Chimeric Proteins Containing MAP-1 and Functional Domains of C4b-Binding Protein Reveal Strong Complement Inhibitory Capacities

Properdin binding to complement activating surfaces depends on initial C3b deposition

(2017) Morten Harboe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend

(2016) David Ermert et al.   IMMUNOLOGY LETTERS

New milestones ahead in complement-targeted therapy

(2016) Daniel Ricklin et al.   SEMINARS IN IMMUNOLOGY

Genetically engineered fusion of MAP-1 and factor H domains 1–5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways

(2015) Mie Anemone Nordmaj et al.   FASEB JOURNAL

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

A novel CRIg-targeted complement inhibitor protects cells from complement damage

(2014) Qian Qiao et al.   FASEB JOURNAL

Essential Role for the Lectin Pathway in Collagen Antibody–Induced Arthritis Revealed through Use of Adenovirus Programming Complement Inhibitor MAp44 Expression

(2014) Nirmal K. Banda et al.   JOURNAL OF IMMUNOLOGY

Restoration of MBL-deficiency: Redefining the safety, efficacy and viability of MBL-substitution therapy

(2014) M.P. Keizer et al.   MOLECULAR IMMUNOLOGY

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

An Engineered Construct Combining Complement Regulatory and Surface-Recognition Domains Represents a Minimal-Size Functional Factor H

(2013) M. Hebecker et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

Mannan-Binding Lectin Mediates Renal Ischemia/Reperfusion Injury Independent of Complement Activation

(2012) P. van der Pol et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Endogenous and Natural Complement Inhibitor Attenuates Myocardial Injury and Arterial Thrombogenesis

(2012) Vasile I. Pavlov et al.   CIRCULATION

Role of complement and perspectives for intervention in transplantation

(2012) Gang Chen et al.   IMMUNOBIOLOGY

Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)

(2012) Mikkel-Ole Skjoedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human C1q Globular Domain: Structure and Recognition of Non-Immune Self Ligands

(2012) Christine Gaboriaud et al.   Frontiers in Immunology

Visual gene developer: a fully programmable bioinformatics software for synthetic gene optimization

(2011) Sang-Kyu Jung et al.   BMC BIOINFORMATICS

NOD-like receptors and the innate immune system: Coping with danger, damage and death

(2011) Kristof Kersse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Serum concentration and interaction properties of MBL/ficolin associated protein-1

(2010) Mikkel-Ole Skjoedt et al.   IMMUNOBIOLOGY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement Activation

(2010) Mikkel-Ole Skjoedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collectin 11 (CL-11, CL-K1) Is a MASP-1/3-Associated Plasma Collectin with Microbial-Binding Activity

(2010) S. Hansen et al.   JOURNAL OF IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation

(2009) Mikkel-Ole Skjoedt et al.   IMMUNOBIOLOGY

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

(2009) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice

(2008) A M Blom et al.   ANNALS OF THE RHEUMATIC DISEASES

Crystal Structure of the CUB1-EGF-CUB2Domain of Human MASP-1/3 and Identification of Its Interaction Sites with Mannan-binding Lectin and Ficolins

(2008) Florence Teillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The alternative complement pathway revisited

(2008) Morten Harboe et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Biological activities of C1 inhibitor

(2008) Alvin E. Davis et al.   MOLECULAR IMMUNOLOGY

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

(2007) Fredrik Bexborn et al.   MOLECULAR IMMUNOLOGY