Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: The study found that IL-10 promotes fibrosis in endometriosis instead of having an anti-fibrotic effect. Inhibition of STAT3 gene activation can reduce the pro-fibrotic phenotype induced by IL-10 in endometriotic stromal cells.
HUMAN REPRODUCTION
(2023)
Review
Medicine, General & Internal
Xinjuan Fu, Zhigang Xiu, Hongwei Xu
Summary: Acute pancreatitis is a common gastrointestinal disease, and IL-22 plays a role in its pathogenesis and treatment.
Article
Pharmacology & Pharmacy
Ge Jin, Lintao Wang, Jun Ma
Summary: Cardiac hypertrophy is a compensatory response to chronic pressure overload, and excessive angiotensin II plays a significant role in inducing cardiac hypertrophy. Previous studies have shown that STAT5, a member of the STATs family, is closely linked to non-tumor diseases, but its specific role in hypertrophy progression remains unclear. In this study, STAT5-IN-1, a STAT5 inhibitor, was administered to mice and H9c2s cells were used as cell models to investigate the effects of STAT5-IN-1 on cardiac hypertrophy induced by angiotensin II. The findings demonstrated that STAT5 inhibitor substantially decreased cardiac hypertrophy by reducing inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Sachiko Matsuzaki, Jean-Luc Pouly, Michel Canis
Summary: Persistent activation of signal transducer and activator of transcription 3 (STAT3) via interleukin-6 (IL-6) trans-signaling is involved in fibrosis of endometriosis.
HUMAN REPRODUCTION
(2022)
Article
Medicine, General & Internal
Wenjun Ji, Jing Li, Xin Wang, Dongsheng Gao, Tiantian Zhang
Summary: The study found that increased levels of IL-22 and IL-22R1 in laryngeal squamous cell carcinoma may be associated with the pathogenesis and prognosis of the cancer. This suggests that IL-22 could be an important biomarker that requires further research.
Article
Medicine, Research & Experimental
Jiameng Lu, Xiaoqing Ji, Lixia Wang, Fei Sun, Chuanjun Huang, Haiying Peng, Yunxiu Jiang, Zihan Guo, Xinyi Liu, Yanbo Ji, Degan Lu
Summary: This study found that prophylactic administration of IL-27 can improve asthma by restoring the STAT1 and STAT3 pathways, alleviating the Th2 inflammatory environment in the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Caitlin C. Zebley, Hossam A. Abdelsamed, Hazem E. Ghoneim, Shanta Alli, Charmaine Brown, Dalia Haydar, Tian Mi, Tarsha Harris, Maureen A. McGargill, Giedre Krenciute, Ben Youngblood
Summary: The study found that IL-12 plays an important role in the priming of CD8 T cells, promoting TET2-mediated demethylation programming and influencing the expression of IFNg. This suggests that cytokines can guide the induction of epigenetically regulated traits in T cells.
Review
Cell Biology
Philippe Georgel
Summary: This review examines the roles of IL-1 beta and type I IFNs in autoinflammatory/rheumatic diseases and analyzes their potential connections in the pathophysiology of some of these diseases, providing new therapeutic opportunities.
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xiaodong Wang, Xiaoji Ding, Jin Yan, Ziying Lu, Haoyang Cao, Xiaolong Ni, Yin Ying
Summary: The study showed that inhibiting STAT5 significantly reduced atherosclerosis induced by high-fat diet and decreased inflammation. Furthermore, targeting STAT5 could also reduce inflammation induced by oxLDL.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jing Wang, Tianshu Liu, Xiongwen Chen, Qiaofeng Jin, Yihan Chen, Li Zhang, Zhengyang Han, Dandan Chen, Yuman Li, Qing Lv, Mingxing Xie
Summary: Th17 cells play a significant role in the pathogenesis of myocarditis, and Bazedoxifene can affect STAT3 signaling to effectively inhibit the progression of cardiac inflammation. Therefore, Bazedoxifene may be a promising therapeutic strategy for the treatment of experimental autoimmune myocarditis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Wei-ping Hu, Liang Xie, Sheng-yu Hao, Qin-han Wu, Gui-ling Xiang, Shan-qun Li, Dong Liu
Summary: In this study, it was found that progesterone played a protective role on human pulmonary artery smooth muscle cells under inflammation by blocking the functions of STAT3. This could help explain the better prognosis for women with PAH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Huang Chen, Wenbo Zhou, Aiwu Bian, Qiansen Zhang, Ying Miao, Xuan Yin, Jiangnan Ye, Shifen Xu, Chaowen Ti, Zhenliang Sun, Jianghua Zheng, Yihua Chen, Mingyao Liu, Zhengfang Yi
Summary: This study identifies a novel drug called WB436B as a selective STAT3 inhibitor for the treatment of pancreatic cancer. WB436B effectively inhibits tumor growth and metastasis, providing hope for the treatment of pancreatic cancer.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sarah M. M. AL-Qabbaa, Samaher I. I. Qaboli, Tahani K. K. Alshammari, Maha A. A. Alamin, Haya M. M. Alrajeh, Lama A. A. Almuthnabi, Rana R. R. Alotaibi, Asma S. S. Alonazi, Anfal F. F. Bin Dayel, Nawal M. M. Alrasheed, Nouf M. M. Alrasheed
Summary: This study examined the therapeutic effects of sitagliptin, a dipeptidyl peptidase inhibitor, on diabetic nephropathy (DN). The results showed that sitagliptin can reduce inflammation and improve DN by inhibiting PTP1B and modulating the JAK/STAT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Zheng-nan Ren, Jun Yang, Meng-ya Zhang, Yi-wen Huang, Dong-xiao Song, Xun Sun, Li-long Pan, Jia Sun
Summary: This study demonstrated that (R)-TML104 alleviates experimental pancreatitis by activating AMP-activated protein kinase and inducing SIRT1 expression, which in turn reduces inflammatory cell infiltration. The mechanism involves inhibition of the inflammatory response mediated by the interleukin 6-STAT3 pathway through modulation of SIRT1.
ACTA PHARMACOLOGICA SINICA
(2022)