Article
Oncology
Anil Belur Nagaraj, Matthew Knarr, Sreeja Sekhar, R. Shae Connor, Peronne Joseph, Olga Kovalenko, Alexis Fleming, Arshia Surti, Elmar Nurmemmedov, Luca Beltrame, Sergio Marchini, Michael Kahn, Analisa DiFeo
Summary: Wnt signaling plays a critical role in ovarian cancer, and miR-181a has been identified as a novel driver of the Wnt/β-catenin signaling pathway, promoting stemness and chemoresistance. Targeting the miR-181a-SFRP4 axis may offer a potential therapeutic strategy for HGSOC.
Article
Oncology
Yuanyuan Li, Han Lei, Rihan Hai, Guang Shu, Wenguang Yan, Gang Yin
Summary: This study found that HOXC10 is upregulated in ovarian cancer and is associated with carboplatin resistance. Further investigation revealed that HOXC10 can promote the expression of ABCC3 by upregulating beta-catenin, resulting in decreased sensitivity of cells to carboplatin. These findings suggest that the expression of HOXC10/ABCC3 could serve as a novel biomarker for predicting carboplatin resistance and prognosis in ovarian cancer patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Zhibao Zheng, Na Luan, Kai Tu, Feiyan Liu, Jianwei Wang, Jianguo Sun
Summary: PCDH7 expression in colorectal cancer cells is positively correlated with cell proliferation and drug resistance, while negatively correlated with cell migration and invasion. PCDH7 mediates drug resistance by inhibiting cell apoptosis through upregulating Mcl-1 expression and activating the Wnt signaling pathway. The Mcl-1 inhibitor S63845 can attenuate the anti-apoptotic effect of PCDH7 and sensitizes PCDH7-overexpressing colorectal cancer cells to ABT-263.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Tong Lou, Chongdong Liu, Hong Qu, Zhiqiang Zhang, Shuzhen Wang, Huiyu Zhuang
Summary: This study explored the function of FOXA1 in ovarian cancer and the relationship between FOXA1 and HDAC3. It was found that FOXA1 can be modulated by HDAC3 through the Wnt/beta-catenin signaling pathway and plays essential roles in proliferation, apoptosis, and invasion of EOC cell lines and xenograft experiments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lipeng Pei, Feng Zhao, Yi Zhang
Summary: This study reveals that USP43 is highly expressed in epithelial ovarian cancer (EOC) and its overexpression promotes cancer cell proliferation, migration, invasion, and chemoresistance. USP43 achieves these effects by inhibiting HDAC2 degradation and activating the Wnt/beta-catenin signaling pathway. These findings suggest that USP43 may be a potential target for controlling ovarian cancer progression.
Article
Cell Biology
Yanlin Cai, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Shunliang Sheng, Jiayu Zhu
Summary: Globally, ovarian cancer ranks as the second most common cause of gynecologic-related cancer deaths among women, with a poor prognosis. Research has shown that downregulation of AHNAK in ovarian cancer cells can significantly inhibit cell growth and metastasis, partly by dampening the Canonical Wnt cascade. Therefore, AHNAK may serve as a biomarker and potential treatment target for ovarian cancer.
Article
Biochemistry & Molecular Biology
Tian-Huei Chu, Chou-Yuan Ko, Po-Han Tai, Yi-Chen Chang, Chao-Cheng Huang, Tung-Yang Wu, Hoi-Hung Chan, Ping-Hsuan Wu, Chien-Hui Weng, Yu-Wei Lin, Mei-Lang Kung, Cheng-Chieh Fang, Jian-Ching Wu, Zhi-Hong Wen, Yung-Kuo Lee, Tsung-Hui Hu, Ming-Hong Tai
Summary: In this study, it was found that LECT2 expression in HCC is associated with tumor development and patient survival. Functional assays revealed that LECT2 can suppress oncogenic behaviors in hepatoma cells and inhibit CSC functions. Increasing LECT2 expression through therapy could effectively treat HCC by suppressing the HGF/c-MET axis to reduce CSC expansion.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Qi Qin, Bingwei Yang, Zixuan Liu, Lei Xu, Erqun Song, Yang Song
Summary: The study found that the metabolite PCB29-pQ of polychlorinated biphenyls can induce the metastasis of breast cancer by increasing the expression of cancer stem cell markers and activating the Wnt/beta-catenin pathway, with the overproduction of reactive oxygen species playing a key role in this process.
Article
Biotechnology & Applied Microbiology
Yang Liu, Wen Li Zhou
Summary: This study reveals that LINC01315 promotes the growth, metastatic characteristics, and EMT of CRC cells by activating the Wnt/beta-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Long Xu, Jian Wang, Buhan Liu, Jiaying Fu, Yuanxin Zhao, Sihang Yu, Luyan Shen, Xiaoyu Yan, Jing Su
Summary: Epithelial ovarian cancer has the highest mortality rate among gynecological malignant tumors, largely due to metastasis. This study found that HDAC9 plays different roles in different histological subtypes of ovarian cancer and may be a potential target for personalized treatment.
Article
Reproductive Biology
Wenjing Hu, Min Li, Youguo Chen, Xinxian Gu
Summary: The research revealed that high expression of UBE2S in HGSOC is associated with poor prognosis. UBE2S promotes proliferation, migration, and invasion of ovarian cancer, and increases Olaparib resistance by activating the Wnt/β-catenin signaling pathway.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xichao Xu, Yi Zhang, Xing Wang, Shun Li, Liling Tang
Summary: In liver cancer, higher liver tissue stiffness enhances malignant cell phenotypes and promotes G1/S transition. NEAT1 is identified as a matrix stiffness-responsive lncRNA regulating proliferation and EMT. The activation of the WNT/beta-catenin pathway by NEAT1 in response to increasing matrix stiffness drives EMT and proliferation in liver cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hu Han, Yan Li, Wan Qin, Lu Wang, Han Yin, Beibei Su, Xianglin Yuan
Summary: The study found that miR-199b-3p is significantly up-regulated in CTx-resistant colorectal cancer cells. Inhibiting miR-199b-3p can improve the sensitivity of CTx-resistant cells to CTx by regulating the Wnt/β-catenin signaling pathway. Mouse models confirmed that down-regulating miR-199b-3p can restore the inhibitory effect of CTx on tumor growth.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Wenyu Wang, Untack Cho, Anna Yoo, Chae-Lim Jung, Boyun Kim, Heeyeon Kim, Juwon Lee, HyunA Jo, Youngjin Han, Myoung-Hyun Song, Ja-Oh Lee, Se Ik Kim, Maria Lee, Ja-Lok Ku, Cheol Lee, Yong Sang Song
Summary: This study provides the first evidence for the anti-tumor effect of CWP232291 in ovarian cancer and suggests the inhibition of the Wnt/beta-catenin pathway as a novel therapeutic strategy against ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Rong Lu, Peipei Tang, Di Zhang, Sen Lin, Hong Li, Xian Feng, Meiling Sun, Hong Zhang
Summary: This study investigates the role of SOX9 in ovarian cancer and its potential molecular mechanisms. The results show that high expression of SOX9 is correlated with poor prognosis and various aggressive features of ovarian cancer. Knockdown of SOX9 inhibits migration and invasive ability of ovarian cancer cells, while overexpression has the opposite effect. Additionally, SOX9 promotes tumor metastasis by upregulating NFIA and activating the Wnt/β-catenin signaling pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Safa Majeed, Mansi K. Aparnathi, Kevin C. J. Nixon, Vidhyasagar Venkatasubramanian, Fariha Rahman, Lifang Song, Jessica Weiss, Ranya Barayan, Vijithan Sugumar, Samir H. Barghout, Joel D. Pearson, Rod Bremner, Aaron D. Schimmer, Ming S. Tsao, Geoffrey Liu, Benjamin H. Lok
Summary: TAK-243 exhibits efficacy in preclinical models of small cell lung cancer (SCLC), with associations to various gene sets. TAK-243 synergizes with cisplatin/etoposide chemotherapy (C/E) and PARP inhibitor olaparib. TAK-243 is a potential therapeutic strategy to improve SCLC patient outcomes.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Eileen O. Dareng, Jonathan P. Tyrer, Daniel R. Barnes, Michelle R. Jones, Xin Yang, Katja K. H. Aben, Muriel A. Adank, Simona Agata, Irene L. Andrulis, Hoda Anton-Culver, Natalia N. Antonenkova, Gerasimos Aravantinos, Banu K. Arun, Annelie Augustinsson, Judith Balmana, Elisa Bandera, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Marina Bermisheva, Marcus Q. Bernardini, Line Bjorge, Amanda Black, Natalia Bogdanova, Bernardo Bonanni, Ake Borg, James D. Brenton, Agnieszka Budzilowska, Ralf Butzow, Saundra S. Buys, Hui Cai, Maria A. Caligo, Ian Campbell, Rikki Cannioto, Hayley Cassingham, Jenny Chang-Claude, Stephen J. Chanock, Kexin Chen, Yoke-Eng Chiew, Wendy K. Chung, Kathleen B. M. Claes, Sarah Colonna, Linda S. Cook, Fergus J. Couch, Mary B. Daly, Fanny Dao, Eleanor Davies, Miguel de la Hoya, Robin de Putter, Joe Dennis, Allison DePersia, Peter Devilee, Orland Diez, Yuan Chun Ding, Jennifer A. Doherty, Susan M. Domchek, Thilo Dork, Andreas du Bois, Matthias Durst, Diana M. Eccles, Heather A. Eliassen, Christoph Engel, Gareth D. Evans, Peter A. Fasching, James M. Flanagan, ReneeT Fortner, Eva Machackova, Eitan Friedman, Patricia A. Ganz, Judy Garber, Francesca Gensini, Graham G. Giles, Gord Glendon, Andrew K. Godwin, Marc T. Goodman, Mark H. Greene, Jacek Gronwald, Opal Study Group, AOCSGroup, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Ute Hamann, Thomas V. O. Hansen, Holly R. Harris, Mikael Hartman, Florian Heitz, Michelle A. T. Hildebrandt, Estrid Hogdall, Claus K. Hogdall, John L. Hopper, Ruea-Yea Huang, Chad Huff, Peter J. Hulick, David G. Huntsman, Evgeny N. Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Allan Jensen, Oskar Th Johannsson, Esther M. John, Michael E. Jones, Daehee Kang, Beth Y. Karlan, Anthony Karnezis, Linda E. Kelemen, Elza Khusnutdinova, Lambertus A. Kiemeney, Byoung-Gie Kim, Susanne K. Kjaer, Ian Komenaka, Jolanta Kupryjanczyk, Allison W. Kurian, Ava Kwong, Diether Lambrechts, Melissa C. Larson, Conxi Lazaro, Nhu D. Le, Goska Leslie, Jenny Lester, Fabienne Lesueur, Douglas A. Levine, Lian Li, Jingmei Li, Jennifer T. Loud, Karen H. Lu, Phuong L. Mai, Siranoush Manoukian, Jeffrey R. Marks, Rayna KimMatsuno, Keitaro Matsuo, Taymaa May, Lesley McGuffog, John R. McLaughlin, Iain A. McNeish, Noura Mebirouk, Usha Menon, Austin Miller, Roger L. Milne, Albina Minlikeeva, Francesmary Modugno, Marco Montagna, Kirsten B. Moysich, Elizabeth Munro, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Henriette Roed Nielsen, Finn C. Nielsen, Liene Nikitina-Zake, Kunle Odunsi, Kenneth Offit, Edith Olah, Siel Olbrecht, Olufunmilayo Olopade, Sara H. Olson, Hakan Olsson, Ana Osorio, Laura Papi, Sue K. Park, Michael T. Parsons, Harsha Pathak, Inge Sokilde Pedersen, Ana Peixoto, Tanja Pejovic, Pedro Perez-Segura, Jennifer B. Permuth, Beth Peshkin, Paolo Peterlongo, Anna Piskorz, Darya Prokofyeva, Paolo Radice, Johanna Rantala, Marjorie J. Riggan, Harvey A. Risch, Cristina Rodriguez-Antona, Eric Ross, Mary Anne Rossing, Ingo Runnebaum, Dale P. Sandler, Marta Santamarina, Penny Soucy, Rita K. Schmutzler, V. Wendy Setiawan, Kang Shan, Weiva Sieh, Jacques Simard, Christian F. Singer, Anna P. Sokolenko, Honglin Song, Melissa C. Southey, Helen Steed, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Anthony J. Swerdlow, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Kathryn L. Terry, Mary BethTerry, Mads Thomassen, Pamela J. Thompson, Liv Cecilie Vestrheim Thomsen, Darcy L. Thull, Marc Tischkowitz, Linda Titus, Amanda E. Toland, Diana Torres, Britton Trabert, Ruth Travis, Nadine Tung, Shelley S. Tworoger, Ellen Valen, Anne M. van Altena, Annemieke H. van der Hout, ElsVan Nieuwenhuysen, Elizabeth J. van Rensburg, Ana Vega, Digna Velez Edwards, Robert A. Vierkant, Frances Wang, Barbara Wappenschmidt, Penelope M. Webb, Clarice R. Weinberg, Jeffrey N. Weitzel, Nicolas Wentzensen, Emily White, Alice S. Whittemore, Stacey J. Winham, Alicja Wolk, Yin-Ling Woo, Anna H. Wu, Li Yan, Drakoulis Yannoukakos, Katia M. Zavaglia, Wei Zheng, Argyrios Ziogas, Kristin K. Zorn, Zdenek Kleibl, Douglas Easton, Kate Lawrenson, Anna DeFazio, Thomas A. Sellers, Susan J. Ramus, Celeste L. Pearce, Alvaro N. Monteiro, Julie Cunningham, Ellen L. Goode, Joellen M. Schildkraut, Andrew Berchuck, Georgia Chenevix-Trench, Simon A. Gayther, Antonis C. Antoniou, Paul D. P. Pharoah
Summary: This study developed polygenic risk score models for risk prediction of epithelial non-mucinous ovarian cancer and validated their predictive value in diverse populations and BRCA1/BRCA2 mutation carriers, suggesting potential clinical utility in ovarian cancer prevention programs.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Oncology
Sarah D. Kosa, Sarah E. Ferguson, Tony Panzarella, Susie Lau, Jeremie Abitbol, Vanessa Samouelian, Christopher Giede, Helen Steed, Benjamin Renkosinski, Lilian T. Gien, Marcus Q. Bernardini
Summary: Compared the immediate operating room (OR), inpatient, and overall costs between three surgical modalities among women with endometrial cancer and Class III obesity or higher, it was found that there were lower costs for robotic-assisted laparoscopy in both OR and inpatient, with no significant difference in overall costs.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Pathology
Eun Young Kang, Joshua Millstein, Gordana Popovic, Nicola S. Meagher, Adelyn Bolithon, Aline Talhouk, Derek S. Chiu, Michael S. Anglesio, Betty Leung, Katrina Tang, Neil Lambie, Marina Pavanello, Annalyn Da-Anoy, Diether Lambrechts, Liselore Loverix, Siel Olbrecht, Christiani Bisinotto, Jesus Garcia-Donas, Sergio Ruiz-Llorente, Monica Yague-Fernandez, Robert P. Edwards, Esther Elishaev, Alexander Olawaiye, Sarah Taylor, Beyhan Ataseven, Andreas du Bois, Philipp Harter, Jenny Lester, Claus K. Hogdall, Sebastian M. Armasu, Yajue Huang, Robert A. Vierkant, Chen Wang, Stacey J. Winham, Sabine Heublein, Felix K. F. Kommoss, Daniel W. Cramer, Naoko Sasamoto, Lilian Van-Wagensveld, Maria Lycke, Constantina Mateoiu, Janine Joseph, Malcolm C. Pike, Kunle Odunsi, Chiu-Chen Tseng, Celeste L. Pearce, Sanela Bilic, Thomas P. Conrads, Arndt Hartmann, Alexander Hein, Michael E. Jones, Yee Leung, Matthias W. Beckmann, Matthias Ruebner, Minouk J. Schoemaker, Kathryn L. Terry, Mona A. El-Bahrawy, Penny Coulson, John L. Etter, Katherine LaVigne-Mager, Juergen Andress, Marcel Grube, Anna Fischer, Nina Neudeck, Greg Robertson, Rhonda Farrell, Ellen Barlow, Carmel Quinn, Anusha Hettiaratchi, Yovanni Casablanca, Ramona Erber, Colin J. R. Stewart, Adeline Tan, Yu Yu, Jessica Boros, Alison H. Brand, Paul R. Harnett, Catherine J. Kennedy, Nikilyn Nevins, Terry Morgan, Peter A. Fasching, Ignace Vergote, Anthony J. Swerdlow, Francisco J. Candido Dos Reis, G. Larry Maxwell, Susan L. Neuhausen, Arantzazu Barquin-Garcia, Francesmary Modugno, Kirsten B. Moysich, Philip J. Crowe, Akira Hirasawa, Florian Heitz, Beth Y. Karlan, Ellen L. Goode, Peter Sinn, Hugo M. Horlings, Estrid Hogdall, Karin Sundfeldt, Stefan Kommoss, Annette Staebler, Anna H. Wu, Paul A. Cohen, Anna DeFazio, Cheng-Han Lee, Helen Steed, Nhu D. Le, Simon A. Gayther, Kate Lawrenson, Paul D. P. Pharoah, Gottfried Konecny, Linda S. Cook, Susan J. Ramus, Linda E. Kelemen, Martin Kobel
Summary: MCM3 mRNA and protein expression levels are associated with survival in patients with tubo-ovarian high-grade serous carcinomas (HGSC), showing a correlation between high MCM3 expression and longer overall survival.
Article
Oncology
Samir H. Barghout
Summary: Proteolysis targeting chimeras (PROTACs) are a novel class of targeted protein degraders that selectively degrade their respective targets by utilizing the intracellular degradation machinery. Compared to conventional inhibitors, PROTACs exhibit superior pharmacologic properties in terms of efficacy, potency, selectivity, and efficacy against undruggable proteins.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Samir H. Barghout, Yifan Yu, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Review
Environmental Sciences
Ana Paula Pagano, Katherine L. Ford, Kathryn N. Porter Starr, Nicole Kiss, Helen Steed, Janice Y. Kung, Rajavel Elango, Carla M. Prado
Summary: Determining energy requirements in gynecological cancers is essential for optimizing nutrition interventions. However, there is a lack of research in this area. This review suggests that commonly used equations may not accurately predict energy expenditure in gynecological cancers, highlighting the importance of accurate assessment and intervention.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Summary: This study identifies the important role of the PRMT5-ATF4 axis in AML, showing that PRMT5 inhibition leads to abnormal transcription and splicing of the ATF4 gene, resulting in nuclear retention of ATF4 mRNA and decreased cytoplasmic ATF4 transcript levels, leading to decreased ATF4 protein levels and downregulation of ATF4 target gene expression, increased oxidative stress, growth arrest, and cellular senescence. Leukemia cells with EVI1 oncogene overexpression demonstrate dependence on PRMT5 function and regulation of oxidative stress response.
Article
Biochemistry & Molecular Biology
Samir H. Barghout, Raquel Arminda Carvalho Machado, Dalia Barsyte-Lovejoy
Summary: Histone lysine methylation plays a key role in epigenetic regulation, and dysregulation of this process is implicated in various diseases, especially cancer. KMTs have emerged as attractive therapeutic targets, with several inhibitors already in clinical trials.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Obstetrics & Gynecology
Jennifer Mateshaytis, Marina Brawner, Helen Steed, Sophia Pin
Summary: By implementing quality improvement interventions, the rate of same-day discharge was increased from the target of 70% to 78.3%, without affecting patient satisfaction or readmission rates.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Oncology
Ashley Weir, Eun-Young Kang, Nicola S. Meagher, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Aleksandra Gentry-Maharaj, Andy Ryan, Naveena Singh, Martin Widschwendter, Jennifer Alsop, Michael S. Anglesio, Matthias W. Beckmann, Jessica Berger, Christiani Bisinotto, Jessica Boros, Alison H. Brand, James D. Brenton, Angela Brooks-Wilson, Michael E. Carney, Julie M. Cunningham, Kara L. Cushing-Haugen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Sian Fereday, Anna Fischer, Luis Paz-Ares, Javier Gayarre, Blake C. Gilks, Marcel Grube, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Sabine Heublein, Yajue Huang, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Felix K. F. Kommoss, Jennifer M. Koziak, Bernhard Kraemer, Nhu D. Le, Jaime Lesnock, Jenny Lester, Jan Lubinski, Janusz Menkiszak, Britta Ney, Alexander Olawaiye, Sandra Orsulic, Ana Osorio, Luis Robles-Diaz, Matthias Ruebner, Mitul Shah, Raghwa Sharma, Yurii B. Shvetsov, Helen Steed, Aline Talhouk, Sarah E. Taylor, Nadia Traficante, Robert A. Vierkant, Chen Wang, Lynne R. Wilkens, Stacey J. Winham, Javier Benitez, Andrew Berchuck, David D. Bowtell, Francisco J. Candido dos Reis, Linda S. Cook, Anna DeFazio, Jennifer A. Doherty, Peter A. Fasching, Maria J. Garcia, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Stefan Kommoss, Francesmary Modugno, Joellen M. Schildkraut, Hans-Peter Sinn, Annette Staebler, Linda E. Kelemen, Caroline E. Ford, Usha Menon, Paul D. P. Pharoah, Martin Koebel, Susan J. Ramus, D. Bowtell, A. DeFazio, N. Traficante, S. Fereday, A. Brand, P. Harnett, R. Sharma
Summary: Recently, a study found a positive correlation between protein expression of FOXJ1 and the 5-year survival rate of patients with tubo-ovarian high-grade serous carcinoma (HGSC). However, protein expression of GMNN was not significantly associated with patient survival. This study provides preliminary evidence for the prognostic value of FOXJ1 in HGSC and validates the prior mRNA-based prognostic association through immunohistochemistry.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Nicola S. Meagher, Kylie L. Gorringe, Matthew Wakefield, Adelyn Bolithon, Chi Nam Ignatius Pang, Derek S. Chiu, Michael S. Anglesio, Kylie-Ann Mallitt, Jennifer A. Doherty, Holly R. Harris, Joellen M. Schildkraut, Andrew Berchuck, Kara L. Cushing-Haugen, Ksenia Chezar, Angela Chou, Adeline Tan, Jennifer Alsop, Ellen Barlow, Matthias W. Beckmann, Jessica Boros, David D. L. Bowtell, Alison H. Brand, James D. Brenton, Ian Campbell, Dane Cheasley, Joshua Cohen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Rhonda Farrell, Anna Fischer, Zhuxuan Fu, Blake Gilks, Anthony J. Gill, Charlie Gourley, Marcel Grube, Paul R. Harnett, Arndt Hartmann, Anusha Hettiaratchi, Claus K. Hogdall, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Byoung-Gie Kim, Jae-Weon Kim, Jae-Hoon Kim, Kayla Klett, Jennifer M. Koziak, Tiffany Lai, Angela Laslavic, Jenny Lester, Yee Leung, Na Li, Winston Liauw, Belle W. X. Lim, Anna Linder, Jan Lubinski, Sakshi Mahale, Constantina Mateoiu, Simone McInerny, Janusz Menkiszak, Parham Minoo, Suzana Mittelstadt, David Morris, Sandra Orsulic, Sang-Yoon Park, Celeste Leigh Pearce, John Pearson, Malcolm C. Pike, Carmel M. Quinn, Ganendra Raj Mohan, Jianyu Rao, Marjorie J. Riggan, Matthias Ruebner, Stuart Salfinger, Clare L. Scott, Mitul Shah, Helen Steed, Colin J. R. Stewart, Deepak Subramanian, Soseul Sung, Katrina Tang, Paul Timpson, Robyn L. Ward, Rebekka Wiedenhoefer, Heather Thorne, Paul A. Cohen, Philip Crowe, Peter A. Fasching, Jacek Gronwald, Nicholas J. Hawkins, Estrid Hogdall, David G. Huntsman, Paul A. James, Beth Y. Karlan, Linda E. Kelemen, Stefan Kommoss, Gottfried E. Konecny, Francesmary Modugno, Sue K. Park, Annette Staebler, Karin Sundfeldt, Anna H. Wu, Aline Talhouk, Paul D. P. Pharoah, Lyndal Anderson, Anna DeFazio, Martin Kobel, Michael L. Friedlander, Susan J. Ramus
Summary: Clinical and gene expression data were analyzed to identify prognostic and diagnostic features of advanced-stage mucinous ovarian carcinoma (MOC) and differentiate it from gastrointestinal (GI) metastases. An infiltrative growth pattern was associated with poor prognosis, and high expression of THBS2 and TAGLN was linked to adverse prognosis in MOC. HER2 amplification or high mRNA expression was detected in some MOC cases, suggesting the potential of HER2-targeted therapy. MOC samples clustered with upper GI tumors, indicating similar biology and treatment strategies.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Samir H. Barghout, Mandeep K. Mann, Ahmed Aman, Yifan Yu, Matthew G. Alteen, Aaron D. Schimmer, Matthieu Schapira, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Summary: This study identifies epigenetic regulators that can significantly enhance the cytotoxicity of the anticancer drug TAK-243. These regulators exert their effects by inhibiting the efflux transporter ABCG2. The study also develops a cell-based assay to quantitatively evaluate the ABCG2-inhibitory activity of drug candidates.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Francesco Fazzari, Sue Chow, May Cheung, Samir H. Barghout, Aaron D. Schimmer, Qing Chang, David Hedley
Summary: The study evaluated the combined inhibition of the glutathione and thioredoxin antioxidant systems in pancreatic ductal adenocarcinoma, finding that BSO potentiated the cytotoxicity of auranofin and induced lethal oxidative stress.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Samir H. Barghout, Mandeep K. Mann, Ahmed Aman, Yifan Yu, Matthew G. Alteen, Aaron D. Schimmer, Matthieu Schapira, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Summary: This study identified epigenetic probes that significantly enhance the cytotoxicity of TAK-243 through off-target ABCG2 inhibition. A cell-based assay was developed to quantitatively evaluate ABCG2 inhibition by drug candidates based on the potentiation of TAK-243 cytotoxicity.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
