Article
Immunology
Eunbyeol Ko, Soyoung Jeong, Min Yong Jwa, A. Reum Kim, Ye-Eun Ha, Sun Kyung Kim, Sungho Jeong, Ki Bum Ahn, Ho Seong Seo, Cheol-Heui Yun, Seung Hyun Han
Summary: The study showed that compared to h-SP or f-SP vaccine, r-SP vaccine can provide higher protection against S. pneumoniae, enhance specific antibody levels, and promote follicular helper T cell activation.
Article
Multidisciplinary Sciences
Jieni Fu, Xiangmei Liu, Zhenduo Cui, Yufeng Zheng, Hui Jiang, Yu Zhang, Zhaoyang Li, Yanqin Liang, Shengli Zhu, Paul K. Chu, Kelvin Wai Kwok Yeung, Shuilin Wu
Summary: Probiotic-based nanoparticles can effectively treat immunocompetent primary and immunocompromised secondary bacterial pneumonia by restoring host immunity. These nanoparticles can kill common pathogens, modulate lung microbiota, and alleviate overactive immune responses. This research provides a new strategy for treating bacterial pneumonia in individuals with normal and compromised immunity.
NATIONAL SCIENCE REVIEW
(2023)
Article
Nutrition & Dietetics
Marcella Reale, Claudio Ucciferri, Erica Costantini, Marta Di Nicola, Annamaria Porreca, Pamela Di Giovanni, Michela Pontolillo, Antonio Auricchio, Jacopo Vecchiet, Katia Falasca
Summary: The study found that supplementation with Vivomixx(R) probiotics improved the immune response to PCV13 vaccine, leading to greater changes in anti-Pn CPS13 IgG and an increase in salivary IgA, IL-10 and IL-8. Further research is needed to determine the optimal strains, doses, and timing of probiotic administration for enhancing vaccination efficacy in immunocompromised individuals and the elderly.
Article
Biochemical Research Methods
Maruthi Prasanna, Ruben Varela Calvino, Annie Lambert, Maria Arista Romero, Sylvia Pujals, Francois Trottein, Emilie Camberlein, Cyrille Grandjean, Noemi Csaba
Summary: This study demonstrates the potential of chitosan-based nanovaccines for efficient delivery of glycoconjugate antigens. Encapsulated glycoconjugates showed enhanced uptake by cells and better immunostimulatory properties compared to naked antigens. The study also showed a 100-fold increase in IgG response with the encapsulated glycoconjugate compared to the nonencapsulated group in mice.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Biochemical Research Methods
Maruthi Prasanna, Ruben Varela Calvino, Annie Lambert, Maria Arista Romero, Sylvia Pujals, Francois Trottein, Emilie Camberlein, Cyrille Grandjean, Noemi Csaba
Summary: This study demonstrates the potential of chitosan-based nanovaccine for efficient delivery of glycoconjugate antigens. The encapsulation of the glycoconjugate using chitosan nanoparticles (CNPs) enhanced its immunogenicity and resulted in a significantly higher immune response compared to the nonencapsulated glycoconjugate. These findings suggest that CNPs could be a promising delivery system for pneumococcal conjugate vaccines.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Fisheries
Withanage Prasadini Wasana, Amal Senevirathne, Chamilani Nikapitiya, Jong-Soo Lee, Do-Hyung Kang, Kae Kyoung Kwon, Chulhong Oh, Mahanama De Zoysa
Summary: This study characterizes and evaluates the probiotic properties of a newly isolated marine bacterium, Pseudoalteromonas ruthenica. The results show that P. ruthenica enhances disease tolerance and thermal stress resistance in larval and adult zebrafish, and modulates the gut microbiota and immune-stress response. The findings suggest that P. ruthenica has potential as a probiotic for enhancing host defense mechanisms.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Kristiana Alexandrova Nikolova, Mikael Andersson, Hans-Christian Slotved, Anders Koch
Summary: The introduction of PCV13 in Greenland's childhood vaccination program in 2010 led to a decrease in overall incidence rates of IPD, with a significant decrease in children but a notable increase among the elderly. The incidence of vaccine serotype IPD decreased across all ages, while non-vaccine serotype IPD increased during the post-PCV13 period, particularly among the elderly aged 60 years and above. Continued surveillance of IPD in the Greenlandic population is needed to monitor the trend.
Article
Infectious Diseases
Marianna Riekkinen, Sari H. Pakkanen, Veronik Hutse, Inge Roukaerts, Jukka Ollgren, Helena Kayhty, Christian Herzog, Lars Rombo, Anu Kantele
Summary: This study examined the influence of coadministration of HepA and PCV13 on safety and immunogenicity. The results showed that coadministration of PCV13 significantly impaired antibody responses to HepA, but did not impact the response to PCV13. Overall, there were no major safety concerns.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Chemistry, Multidisciplinary
Qingqing Deng, Lu Zhang, Xuemeng Liu, Lihua Kang, Jiadai Yi, Jinsong Ren, Xiaogang Qu
Summary: Conventional strategies for treating inflammatory bowel disease focus on relieving inflammation but fail to address the underlying causes of the disease. Natural probiotics have shown potential for IBD treatment, but are not recommended due to potential risks. This study introduces artificial probiotics (Aprobiotics) based on artificial enzyme-dispersed covalent organic frameworks (COFs) and a yeast shell as a new approach for IBD management. These COF-based Aprobiotics can effectively relieve inflammation and regulate the gut microbiota, offering a promising solution for IBD treatment and inspiring the development of artificial systems for other diseases.
Article
Multidisciplinary Sciences
Thiago Rojas Converso, Cibelly Goulart, Dunia Rodriguez, Maria Eduarda Souza Guerra, Michelle Darrieux, Luciana C. C. Leite
Summary: The hybrid protein rPotD-PdT can induce stronger immune responses, but is not sufficient to provide full protection against highly virulent pneumococcal strains. Therefore, combination with other antigens may be necessary for sufficient protection.
Article
Immunology
Rodolfo F. Marques, Filipe Menegatti de Melo, Janaina Tenorio Novais, Irene S. Soares, Daniel Youssef Bargieri, Alba Marina Gimenez
Summary: This study describes the immune response induced by Poly(I:C) and Montanide ISA 720 in mice immunized with a recombinant protein vaccine against Plasmodium vivax. The results showed that mice vaccinated with the recombinant protein and Montanide ISA 720 exhibited a stronger humoral immune response with antibodies of higher affinity to the antigen. Additionally, Poly(I:C) caused more perturbations in the T cell transcriptome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Guangmang Liu, Ting Zhang, Xinlian Liu, Gang Jia, Hua Zhao, Xiaoling Chen, Ruinan Zhang, Jing Wang
Summary: This study found that N-carbamylglutamate can improve the growth performance of piglets and alleviate LPS-induced intestinal inflammation by modulating microbiota and Th17/Treg balance-related immune signaling pathways.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Food Science & Technology
Jing Yang, Hong Kuang, Ning Li, Ahmed Mahmoud Hamdy, Jiajia Song
Summary: Probiotic-derived polysaccharide capsules have a significant impact on regulating the immune system and alleviating allergic diseases. They can modulate the Th1/Th2 balance, induce differentiation of T regulatory cells, and activate dendritic cells, thereby providing protection against allergic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Oncology
Sara Pischedda, Daniel O'Connor, Benjamin P. Fairfax, Antonio Salas, Federico Martinon-Torres, Andrew J. Pollard, Johannes Truck
Summary: Epigenetic changes during early childhood may be associated with antigen-specific antibody responses to pneumococcal vaccines, with differences in methylation patterns observed between high and low vaccine responders. Pathways involved in the regulation of cell-cell adhesion and T cell activation were found to be enriched in the differentially methylated positions identified between 12 and 24 months of age.
CLINICAL EPIGENETICS
(2021)
Review
Immunology
Jeffrey A. Bluestone, Brent S. McKenzie, Joshua Beilke, Fred Ramsdell
Summary: Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing various immune-related diseases. They are able to develop in both the thymus and peripheral tissues through the expression of a transcription factor called FOXP3. Treg cells exert their tolerogenic effects by using multiple mechanisms, such as producing inhibitory cytokines, suppressing T effector cells, and modulating antigen-presenting cell function. Recently, there has been a focus on genetically engineering Treg cells to enhance their therapeutic potential, leading to ongoing clinical trials. This review highlights the advancements and challenges in harnessing Treg cells as a new approach for treating diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Daniel J. Tan, Caroline J. Lodge, Eugene Haydn Walters, Adrian J. Lowe, Dinh S. Bui, Gayan Bowatte, Rangi Kandane-Rathnayake, Fahad M. Aldakheel, Bircan Erbas, Garun S. Hamilton, Paul S. Thomas, Mark Hew, Mimi L. K. Tang, Michael J. Abramson, Jennifer L. Perret, Shyamali C. Dharmage
Summary: This study found that subclinical inflammation exists in adults with spontaneous asthma remission, and these inflammatory biomarkers are associated with future asthma relapse and lung function decline. Bronchial hyperresponsiveness (BHR) and serum inflammatory cytokines have prognostic value in predicting outcomes in adults with spontaneous asthma remission, suggesting the need for closer monitoring and follow-up in high-risk individuals.
Article
Surgery
Michelle Zhiyun Chen, Xinyi Zhang, Milton Mui, Joseph C. H. Kong, Alexander G. Heriot, Jodie Ellis-Clark
Summary: PET scan can be a valuable tool in accurate staging, especially for ambiguous or equivocal lesions on CT. The study showed that PET provided additional information and resulted in an altered management plan in 18.2% of the patients.
ANZ JOURNAL OF SURGERY
(2023)
Editorial Material
Surgery
Milton Mui, Joseph C. H. Kong, Glen R. R. Guerra, Corina C. C. Behrenbruch, Michael Michael, Alexander G. G. Heriot
ANZ JOURNAL OF SURGERY
(2023)
Review
Allergy
Melanie Lloyd, Nandinee Patel, Daniel Munblit, Mimi L. K. Tang
Summary: Multiple novel interventions for food allergy are currently in development, aiming to reduce or eliminate allergic reactions. However, the success of these therapies in improving patients' lives is difficult to determine due to limited understanding of the alignment between clinical trial efficacy endpoints and patient-centered outcomes. This review assists clinicians in interpreting clinical trial outcomes and effectively communicating risks and outcomes to patients during shared decision-making.
(c) 2023 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:998-1007)
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Geography
Laura H. Oostenbach, Jennifer Noall, Karen E. Lamb, Amber L. Pearson, Suzanne Mavoa, Lukar E. Thornton
Summary: Limited research has explored the associations between blue spaces (coastal environments) and mental health in children. This study found that living closer to the coast was associated with lower levels of depression in childhood, but not in adolescence. No associations were found with anxiety. The duration of residency at the current address appeared to have a weak effect on associations. Further research is needed to understand the specific characteristics of coastal environments that may benefit children's mental health.
GEOGRAPHICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Toby Mansell, Annalee Furst, Martin O'Hely, Melinda Chang, Anne-Louise Ponsonby, Peter Vuillermin, Mimi L. K. Tang, David Burgner, Richard Saffery, Lars Bode
Summary: The concentration of human milk oligosaccharides (HMOs) at 6 weeks postpartum is associated with infant anthropometry, particularly within the first 6 months. For secretor mothers, higher levels of 2'FL are associated with increased weight and length in infants, while higher levels of lacto-N-tetraose are associated with increased weight and length in nonsecretor mothers.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Muhammad Akram, Ester Cerin, Karen E. Lamb, Simon R. White
Summary: Inference using standard linear regression models (LMs) relies on assumptions that are rarely satisfied in practice. Count, bounded, and skewed outcomes can substantially violate LM assumptions. Instead of relying on transformations, generalized linear models (GLMs) should be considered as more suitable approaches for managing these types of outcomes. Physical activity researchers should add GLMs to their statistical toolboxes and be aware of situations when GLMs are a better method than traditional approaches.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Letter
Pediatrics
Shivanthan Shanthikumar, Katherine Chen, Victoria X. Soriano, Lily Nguyen, Jennifer J. Koplin, Mimi L. K. Tang, Adrian J. Lowe, Caroline J. Lodge, Nur Sabrina Idrose, Sarath Ranganathan, Bruce Thompson, Shyamali C. Dharmage, Rachel L. Peters
PEDIATRIC PULMONOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Laura Helena Oostenbach, Karen Elaine Lamb, David Crawford, Anna Timperio, Lukar Ezra Thornton
Summary: This study aimed to examine the associations between work and commute hours with food consumption and test the moderating effect of neighbourhood type. The findings suggest that non-workers and overtime workers have less healthy food behaviours compared to full-time workers. Among those employed, longer work and commute hours were positively associated with takeaway consumption. Although behaviours appeared healthier for individuals in the 20-minute neighbourhood, the differences in associations between work and commute hours with food consumption across neighbourhood type were negligible.
PUBLIC HEALTH NUTRITION
(2023)
Article
Allergy
Melanie Lloyd, Paxton Loke, Douglas P. Mack, Scott H. Sicherer, Michael R. Perkin, Robert Boyle, Agnes Sze Yin Leung, Bee Wah Lee, Michael Levin, Katharina Blumchen, Alessandro Fiocchi, Motohiro Ebisawa, Lucila Camargo Lopes de Oliveira, Mimi L. K. Tang
Summary: Food allergy is a chronic disease that affects individuals of all ages and is a significant public health problem globally. This narrative overview examines clinical management strategies for IgE-mediated food allergy in children around the world to understand variations in practice.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Letter
Allergy
Gabriel Lins de Holanda Coelho, Melanie Lloyd, Mimi L. K. Tang, Audrey DunnGalvin
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Allergy
Elizabeth Huiwen Tham, Agnes Sze Yin Leung, Kiwako Yamamoto-Hanada, Lamia Dahdah, Thulja Trikamjee, Vrushali Vijay Warad, Matthew Norris, Elsy Navarrete, Daria Levina, Miny Samuel, Andre van Niekerk, Santiago Martinez, Anne K. Ellis, Leonard Bielory, Hugo van Bever, Dana Wallace, Derek K. Chu, Daniel Munblit, Mimi L. K. Tang, James Sublett, Gary Wing Kin Wong
Summary: This study conducted a comprehensive assessment of Clinical Practice Guidelines (CPGs) for primary prevention of food allergy and atopic dermatitis. It found that although some guidelines had high quality, they performed poorly in terms of global applicability. The study calls for guideline developers to consider stakeholders' preferences, local applicability, and adapt existing recommendations to different geographical settings.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Allergy
Chia-Lun Chang, Gulshan Bano Ali, Jonathan Pham, Shyamali C. C. Dharmage, Caroline J. J. Lodge, Mimi L. K. Tang, Adrian J. J. Lowe
Summary: This study systematically synthesized the association between BMI trajectories in childhood and allergic diseases. The findings suggest that a persistently high BMI between 6 and 10 years of age may be associated with an increased risk of asthma at 18 years, and a rapid increase in BMI in the first 2 years of life may be associated with subsequent asthma. Maintaining a normal BMI trajectory during childhood may reduce the risk of asthma.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Medicine, General & Internal
Harriet Koorts, Anna Timperio, Chris Lonsdale, Nicola D. Ridgers, David R. Lubans, Jacqueline Della Gatta, Adrian Bauman, Amanda Telford, Lisa Barnett, Karen E. Lamb, Natalie Lander, Samuel K. Lai, Taren Sanders, Lauren Arundell, Helen Brown, Katrina Wilhite, Jo Salmon
Summary: The TransformUs programme is being disseminated to all primary schools in Victoria, Australia, aiming to increase physical activity and reduce sedentary behavior among school children. The study protocol involves a 5-year effectiveness-implementation trial to assess the scalability and effectiveness of the programme, using mixed methods and a quasi-experimental design. Findings will be used to inform education policy and practice on promoting physical activity and reducing sedentary behaviors on a population-wide scale.
Review
Allergy
Caroline J. Lodge, Nilakshi Waidyatillake, Rachel L. Peters, Merryn Netting, Xin Dai, John Burgess, Catherine J. Hornung, Kirsten P. Perrett, Mimi L. K. Tang, Jennifer J. Koplin, Shyamali C. Dharmage
Summary: This study synthesized the best available evidence from randomized controlled trials to evaluate the efficacy and safety of oral immunotherapy (OIT) for desensitization (DS) and remission (SU) in peanut, hen's egg, and cow's milk allergies. The results showed that OIT had a positive effect on desensitization, but it also increased the risk of allergic reactions.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)