Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase

Emerging role of Cdc42-specific guanine nucleotide exchange factors as regulators of membrane trafficking in health and disease

(2017) M.V. Egorov et al.   TISSUE & CELL

The modulatory effect of TLR2 on LL-37-induced human mast cells activation

(2016) Yuan-Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of LL-37-induced receptor activation: An overview

(2016) Eddy-Tim Verjans et al.   PEPTIDES

Human-derived cathelicidin LL-37 directly activates mast cells to proinflammatory mediator synthesis and migratory response

(2015) Edyta Bąbolewska et al.   CELLULAR IMMUNOLOGY

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

P2X7Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance

(2015) Xiao Tang et al.   JOURNAL OF IMMUNOLOGY

Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology

(2014) Louis Tong et al.   BIOSCIENCE REPORTS

Targeting Rho-GTPases in immune cell migration and inflammation

(2014) Maté Biro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation

(2014) Ka-Yee G. Choi et al.   IMMUNOLOGY

IFN-  and STAT1 Arrest Monocyte Migration and Modulate RAC/CDC42 Pathways

(2014) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Cathelicidin Host Defence Peptide Augments Clearance of Pulmonary Pseudomonas aeruginosa Infection by Its Influence on Neutrophil Function In Vivo

(2014) Paula E. Beaumont et al.   PLoS One

A Crucial Role for CDC42 in Senescence-Associated Inflammation and Atherosclerosis

(2014) Takashi K. Ito et al.   PLoS One

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

(2013) Ralph Fritsch et al.   CELL

Antimicrobial peptide LL-37 attenuates LTA induced inflammatory effect in macrophages

(2013) Yang Ruan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Orphan Adhesion G Protein-coupled Receptor GPR97 Regulates Migration of Lymphatic Endothelial Cells via the Small GTPases RhoA and Cdc42

(2013) Nadejda Valtcheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small GTPase and Regulation of Inflammation Response in Atherogenesis

(2013) Yuyan Lu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Cdc42 GTPases facilitate TNF-α-mediated secretion of CCL2 from peripheral nerve microvascular endoneurial endothelial cells

(2013) Kelly A. Langert et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Cathelicidin LL-37: An Antimicrobial Peptide with a Role in Inflammatory Skin Disease

(2012) Markus Reinholz et al.   Annals of Dermatology

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

(2012) Dieter Vandamme et al.   CELLULAR IMMUNOLOGY

Cationic Host Defence Peptides: Multifaceted Role in Immune Modulation and Inflammation

(2012) Ka-Yee Choi et al.   Journal of Innate Immunity

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Multiple Immune-Modulatory Functions Of Cathelicidin Host Defense Peptides

(2012) Ka-Yee (Grace) Choi et al.   Frontiers in Immunology

Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses

(2011) K. L. Brown et al.   JOURNAL OF IMMUNOLOGY

Suppressive effect of the antimicrobial peptide LL-37 on expression of IL-6, IL-8 and CXCL10 induced by Porphyromonas gingivalis cells and extracts in human gingival fibroblasts

(2010) Megumi Inomata et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds

(2010) Gimano D. Amatngalim et al.   INFLAMMATION

LL-37 Directs Macrophage Differentiation toward Macrophages with a Proinflammatory Signature

(2010) A. M. van der Does et al.   JOURNAL OF IMMUNOLOGY

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes

(2009) N. Mookherjee et al.   JOURNAL OF IMMUNOLOGY

Human defensins and LL-37 in mucosal immunity

(2009) Mona Doss et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells

(2009) Neeloffer Mookherjee et al.   Molecular BioSystems