Review
Immunology
Trevor Ung, Nakisha S. Rutledge, Adam M. Weiss, Aaron P. Esser-Kahn, Peter Deak
Summary: This article summarizes the recent advancements in immunology and chemistry in targeted vaccine technology, including cellular targets, methods of targeting, and their effects on immune responses. The relationships between vaccine targets and subsequent adaptive immune responses are crucial for effective vaccine design, potentially leading to more effective, disease-specific vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Anneloes van Duijn, Sjoerd H. Van der Burg, Ferenc A. Scheeren
Summary: This article focuses on the interactions between myeloid immune cells and anti-tumor immune responses in the tumor microenvironment. Blocking the CD47/SIRP alpha axis can enhance adaptive immune response. The potential therapeutic role of CD47/SIRP alpha axis is discussed in tumors with acquired resistance to classic immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Tianmeng Yan, Zhenying Zhang
Summary: Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting elderly individuals. It presents with heterogeneous manifestations, typically characterized by microscopically subepidermal separation and mixed inflammatory infiltrate. The development mechanism of BP remains unclear. B cells are involved in pathogenic autoantibody production, and other immune cells such as T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes also contribute to the pathogenesis of BP. This review focuses on the roles and crosstalk between innate and adaptive immune cells in BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
George W. Burke III, Alla Mitrofanova, Antonio Fontanella, Gaetano Ciancio, David Roth, Phil Ruiz, Carolyn Abitbol, Jayanthi Chandar, Sandra Merscher, Alessia Fornoni
Summary: This article focuses on the podocyte as the target of circulating factors causing recurrent proteinuria in patients with FSGS after kidney transplantation. Studies involving pre- and post-reperfusion biopsies, as well as in vitro podocyte liquid biopsies/assays, have provided insights into new pathways and potential therapeutic targets. The successful use of immunomodulating agents, such as rituximab and abatacept, suggests direct effects on the podocyte beyond immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ashleigh R. Murphy-Schafer, Silke Paust
Summary: Mast cells are initially implicated as a source of immunopathology in severe influenza, but emerging evidence suggests they also play a crucial role in suppressing inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Daniel P. Reay, Tracy Tabib, Ying Wang, Timothy B. Oriss, Nicholas A. Young, Robert A. Lafyatis, Wael N. Jarjour, Paula R. Clemens, Dana P. Ascherman
Summary: This study demonstrated the essential role of T cells in HRS-induced myositis in mice, while also highlighting the importance of macrophage/myeloid cell populations in supporting T cell infiltration. The perturbations of T cell signaling/function were found to alter the distribution and phenotype of other non-lymphoid cell populations contributing to myositis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Multidisciplinary Sciences
Hongliang Zhang, Jie Gao, Yujie Tang, Tengchuan Jin, Jinhui Tao
Summary: Inflammasomes play a crucial role in both the innate and adaptive immune systems, acting as a bridge between these two components to maintain a fine balance in immune responses. Understanding the function of inflammasomes in lymphocytes can provide new insights into the mechanisms and treatment of various diseases, including autoimmune diseases and tumors.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Immunology
Michelle Felicia Lee, Guan Zhong Voon, Hui Xuan Lim, Mun Lok Chua, Chit Laa Poh
Summary: Dengue is a mosquito-borne disease that poses significant public health concerns in tropical and subtropical countries. The dengue virus has evolved various strategies to manipulate the host's immune responses, and miRNAs and DENV non-structural proteins (NS) are promising targets for anti-dengue therapeutics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anuradha Ray, Sagar L. Kale, Richard P. Ramonell
Summary: Despite advancements in pulmonary immunology, there is still much work to be done in understanding coordinated immune responses in the lung. The SARS-CoV-2 pandemic has shown the inadequacy of current models of host-pathogen interactions and emphasized the importance of unraveling complex biological questions for immunologists. The 64th Annual Thomas L. Petty Aspen Lung Conference focused on bridging the gap between innate and adaptive immunity in the lung, discussing disease pathogenesis, immune responses, autoimmune lung diseases, immunologic cancer treatments, and new paradigms for lung disease prevention and treatment.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Konstantinos Karagiannis, Sreenivas Gannavaram, Chaitenya Verma, Thalia Pacheco-Fernandez, Parna Bhattacharya, Hira L. Nakhasi, Abhay R. Satoskar
Summary: In this study, unbiased single-cell RNA sequencing was used to analyze the host cell and Leishmania transcriptomes, revealing that various cell types can be infected by the parasites. This research has important implications for understanding the pathogenesis, persistence, and protective immunity of Leishmania infection.
Review
Biology
Xinxin Chi, Miaozhen Huang, Hailin Tu, Bin Zhang, Xin Lin, Huji Xu, Chen Dong, Xiaoyu Hu
Summary: Except for a few cases caused by single gene mutations, the majority of autoimmune diseases are influenced by both environmental and genetic factors. Despite progress in understanding certain effector cells and molecules associated with inflammation and tissue damage, the exact cause of common autoimmune disorders remains unknown. Population genetics approaches have contributed greatly to our knowledge of genetic susceptibility to autoimmunity, allowing for a comprehensive re-examination of genes and pathways. This review aims to discuss the etiology and pathogenesis of common autoimmune disorders from a human genetics perspective, covering innate immunity, adaptive immunity, and inflammatory cell death processes. By exploring new molecules and pathways, we hope to broaden our understanding of autoimmunity beyond the current limited therapeutic targets.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Review
Geriatrics & Gerontology
Anke Zhang, Yibo Liu, Xiaoyu Wang, Houshi Xu, Chaoyou Fang, Ling Yuan, KaiKai Wang, Jingwei Zheng, Yangjian Qi, Sheng Chen, Jianmin Zhang, Anwen Shao
Summary: Subarachnoid hemorrhage (SAH) is a severe subtype of stroke that induces an immune response and triggers brain injury, but the underlying mechanisms are not fully understood. Current research mainly focuses on the production of specific subtypes of immune cells, especially innate immune cells, after SAH onset. There is increasing evidence of the critical role of immune responses in SAH pathophysiology, but studies on the role and clinical significance of adaptive immunity post-SAH are limited. In this study, we provide a brief review of the mechanistic dissection of innate and adaptive immune responses post-SAH, as well as summarize experimental studies and clinical trials of immunotherapies for SAH treatment, which may contribute to the development of improved therapeutic approaches for SAH management in the future.
Review
Biochemistry & Molecular Biology
Martin Voss, Johanna Kotrba, Evelyn Gaffal, Konstantinos Katsoulis-Dimitriou, Anne Dudeck
Summary: Mast cells are key effector cells in immediate-type allergic reactions, but they also play an important role in the first-line defense against pathogens, although this can lead to detrimental overshooting responses and exacerbation of inflammatory disorders. In the skin, mast cells have both beneficial functions in maintaining skin barrier integrity and host defense mechanisms, as well as causing inflammatory skin disorders, with their IgE-independent activation pathways playing a crucial role in sustained chronic skin inflammation and disease exacerbation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Chang Min Kim, Hyunseok Jang, Eunmi Hong, Jun Hyuck Lee, Hyun Ho Park
Summary: In this study, the TRAF4 gene was cloned and purified from the Antarctic yellowbelly rockcod. The crystal structure of teleost fish TRAF4 was determined, and the mechanisms of cold adaptiveness of signaling molecules were elucidated. The interaction between the platelet receptor GPIb beta homolog and ncTRAF4 was also identified, indicating the role of ncTRAF4 in mediating cellular signaling. These findings provide new insights into TRAF4-mediated immune cell and platelet signaling in fish and the cold adaptiveness of signaling molecules.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Oncology
Valentina Cazzetta, Sara Franzese, Claudia Carenza, Silvia Della Bella, Joanna Mikulak, Domenico Mavilio
Summary: The reciprocal crosstalk between dendritic cells (DCs) and natural killer (NK) cells plays a crucial role in regulating immune defense against viruses and tumors, with potential therapeutic implications in liver malignancies. NK cells and DCs are innate immune cells that interact to control activation and immune responses, particularly in the context of liver cancer.
Article
Immunology
Marco De Zuani, Giuseppe Paolicelli, Teresa Zelante, Giorgia Renga, Luigina Romani, Alessandra Arzese, Carlo E. M. Pucillo, Barbara Frossi
FRONTIERS IN IMMUNOLOGY
(2018)
Letter
Allergy
Lorenzo Cereser, Riccardo De Carli, Rossano Girometti, Alessandro De Pellegrin, Federico Reccardini, Barbara Frossi, Marco De Carli
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2019)
Article
Biochemistry & Molecular Biology
Barbara Frossi, Giulia Antoniali, Kefei Yu, Nahid Akhtar, Mark H. Kaplan, Mark R. Kelley, Gianluca Tell, Carlo E. M. Pucillo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Cell Biology
Elena Jachetti, Federica D'Inca, Luca Danelli, Raffaella Magris, Chiara Dal Secco, Filippo Vit, Valeria Cancila, Claudio Tripodo, Patrizia Scapini, Mario Paolo Colombo, Carlo Pucillo, Barbara Frossi
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Immunology
Silvia Tonon, Francesca Mion, Jun Dong, Hyun-Dong Chang, Emiliano Dalla, Patrizia Scapini, Giuseppe Perruolo, Andrea Zanello, Matteo Dugo, Marco A. Cassatella, Mario P. Colombo, Andreas Radbruch, Claudio Tripodo, Carlo E. Pucillo
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Barbara Frossi, Marco De Carli, Antonino Calabro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Genetics & Heredity
Marta Codrich, Marina Comelli, Matilde Clarissa Malfatti, Catia Mio, Dilara Ayyildiz, Chi Zhang, Mark R. Kelley, Giovanni Terrosu, Carlo Em Pucillo, Gianluca Tell
Review
Immunology
Carlo Pucillo, Gaetano Vitale
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Roberta Sulsenti, Barbara Frossi, Lucia Bongiovanni, Valeria Cancila, Paola Ostano, Irene Fischetti, Claudia Enriquez, Francesca Guana, Giovanna Chiorino, Claudio Tripodo, Carlo E. Pucillo, Mario P. Colombo, Elena Jachetti
Summary: Levetiracetam has the potential to be an effective drug for the treatment of prostate cancer by targeting both MCs and NEPC cells. Experimental results demonstrate that levetiracetam can directly inhibit NEPC development and block adenocarcinoma progression through the inhibition of some MCs functions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marco De Zuani, Chiara Dal Secco, Silvia Tonon, Alessandra Arzese, Carlo E. M. Pucillo, Barbara Frossi
Summary: Mast cells are important innate immune cells that can sense and respond to different stimuli. Studies have shown that mast cells can develop immunological memory, and their responses can be shaped by different stimulatory environments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Paolo Beltrami, Maria De Martino, Emiliano Dalla, Matilde Clarissa Malfatti, Federica Caponnetto, Marta Codrich, Daniele Stefanizzi, Martina Fabris, Emanuela Sozio, Federica D'Aurizio, Carlo E. M. Pucillo, Leonardo A. Sechi, Carlo Tascini, Francesco Curcio, Gian Luca Foresti, Claudio Piciarelli, Axel De Nardin, Gianluca Tell, Miriam Isola
Summary: This study identified nine potential serum biomarkers for predicting the severity of COVID-19 by analyzing serum proteins and clinical data. Three of these biomarkers were associated with central nervous system pathologies and protective factors, and were downregulated in the most severe cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Allergy
Marco De Carli, Eleonora Capezzali, Silvia Tonon, Barbara Frossi
Summary: Allergic rhinitis is an upper airway disease caused by hypersensitivity to aeroallergens, and it can lead to increased inflammation throughout the body. Immunotherapy is a possible treatment approach to reduce the use of antihistamines and corticosteroids. It has been shown to prevent new sensitizations and reduce the risk of developing asthma in patients with allergic rhinitis, but its effectiveness in reducing symptom severity and relapse is still debated. This review focuses on the impact of sexual dimorphism on disease manifestation and the efficacy of allergen-specific immunotherapy.
FRONTIERS IN ALLERGY
(2023)
Meeting Abstract
Immunology
Roberta Sulsenti, Valeria Cancila, Claudia Enriquez, Barbara Frossi, Renata Ferri, Laura Botti, Claudia Chiodoni, Carlo E. Pucillo, Claudio Tripodo, Mario P. Colombo, Elena Jachetti
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)