Cytosolic Internalization of Anti-DNA Antibodies by Human Monocytes Induces Production of Pro-inflammatory Cytokines Independently of the Tripartite Motif-Containing 21 (TRIM21)-Mediated Pathway

A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway

(2018) Jun-Fang Zhang et al.   Theranostics

Heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) function as endocytic receptors for an internalizing anti-nucleic acid antibody

(2017) Hyunjoon Park et al.   Scientific Reports

Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus

(2017) Shuhei Sakakibara et al.   Scientific Reports

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

(2016) Hui Zhang et al.   Journal of Translational Medicine

TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity

(2015) Stian Foss et al.   IMMUNOLOGICAL REVIEWS

Self-reactive IgE exacerbates interferon responses associated with autoimmunity

(2015) Jill Henault et al.   NATURE IMMUNOLOGY

The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved

(2014) Ole Petter Rekvig et al.   Seminars in Immunopathology

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Simultaneous Neutralization and Innate Immune Detection of a Replicating Virus by TRIM21

(2013) R. E. Watkinson et al.   JOURNAL OF VIROLOGY

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

An inside job for antibodies: tagging pathogens for intracellular sensing

(2013) Teunis B H Geijtenbeek et al.   NATURE IMMUNOLOGY

Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus

(2012) Brendan M. Giles et al.   IMMUNOLOGIC RESEARCH

An Anti-Nucleic Acid Antibody Delivers Antigen to the Cross-Presentation Pathway in Dendritic Cells and Potentiates Therapeutic Antitumor Effects

(2012) C. D. Pham et al.   JOURNAL OF IMMUNOLOGY

Regulation of Virus Neutralization and the Persistent Fraction by TRIM21

(2012) W. A. McEwan et al.   JOURNAL OF VIROLOGY

AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization

(2012) F. Hauler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular antibody-mediated immunity and the role of TRIM21

(2011) William A. McEwan et al.   BIOESSAYS

Targeting antibodies to the cytoplasm

(2011) Andrea L.J. Marschall et al.   mAbs

Anti-dsDNA Antibodies Bind to Mesangial Annexin II in Lupus Nephritis

(2010) S. Yung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cytokines as therapeutic targets in SLE

(2010) Lars Rönnblom et al.   Nature Reviews Rheumatology

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

(2008) H. M. Horton et al.   CANCER RESEARCH

Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalizationviaelectrostatic interactions

(2008) Ying-Chyi Song et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

(2008) A. H. Keeble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system

(2007) Mutsumi Takahata et al.   MOLECULAR IMMUNOLOGY