期刊
FRONTIERS IN IMMUNOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00499
关键词
antigen-presenting cells; dendritic cells; helminth; Th2 cells; obesity; metabolic diseases; insulin resistance; type 2 inflammation
类别
资金
- EFSD/Lilly Research Grant Fellowship from the European Federation
- SPIN-KNAW Grant from the Royal Netherlands Academy of Sciences
- EU-funded project IDEA [HEALTH-F3-2009-241642]
- ZonMW TOP Grant from the Dutch Organization for Scientific Research [912-03-048]
Nearly one quarter of the world's population is infected with helminth parasites. A common feature of helminth infections is the manifestation of a type 2 immune response, characterized by T helper 2 (Th2) cells that mediate anti-helminth immunity. In addition, recent literature describes a close association between type 2 immune responses and wound repair, suggesting that a Th2 response may concurrently mediate repair of parasite-induced damage. The molecular mechanisms that govern Th2 responses are poorly understood, although it is clear that dendritic cells (DCs), which are the most efficient antigen-presenting cells in the immune system, play a central role. Here, we review the molecular mechanisms by which DCs polarize Th2 cells, examining both helminth antigens and helminth-mediated tissue damage as Th2-inducing triggers. Finally, we discuss the implication of these findings in the context of metabolic disorders, as recent literature indicates that various aspects of the Th2-associated inflammatory response contribute to metabolic homeostasis.
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