terrassa
Summary: LCOR plays a critical role in breast cancer stem cell differentiation and immunotherapy. Immune-checkpoint blockade therapy selects for LCORlow cancer stem cells, disrupting antigen processing/presentation mechanisms and leading to immune escape and therapy resistance. LCOR can activate APM genes independently of IFN signaling, regulating tumor immunogenicity.
Article
Oncology
Minhong Shen, Yong Wei, Hahn Kim, Liling Wan, Yi-Zhou Jiang, Xiang Hang, Michael Raba, Stacy Remiszewski, Michelle Rowicki, Cheng-Guo Wu, Songyang Wu, Lanjing Zhang, Xin Lu, Min Yuan, Heath A. Smith, Aiping Zheng, Joseph Bertino, John F. Jin, Yongna Xing, Zhi-Ming Shao, Yibin Kang
Summary: Targeting the MTDH-SND1 complex shows significant therapeutic potential for metastatic breast cancer. Specific compounds C26-A2 and C26-A6 inhibit tumor growth and metastasis, as well as enhancing chemotherapy sensitivity.
Article
Oncology
Minhong Shen, Heath A. Smith, Yong Wei, Yi-Zhou Jiang, Sheng Zhao, Nicole Wang, Michelle Rowicki, Yong Tang, Xiang Hang, Songyang Wu, Liling Wan, Zhi-Ming Shao, Yibin Kang
Summary: By targeting the MTDH-SND1 interaction through genetic and pharmacological approaches, it has been found that the complex plays a crucial role in suppressing antitumor T cell responses in breast cancer, ultimately enhancing immune surveillance and sensitivity to anti-programmed cell death protein 1 therapy. This suggests that combination therapy could be a viable approach to increase immune-checkpoint blockade therapy responses in metastatic breast cancer, providing a potential new strategy for treatment.
Review
Oncology
Mark Esposito, Shridar Ganesan, Yibin Kang
Summary: The systemic spread of tumor cells is the major cause of cancer deaths, with few effective therapeutic strategies targeting metastasis. Recent advances in understanding tumor-intrinsic pathways, immune-activating strategies, and emerging areas offer potential for innovative treatments against metastatic cancer. Kang and colleagues review recent progress and challenges in developing therapies for metastatic disease and discuss the clinical implications of ongoing and completed studies.
