Article
Agricultural Engineering
Jinpeng Wang, Xiao Yu, Kaifeng Wang, Lu Lin, Hu-Hu Liu, Rodrigo Ledesma-Amaro, Xiao-Jun Ji
Summary: This study explored the optimal biosynthetic pathways for customized production of co6-PUFAs in Y. lipolytica and effectively increased the proportions of co6-PUFAs in total fatty acids through various strategies. The customized strains synthesized GLA, DGLA, and ARA with high titers, providing valuable insights into the production of functional co6-PUFAs.
BIORESOURCE TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anne-Mari Mustonen, Petteri Nieminen
Summary: This review examines the potential roles of DGLA and related n-6 PUFAs in inflammatory conditions. The balance of ARA to DGLA is critical in inflammatory processes, but clinical data on the therapeutic potential of DGLA remain limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Kaori Yokoi, Kenichi Yanagimoto, Kohsuke Hayamizu
Summary: This study investigated the effects of DGLA on pollen-induced allergic symptoms in healthy adults. The results showed that DGLA can reduce sneezing and a blocked nose symptoms associated with pollen allergies.
Article
Medicine, Research & Experimental
Linda Ljungblad, Filip Bergqvist, Conny Tummler, Samanthi Madawala, Thale Kristin Olsen, Teodora Andonova, Per-Johan Jakobsson, John Inge Johnsen, Jana Pickova, Birgitta Strandvik, Per Kogner, Helena Gleissman, Malin Wickstrom
Summary: The study demonstrated that omega 3-LCPUFA had negative effects on medulloblastoma cells, reducing their viability, clonogenic ability, and inducing apoptosis. DHA showed a tumor growth-inhibiting effect in vivo and decreased inflammatory factors in tumor tissues.
Article
Biochemistry & Molecular Biology
Yongnan Li, Douglas R. Tocher, Yuning Pang, Jianlong Du, Xiaojun Xiang, Kangsen Mai, Qinghui Ai
Summary: This study compared the transcriptional regulation of the critical enzyme, elovl5, in the LC-PUFA biosynthesis pathway in marine large yellow croaker and freshwater rainbow trout. The expression of elovl5 and chromatin accessibility in the regulatory region were higher in rainbow trout than in large yellow croaker. Additionally, differences in the sequence and activity of the elovl5 promoter were observed between the two species, as well as differences in the regulatory roles of transcription factors. These findings suggest that changes in the gene regulatory region driven by natural selection likely play a key role in differences in elovl5 expression and activity, influencing the LC-PUFA biosynthesis capacities of rainbow trout and large yellow croaker.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Infectious Diseases
Panjamaphon Chanthasena, Yanling Hua, A'liyatur Rosyidah, Wasu Pathom-Aree, Wanwisa Limphirat, Nawarat Nantapong
Summary: Antibiotic-resistant strains pose a global health threat, necessitating the search for new antibacterial drugs. Streptomycetes are known for being a rich source of bioactive compounds, including antibiotics. In this study, Streptomyces sp. PJ85 isolated from soil in Northeast Thailand was found to possess antibacterial compounds active against methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacteria. The active compounds, actinomycin D and dihomo-gamma-linolenic acid (DGLA), were purified and characterized.
Article
Immunology
Zhubiao Ye, Jianru Chen, Pengran Du, Qingrong Ni, Baizhang Li, Zhe Zhang, Qi Wang, Tingting Cui, Xiuli Yi, Chunying Li, Shuli Li
Summary: This study aimed to determine the differences in specific fatty acids between vitiligo patients and healthy individuals and to investigate their association with clinical features. The results showed that the serological level of alpha-linolenic acid (ALA) was increased in vitiligo patients, while the levels of arachidonic acid (ARA), arachidic acid (AA), and behenic acid were decreased. ALA levels were positively associated with the vitiligo area scoring index (VASI). Supplementation with ARA or nordihydroguaiaretic acid (NDGA) could suppress the function of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robert A. DiSilvestro, Susan Olivo Marston, Autumn Zimmerman, Elizabeth Joseph, Carolynn Boeh McCarty
Summary: Research suggests that GLA may affect resting metabolic rate and help with weight control. However, in overweight young adults with a family history of obesity, borage oil did not affect resting metabolic rate but could improve blood lipid measures.
Article
Medicine, Research & Experimental
Hongshuai Lv, Weiping Jia, Li Yang, Peng Dong, Jiaojiao Liu, Si Wang, Xiaohai Li, Jinghua Hu, Ling Zhao, Yikang Shi
Summary: This study developed three dual drug conjugates by connecting unsaturated fatty acids with Cabazitaxel on dextran. The conjugates showed enhanced water solubility and antitumor effects, with dextran-GLA-CTX exhibiting the strongest activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Lizhi Pang, Harshit Shah, Steven Qian, Venkatachalem Sathish
Summary: Instead of directly inhibiting COX-2, the study used a small molecule to reprogram the COX-2 catalyzed omega-6 PUFAs peroxidation in lung cancer cells by inhibiting D5D activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Dennis Winston T. Nilsen, Peder Langeland Myhre, Are Kalstad, Erik Berg Schmidt, Harald Arnesen, Ingebjorg Seljeflot
Summary: Low levels of DGLA were associated with a high LA:DGLA ratio and risk of total death in elderly patients with recent MI.
Article
Biochemistry & Molecular Biology
Prasad Parchuri, Anjali Pappanoor, Abdulrahman Naeem, Timothy P. Durrett, Ruth Welti, R. V. Sreedhar
Summary: Buglossoides arvensis is a burgeoning oilseed crop with a unique combination of omega-3 and omega-6 poly-unsaturated fatty acids. During seed development, DGATs play a crucial role in enriching TAGs with PUFA compared to PDATs.
Article
Food Science & Technology
Bhuvnesh Sareen, Amita Bhattacharya, Vidyashankar Srivatsan
Summary: Diplazium maximum is a wild edible fern with high nutritional value and phytochemical composition. The dried young fronds contain high levels of dietary fiber and crude protein, along with beneficial components like branched-chain essential amino acids and polyunsaturated fatty acids. Research suggests its potential application in instant convenience food products and its sensory characteristics are similar to commercially available soups.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Environmental Sciences
Rihab Rasheed, Mahmoud Thaher, Nadin Younes, Touria Bounnit, Kira Schipper, Gheyath K. Nasrallah, Hareb Al Jabri, Imma Gifuni, Olivier Goncalves, Jeremy Pruvost
Summary: The study investigates the solar production and application of two native microalgae strains in Qatar, which have high biomass productivity under high light and temperature conditions. However, extreme seasons significantly reduce their productivity. The implementation of a ground heat exchanger can enhance biomass productivity. One strain produces high protein content in winter while the other has high lipid content in summer.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Biomedical
Jiyuan Chen, Yujie Wang, Lu Han, Rong Wang, Chunai Gong, Gang Yang, Zhe Li, Shen Gao, Yongfang Yuan
Summary: This study successfully induced ferroptosis, a type of cell death, in drug-resistant prostate cancer using a biomimetic nanoparticle, leading to the suppression of tumor growth and metastasis.
MATERIALS TODAY BIO
(2022)
Review
Fisheries
Inbal Zaibel, Shai Arnon, Dina Zilberg
Summary: Aquaculture has been the fastest-growing food production sector in recent decades, with treated wastewater being explored as an alternative water resource to cope with increasing water demand in agriculture. Reuse of treated wastewater for aquaculture has shown economic and environmental advantages, but faces challenges such as sociocultural perception and the need for further research and legislation to support implementation.
REVIEWS IN AQUACULTURE
(2022)
Article
Biochemistry & Molecular Biology
Lena Trifonov, Mariya Yurchenko, Astrid Skjesol, Guy Cohen, Terje Espevik, Edward E. Korshin, Lene Melsaether Grovdal, Harald Husebye, Arie Gruzman
Summary: A derivative named LT127, developed by the research team, showed inhibition of IFN-beta and could potentially serve as a therapeutic approach to prevent septic shock.
MOLECULAR DIVERSITY
(2022)
Article
Environmental Sciences
Ram Chandra Shrestha, Lusine Ghazaryan, Ben Poodiack, Boris Zorin, Avner Gross, Osnat Gillor, Inna Khozin-Goldberg, Ilya Gelfand
Summary: The study found that fertilization with algal biomass reduced wheat grain nitrogen content and soil nitrogen oxide emissions, leading to lower greenhouse gas emissions and global warming impact compared to urea fertilization.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Plant Sciences
Yogesh Taparia, Achintya Kumar Dolui, Sammy Boussiba, Inna Khozin-Goldberg
Summary: This study describes the construction of a modular two-component transcriptional unit system to express SpCas9 in a diatom. The system enables multiplexed targeting and marker-free genome editing. The editing efficiency of the system was evaluated by targeting the StLDP gene, and the results showed the importance of StLDP in lipid droplet regulation.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Shirin Kahremany, Lukas Hofmann, Arie Gruzman, Albena T. Dinkova-Kostova, Guy Cohen
Summary: The skin barrier and its protective mechanisms are constantly dealing with external stressors, with ultraviolet radiation (UVR) being a major threat. Comprehensive strategies and pharmacological treatments are essential for protecting against photocarcinogenesis and exacerbation of photodermatosis conditions. Activation of NRF2 offers comprehensive and long-lasting protection by upregulating cytoprotective proteins to counteract the damaging effects of UVR.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Environmental Sciences
Avraham Kudish, Efim G. Evseev, Guy Cohen, Marco Harari
Summary: This research study aims to determine the characteristics of solar ultraviolet irradiation and understand the mechanism of action of photoclimatotherapy. The results of long-term measurements and correlation with the success of psoriasis treatments have led to the establishment of a database that significantly improves the results and safety of photoclimatotherapy at the Dead Sea.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Giulia Trentin, Francesca Piazza, Marta Carletti, Boris Zorin, Inna Khozin-Goldberg, Alberto Bertucco, Eleonora Sforza
Summary: Two diazotrophic cyanobacteria were cultivated to produce cyanophycin under nitrogen fixing conditions. Nostoc sp. showed higher efficiency in accumulating cyanophycin and fixing atmospheric nitrogen. The operating conditions were optimized, with nitrogen availability and/or pH playing a major role in biomass production and phosphorus limitation maximizing cyanophycin accumulation.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Fisheries
Sagar Nayak, Uri Yogev, Yohannes Kpordzaxor, Ze Zhu, Natan Gur, Amit Gross, Dina Zilberg
Summary: This study evaluated the potential of using biofloc as a dietary ingredient for barramundi fish. The results showed that while the weight gain of the fish fed with biofloc was lower, they exhibited higher survival rates and stronger immune functions after bacterial challenge.
Article
Food Science & Technology
Ekaterina Novichkova, Sagar Nayak, Sammy Boussiba, Jacob Gopas, Dina Zilberg, Inna Khozin-Goldberg
Summary: The study investigates the anti-inflammatory and immunomodulatory potential of the microalga Lobosphaera incisa P127 in the zebrafish model of IBD. Results show that diets containing 15% non-starved (Ns) and 7.5% and 15% nitrogen-starved (St) algal biomass effectively attenuate gut injury, while diets containing 7.5% Ns and DGLA ethyl ester have no effect on gut condition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Plant Sciences
Avital Friedjung Yosef, Lusine Ghazaryan, Linda Klamann, Katherine Sarah Kaufman, Capucine Baubin, Ben Poodiack, Noya Ran, Talia Gabay, Shoshana Didi-Cohen, Manuela Bog, Inna Khozin-Goldberg, Osnat Gillor
Summary: This study investigates the diversity of duckweeds in Israel and finds that the duckweed population in aquatic environments consists of both native and transient species. The analysis of fatty acids and protein content suggests functional differences among the identified species. Additionally, potential invasive species are identified.
Article
Dermatology
Guy Cohen, Jeannette Jakus, Mauricio Portillo, Raanan Gvirtz, Navit Ogen-Shtern, Eldad Silberstein, Tomer Ayzenberg, Sharon Rozenblat
Summary: This study evaluated the compatibility of cannabidiol (CBD) and eicosapentaenoic acid (EPA) in the prevention and treatment of skin aging. The results showed that EPA potentiated the protective effects of CBD by reducing inflammatory agents associated with photoaging. Clinical validation demonstrated significant reduction in wrinkles, increased skin hydration and elasticity, and high satisfaction ratings.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Editorial Material
Plant Sciences
Zhi-Yan Du, Wajid Waheed Bhat, Guoyin Kai, Inna Khozin-Goldberg, Xiao-Hong Yu, Agnieszka Zienkiewicz, Krzysztof Zienkiewicz
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yael Cohen, Guy Cohen, Dmitry Tworowski, Noy Eretz-Kdosha, Eldad Silberstein, Elazar Fallik, Elena Poverenov
Summary: The study introduces biocompatible nanocarriers based on modified polysaccharides for transdermal delivery of insulin, showing increased insulin permeation in lipid media and improved transdermal delivery on human skin without toxicity. These carriers have potential as safe and effective platforms for transdermal delivery of bioactive macromolecules, offering advantages over traditional injections for diabetic patients in terms of pain and infection risk reduction.
NANOSCALE ADVANCES
(2022)