Review
Biochemistry & Molecular Biology
Oana Baru, Andreea Nutu, Cornelia Braicu, Cosmin Andrei Cismaru, Ioana Berindan-Neagoe, Smaranda Buduru, Mindra Badea
Summary: This paper discusses the importance of angiogenesis in regenerative dentistry, researchers are striving to accelerate healing and tissue remodeling through stem cells, growth factors, etc., the host response through vascularization plays a significant role in dental implants and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Martin Klein, Maria Csobonyeiova, Stanislav Ziaran, Lubos Danisovic, Ivan Varga
Summary: The regeneration of a diseased heart is a major challenge in modern cardiovascular medicine, with ongoing research on stem cell-based therapies. Telocytes (TCs) play a significant role in cardiovascular regeneration by signaling, nursing stem cells, and providing mechanical support. Dysfunction or loss of TCs is implicated in conditions like myocardial infarction and heart failure, suggesting a potential avenue for future management through TC-based cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Ria Margiana, Alexander Markov, Angelina O. Zekiy, Mohammed Ubaid Hamza, Khalid A. Al-Dabbagh, Sura Hasan Al-Zubaidi, Noora M. Hameed, Irshad Ahmad, R. Sivaraman, Hamzah H. Kzar, Moaed E. Al-Gazally, Yasser Fakri Mustafa, Homayoon Siahmansouri
Summary: MSCs have great potential for immunomodulation and tissue regeneration, and can be used for the treatment of various diseases. Recent advances in MSCs biology have facilitated their clinical application.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Yanmeng Yang, Eng Hin Lee, Zheng Yang
Summary: Mesenchymal stem cells (MSCs) are promising cell sources for tissue regeneration due to their self-regeneration, differentiation, and immunomodulation abilities. Preconditioning MSCs with hypoxia can improve their therapeutic potential by enhancing cell functionality and survival, as well as promoting cell proliferation and migration.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Review
Biotechnology & Applied Microbiology
Lina Yu, Guanxiong Zhu, Zeyu Zhang, Yang Yu, Liting Zeng, Zidan Xu, Jinlong Weng, Junyi Xia, Jiang Li, Janak L. L. Pathak
Summary: Apoptotic bodies (ApoBDs) are extracellular vesicles released by dying cells that play an important role in intercellular communications and have potential applications in disease diagnosis and treatment. Recent studies have shown that defective clearance of ApoBDs and infected-cells-derived ApoBDs can contribute to certain diseases. ApoBDs have demonstrated immunomodulatory, virus removal, vascular protection, tissue regenerative, and disease diagnostic potential, and can also enhance drug stability and targeted therapy efficacy. This review summarizes the recent advances in ApoBDs-related research and discusses their role in health and diseases, as well as the challenges and prospects of their diagnostic and therapeutic applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Cell & Tissue Engineering
Liangrui Chen, Shasha Zhu, Shujuan Guo, Weidong Tian
Summary: Periodontitis is a common oral disease that causes damage to both hard and soft tissues of the periodontium, leading to tooth mobility and loss. Mesenchymal stem cells (MSCs) have emerged as a promising therapy for periodontitis due to their unique characteristics. Accumulating evidence suggests that the regenerative effects of MSCs are mainly mediated through paracrine signaling, including the release of extracellular vesicles (EVs) that contain bioactive substances. These MSC-EVs play a crucial role in regulating the biological functions of periodontal tissue cells, immune cells, and the local microenvironment, promoting tissue regeneration and repair. As a cell-free therapy, MSC-EVs offer advantages in terms of stability, immune rejection, and ethical concerns, making them potentially valuable for clinical applications in periodontal regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Cell Biology
Kyu Hwan Kwack, Hyeon-Woo Lee
Summary: Dental caries is a common disease that causes damage to teeth and pulp tissue. Dental pulp stem cells have multipotency, high proliferation rate, and immunosuppressive properties, making them ideal for regenerating damaged pulp tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Qian Zhang, Yixin Hu, Xuan Long, Lingling Hu, Yu Wu, Ji Wu, Xiaobing Shi, Runqi Xie, Yu Bi, Fangyuan Yu, Pinxue Li, Yu Yang
Summary: Cartilage regeneration relies on cellular-ECM interactions. Traditional tissue engineering methods have not been able to replicate the physiological structure of natural cartilage, but recent advances in ECM-based scaffolds show promise in improving cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Batoul Chouaib, Mandana Haack-Sorensen, Franck Chaubron, Frederic Cuisinier, Pierre-Yves Collart-Dutilleul
Summary: Mesenchymal stem cell secretome or conditioned medium (MSC-CM) is a crucial starting point for various derived products and can be used for regenerative medicine. However, issues such as manufacturing protocols and quality control must be addressed before their clinical application. This review highlights the importance of standardized procedures in conditioned medium production and the influence of various factors on the quality of the secretome and its derivatives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Jiaxi Liu, Jinfang Gao, Zixie Liang, Chong Gao, Qing Niu, Fengping Wu, Liyun Zhang
Summary: This review discusses the characteristics of MSCs, their interaction with the microenvironment, and the importance of the microenvironment in maintaining cell function and disease progression.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell & Tissue Engineering
Yufan Zhu, Xihang Chen, Yunjun Liao
Summary: Mesenchymal stem cells (MSCs) are commonly used for cellular therapy due to their immunosuppressive and regenerative effects. However, MSCs undergo extensive apoptosis after transplantation. During apoptosis, MSCs generate apoptotic extracellular vesicles (MSCs-ApoEVs), which play a critical role in intercellular communication and tissue regeneration. This review provides a detailed overview of the production, release, isolation, functionality, and potential clinical applications of MSCs-ApoEVs.
Article
Cell & Tissue Engineering
Arvind Manikantan Padma, Laura Carriere, Frida Krokstrom Karlsson, Edina Sehic, Sara Bandstein, Tom Tristan Tiemann, Mihai Oltean, Min Jong Song, Mats Brannstrom, Mats Hellstrom
Summary: Uterine factor infertility was long considered incurable, until the successful live birth after uterus transplantation was reported. Through bioengineering approaches, risky donor surgery and immunosuppressive therapy can potentially be avoided. By decellularizing and recellularizing sheep uterus scaffolds with different protocols, it was found that matrix metalloproteinase preconditioned scaffolds showed significantly better recellularization efficiency, paving the way for potential future clinical applications.
NPJ REGENERATIVE MEDICINE
(2021)
Article
Neurosciences
Elsa Gonzalez-Cubero, Maria Luisa Gonzalez-Fernandez, Maria Rodriguez-Diaz, Marta Palomo-Irigoyen, Ashwin Woodhoo, Vega Villar-Suarez
Summary: The study investigated the therapeutic benefits of adipose tissue derived-mesenchymal stem cells (ASCs) and ASC-conditioned medium (CM) in promoting myelination and axonal regeneration. Results showed that both ASCs and CM could potentially aid in nerve regeneration, especially in reversing the effects of TNF-induced nerve damage on myelination-related genes and proteins.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Jonathan Solomon, Magdalena Raskova, Daniel Rosel, Jan Brabek, Hava Gil-Henn
Summary: Metastasis is a significant factor in the mortality rates of solid tumor cancer patients, yet research has traditionally focused on characteristics that make tumor cells proliferative and different from normal cells, neglecting the importance of metastasis. Metastasis-free survival has been approved as a primary endpoint in clinical trials, shifting the focus towards evaluating the prognosis of nonmetastatic cancer patients.
Review
Cell & Tissue Engineering
Kangkang Zha, Xu Li, Zhen Yang, Guangzhao Tian, Zhiqiang Sun, Xiang Sui, Yongjing Dai, Shuyun Liu, Quanyi Guo
Summary: Articular cartilage is difficult to repair due to its avascular nature, but mesenchymal stem cells (MSCs) show promise in cartilage regeneration. However, the heterogeneous nature of MSCs can lead to unstable therapeutic effects. Understanding MSC heterogeneity and utilizing different types of MSCs for cartilage regeneration can improve treatment efficiency.
NPJ REGENERATIVE MEDICINE
(2021)
