Article
Immunology
Weize Gao, Zhan Wang, Wenshuai Li, Yongxin Li, Mingjun Liu
Summary: This review systematically demonstrates the research progress of psoriasis-related biomarkers and elaborates their related mechanisms in the pathological development of psoriasis and psoriatic arthritis. In addition, we summarize the development of biologic therapies for psoriasis and psoriatic arthritis in order to drive the broader discussion of psoriasis as an autoimmune-mediated inflammatory skin disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Liam J. O'Neil, Christopher B. Oliveira, Donavon Sandoval-Heglund, Ana Barrera-Vargas, Javier Merayo-Chalico, Eduardo Aguirre-Aguilar, Mariana J. Kaplan, Carmelo Carmona-Rivera
Summary: Anti-CarP antibodies are linked to poor prognosis and bone erosion in rheumatoid arthritis (RA). Neutrophils in RA release modified autoantigens via NETs, including carbamylated LL37. Elevated levels of carbamylated LL37 were found in RA patients' plasma and synovial fluid, and could lead to autoantibody responses and bone damage in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyung Jin Hahn, Sang Gyu Kwak, Dong-Kyu Kim, Jong-Yeup Kim
Summary: Research indicates that individuals with Behcet disease are more likely to develop psoriasis, with higher risk seen in male BD patients and older individuals. Additionally, Behcet disease patients are also more prone to developing psoriatic arthritis.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Holly R. Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A. Qureshi, Mauricio Abrao, Stacey A. Missmer
Summary: A bidirectional association between endometriosis and psoriasis with PsA was found in this study. Psoriasis with concomitant PsA was associated with a higher risk of laparoscopically confirmed endometriosis, while the diagnosis of endometriosis was suggestive of subsequent risk of psoriasis with PsA.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Medicine, General & Internal
Fei Qi, Yaqi Tan, Amin Yao, Xutong Yang, Yanling He
Summary: Psoriatic disease is a spectrum of diseases affecting both skin and musculoskeletal features, with a considerable number of patients progressing from cutaneous psoriasis to psoriatic arthritis. The use of proteomics technologies provides a unique opportunity to explore potential biomarkers for psoriatic arthritis.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Guillaume Larid, Adriana Delwail, Thomas Dalle, Philippe Vasseur, Christine Silvain, Jean-Francois Jegou, Franck Morel, Jean-Claude Lecron, Elisabeth Gervais
Summary: Psoriatic arthritis (PsA) and cutaneous psoriasis (PsO) exhibit distinct cytokine production profiles, which are influenced by clinical phenotype and metabolic syndrome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Judith Haschka, David Simon, Sara Bayat, Zora Messner, Eleni Kampylafka, Filippo Fagni, Susanna Skalicky, Matthias Hackl, Heinrich Resch, Jochen Zwerina, Arnd Kleyer, Alexander Cavallaro, Michael Sticherling, Goerg Schett, Roland Kocijan, Juergen Rech
Summary: This study aimed to identify circulating miRNA signatures associated with psoriasis (PsO) and psoriatic arthritis (PsA) patients. The results show significant differences in miRNA signatures between PsA and PsO patients compared to controls, with five miRNAs being involved in bone and cartilage metabolism, suggesting a link between psoriatic inflammation and bone/cartilage changes.
Review
Medicine, General & Internal
Mihaela Agache, Claudiu C. Popescu, Luminita Enache, Bianca M. Dumitrescu, Catalin Codreanu
Summary: Ultrasonography is advantageous for assessing psoriatic arthritis (PsA) due to its ability to evaluate multiple targets, including joints, entheses, and tendons, as well as skin and nails. However, the use of nail ultrasound in medical practice is limited due to the requirement for probes with a higher frequency. This article narratively evaluates recent studies on the value of nail ultrasound in diagnosing and monitoring PsA.
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Medicine, General & Internal
Stephen R. Pennington, Oliver FitzGerald
Summary: Although having skin/nail psoriasis is an important risk factor for developing psoriatic arthritis (PsA), it alone is not sufficient to identify which patients with psoriasis will develop PsA. Further molecular assessment of psoriasis patients may help refine the profile of those at risk of developing PsA, leading to the design of disease prevention studies and new treatment approaches.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Valentina Natoli, Amandine Charras, Sigrun R. Hofmann, Sarah Northey, Susanne Russ, Felix Schulze, Liza Mccann, Susanne Abraham, Christian M. Hedrich
Summary: This study investigated disease-associated DNA methylation patterns in CD4(+) T-cells from psoriasis and psoriatic arthritis (PsA) patients. The DNA methylation profiles in CD4(+) T-cells can distinguish between skin psoriasis and PsA, and may be used to quantify disease activity and guide individualized treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Tong Chen, Rong-Fen Chen, Xiao-Long Li, Qiao Wang, Wei-Wei Ren, Dan-Dan Shan, Yu-Jing Zhao, Li-Ping Sun, Hui-Xiong Xu, Yu-Ling Shi, Le-Hang Guo
Summary: Objective is to identify patients in the subclinical psoriatic arthritis (Sub-PsA) phase by ultrasound (US) and provide a solution to screen them.
EUROPEAN RADIOLOGY
(2023)
Article
Rheumatology
Fabian Proft, Susanne Lueders, Theresa Hunter, Gustavo Luna, Valeria Rios Rodriguez, Mikhail Protopopov, Katharina Meier, Georgios Kokolakis, Kamran Ghoreschi, Denis Poddubnyy
Summary: A dermatologist-centred screening tool followed by a structured rheumatological examination, including MRI, can be effective in recognizing psoriatic arthritis with axial involvement.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Maria Laura Acosta Felquer, Luciano LoGiudice, Maria Laura Galimberti, Javier Rosa, Luis Mazzuoccolo, Enrique R. Soriano
Summary: The study found that using biologics in patients with psoriasis can reduce the risk of developing psoriatic arthritis (PsA).
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Dermatology
Luca Stingeni, Leonardo Bianchi, Elettra Antonelli, Elena Sofia Caroppo, Silvia Mariel Ferrucci, Carlotta Gurioli, Michela Ortoncelli, Gabriella Fabbrocini, Eustachio Nettis, Donatella Schena, Maddalena Napolitano, Massimo Gola, Laura Bonzano, MariaTeresa Rossi, Anna Belloni Fortina, Anna Balato, Ketty Peris, Caterina Foti, Fabrizio Guarneri, Marco Romanelli, Cataldo Patruno, Paola Savoia, Maria Esposito, Filomena Russo, Enzo Errichetti, Tommaso Bianchelli, Luca Bianchi, Giovanni Pellacani, Claudio Feliciani, Annamaria Offidani, Monica Corazza, Giuseppe Micali, Nicola Milanesi, Giovanna Malara, Andrea Chiricozzi, Marta Tramontana, Katharina Hansel
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Giovanni Fiorillo, Francesco Toso, Andrea Cortese, Francesco Piscazzi, Alessandra Bressan, Stefania Bramanti, Sofia Manara, Alessandra Narcisi, Antonio Costanzo, Mario Valenti
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Lars Iversen, Curdin Conrad, Liv Eidsmo, Antonio Costanzo, Joanna Narbutt, Andreas Pinter, Kulli Kingo, Raquel Rivera Diaz, Frank Kolbinger, ManikPrabhu Nanna, Jennifer Annika Frueh, Piotr Jagiello
Summary: The purpose of this study was to compare the effectiveness of early intervention with secukinumab and traditional nb-UVB phototherapy in patients with new-onset moderate to severe plaque psoriasis. The results showed that secukinumab was more effective than nb-UVB, and early use of biologic treatment may be more effective in treating psoriasis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Cell Biology
Daniela Peruzzu, Zaira Boussadia, Federica Fratini, Francesca Spadaro, Lucia Bertuccini, Massimo Sanchez, Maria Carollo, Paola Matarrese, Mario Falchi, Francesca Iosi, Carla Raggi, Isabella Parolini, Alessandra Care, Massimo Sargiacomo, Maria Cristina Gagliardi, Katia Fecchi
Summary: In this study, the role of cholesterol transport in the endosomal degradative-secretory system was explored using the U18666A inhibitor in a metastatic human melanoma cell line (WM266-4). The results showed that U18666A induced a shift of Cav-1 from the plasma membrane to the endolysosomal compartment, affecting the formation and release of small extracellular vesicles (sEVs). The inhibitor also altered the protein composition of sEVs and reduced their transfer capacity on target cells.
Article
Cell Biology
Ilenia Masi, Flavia Ottavi, Danila Del Rio, Valentina Caprara, Cristina Vastarelli, Sara Maria Giannitelli, Giulia Fianco, Pamela Mozetic, Marianna Buttarelli, Gabriella Ferrandina, Giovanni Scambia, Daniela Gallo, Alberto Rainer, Anna Bagnato, Francesca Spadaro, Laura Rosano
Summary: Dissemination of high-grade serous ovarian cancer (HG-SOC) in the omentum and intercalation into a mesothelial cell (MC) monolayer depends on functional alpha 5 beta 1 integrin (Int alpha 5 beta 1) activity. This study reveals a novel interactive signaling involving beta-arrestin1 (beta-arr1), the activation of the endothelin A receptor (ETAR) by endothelin-1 (ET-1), and the activation of Int alpha 5 beta 1, which promotes tumor cells towards invasive disease. The findings suggest that ETAR/beta-arr1 may regulate the functional pathway of Int alpha 5 beta 1 and could be considered in integrin-targeting programs.
CELL DEATH & DISEASE
(2023)
Article
Dermatology
P. Gisondi, M. Maurelli, A. Costanzo, M. Esposito, G. Girolomoni
Summary: This study aimed to investigate the safety of combining Dupilumab with other monoclonal antibodies. Through the examination of 16 cases and our clinical practice involving 8 patients, it was found that there were no adverse events related to the combination of two monoclonal antibodies, except for a few mild reactions.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Antonio Costanzo, Mar Llamas-Velasco, Gabriella Fabbrocini, Aldo Cuccia, Raquel Rivera-Diaz, Kristian Gaarn Du Jardin, Ismail Kasujee, Lluis Puig, Jose Manuel Carrascosa
Summary: The TRIBUTE study assessed the efficacy and impact on health-related quality of life of Tildrakizumab in moderate-to-severe psoriasis patients in conditions similar to clinical practice. After 24 weeks, a high proportion of patients achieved significant improvement in psoriasis signs and quality of life. Patient-reported outcomes showed improvements in sleep outcomes, work productivity, and treatment satisfaction. The safety profile was favorable.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Medicine, General & Internal
Simone Perniola, Maria Sole Chimenti, Francesca Romana Spinelli, Bruno Frediani, Rosario Foti, Sara Ferrigno, Cristina Garufi, Giulia Cassone, Vincenzo Venerito, Fabiola Atzeni, Roberto Caporali, Fabrizio Conti, Ennio Giulio Favalli, Florenzo Iannone, Marco Sebastiani, Gian Franco Ferraccioli, Giovanni Lapadula, Elisa Gremese
Summary: Rheumatoid Arthritis (RA) is a complex disease with various clinical phenotypes, categorized by disease duration, seropositivity for rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA), joint subtype, clinical behavior, and other subgroups. This review provides a summary of the multifaceted aspects of RA, specifically focusing on the association between autoimmune status and clinical outcomes, achievement of remission, and treatment response, as discussed in the 2022 International GISEA/OEG Symposium.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Ennio Lubrano, Silvia Scriffignano, Mauro Fatica, Paola Triggianese, Paola Conigliaro, Fabio Massimo Perrotta, Maria Sole Chimenti
Summary: The study aimed to evaluate the differences and similarities in psoriatic arthritis (PsA) between sexes, as well as to assess the potential impact of psoriasis on disease burden in PsA patients. The results showed that female PsA patients had a higher disease severity, greater disease activity, worse function, and higher disease burden, while males were more prone to skin involvement. However, there was no significant association between skin involvement and patient global assessment in the regression analysis.
RHEUMATOLOGY AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Cosimo Di Raimondo, Flavia Lozzi, Pier Paolo Di Domenico, Elena Campione, Luca Bianchi
Summary: Melanoma, the deadliest form of skin cancer, accounts for almost 90% of skin cancer mortality. Despite advances in immune and targeted therapies, many patients still experience disease progression. Skin metastases, a common occurrence in melanoma, can be treated through various methods including surgery, injections, and systemic therapies. Further research is needed to understand the underlying mechanisms and differences in behavior and prognosis among melanoma patients with skin metastases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Elisa Gremese, Dario Bruno, Valentina Varriano, Simone Perniola, Luca Petricca, Gianfranco Ferraccioli
Summary: Serum albumin, as an important protein in human physiology, plays a crucial role in various clinical settings. The reduction in serum albumin levels serves as a significant biomarker for poor prognosis in multiple diseases, and clinicians should consider it as a valuable tool to evaluate the efficacy of specific therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Andrea Picchianti-Diamanti, Assunta Navarra, Alessandra Aiello, Bruno Lagana, Gilda Cuzzi, Andrea Salmi, Valentina Vanini, Fabrizio Maggi, Silvia Meschi, Giulia Matusali, Stefania Notari, Chiara Agrati, Simonetta Salemi, Roberta Di Rosa, Damiano Passarini, Valeria Di Gioia, Giorgio Sesti, Fabrizio Conti, Francesca Romana Spinelli, Angela Corpolongo, Maria Sole Chimenti, Mario Ferraioli, Gian Domenico Sebastiani, Maurizio Benucci, Francesca Li Gobbi, Anna Paola Santoro, Andrea Capri, Vincenzo Puro, Emanuele Nicastri, Delia Goletti
Summary: Breakthrough infections (BIs) in rheumatoid arthritis (RA) patients after a COVID-19 vaccination booster dose were analyzed. Older age, receiving conventional synthetic disease modifying antirheumatic drugs (csDMARDs), and higher neutralising antibody titres were identified as protective factors, while anti-IL6R treatment and anti-CD20 therapy increased the risk. The incidence of hospitalization for BIs was significantly higher in RA patients compared to healthcare workers.
Article
Rheumatology
Silvia Scriffignano, Fabio Massimo Perrotta, Paola Conigliaro, Mario Ferraioli, Paola Triggianese, Maria Sole Chimenti, Ennio Lubrano
Summary: The aim of this study was to determine the main MDA domains achieved in PsA patients based on different treatments. Patient global assessment and pain were found to be the least frequently achieved MDA domains, indicating an unmet need for patient-driven outcomes. Larger and prospective studies are needed to confirm these preliminary results and advance personalized treatment approaches in PsA.
RHEUMATOLOGY AND THERAPY
(2023)