Article
Multidisciplinary Sciences
Viviane Nascimento Da Conceicao, Yuyang Sun, Karthik Ramachandran, Arun Chauhan, Amritha Raveendran, Manigandan Venkatesan, Bony DeKumar, Soumya Maity, Neelanjan Vishnu, George A. Kotsakis, Paul F. Worley, Donald L. Gill, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh
Summary: The transformation of naive macrophages into M1 or M2 phenotypes is regulated by distinct Ca2+ entry channels. Blocking Ca2+ entry can suppress signaling events related to cytokine production and reduce the inflammatory response of macrophages, depending on the expression levels of Orai1 and TRPC1 channels.
Review
Cell Biology
Akito Nakao, Yoshihiro Matsunaga, Katsumi Hayashida, Nobuaki Takahashi
Summary: Psychiatric disorders are believed to be caused by complex and diverse factors, with oxidative stress playing a crucial role in the pathogenesis of major disorders such as bipolar disorder, depression, anxiety disorder, and schizophrenia. Calcium channels are essential for neuronal functions, and the investigation of redox-sensitive TRP channels could lead to the development of new therapeutic strategies for psychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carmen Costas-Ferreira, Lilian R. F. Faro
Summary: Pesticides from different chemical classes exert toxic effects on the nervous system by altering calcium homeostasis, leading to oxidative stress, neuroinflammation, and ultimately neuronal death. Proposed strategies to counteract these effects are also discussed in the review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Suhasini Rajan, Christian Schremmer, Jonas Weber, Philipp Alt, Fabienne Geiger, Alexander Dietrich
Summary: Members of the TRP superfamily, particularly TRPV4, play crucial roles in respiratory system physiology and pathology, serving as potential therapeutic targets for diseases like asthma, lung fibrosis, edema, and infections.
Review
Biochemistry & Molecular Biology
Madelaine Magali Audero, Natalia Prevarskaya, Alessandra Fiorio Pla
Summary: This review presents the impact of hypoxia and acidosis in the tumor microenvironment (TME) on cancer progression, and focuses on the role of Ca2+ channels in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ishak Suat Ovey, Ahmet Ozsimsek, Halil Aziz Velioglu, Ozlem Altay, Adil Mardinoglu, Burak Yulug
Summary: This study aimed to investigate the effects of EGb 761 on a controlled model of pentylenetetrazole-induced generalized epilepsy. The results showed that EGb 761 reduced Ca release, restored apoptosis, ROS changes, mitochondrial depolarization and caspase levels, suggesting its prophylactic and therapeutic effects. It is the first study to investigate the combined effects of EGb 761 and pentylenetetrazole on TRP channels in a relevant model of human epileptic diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Wenya Du, Geng Liu, Na Shi, Dongmei Tang, Pawel E. Ferdek, Monika A. Jakubowska, Shiyu Liu, Xinyue Zhu, Jiayu Zhang, Linbo Yao, Xiongbo Sang, Sailan Zou, Tingting Liu, Rajarshi Mukherjee, David N. Criddle, Xiaofeng Zheng, Qing Xia, Per-Olof Berggren, Wendong Huang, Robert Sutton, Yan Tian, Wei Huang, Xianghui Fu
Summary: This study discovers the crucial role of miR-26a in acute pancreatitis by inhibiting Ca2+ overload in pancreatic acinar cells. The study also reveals that during acute pancreatitis, SOCE channels are induced in pancreatic acinar cells, while the expression of miR-26a is reduced, and its expression is correlated with the severity of acute pancreatitis.
Article
Cell Biology
Nolwenn Tessier, Mallory Ducrozet, Maya Dia, Sally Badawi, Christophe Chouabe, Claire Crola Da Silva, Michel Ovize, Gabriel Bidaux, Fabien Van Coppenolle, Sylvie Ducreux
Summary: This study provides the first evidence that TRPV1 channels contribute to Ca2+ exchanges in MAMs.
Article
Multidisciplinary Sciences
Serap Erdogmus, Axel R. Concepcion, Megumi Yamashita, Ikjot Sidhu, Anthony Y. Tao, Wenyi Li, Pedro P. Rocha, Bonnie Huang, Ralph Garippa, Boram Lee, Amy Lee, Johannes W. Hell, Richard S. Lewis, Murali Prakriya, Stefan Feske
Summary: The regulatory beta subunit of voltage-gated calcium channels regulates T cell function despite no evidence that these channels were functional within T cells during activation.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Louay Bettaieb, Maxime Brule, Axel Chomy, Mel Diedro, Malory Fruit, Eloise Happernegg, Leila Heni, Anais Horochowska, Mahya Housseini, Kekely Klouyovo, Agathe Laratte, Alice Leroy, Paul Lewandowski, Josephine Louvieaux, Amelie Moitie, Remi Tellier, Sofia Titah, Dimitri Vanauberg, Flavie Woesteland, Natalia Prevarskaya, V'yacheslav Lehen'kyi
Summary: Pancreatic adenocarcinoma is a major cause of cancer-related mortality, with Ca2+ signaling playing a crucial role in controlling signaling pathways that promote cancer hallmarks. Understanding and targeting Ca2+ signaling in pancreatic cancer treatment may be a key strategy in overcoming drug resistance and improving outcomes.
Article
Multidisciplinary Sciences
Jin-Bin Tian, Jane Yang, William C. Joslin, Veit Flockerzi, Steven A. Prescott, Lutz Birnbaumer, Michael X. Zhu
Summary: Transient receptor potential canonical 4 (TRPC4) is a receptor-operated cation channel that can sense neurotransmission through G(q/11)- and G(i/o)-coupled receptors. TRPC4 mediates a depolarizing plateau in lateral septal neurons, shutting down action potential firing, and the duration of the depolarization depends on the strength of G(i/o) stimulation. The depolarizing plateau is dependent on G(q/11)-coupled group I metabotropic glutamate receptors and G(i/o)-coupled gamma-aminobutyric acid type B receptors, while the hyperpolarization is mediated by G(i/o) activation of GIRK channels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Bok-Eum Choi, Samuel Shin, Sade Evans, Brij B. Singh, Bidhan C. Bandyopadhyay
Summary: Clinical studies and structural analyses indicate a connection between higher saliva calcium levels and salivary stone formation. The mechanism of calcium overload during sialolithiasis is not well understood. This study shows that TRPC3 plays a crucial role in preventing the expression of calcification genes in salivary ductal cells, leading to elevated levels of calcium in saliva and the formation of salivary gland stones.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Etienne de Coulon, Christian Dellenbach, Stephan Rohr
Summary: The LSSE system allows for comprehensive intracellular electrical recordings on cells undergoing strain events, providing stable conditions for studying mechanically activated ion currents. This system offers advanced insights into mechanosensitive ion channel function and allows for quantitative comparisons among different types of channels and cells.
Review
Biochemistry & Molecular Biology
Yaping Wang, Jian Shi, Xiaoyong Tong
Summary: Mechanosensitive ion channels play a crucial role in the cardiovascular system by translating mechanical forces into biological signals, particularly in regulating calcium ion channels involved in cardiovascular physiological activity. Moreover, their interactions with Ca2+ regulatory proteins are important for maintaining calcium homeostasis and cardiovascular health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Andre G. Kamkin, Olga V. Kamkina, Viktor E. Kazansky, Vadim M. Mitrokhin, Andrey Bilichenko, Elizaveta A. Nasedkina, Stanislav A. Shileiko, Anastasia S. Rodina, Alexandra D. Zolotareva, Valentin I. Zolotarev, Pavel V. Sutyagin, Mitko I. Mladenov
Summary: This study identified specific ion channels and their potential role in regulating ionic currents in rat ventricular cardiomyocytes in response to mechanical stimulation. TRPM7, TRPC1, and TRPM4 channels were found to be mechanosensitive, while Ca(V)1.2 channels showed mechanosensitive properties. These findings provide insights into the molecular mechanisms underlying stretch-induced responses in rat ventricular myocytes and have implications for understanding cardiac physiology and pathophysiology.
Article
Endocrinology & Metabolism
Martijn van der Velde, Bram C. J. van der Eerden, Yuxiang Sun, Julia M. M. Almering, Aart-Jan van der Lely, Patric J. D. Delhanty, Roy G. Smith, Johannes P. T. M. van Leeuwen
Correction
Endocrinology & Metabolism
Martijn van der Velde, Bram C. J. van der Eerden, Yuxiang Sun, Julia M. M. Almering, Aart-Jan van der Lely, Patric J. D. Delhanty, Roy G. Smith, Johannes P. T. M. van Leeuwen
Article
Endocrinology & Metabolism
Patric J. D. Delhanty, Martijn van der Velde, Bram C. J. van der Eerden, Yuxiang Sun, Julia M. M. Geminn, Aart-Jan van der Lely, Roy G. Smith, Johannes P. T. M. van Leeuwen
Article
Immunology
Volodymyr Tsvilovskyy, Alejandra Solis-Lopez, Julia Almering, Christin Richter, Lutz Birnbaumer, Alexander Dietrich, Marc Freichel
FRONTIERS IN IMMUNOLOGY
(2020)