Article
Immunology
Michal Rudnik, Amela Hukara, Ievgeniia Kocherova, Suzana Jordan, Janine Schniering, Vincent Milleret, Martin Ehrbar, Karin Klingel, Carol Feghali-Bostwick, Oliver Distler, Przemyslaw Blyszczuk, Gabriela Kania
Summary: The study identified activated profibrotic features in CD14(+) monocytes and CD14(+) pulmonary macrophages in Systemic sclerosis (SSc) patients, highlighting their capability to produce profibrotic fibronectin. This suggests that tissue-infiltrating CD14(+) monocytes/macrophages play a role in ECM production in the pathogenesis of SSc.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Desh Raj, Vinesh Sharma, Ashwani Upadhyaya, Neeraj Kumar, Robin Joshi, Vishal Acharya, Dinesh Kumar, Vikram Patial
Summary: The study evaluated the efficacy of Swertia purpurascens Wall extract against CCl4-induced hepatic fibrosis in rats and found that it significantly improved biochemical parameters, histopathology, and antioxidant enzyme levels. Additionally, the extract effectively reduced fibrotic tissue deposition and inhibited TGF beta/SMAD/NF kappa B signaling in the liver tissue.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiyun Zhu, Jiangfeng Qiu, Kaibo Chen, Wenbo Wang, Siming Zheng
Summary: The study demonstrated that TP and Levofloxacin could alleviate pulmonary injury in CBDL rats for short and long term, respectively, while preventing endotoxin and the development of HPS, possibly by regulating the Endotoxin-TNF-alpha pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Brian Rady, Takahiro Nishio, Debanjan Dhar, Xiao Liu, Mark Erion, Tatiana Kisseleva, David A. Brenner, Alessandro Pocai
Summary: Studies show that the I148M PNPLA3 gene mutation does not affect baseline activation in HSCs, but downregulation of PNPLA3 exacerbates fibrotic response.
Article
Immunology
Haley F. Spencer, Rina Y. Berman, Martin Boese, Michael Zhang, Sharon Y. Kim, Kennett D. Radford, Kwang H. Choi
Summary: The administration of sub-anesthetic doses of IV ketamine infusion may produce sex-related differences in peripheral inflammatory markers in rodents. However, most cytokine levels return to control levels at 4 hours post-infusion, except for specific cytokines in male and female rats, indicating a different trajectory of certain cytokine changes over time following ketamine administration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medicine, Research & Experimental
Chao Sun, Wei Liu, Zhiqiang Lu, Yan Li, Shengnan Liu, Zhili Tang, Ying Yan, Zhiyang Li, Hua Feng, Duo Zhang, Yun Liu, Zhong-Ze Fang, Changtao Jiang, Qiurong Ding, Jingjing Jiang, Hao Ying
Summary: The study demonstrates that TH-responsive hepatic miR-378 can modulate serum cholesterol levels by regulating both the classic and alternative bile acid synthetic pathways.
Article
Cell Biology
Akanksha Sharma, Jiang Wang, Chandrashekhar R. Gandhi
Summary: In both in vivo and in vitro experiments, it was found that the effects of LPS on hepatic stellate cells (aHSCs) are independent of CD14, and CD14 is not necessary for hepatic fibrosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Immunology
Esmaeil Mortaz, Payam Tabarsi, Hamidreza Jamaati, Neda Dalil Roofchayee, Neda K. Dezfuli, Seyed MohammadReza Hashemian, Afshin Moniri, Majid Marjani, Majid Malekmohammad, Davood Mansouri, Mohammad Varahram, Gert Folkerts, Ian M. Adcock
Summary: The study found that the serum levels of sTNFR1 were significantly higher in ICU patients and non-ICU patients compared to healthy subjects. sTNFR1 levels in ICU patients were significantly higher than in non-ICU patients. The sTNFR1 levels in ICU patients positively correlated with age and negatively correlated with ESR.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Manar A. Didamoony, Ahmed M. Atwa, Lamiaa A. Ahmed
Summary: This study aimed to assess the modulatory effect of rupatadine (RUP) on MSC-EXOs in diethylnitrosamine (DEN)-induced liver fibrosis (LF) and explore the possible underlying mechanisms. The combined therapy of MSC-EXOs and RUP showed additional improvement in inhibiting DEN-induced LF through anti-oxidant, anti-inflammatory, anti-necroptotic, and anti-fibrotic effects of RUP, creating a more favorable environment for MSC-EXOs homing and action.
Article
Chemistry, Multidisciplinary
Hany Ezzat Khalil, Hairul-Islam Mohamed Ibrahim, Kareem Ahmed El-Fass, Sabah H. Akrawi, Mohamed A. Morsy
Summary: Orientin has anti-inflammatory effects and can reduce the risk of liver inflammation and fibrosis. It protects against liver injury by inhibiting fibrotic markers and reducing pro-inflammatory mediators.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Mohamed N. Amin, Mohammed El-Mowafy, Ali Mobark, Naglaa Abass, Abdelaziz Elgaml
Summary: The study analyzed inflammatory mediators in serum of handball players before and after exercise, revealing a significant decrease in IL-6 and TNF-alpha levels post-exercise. Additionally, there was an increase in WBCs and platelet count, indicating that moderate exercise can help reduce inflammation and promote muscle healing and recovery.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Yan Guo, Anqi Zhou, Yuanyuan Zhang, Ying Chen, Yifei Chen, Yuan Gao, Xiulian Miao
Summary: Aberrant liver fibrosis is a hallmark event in end-stage liver diseases. Hepatic stellate cells (HSCs) are considered the major source of myofibroblasts in the liver that produce extracellular matrix proteins to promote liver fibrosis. We investigated the role of serum response factor (SRF) in this process.
Article
Multidisciplinary Sciences
Johanna Beil, Juliane Perner, Lena Pfaller, Marie-Apolline Gerard, Alessandro Piaia, Arno Doelemeyer, Adi Wasserkrug Naor, Lori Martin, Aline Piequet, Valerie Dubost, Salah-Dine Chibout, Jonathan Moggs, Remi Terranova
Summary: The possibility of adaptive inherited effects in mammals due to ancestral environmental exposure has long been debated. This study comprehensively investigates the transgenerational effects of exposure to a hepatotoxicant in rats and finds no morphological replication of enhanced wound healing response. However, transcriptional effects suggest transmission at the molecular level, although the functional relevance remains unclear.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Ilin Kandilarov, Petya Gardjeva, Maria Georgieva-Kotetarova, Hristina Zlatanova, Natalia Vilmosh, Ivanka Kostadinova, Mariana Katsarova, Kiril Atliev, Stela Dimitrova
Summary: This study aimed to investigate the effects of two combined plant extracts, rich in flavonoids, on cytokine levels in rats subjected to acute and chronic stress models. The results showed that these combined extracts had a more pronounced effect in reducing cytokine levels compared to individual plant extracts.
Article
Cell Biology
Jiajia Fu, Sihui Chen, Jiao Liu, Jing Yang, Ruwei Ou, Lingyu Zhang, Xueping Chen, Huifang Shang
Summary: This study investigated the serum levels of inflammatory cytokines and their correlations with clinical symptoms in Parkinson's disease (PD) patients. The results showed that PD patients had higher levels of IL-6 and TNF-alpha compared to healthy controls, and IL-6 was associated with non-motor symptoms and cognitive dysfunction, while TNF-alpha had diagnostic value for PD despite its irrelevance to clinical symptoms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
