Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

Crystal structure of deglycosylated human IgG4-Fc

(2014) Anna M. Davies et al.   MOLECULAR IMMUNOLOGY

Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages

(2014) Kirsten M. Pondman et al.   Nanomedicine-Nanotechnology Biology and Medicine

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Antibody-mediates inhibition of human C1s and the classical complement pathway

(2013) Sean Carroll et al.   IMMUNOBIOLOGY

Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

(2013) Peter D. Arkwright et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

(2013) Andrew J. Perry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

(2013) Omid Vafa et al.   METHODS

Boosting ADCC and CDC activity by Fc engineering and evaluation of antibody effector functions

(2013) Christian Kellner et al.   METHODS

Toward a structure-based comprehension of the lectin pathway of complement

(2013) Troels R. Kjaer et al.   MOLECULAR IMMUNOLOGY

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

(2013) I. Bally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

(2013) Umakhanth Venkatraman Girija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational selection in trypsin-like proteases

(2012) Nicola Pozzi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis for activation of the complement system by component C4 cleavage

(2012) R. T. Kidmose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The New View of Complement

(2012) M. Leslie   SCIENCE

The Human C1q Globular Domain: Structure and Recognition of Non-Immune Self Ligands

(2012) Christine Gaboriaud et al.   Frontiers in Immunology

Proteins of the Innate Immune System Crystallize on Carbon Nanotubes but Are Not Activated

(2011) Wai Li Ling et al.   ACS Nano

Structure and properties of the Ca2+-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions

(2011) Christine Gaboriaud et al.   BIOCHEMICAL JOURNAL

Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance

(2011) Lubka T. Roumenina et al.   JOURNAL OF IMMUNOLOGY

Grand Challenges in Molecular Innate Immunity

(2011) Mohamed R. Daha   Frontiers in Immunology

Calcium-dependent Conformational Flexibility of a CUB Domain Controls Activation of the Complement Serine Protease C1r

(2010) Balázs Major et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Surface Accessibility of the C1r/C1s Tetramer by Chemical Modification and Mass Spectrometry Provides New Insights into Assembly of the Human C1 Complex

(2010) Sébastien Brier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: C1q Binds Deoxyribose and Heparan Sulfate through Neighboring Sites of Its Recognition Domain

(2010) V. Garlatti et al.   JOURNAL OF IMMUNOLOGY

Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions

(2010) Gregory L. Moore et al.   mAbs

Complement activation on platelets: Implications for vascular inflammation and thrombosis

(2010) Ellinor I. Peerschke et al.   MOLECULAR IMMUNOLOGY

C1 inhibitor, a multi-functional serine protease inhibitor

(2010) Fengxin Lu et al.   THROMBOSIS AND HAEMOSTASIS

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

Identification of the C1q-binding Sites of Human C1r and C1s

(2009) Isabelle Bally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Human C1q by Combined Bottom-up and Top-down Mass Spectrometry

(2009) Delphine Pflieger et al.   MOLECULAR & CELLULAR PROTEOMICS

Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r

(2007) József Kardos et al.   MOLECULAR IMMUNOLOGY