Review
Biochemistry & Molecular Biology
Ewa Rudnicka, Katarzyna Suchta, Monika Grymowicz, Anna Calik-Ksepka, Katarzyna Smolarczyk, Anna M. Duszewska, Roman Smolarczyk, Blazej Meczekalski
Summary: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, often leading to health issues like obesity and insulin resistance. Studies suggest a link between PCOS and chronic inflammation, which may contribute to cardiovascular diseases and other complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Maryam Rostamtabar, Sedigheh Esmaeilzadeh, Mehdi Tourani, Abolfazl Rahmani, Masoud Baee, Fatemeh Shirafkan, Kiarash Saleki, Sajedeh S. Mirzababayi, Soheil Ebrahimpour, Hamid Reza Nouri
Summary: PCOS is the most common hormonal imbalance disease in reproductive-aged women, characterized by ovulatory dysfunction and ovarian overproduction of androgens. Recent studies have shown that inflammation processes are involved in ovulation and play a key role in ovarian follicular dynamics.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Obstetrics & Gynecology
Joanne Michelle D. Gomez, Katherine VanHise, Nina Stachenfeld, Jessica L. Chan, Noel Bairey Merz, Chrisandra Shufelt
Summary: Polycystic ovary syndrome (PCOS) affects approximately 6%-10% of women worldwide, with features of hyperandrogenism, irregular menses, infertility, and polycystic appearing ovaries on ultrasound. PCOS is also associated with endocrine and metabolic disorders that increase the risk for subclinical cardiovascular disease.
FERTILITY AND STERILITY
(2022)
Article
Biochemistry & Molecular Biology
Zhuqing Li, Qi Li, Li Wang, Chao Li, Mengping Xu, Yajun Duan, Likun Ma, Tingting Li, Qiao Chen, Yilin Wang, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Xiaolin Wang, Jihong Han, Chengzhi Lu
Summary: Chronic sympathetic hyperactivity can lead to oxidative stress and inflammation in endothelial cells, contributing to atherosclerosis development. Renal denervation (RDN) may protect endothelial cells by reducing oxidative stress-induced inflammation, thus reducing atherosclerosis.
Article
Endocrinology & Metabolism
Jin Yu, Yulai Zhou, Jie Ding, Danying Zhang, Chaoqin Yu, Hefeng Huang
Summary: This study aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze the possible mechanisms. The results showed that overweight PCOS patients were prone to hypertension, diabetes, low gonadal levels, and insulin resistance. Inflammatory cytokines CXCL12/SDF-1, Serpin E1/PAI-1, and MIF were predicted to play a crucial role in inducing insulin resistance in overweight PCOS through various biological functions and signal transductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Linda Al-Hassany, Katie M. Linstra, Cindy Meun, Jeffrey van den Berg, Eric Boersma, A. H. Jan Danser, Bart C. J. M. Fauser, Joop S. E. Laven, Marieke J. H. Wermer, Gisela M. Terwindt, Antoinette Maassen Van Den Brink
Summary: The study aimed to understand the pathophysiological mechanisms underlying migraine as a cardiovascular risk factor. The results suggested that neuropeptide action was lower in patients with polycystic ovary syndrome and migraine, indicating that migraine may be independent from traditional risk factors, such as atherosclerosis.
Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Shrook Mousa, Aasem Saif, Marwa Fathy, Mona Mansour, Alaa Mahmoud Abd Elhamid, Adel Atef, Mai Galal, Samar Saad, Samar Aboulsoud
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women and is associated with increased risk of metabolic and cardiovascular complications. PCOS can occur in non-obese women, suggesting its role in the development of these co-morbidities. Early detection of atherosclerosis and assessment of vascular endothelial function (ED) can help identify modifiable cardiovascular risk factors. Our study in Egyptian women with PCOS found significant ED and premature atherosclerosis, independent of obesity and insulin resistance, suggesting an increased risk for premature cardiovascular disease in these patients.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Leili Rahmatnezhad, Lida Moghaddam-Banaem, Tahereh Behroozi-Lak, Afshin Shiva, Javad Rasouli
Summary: This study aimed to assess the prevalence of insulin resistance (IR) in 4 phenotypes of PCOS, and its relationship with demographic, clinical, and paraclinical individual characteristics in a sample of Iranian PCOS patients. The results showed that PCOS phenotypes were significantly related to insulin resistance and HOMA-IR, with the highest levels observed in phenotype B.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aida Collado, Elena Domingo, Laura Piqueras, Maria-Jesus Sanz
Summary: Primary hypercholesterolemia is associated with cardiovascular diseases, mainly due to low-density lipoproteins and low-grade systemic inflammation leading to arteriosclerosis. Studying cellular and molecular mechanisms can provide insights into these processes and guide novel therapeutic strategies.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Nikita G. Nikiforov, Ali H. Eid, Ludmila V. Nedosugova, Antonina V. Starodubova, Tatyana V. Popkova, Evgeny E. Bezsonov, Alexander N. Orekhov
Summary: PCOS is the most common endocrine-metabolic disorder worldwide, associated with anovulation, mitochondrial dysfunctions, and hormonal disbalance; patients with PCOS have elevated levels of inflammatory markers, highlighting the need for further research to understand the pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Summary: By analyzing human plaque tissue data and conducting experiments on mice, this study identifies PHACTR1 as being associated with endothelial dysfunction, which it regulates through inflammation response and NO production, and finds that its expression can be reduced by certain drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Gloria Orlando, Barbara Molon, Antonella Viola, Mauro Alaibac, Roberta Angioni, Stefano Piaserico
Summary: Psoriasis is a chronic inflammatory skin disease associated with various comorbidities, including cardiovascular diseases. Current research focuses on the pathways linking psoriatic plaques to the cardiovascular system, as well as the potential involvement of endothelial cells in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ramshanker Ramanathan, Damini Dey, Bjarne L. Norgaard, Markus Goeller, Ida S. Bjerrum, Ronald Antulov, Axel C. P. Diederichsen, Johannes J. Sidelmann, Jorgen B. Gram, Niels Peter R. Sand
EUROPEAN RADIOLOGY
(2019)
Article
Hematology
Ramshanker Ramanathan, Jorgen B. Gram, Johannes J. Sidelmann, Damini Dey, Martin W. Kusk, Bjarne L. Norgaard, Niels Peter R. Sand
THROMBOSIS RESEARCH
(2019)
Article
Obstetrics & Gynecology
Anne C. M. Godtfredsen, Johannes J. Sidelmann, Jorgen B. Gram, Marianne Andersen, Dorte Glintborg
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Article
Medical Laboratory Technology
Tyrillshall Damiana, Dres Damgaard, Johannes J. Sidelmann, Claus H. Nielsen, Moniek P. M. de Maat, Anna-Marie B. Munster, Yaseelan Palarasah
CLINICA CHIMICA ACTA
(2020)
Article
Environmental Sciences
Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye Kyhl, Hanne Frederiksen, Anna-Maria Andersson, Anders Juul, Johannes J. Sidelmann, Helle Raun Andersen, Philippe Grandjean, Marianne S. Andersen, Tina Kold Jensen
ENVIRONMENTAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Johannes J. Sidelmann, Jorgen B. Gram, Anne C. M. Godtfredsen, Jens J. Thorn, Janne Ingerslev, Else M. Pinholt
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2020)
Article
Hematology
Sai Sindhu Thangaraj, Stig Hill Christiansen, Jonas Heilskov Graversen, Johannes Jakobsen Sidelmann, Soren Werner Karlskov Hansen, Anette Bygum, Jorgen Brodersen Gram, Yaseelan Palarasah
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Hematology
Johannes Jakobsen Sidelmann, Jorgen Brodersen Gram, Jon J. Rasmussen, Caroline Kistorp
Summary: Abuse of anabolic-androgenic steroids (AAS) is associated with reduced fibrin clot lysis, likely due to increased plasma concentrations of fibrinogen, FXIII, and plasmin inhibitor, rather than alterations in fibrin structure. This suggests a potential link between AAS abuse and increased thrombotic disease risk.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Hematology
Johannes Jakobsen Sidelmann, Jorgen Brodersen Gram, Yaseelan Palarasah, Jon Jarlov Rasmussen, Caroline Kistorp
Summary: Current AAS abuse reduces the kallikrein-generating capacity of CAS by increasing the concentration of C1inh and reducing the concentration of prekallikrein. These changes may contribute to the anti-inflammatory effect of testosterone.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Mustafa Vakur Bor, Soren Feddersen, Inge Sokilde Pedersen, Johannes Jakobsen Sidelmann, Soren Risom Kristensen
Summary: This study reviews 29 papers on dysfibrinogenemia caused by mutations affecting fibrinogen knob A, with Gly17, Pro18, and Val20 residues being associated with bleeding tendency, and Arg19 residue showing varying clinical manifestations. The study on a Danish family with A alpha Arg19Gly mutation suggests that compound genotypes may contribute to the thrombogenic phenotype of these patients, focusing on the significance of SNPs, compound genotypes, and fibrin structure measures affecting the genotype-phenotype associations in fibrinogen knob A mutations.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Jackie Trink, Renzhong Li, Yaseelan Palarasah, Stephan Troyanov, Thomas E. Andersen, Johannes J. Sidelmann, Mark D. Inman, Salvatore Pizzo, Bo Gao, Joan C. Krepinsky
Summary: The study reveals an important role of alpha 2M* in the pathogenesis of diabetic kidney disease (DKD) and suggests its potential as a novel therapeutic target.
Article
Hematology
Kirsten L. Wahlstrom, Sarah Ekeloef, Johannes J. Sidelmann, Ismail Gogenur, Anna-Marie B. Munster
Summary: This study investigated the antithrombotic mechanisms of remote ischemic preconditioning (RIPC) in patients undergoing hip fracture surgery. The results showed that RIPC did not affect thrombin generation, fibrinogen/fibrin turnover, or fibrin structure in these patients.
BLOOD COAGULATION & FIBRINOLYSIS
(2022)
Article
Hematology
Else-Marie Bladbjerg, Charlotte R. Stolberg, Lene H. Mundbjerg, Bibi Gram, Yaseelan Palarasah, Claus B. Juhl, Johannes J. Sidelmann, Jorgen B. Gram
Summary: The contact system was affected 6 months after Roux-en-Y gastric bypass surgery. Absolute values of kallikrein generation before and after surgery correlated with contact system proteins, whereas changes after surgery associated with changes in C1-inh and metabolic variables.
THROMBOSIS RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yaseelan Palarasah, Stephanie Thuy Duong Pham, Jorgen Brodersen Gram, Jonas Heilskov Graversen, Katrine Pilely, Johannes Jakobsen Sidelmann
Summary: In this study, a specific and precise ELISA was developed for the determination of cleaved H-kininogen (cHK) in vitro and ex vivo. The results showed ongoing contact activation of cHK in healthy individuals and augmentation of this activation by the use of oral contraceptives.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sven O. Skouby, Johannes J. Sidelmann
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2019)