Article
Cell Biology
Theinmozhi Arulraj, Sebastian C. Binder, Michael Meyer-Hermann
Summary: In this study, computer simulations were used to investigate the role of soluble antibodies in the interaction between germinal centers (GCs). The findings suggest that intense interactions by soluble antibodies can limit the magnitude and lifetime of GC responses, and also lead to a bias in epitope recognition. The study also highlights the importance of GC-GC interactions in the affinity maturation towards antigenic variants during an ongoing GC reaction.
Article
Microbiology
Akito Sakanaka, Masae Kuboniwa, Shuichi Shimma, Samar A. Alghamdi, Shota Mayumi, Richard J. Lamont, Eiichiro Fukusaki, Atsuo Amano
Summary: This study reveals that Fusobacterium nucleatum can enhance polyamine production by increasing amino acid availability through cocultivation with other microbial communities, which has implications for the pathogenesis of periodontal disease.
Review
Rheumatology
Gaetane Nocturne, Elena Pontarini, Michele Bombardieri, Xavier Mariette
Summary: Lymphoma development is a serious complication of Sjögren's syndrome, commonly presenting as B-cell lymphomas. The progression towards lymphoma may be influenced by chronic antigenic stimulation and autoreactive B cell clones. Early identification and controlling disease activity could potentially reduce the risk of lymphoma in patients.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Stefanie W. Y. Yip, Sonia Hiu Yin Lam, Christine Shing-yen Lo, Ho Yuen Frank Wong, Wai Meng Tai
Summary: A 46-year-old woman with mixed connective tissue disease presented with clinical features of scleroderma and polymyositis. Despite having seropositive antibodies, she remained asymptomatic for respiratory issues over a 14-year period, but showed a decline in diffusing capacity for carbon monoxide, indicating interval development of restrictive lung function.
Article
Hematology
Maria Condom, Fina Climent, Davinia Fernandez, Dolors Colomer, Monica Lopez-Guerra, Mar Varela, Itziar Carro, Clara Maluquer, Santiago Mercadal, Ana Carla Oliveira, Maria Pane, Xavier Matias-Guiu, Eva Gonzalez-Barca, Anna Sureda, Eva Domingo-Domenech
Summary: Research has shown that clonal heterogeneity exists in multisited MALT lymphomas, with some patients having different clones formed in different organs. Most patients show the same clone in different organs, while those with late relapses exhibit different clones, possibly representing the occurrence of de novo neoplasms.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hee Kyong Na, Sung Hyun Won, Ji Yong Ahn, Kim Ga Hee, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Hwa Jung Kim
Summary: Duodenal MALT lymphoma is very rare, and treatment outcomes seem to be inferior to those of gastric MALT lymphoma. The study findings showed lower rates of H. pylori infection and lymph node metastasis in patients with duodenal MALT lymphoma compared to gastric MALT lymphoma, as well as lower complete remission rates. Complications such as bleeding, stricture, and transformation to high-grade lymphoma were also more common in duodenal MALT lymphoma patients than in gastric MALT lymphoma patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Yan Zhang, Lin Shang, Sanne Roffel, Bastiaan P. Krom, Susan Gibbs, Dongmei Deng
Summary: This study developed a model that effectively represents the interactions between oral mucosa and microbiome and maintains the viability of both host and microbes for a period of 72 hours. Using this model, researchers found differences in innate immune responses triggered by S. gordonii and A. actinomycetemcomitans.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Evanthia Tourkochristou, Christos Triantos, Athanasia Mouzaki
Summary: Nutrients play an important role in modulating immune homeostasis by regulating the expression of pro- and anti-inflammatory cytokines and interfering with immune cell crosstalk and signaling. They also contribute to the formation of cell membrane structure, energy production, and prevention of cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Botia-Sanchez, Marta E. Alarcon-Riquelme, Georgina Galicia
Summary: This article explores the bidirectional interaction between gut microbiota and B-cell responses in the context of autoimmune inflammation, emphasizing the crucial role of commensals in maintaining a healthy microbial ecosystem and regulating autoimmune inflammation. It also highlights how dysbiosis may contribute to the development of autoimmune diseases. Further research is needed to fully understand the complex interplay between microorganisms, genes, and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zijun Wang, Frauke Muecksch, Alice Cho, Christian Gaebler, Hans-Heinrich Hoffmann, Victor Ramos, Shuai Zong, Melissa Cipolla, Briana Johnson, Fabian Schmidt, Justin DaSilva, Eva Bednarski, Tarek Ben Tanfous, Raphael Raspe, Kaihui Yao, Yu E. Lee, Teresia Chen, Martina Turroja, Katrina G. Milard, Juan Dizon, Anna Kaczynska, Anna Gazumyan, Thiago Y. Oliveira, Charles M. Rice, Marina Caskey, Paul D. Bieniasz, Theodora Hatziioannou, Christopher O. Barnes, Michel C. Nussenzweig
Summary: SARS-CoV-2 infection or vaccination induces neutralizing antibody responses targeting the receptor-binding domain (RBD) and the N-terminal domain (NTD) of the spike protein. This study identifies different groups of neutralizing antibodies, including some that can neutralize the Omicron variant. Structural analysis reveals the mechanism of action of broad neutralizers.
Review
Immunology
Teresa Fuertes, Irene Salgado, Virginia G. de Yebenes
Summary: miRNAs play crucial roles in regulating GC responses, influencing the physiological processes of B cells and T follicular helper cells, as well as diseases associated with dysregulation of GC responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Penny Fang, Jillian R. Gunther, Chelsea C. Pinnix, Wenli Dong, Paolo Strati, Loretta J. Nastoupil, Raphael E. Steiner, Sairah Ahmed, Ethan P. Damron, Nathan Fowler, Ranjit Nair, Jason R. Westin, Sattva Neelapu, Chul S. Ha, Bouthaina S. Dabaja
Summary: This prospective study demonstrates that radiation therapy for MALT lymphoma provides excellent long-term relapse-free survival with acceptable toxicity rates. Efforts are now focused on reducing radiation treatment to further minimize treatment-related morbidity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Hematology
Yi-Min Ren, Chun-Yu Shang, Jin-Hua Liang, Hua Yin, Yi Xia, Jia-Zhu Wu, Li Wang, Li Jian-Yong, Yue Li, Wei Xu
Summary: The presence of Ig paraprotein in MALT lymphoma patients is associated with various prognostic factors, such as advanced age, disease stage, and treatment regimen. A new prognostic index combining MALT-IPI and Ig paraproteinaemia shows better predictive ability for progression-free survival than MALT-IPI alone. Ig paraproteinaemia could be a promising prognostic predictor for MALT lymphoma and help optimize therapeutic management in clinical practice.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Urology & Nephrology
Toshiki Kano, Hitoshi Suzuki, Yuko Makita, Yusuke Fukao, Yusuke Suzuki
Summary: The dysregulation of mucosal immunity may play a role in the pathogenesis of IgA nephropathy. Researchers found that in murine IgAN, NALT cells produce more aberrantly glycosylated IgA than cells from mesenteric lymph nodes and Peyer's patch, leading to the formation of IgG-IgA immune complexes.
KIDNEY INTERNATIONAL
(2021)
Review
Oncology
Xi Tu, Xiyao Zhuang, Fen Li, Chaoyou Huang, Youliang Qian
Summary: This study presents a rare case of primary bladder MALT lymphoma in an 81-year-old female patient. The patient's symptoms included frequent urination and dysuria, and MRI indicated bladder cancer. After transurethral resection, the histopathology confirmed the tumor as bladder MALT lymphoma. The patient refused further treatment and remained disease-free after one year.
FRONTIERS IN ONCOLOGY
(2023)