Article
Endocrinology & Metabolism
Di Wu, Zongxian Li, Yime Zhang, Yinlian Zhang, Guanqun Ren, Yanyu Zeng, Huiying Liu, Weiqiang Guan, Xingyu Zhao, Peng Li, Luni Hu, Zhiyuan Hou, Jingjing Gong, Jun Li, Wenfei Jin, Zeping Hu, Changtao Jiang, Houhua Li, Chao Zhong
Summary: This study reveals the importance of proline uptake in the activation of innate lymphoid cells and its contribution to gut homeostasis. Deficiency in proline uptake impairs lymphoid tissue inducer cell activation and worsens colitis. The study highlights the role of proline metabolism in specific subsets of lymphoid cells and its involvement in the regulation of reactive oxygen species and interleukin-22.
Article
Endocrinology & Metabolism
Di Wu, Luni Hu, Mengwei Han, Yichen Deng, Yime Zhang, Guanqun Ren, Xingyu Zhao, Zongxian Li, Peng Li, Yinlian Zhang, Shanwen Chen, Jun Li, Yanyan Shi, Jianxin Xue, Pengyuan Wang, Chao Zhong
Summary: In this study, the researchers found that a metabolic reconfiguration in colonic lymphoid tissue inducer (LTi) cells regulated by PD-1 signaling modulates inflammatory states in the gut during anti-PD-1 immunotherapy.
Review
Immunology
Eric Y. Helm, Liang Zhou
Summary: The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor that plays a role in immune cell environmental sensing. It regulates the development and function of innate lymphoid cells (ILCs) and their adaptive T cell counterparts. Both ILCs and T cells share some core transcription factors and effector molecules, but they have both shared and distinct mechanisms of regulation by Ahr. This review highlights the latest findings on Ahr's transcriptional regulation of ILCs and T cells, focusing on the shared and distinct mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Serge A. van de Pavert
Summary: The ILC family, a recently described immune cell family, is involved in innate immune responses and tissue homeostasis. LTi cells, part of the ILC3 family, play a critical role in embryonic lymph node formation. Recent studies have provided insights into the origin of ILCs, including embryonic LTi cells being replaced by HSC derived progenitors in adults. This review focuses on the layered origin of the ILC3 family with an emphasis on the LTi cell lineage.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Cell Biology
Roser Tacho-Pinot, Christopher T. Stamper, James I. King, Veronika Matei-Rascu, Erin Richardson, Zhi Li, Luke B. Roberts, John W. Bassett, Felipe Melo-Gonzalez, Remi Fiancette, I-Hsuan Lin, Alexander Dent, Yohsuke Harada, Conor Finlay, Jenny Mjosberg, David R. Withers, Matthew R. Hepworth
Summary: Innate lymphoid cells (ILCs) are tissue-resident effector cells with diverse roles in tissue homeostasis, immunity, and inflammatory disease. Among them, ILC3 subset, specifically the LTi-like ILC3s, is defined by the transcription factor Bcl6, which plays a crucial role in their phenotypic and functional regulation. The dysregulation of LTi-like ILC3s due to Bcl6 deletion leads to increased expression of IL-17A and IL-17F, worsening inflammation in a colitis model.
Review
Immunology
Nicolas Jacquelot, Cyril Seillet, Eric Vivier, Gabrielle T. Belz
Summary: Innate lymphoid cells (ILCs) play a role in immune responses and have been found to have pleiotropic effects in various tissues, including both tissue repair and immunopathology toward allergens and promotion of tumorigenesis. Recent studies suggest that non-NK ILCs might be harnessed for anti-tumor responses. Gabrielle Belz and colleagues review the influence of ILCs on cancer immune responses.
Review
Immunology
Dan Yang, Xinning Guo, Tingxuan Huang, Chuntao Liu
Summary: Innate lymphoid cells play a crucial role in maintaining mucosal homeostasis and protecting against pathogens, with ILC3s emerging as key mediators of mucosal protection and repair through producing IL-17 and IL-22. Further research is needed to understand the role of pulmonary ILC3s in respiratory infections and chronic pulmonary inflammatory diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Ramzi Nehmar, Louis Fauconnier, Jose Alves-Filho, Dieudonnee Togbe, Aurore DeCauwer, Seiamak Bahram, Marc Le Bert, Bernhard Ryffel, Philippe Georgel
Summary: The study revealed the crucial role of AHR activation in the development of arthritis, while IL-22 deficiency aggravated arthritis symptoms. Activation of AHR can alleviate inflammation and reduce joint destruction, with a protective effect on type 3 innate lymphoid cells during acute arthritis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Baoyi Liu, Yongyi Xie, Xingyu Mei, Yue Sun, Weimin Shi, Zhouwei Wu
Summary: Reduced AhR expression is associated with progressive, unstable vitiligo, while IL17A and IL22 expression levels are significantly higher in patients with vitiligo. Knockdown of AhR results in increased IL17A production, while activation of AhR with Ginkgo biloba extract EGb 761 inhibits IL17A secretion.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yan-yang Li, Xiao-jing Wang, Yu-lin Su, Qing Wang, Shao-wei Huang, Zeng-feng Pan, Yan-ping Chen, Jun-jie Liang, Mei-ling Zhang, Xue-qian Xie, Zhi-yun Wu, Jin-yan Chen, Lian Zhou, Xia Luo
Summary: This study elucidates the molecular mechanisms underlying the protective effect of baicalein on intestinal barrier function in colitis mice, demonstrating that baicalein improves gut inflammation, reduces intestinal permeability, and restores tight junctions possibly via promoting AhR/IL-22 pathway. Co-administration of AhR antagonist CH223191 partially blocks the therapeutic effects of baicalein, while AhR agonist FICZ ameliorates symptoms and gut barrier function in colitis mice.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Immunology
Lingzhen Hu, Jingyi Hu, Liheng Chen, Yi Zhang, Qingqing Wang, Xuyan Yang
Summary: Our study demonstrated that IL-22 overexpression in LN activated the STAT3 signaling pathway, increased chemokine secretion, promoted macrophage infiltration, and thus aggravated LN in lupus-prone mice. This suggests that IL-22 may play a pathogenic role in LN and serve as a potential therapeutic target for LN.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Farooq Riaz, Fan Pan, Ping Wei
Summary: The aryl hydrocarbon receptor (AhR) is a widely studied ligand-activated transcription factor that is associated with various diseases. It regulates toxicological, biological, and cellular responses by responding to environmental toxins, dietary ligands, and allergens. Recent findings suggest that AhR also interacts with non-canonical factors to affect gene expression. AhR signaling has also been shown to have significant effects on immune cells and play a role in allergens-induced diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Li Xu, Yiyun Liu, Yangsheng Chen, Ruihong Zhu, Siqi Li, Songyan Zhang, Jian Zhang, Heidi Qunhui Xie, Bin Zhao
Summary: This study found that emodin inhibits the migration ability of glioblastoma cells by activating the AhR-IL24 signaling pathway, indicating that the AhR signaling pathway can be a key target for studying the regulatory effects and mechanisms of compounds on glioblastoma migration.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Immunology
Jun Yan, Jing Yu, Ke Liu, Yijia Liu, Changchuin Mao, Wenda Gao
Summary: IL-22 plays a dual role in colitis, both protecting gut epithelium and potentially enhancing inflammation. Innate lymphoid cells play a crucial role in IL-22 production and regulation. The transcription factor Musculin has been identified as a key player in the expression of IL-22, which may impact the development of different immune cell subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xun Lin, Suzanne Tawch, Hoi Tong Wong, Suyasha Roy, Stephen Gaudino, Patricia Castillo, Waleed Elsegeiny, Nobunao Wakabayashi, Tim D. Oury, Derek Pociask, Kong Chen, Nancy McLinskey, Patricia Melville, Olga Syritsyna, Patricia Coyle, Misty Good, Amit Awasthi, Jay K. Kolls, Pawan Kumar
Summary: This study demonstrates that Nrf2 regulates IL-22 response in CD4(+) T cells through the AhR pathway. CDDO-Im induces IL-22 production by indirectly affecting AhR, confirming the AhR-dependent regulation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Anna C. Aschenbrenner, Maria Mouktaroudi, Benjamin Kraemer, Marie Oestreich, Nikolaos Antonakos, Melanie Nuesch-Germano, Konstantina Gkizeli, Lorenzo Bonaguro, Nico Reusch, Kevin Basser, Maria Saridaki, Rainer Knoll, Tal Pecht, Theodore S. Kapellos, Sarandia Doulou, Charlotte Kroeger, Miriam Herbert, Lisa Holsten, Arik Horne, Ioanna D. Gemuend, Nikoletta Rovina, Shobhit Agrawal, Kilian Dahm, Martina van Uelft, Anna Drews, Lena Lenkeit, Niklas Bruse, Jelle Gerretsen, Jannik Gierlich, Matthias Becker, Kristian Haendler, Michael Kraut, Heidi Theis, Simachew Mengiste, Elena De Domenico, Jonas Schulte-Schrepping, Lea Seep, Jan Raabe, Christoph Hoffmeister, Michael ToVinh, Verena Keitel, Gereon Rieke, Valentina Talevi, Dirk Skowasch, N. Ahmad Aziz, Peter Pickkers, Frank L. van de Veerdonk, Mihai G. Netea, Joachim L. Schultze, Matthijs Kox, Monique M. B. Breteler, Jacob Nattermann, Antonia Koutsoukou, Evangelos J. Giamarellos-Bourboulis, Thomas Ulas
Summary: This study provides novel insights into distinct molecular subgroups or phenotypes that are not simply explained by clinical parameters. Whole blood transcriptomes are shown to be extremely informative for COVID-19 as they capture the major drivers of disease severity, granulocytes.
Article
Multidisciplinary Sciences
Marta Ferreira-Gomes, Andrey Kruglov, Pawel Durek, Frederik Heinrich, Caroline Tizian, Gitta Anne Heinz, Anna Pascual-Reguant, Weijie Du, Ronja Mothes, Chaofan Fan, Stefan Frischbutter, Katharina Habenicht, Lisa Budzinski, Justus Ninnemann, Peter K. Jani, Gabriela Maria Guerra, Katrin Lehmann, Mareen Matz, Lennard Ostendorf, Lukas Heiberger, Hyun-Dong Chang, Sandy Bauherr, Marcus Maurer, Guenther Schoenrich, Martin Raftery, Tilmann Kallinich, Marcus Alexander Mall, Stefan Angermair, Sascha Treskatsch, Thomas Doerner, Victor Max Corman, Andreas Diefenbach, Hans-Dieter Volk, Sefer Elezkurtaj, Thomas H. Winkler, Jun Dong, Anja Erika Hauser, Helena Radbruch, Mario Witkowski, Fritz Melchers, Andreas Radbruch, Mir-Farzin Mashreghi
Summary: The study found that in severe COVID-19 patients, plasmablasts shift from IFN to TGF-beta instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Andreas Walker, Torsten Houwaart, Patrick Finzer, Lutz Ehlkes, Alona Tyshaieva, Maximilian Damagnez, Daniel Strelow, Ashley Duplessis, Jessica Nicolai, Tobias Wienemann, Teresa Tamayo, Malte Kohns Vasconcelos, Lisanna Huelse, Katrin Hoffmann, Nadine Luebke, Sandra Hauka, Marcel Andree, Martin P. Daeumer, Alexander Thielen, Susanne Kolbe-Busch, Klaus Goebels, Rainer Zotz, Klaus Pfeffer, Joerg Timm, Alexander T. Dilthey
Summary: Tracing SARS-CoV-2 population transmission chains remains a major challenge, but this study presents an integrated system of genomic surveillance that is capable of detecting infection chains in a large city during ongoing community transmission. The system combines viral surveillance sequencing, genetically based identification of infection clusters, integration of public health authority contact tracing data, and a user-friendly dashboard application. This integrated system can contribute to the monitoring and potentially improve the management of SARS-CoV-2 transmission in the population.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Physiology
Valeriya V. Zinina, Frank Ruehle, Patricia Winkler, Lisa Rebmann, Hanna Lukas, Stefanie Moeckel, Andreas Diefenbach, Maria Mendez-Lago, Natalia Soshnikova
Summary: ID2 plays an important role in cell fate decisions in the adult small intestine, regulating differentiation of various cell types and immune response to microbiota.
Article
Multidisciplinary Sciences
John B. Grigg, Arthi Shanmugavadivu, Tommy Regen, Christopher N. Parkhurst, Anees Ahmed, Ann M. Joseph, Michael Mazzucco, Konrad Gronke, Andreas Diefenbach, Gerard Eberl, Timothy Vartanian, Ari Waisman, Gregory F. Sonnenberg
Summary: This study identified an inflammatory population of group 3 innate lymphoid cells (ILC3s) that play a critical role in a mouse model of multiple sclerosis. These ILC3s stimulate myelin-specific T cells through antigen presentation, leading to T cell responses in the CNS and disease development.
Article
Multidisciplinary Sciences
Mario Witkowski, Caroline Tizian, Marta Ferreira-Gomes, Daniela Niemeyer, Terry C. Jones, Frederik Heinrich, Stefan Frischbutter, Stefan Angermair, Thordis Hohnstein, Irene Mattiola, Philipp Nawrath, Sophie McEwen, Silvia Zocche, Edoardo Viviano, Gitta Anne Heinz, Marcus Maurer, Uwe Koelsch, Robert Lorenz Chua, Tom Aschman, Christian Meisel, Josefine Radke, Birgit Sawitzki, Jobst Roehmel, Kristina Allers, Verena Moos, Thomas Schneider, Leif Hanitsch, Marcus A. Mall, Christian Conrad, Helena Radbruch, Claudia U. Duerr, Joseph A. Trapani, Emanuela Marcenaro, Tilmann Kallinich, Victor M. Corman, Florian Kurth, Leif Erik Sander, Christian Drosten, Sascha Treskatsch, Pawel Durek, Andrey Kruglov, Andreas Radbruch, Mir-Farzin Mashreghi, Andreas Diefenbach
Summary: Research shows that the status of NK cells in COVID-19 patients is negatively correlated with viral load, and NK cells can control SARS-CoV-2 replication by recognizing infected target cells. In severe COVID-19 patients, NK cells exhibit defects in virus control, cytokine production, and cell-mediated cytotoxicity despite high expression of cytotoxic effector molecules.
Article
Cell Biology
Johannes Steffen, Stefanie Ehrentraut, Ute Bank, Aindrila Biswas, Caio Andreeta Figueiredo, Oliver Hoelsken, Henning Peter Duesedau, Vladyslava Dovhan, Laura Knop, Jacqueline Thode, Silvina Romero-Suarez, Carmen Infante Duarte, Jason Gigley, Chiara Romagnani, Andreas Diefenbach, Christoph S. N. Klose, Thomas Schueler, Ildiko Rita Dunay
Summary: This study reveals that innate lymphoid cells (ILC1) accumulate in the brain during the onset of cerebral Toxoplasma gondii infection and contribute to the production of IFN-g and TNF, initiating a neuroinflammatory response and host defense factors.
Article
Multidisciplinary Sciences
Katja J. Jarick, Patrycja M. Topczewska, Manuel O. Jakob, Hiroshi Yano, Mohammad Arifuzzaman, Xuemei Gao, Sotiria Boulekou, Vladislava Stokic-Trtica, Pierre S. Leclere, Alexandra Preusser, Zoe A. Rompe, Anton Stamm, Amy M. Tsou, Coco Chu, Frederik R. Heinrich, Gabriela M. Guerra, Pawel Durek, Andranik Ivanov, Dieter Beule, Sofia Helfrich, Claudia U. Duerr, Anja A. Kuehl, Christina Stehle, Chiara Romagnani, Mir-Farzin Mashreghi, Andreas Diefenbach, David Artis, Christoph S. N. Klose
Summary: This article investigates the role of innate lymphoid cells (ILCs) in protective immunity. Using a mouse model specific to ILCs, researchers found that ILC2s have non-redundant functions during steady state and disease, and they interact with adaptive immune cells to organize the immune system.
Article
Allergy
Margitta Worm, Aikaterina Alexiou, Veronika Hoefer, Till Birkner, Alexander C. S. N. Jeanrenaud, Florent Fauchere, Kristijan Pazur, Carolin Steinert, Aleix Arnau-Soler, Priyanka Banerjee, Andreas Diefenbach, Josefine Dobbertin-Welsch, Sabine Doelle-Bierke, Wojciech Francuzik, Ahla Ghauri, Stephanie Heller, Birgit Kalb, Ulrike Loeber, Ingo Marenholz, Lajos Marko, Joerg Scheffel, Olena Potapenko, Stephanie Roll, Susanne Lau, Young-Ae Lee, Julian Braun, Andreas Thiel, Magda Babina, Sabine Altrichter, Sofia Kirke Forslund, Kirsten Beyer
Summary: This study aims to unravel the complex mechanisms of peanut allergy by analyzing DNA methylation, gut microbiome, immune cell populations, soluble signaling molecules, and allergen-reactive antibody specificities in peanut allergic and non-allergic controls. The findings identified cellular and soluble biomarker signatures that can accurately stratify donors into peanut-allergic and non-allergic groups, as well as differences in DNA methylation and gut microbiota.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Dermatology
Sonja Moos, Tommy Regen, Florian Wanke, Yizhu Tian, Lucas T. Arendholz, Judith Hauptmann, Andre P. Heinen, Lisa Bleul, Katharina Bier, Khalifa El Malki, Christoph Reinhardt, Immo Prinz, Andreas Diefenbach, Christiane Wolz, Birgit Schittek, Ari Waisman, Florian C. Kurschus
Summary: Keratinocytes (KCs) are essential for protecting the body against pathogens, and deficiencies in IL-17RA can lead to spontaneous Staphylococcus aureus skin infections. This study found an expansion of T17 cells in the skin-draining lymph nodes of mice lacking IL-17RA or both IL-17A and IL-17F. Contrary to previous suggestions, this expansion was not due to a negative feedback loop but rather depended on the microbiota and KC deficiency in IL-17RA signaling.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Immunology
Irene Mattiola, Andreas Diefenbach
Summary: Innate effector cells play an important role in regulating inflammation and the development of cancer. The tumor microenvironment and microbiota can modify the functions of these cells, reducing their ability to initiate anti-tumor immune responses. The microbiota can also stimulate innate cells at mucosal tissues and influence immune responses in non-mucosal tissues, impacting cancer development. Additionally, the microbiota has been found to enhance innate immune responses during anti-cancer therapies. This review discusses the role of the microbiota in shaping host innate immune responses in cancer.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Manuel O. Jakob, Daniel Spari, Daniel Sanchez Taltavull, Lilian Salm, Bahtiyar Yilmaz, Remi Doucet Ladeveze, Catherine Mooser, David Pereyra, Ye Ouyang, Theresa Schmidt, Irene Mattiola, Patrick Starlinger, Deborah Stroka, Franziska Tschan, Daniel Candinas, Georg Gasteiger, Christoph S. N. Klose, Andreas Diefenbach, Mercedes Gomez de Agueero, Guido Beldi
Summary: It is commonly believed that surgical infections are primarily caused by environmental or cutaneous bacteria. Accordingly, efforts to prevent postoperative infections have focused on improving hygiene and asepsis. However, our study revealed that the main causative bacteria in postoperative infections are of intestinal origin, which was also confirmed in mice undergoing partial hepatectomy. We found that CCR6+ group 3 innate lymphoid cells (ILC3s) play a crucial role in limiting systemic bacterial spread, and this function is dependent on the production of interleukin-22 (IL-22) and the expression of antimicrobial peptides in hepatocytes. Our findings highlight the significance of endogenous intestinal bacteria as a source of postoperative infection and suggest that ILC3s could be potential therapeutic targets.
Article
Infectious Diseases
Torsten Houwaart, Samir Belhaj, Emran Tawalbeh, Dirk Nagels, Yara Froehlich, Patrick Finzer, Pilar Ciruela, Aurora Sabria, Merce Herrero, Cristina Andres, Andres Anton, Assia Benmoumene, Dounia Asskali, Hussein Haidar, Janina von Dahlen, Jessica Nicolai, Mygg Stiller, Jacqueline Blum, Christian Lange, Carla Adelmann, Britta Schroer, Ute Osmers, Christiane Grice, Phillipp P. Kirfel, Hassan Jomaa, Daniel Strelow, Lisanna Huelse, Moritz Pigulla, Pascal Kreuzer, Alona Tyshaieva, Jonas Weber, Tobias Wienemann, Malte Kohns Vasconcelos, Katrin Hoffmann, Nadine Luebke, Sandra Hauka, Marcel Andree, Claus Jurgen Scholz, Nathalie Jazmati, Klaus Goebels, Rainer Zotz, Klaus Pfeffer, Jorg Timm, Lutz Ehlkes, Andreas Walker, Alexander T. Dilthey
Summary: This study demonstrates the successful application of an integrated genomic surveillance system in tracing the transmission chains of SARS-CoV-2 and investigating travel-associated infection clusters. The findings show the presence of two genetically defined clusters of SARS-CoV-2 isolates in Dusseldorf, with one cluster linked to nightlife venues and a returning traveler, and the other cluster representing multiple independent introductions followed by community transmission.
Meeting Abstract
Immunology
Alba Del Rio Serrato, Borja Latorre Hernandez, Sara Cestari, Oliver Hoelsken, Christina Stehle, Chiara Romagnani, Andreas Diefenbach, Carmen Infante Duarte
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Justus Ninnemann, Lisa Budzinski, Marina Bondareva, Mario Witkowski, Stefan Angermair, Jakob Kreye, Pawel Durek, Momsen S. Reincke, Caroline Tizian, Philipp Enghard, Hyun Dong Chang, Sascha Treskatsch, Andreas Radbruch, Andreas Diefenbach, Harald Pruess, Mir Farzin Mashreghi, Andrey A. Kruglov
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
