Article
Immunology
Yuping Wang, Tengkai Wang, Meijuan Cai, Shuzhen Zhu, Lijun Song, Qian Wang
Summary: The study found that in patients with SLE, the expression of Fc epsilon RI alpha increased while the level of anti-IgE decreased. Additionally, in the CHO3D10 cell line, Fc epsilon RI alpha was found to exist in both monomer and various polymer forms. Mast cell-associated Fc epsilon RI alpha plays a role in the inflammatory lesions of SLE.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Multidisciplinary Sciences
Donald MacGlashan
Summary: This study found that released FceRI-alpha accounted for 7% of total surface FceRI before the reaction, with a molecular weight of approximately 54 kD. The release of FceRI-alpha was found to be independent of internalized processing and starting density of FceRI, and was more effective with non-IgE-dependent stimuli.
Article
Biochemistry & Molecular Biology
Tsubasa Ashikari, Masakazu Hachisu, Kazuki Nagata, Daisuke Ando, Yuki Iizuka, Naoto Ito, Kandai Ito, Yuki Ikeda, Hiroki Matsubara, Takuya Yashiro, Kazumi Kasakura, Chiharu Nishiyama
Summary: Mast cells play a significant role in IgE-mediated immunoresponses, and salicylaldehyde, identified as an inhibitor of mast cell activation, shows potential as an antiallergic compound.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Sathisha Upparahalli Venkateshaiah, Madhavi Rayapudi, Hemanth Kumar Kandikattu, Chandra Sekhar Yadavalli, Anil Mishra
Summary: This study demonstrates that IL-15 responsive T cells and IgE receptors can serve as novel non-invasive biomarkers for distinguishing between EoE and GERD. Additionally, analysis of blood mRNA levels reveals certain receptors significantly reduced in EoE patients, which can be used as predictors for EoE.
CLINICAL IMMUNOLOGY
(2021)
Review
Cell Biology
Yuka Nagata, Ryo Suzuki
Summary: Mast cells (MCs) have different roles in allergic responses, and the interactions between antigens and immunoglobulin E (IgE) can trigger diverse responses in MCs. The clustering of high-affinity IgE receptor Fc epsilon RI is crucial for signal transduction and determines the quality of MC responses. Antigen properties precisely regulate Fc epsilon RI dynamics, which can result in different outcomes by switching the intracellular signaling pathway, suggesting that antigen properties can control MC responses both qualitatively and quantitatively.
Article
Allergy
Cynthia Kanagaratham, Tahereh Derakhshan, Yasmeen S. El Ansari, Kameryn N. Furiness, Eleanor Hollers, Mats Keldsen, Hans C. Oettgen, Daniel F. Dwyer
Summary: In this study, the inhibitory effects of IgG:Fc?RIIb signaling on MC responses to IgE were assessed using complementary transcriptomic and functional approaches. The results showed that IgG signaling via Fc?RIIb has a suppressive effect on IgE-induced MC transcription, especially genes related to bone marrow-derived MCs activation. These findings are important for understanding the regulatory mechanisms of IgG on IgE-induced MC responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Angelica Tiotiu, Yusef Badi, Nazanin Zounemat Kermani, Marek Sanak, Johan Kolmert, Craig E. Wheelock, Philip M. Hansbro, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Yike Guo, Sharon Mumby, Ian M. Adcock, Kian Fan Chung
Summary: By analyzing gene signatures of MC activation, we can identify phenotypes of severe asthma and indicate that MCs can have distinct transcriptional phenotypes associated with specific clinical phenotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Immunology
Mohammed Zghaebi, Maria Byazrova, Sabine Flicker, Sergio Villazala-Merino, Nicholas J. Campion, Victoria Stanek, Aldine Tu, Heimo Breiteneder, Alexander Filatov, Musa Khaitov, Verena Niederberger-Leppin, Julia Eckl-Dorna, Rudolf Valenta
Summary: A new sequential gating strategy was developed to detect cells bearing the IgE BCR on their surface, using a monoclonal anti-IgE antibody. This strategy allowed for the clear identification of allergen-specific IgE(+) memory B cells and plasma cells in human PBMCs, offering new insights into allergic responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Mohammad Fereydouni, Mona Motaghed, Elnaz Ahani, Tal Kafri, Kristen Dellinger, Dean D. Metcalfe, Christopher L. Kepley
Summary: The role of mast cells in cancer pathologies is controversial, but they could serve as a platform for developing novel mechanisms of tumor immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Allergy
Luc Colas, Antoine Magnan, Sophie Brouard
Summary: This article summarizes the recent advances in the regulation, biology, and physiopathology of immunoglobulin E (IgE) beyond allergic diseases, opening up new fields of exploration in IgE biology.
Article
Biochemistry & Molecular Biology
Syed Benazir Alam, Ashley Wagner, Steven Willows, Marianna Kulka
Summary: Quercetin and resveratrol have differential inhibitory effects on mast cells, potentially through modulation of FcεRI expression, signaling, and mediator release.
Article
Allergy
Seong-Dae Woo, Eun-Mi Yang, Jaehyuk Jang, Youngsoo Lee, Yoo Seob Shin, Young-Min Ye, Su Youn Nam, Kyung Wha Lee, Myoung Ho Jang, Hae-Sim Park
Summary: Serum-free IgE levels are significantly higher in adults with asthma compared to healthy controls, and are closely associated with atopic status and type 2 asthma. It may serve as a useful biomarker for assessing asthma severity in adults with asthma.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2021)
Article
Allergy
Shinya Imamura, Ken Washio, Mayuko Mizuno, Yoshiko Oda, Atsushi Fukunaga, Chikako Nishigori
Summary: This study found that basophils in patients with atopic dermatitis exhibited spontaneous activation and lower responsiveness to anti-IgE stimulation compared to healthy controls, despite elevated levels of serum IgE. Additionally, Fc epsilon RI expression on basophils was higher in patients with atopic dermatitis than in healthy controls, while surface-bound IgE was relatively low.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Immunology
Robert W. E. Crozier, Val A. Fajardo, Adam J. MacNeil
Summary: This study aimed to evaluate the potential therapeutic target of GSK3 in allergic inflammation. The results revealed that GSK3 inhibition reduced ROS production and degranulation, and decreased the production/release of pro-inflammatory mediators. Additionally, CHIR99021-mediated GSK3 inhibition altered the pro-inflammatory phenotype of mast cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Greer K. Arthur, Glenn Cruse
Summary: Mast cells are immune cells involved in allergic inflammatory response. This review focuses on IgE-mediated activation and discusses the structure and function of Fc epsilon RI, as well as the role of Fc epsilon RI beta in regulating mast cell function and signaling. Current and emerging approaches to target IgE and Fc epsilon RI signaling are discussed, along with the potential therapeutic use of alternative splicing of Fc epsilon RI beta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)