Article
Medicine, Research & Experimental
Shusaku Hayashi, Chithra K. Muraleedharan, Makito Oku, Sunil Tomar, Simon P. Hogan, Miguel Quiros, Charles A. Parkos, Asma Nusrat
Summary: Acute and chronic intestinal inflammation can cause epithelial damage, and cells in the wound milieu secrete signaling molecules to influence repair. This study shows that BLT1, a receptor for lipid mediators, is expressed in intestinal epithelial cells and plays a role in promoting migration and proliferation of these cells during wound repair. In mouse models, the absence of BLT1 led to impaired intestinal wound healing. These findings reveal a novel mechanism involving BLT1 signaling in the repair of intestinal epithelial wounds.
Article
Multidisciplinary Sciences
Xiaodan Li, Guifang Cao, Hongxin Yang, Dafu Zhi, Lei Li, Daqing Wang, Moning Liu, Hong Su
Summary: This study explored the role of S100A8 in estrogen-regulated oviduct mucosal immunity by treating sheep oviduct epithelial cells with estradiol. Knockdown of S100A8 resulted in excessive immune responses, while estrogen could compensate for this effect by upregulating IL-10 levels.
Article
Gastroenterology & Hepatology
Huiying Lu, Cui Zhang, Wei Wu, Huimin Chen, Ritian Lin, Ruicong Sun, Xiang Gao, Gengfeng Li, Qiong He, Han Gao, Xiaohan Wu, Jian Lin, Ruixin Zhu, Jianli Niu, Pappachan E. Kolattukudy, Zhanju Liu
Summary: This study investigated the roles of MCPIP1 in modulating the differentiation and functions of intestinal macrophages in the pathogenesis of IBD. It was found that MCPIP1 deficiency exacerbated intestinal inflammation.
Article
Gastroenterology & Hepatology
Gang Zhao, Jessica Williams, M. Kay Washington, Yaohua Yang, Jirong Long, Steven D. Townsend, Fang Yan
Summary: The study demonstrates a significant protective effect of 2'-FL in preventing and treating 5-FU-induced intestinal mucositis, by safeguarding small intestinal epithelial cells from apoptosis and ameliorating inflammation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammed Yusuf Zanna, Abd Rahaman Yasmin, Abdul Rahman Omar, Siti Suri Arshad, Abdul Razak Mariatulqabtiah, Saulol Hamid Nur-Fazila, Md Isa Nur Mahiza
Summary: Dendritic cells are crucial antigen-presenting cells in the immune system, playing a significant role in activating T cells and maintaining immune balance. Their distribution and dynamic perspectives in various animal species, as well as their roles in diseases, have been studied.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Alessio Alesci, Gioele Capillo, Angelo Fumia, Emmanuele Messina, Marco Albano, Marialuisa Aragona, Patrizia Lo Cascio, Nunziacarla Spano, Simona Pergolizzi, Eugenia Rita Lauriano
Summary: This study aimed to characterize intestinal dendritic cells (DCs) from myxines to teleosts using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II. The findings reveal the presence of DCs and DC-like cells phylogenetically from myxines to teleosts, providing new insights into the evolution of the immune system and the role of sentinel cells in body defense.
Article
Nutrition & Dietetics
Yang Lyu, Yimin Chen
Summary: Digested human colostrum significantly reduces IL-8 production in human intestinal epithelial cells stimulated with LPS and TNF. However, individual colostrum samples exhibit wide variance in their ability to suppress inflammation and cytotoxicity.
Article
Biochemistry & Molecular Biology
Ying Li, Yudong Jiang, Lei Zhang, Wei Qian, Xiaohua Hou, Rong Lin
Summary: The study showed that exogenous l-fucose can protect intestinal barrier function and reduce the severity of colitis by increasing FUT2-mediated fucosylation of intestinal epithelial cells.
Review
Immunology
Shahram Solaymani-Mohammadi
Summary: Human giardiasis is a common parasitic disease that can lead to malnutrition and developmental disorders. Understanding the interaction between the parasite and the intestinal epithelial cells may provide insights into the pathology and help identify new therapeutic approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jieli Chen, Jun Yao
Summary: T-helper 22 (Th22) cells are a novel subset of CD4(+) T cells that secrete IL-22 while abstaining from secreting IL-17 and IFN-?. These cells are considered as the primary source of IL-22 and are believed to contribute to maintaining intestinal mucosal homeostasis in IBD. However, the exact functions of Th22 cells and IL-22 in this context are still debated. This study aims to provide an overview of the molecular structure characteristics and functional effects of Th22 cells and IL-22, as well as explore targeted treatment approaches and potential therapeutic strategies focusing on the Th22 and IL-22 pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ryan M. Marquardt, Soo Hyun Ahn, Jake J. Reske, Ronald L. Chandler, Margaret G. Petroff, Tae Hoon Kim, Jae-Wook Jeong
Summary: A growing body of work suggests that epigenetic dysregulation is involved in the pathophysiology of endometriosis and female infertility. This study focuses on the chromatin remodeling complex subunit ARID1A and its role in maintaining normal uterine function. The researchers found that ARID1A is decreased in infertile women with endometriosis and hypothesized that it is involved in critical operations in the endometrial epithelium necessary for fertility. Through RNA-sequencing analysis on pre-implantation uteri from mice, they discovered alterations in immune-related gene expression resulting from loss of epithelial ARID1A. These findings demonstrate the importance of endometrial epithelial ARID1A in suppressing inflammation and maintaining uterine immune homeostasis for successful pregnancy and gynecological health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Giulia Rizzo, Samuel Elias Pineda Chavez, Elisa Vandenkoornhuyse, Cindy Lorena Cardenas Rincon, Valeria Cento, Valentina Garlatti, Marek Wozny, Giusy Sammarco, Alessia Di Claudio, Lisa Meanti, Sudharshan Elangovan, Andrea Romano, Giulia Roda, Laura Loy, Arianna Dal Buono, Roberto Gabbiadini, Sara Lovisa, Roberto Rusconi, Alessandro Repici, Alessandro Armuzzi, Stefania Vetrano
Summary: This study found that pomegranate extract has beneficial effects in promoting the recovery phase of colitis and the complete restoration of the intestinal barrier. It also affects pathogen biofilm formation and promotes mucosal regeneration through the regulation of the crosstalk between epithelial and stromal cells.
Article
Gastroenterology & Hepatology
Chiara Muzzi, Norika Watanabe, Eric Twomey, Garrit K. Meers, Holger M. Reichardt, Hanibal Bohnenberger, Sybille D. Reichardt
Summary: This study highlights the important role of intestinal epithelial cells as targets of glucocorticoid action in inflammatory bowel disease, and suggests that the effectiveness of controlling colitis directly impacts the progression of colorectal cancer.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Rienk Gerben van der Meer, Anneke Spoorenberg, Elisabeth Brouwer, Berber van der Meer, Annemieke M. H. Boots, Suzanne Arends, Wayel H. Abdulahad
Summary: This study reveals the changes in the number and phenotype of CD8+ mucosal-associated invariant T-cells (MAIT) in peripheral blood of patients with spondyloarthritis. Additionally, the study suggests that the inflammatory function of these cells is also affected, which might be implicated in the pathogenesis of axial diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Siqingaowa Caidengbate, Yuichi Akama, Anik Banerjee, Khwanchanok Mokmued, Eiji Kawamoto, Arong Gaowa, Louise D. McCullough, Motomu Shimaoka, Juneyoung Lee, Eun Jeong Park
Summary: In a mouse model of sepsis induced by cecal slurry injection, the expression profile of miRNAs in intestinal epithelial cells (IECs) was found to be altered. These changes may have complex and global effects on gene regulation networks, contributing to the development of sepsis.
Article
Immunology
Benedetta Raspini, Mirco Vacca, Debora Porri, Rachele De Giuseppe, Francesco Maria Calabrese, Marcello Chieppa, Marina Liso, Rosa Maria Cerbo, Elisa Civardi, Francesca Garofoli, Maria De Angelis, Hellas Cena
Summary: The development of infant gut microbiota is influenced by various factors, and there is no single factor that can significantly affect its development. There is a complex multifactorial interaction between maternal and neonatal factors determining a unique microbial niche in the gastrointestinal tract.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giulio Verna, Marina Liso, Elisabetta Cavalcanti, Giusy Bianco, Veronica Di Sarno, Angelo Santino, Pietro Campiglia, Marcello Chieppa
Summary: Dendritic cells can be divided into myeloid dendritic cells and plasmacytoid dendritic cells, which play important roles in regulating immune responses. Inflammatory bowel diseases are characterized by leaky intestinal barrier and translocation of bacterial lipopolysaccharide. It was found that quercetin can modulate dendritic cell responses through a specific molecular pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marina Liso, Annamaria Sila, Giulio Verna, Aurelia Scarano, Rossella Donghia, Fabio Castellana, Elisabetta Cavalcanti, Pasqua Letizia Pesole, Eduardo Maria Sommella, Antonio Lippolis, Raffaele Armentano, Anna Maria Giudetti, Daniele Vergara, Pietro Campiglia, Rodolfo Sardone, Margherita Curlo, Mauro Mastronardi, Katia Petroni, Chiara Tonelli, Angelo Santino, Marcello Chieppa
Summary: Antioxidants can be used as adjuvants to improve the effectiveness of pharmacological therapies, especially for chronic inflammatory syndromes. A study found that taking an antioxidant-enriched purple corn supplement can improve the response to medication in patients with inflammatory bowel diseases, although the effect may vary between Crohn's disease and ulcerative colitis.
Article
Nutrition & Dietetics
Mirco Vacca, Benedetta Raspini, Francesco Maria Calabrese, Debora Porri, Rachele De Giuseppe, Marcello Chieppa, Marina Liso, Rosa Maria Cerbo, Elisa Civardi, Francesca Garofoli, Hellas Cena, Maria De Angelis
Summary: This study aimed to characterize the gastrointestinal microbiota in infants during early childhood and determine how different factors during pregnancy, delivery, and postnatal period influenced its composition. The results showed that milk-feeding and weaning played a significant role in shaping the microbiota.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Psychiatry
Sanket B. Raut, Juan J. Canales, Manoj Ravindran, Rajaraman Eri, David M. Benedek, Robert J. Ursano, Luke R. Johnson
Summary: A systematic review and meta-analysis found lack of evidence for the efficacy of propranolol for traumatic memory disruption in PTSD patients. Propranolol did not show beneficial effects on PTSD symptoms and physiological responses, except for a reduction in heart rate. However, the high heterogeneity, variation in propranolol dosage, and inadequate sample sizes require cautious interpretation of these findings.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Ravichandra Vemuri, Christopher J. Martoni, Kylie Kavanagh, Rajaraman Eri
Summary: Age-related changes in gut microbiome are associated with co-occurrence patterns, with reduced nodes and associations in elderly mice. DDS-1 strain can modulate microbial co-occurrence networks, with differential effects on fecal, mucosal, and cecal samples. Beneficial bacteria act as connectors in aging networks in response to DDS-1 supplementation.
Article
Cell Biology
Adelfia Tala, Flora Guerra, Silvia Caterina Resta, Matteo Calcagnile, Amilcare Barca, Salvatore Maurizio Tredici, Maria Dolores De Donno, Mirco Vacca, Marina Liso, Marcello Chieppa, Maria De Angelis, Tiziano Verri, Maria Giuseppina Bozzetti, Cecilia Bucci, Pietro Alifano
Summary: This study demonstrates that the intestinal environment of mice with a missense mutation in the MUC2 mucin gene selects a specific intestinal microbial community characterized by pro-inflammatory, genotoxic, and metabolic features, suggesting its direct involvement in the pathogenesis of chronic intestinal inflammation.
Article
Biochemistry & Molecular Biology
Rhiannon T. Filippone, Narges Dargahi, Rajaraman Eri, Jose A. Uranga, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali
Summary: Targeting eosinophils through the CCR3 axis can alleviate inflammatory bowel disease and contribute to understanding the role of eosinophils as potential targets for IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rachele De Giuseppe, Federica Loperfido, Rosa Maria Cerbo, Maria Cristina Monti, Elisa Civardi, Francesca Garofoli, Micol Angelini, Beatrice Maccarini, Eduardo Sommella, Pietro Campiglia, Laura Bertuzzo, Marcello Chieppa, Stefano Ghirardello, Hellas Cena
Summary: Childhood obesity is a strong predictor of adult obesity, with significant health and economic consequences. Early adiposity rebound (EAR) occurring at around 2 years old may be related to early changes in the gut microbiome due to maternal/lifestyle changes and environmental exposures. The LIMIT study aims to identify the interplay between infant gut microbiome, infant/maternal lifestyle, and environmental factors, in order to find modifiable factors for effective and personalized prevention of childhood obesity.
Review
Pharmacology & Pharmacy
Deeksha Joshi, Rubiya Khursheed, Saurabh Gupta, Diksha Wadhwa, Thakur Gurjeet Singh, Sumit Sharma, Sejal Porwal, Swati Gauniyal, Sukriti Vishwas, Sanjay Goyal, Gaurav Gupta, Rajaraman D. Eri, Kylie A. Williams, Kamal Dua, Sachin Kumar Singh
Summary: Biologic-based medicines, including biosimilars, have the potential to enhance cancer treatment by providing lower-cost options and increasing accessibility. However, there are challenges such as cost, immunogenicity, lack of awareness, extrapolation of indications, and interchangeability.
Review
Pharmacology & Pharmacy
Ankit Awasthi, Leander Corrie, Sukriti Vishwas, Monica Gulati, Bimlesh Kumar, Dinesh Kumar Chellappan, Gaurav Gupta, Rajaraman D. Eri, Kamal Dua, Sachin Kumar Singh
Summary: Diabetic foot ulcer (DFU) is a complication of diabetes that is increasing globally. Gut dysbiosis, a major cause of diabetes mellitus and DFU, can be improved by probiotics, which have the potential to manage DFU.
Review
Biochemistry & Molecular Biology
Aurelia Scarano, Barbara Laddomada, Federica Blando, Stefania De Santis, Giulio Verna, Marcello Chieppa, Angelo Santino
Summary: This article examines the effects of dietary polyphenols on human health, focusing on their antioxidant properties and chelating abilities. It explores the importance of polyphenols and their iron-binding abilities in inflammatory/immunomodulatory responses, with specific attention to macrophages and dendritic cells, as well as their impact on gut microbiota. The article also highlights the need for further investigation into the polyphenol-iron metabolism-inflammatory responses axis and the polyphenol-iron availability-gut microbiota relationship to prevent or counteract pathological conditions.
Article
Endocrinology & Metabolism
Dario Domenico Lofrumento, Alessandro Miraglia, Velia La Pesa, Antonella Sonia Treglia, Marcello Chieppa, Francesco De Nuccio, Giuseppe Nicolardi, Claudia Miele, Francesco Beguinot, Corrado Garbi, Bruno Di Jeso
Summary: In type 2 Diabetes, beta-cell failure is caused by loss of cell mass, mostly by apoptosis, but also by simple dysfunction. The study found that increased flux of glucose in the hexosamine biosynthetic pathway affects beta-cell-beta-cell homotypic interactions.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eduardo Sommella, Giulio Verna, Marina Liso, Emanuela Salviati, Tiziana Esposito, Daniela Carbone, Camilla Pecoraro, Marcello Chieppa, Pietro Campiglia
Summary: This study evaluates the potential of specific Hop fractions in modulating dendritic cells (DCs) metabolism to reduce inflammatory responses, with Hop fraction (HOP C) shown to independently regulate inflammatory cytokines production and related pathways in a mechanism distinct from extracellular iron-sequestration. These findings highlight the anti-inflammatory mechanism of Hop-derived compounds and their potential applications in restoring dysregulated metabolism in DCs to suppress undesirable inflammatory responses.