Review
Orthopedics
Liam D. A. Paget, Milo J. Mokkenstorm, Johannes L. Tol, Gino M. M. J. Kerkhoffs, Gustaaf Reurink
Summary: This systematic review evaluated the efficacy of intra-articular injections for the treatment of ankle osteoarthritis. The results showed no clinically relevant differences between hyaluronic acid (HA), platelet-rich plasma (PRP), botulinum toxin Type A (BoNT-A), and their control groups at 3, 6, or 12 months. Therefore, these treatments should not be used in practice until future high-quality studies provide evidence of efficacy.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Review
Medicine, General & Internal
Maciej Checinski, Kamila Checinska, Natalia Turosz, Anita Brzozowska, Dariusz Chlubek, Maciej Sikora
Summary: This mapping review aims to discuss the current research directions on intracavitary temporomandibular joints (TMJs) injections for patients with temporomandibular joint disorders (TMDs). A total of 152 qualified reports were identified from 2712 records, and the results showed that viscosupplementation with hyaluronic acid (HA) was the best-documented injectable administered into TMJ cavities, but there is a growing trend in the use of centrifuged blood preparations for injections.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ya-peng Chai, Xiao-qiang Han, Jun-zhi Cui
Summary: This retrospective study compared the effects of acupotomy combined with intra-articular injection of sodium hyaluronate (IA-SH) for knee osteoarthritis (KOA) treatment. The results showed that acupotomy plus IA-SH had superior outcomes in terms of pain and function compared to IA-SH alone, with no significant differences in adverse events between the two groups.
Article
Computer Science, Artificial Intelligence
Ming-liang Meng, Feng Gao
Summary: The influence of intra-articular sodium vitreous acid injection on knee function and inflammatory factors was investigated in 92 patients with knee osteoarthritis. The study found that intra-articular sodium hyaluronate injection can significantly improve knee joint function and reduce the level of inflammatory factors.
Article
Multidisciplinary Sciences
Elin Sward, Maria Wilcke
Summary: This study retrospectively analyzed the effect of intra-articular PRP injection on patients with painful osteoarthritis in the thumb basal joint or STT joint. The results showed that PRP injections had no effect on pain, functional evaluation, grip strength, or key pinch. Further placebo-controlled studies are needed to investigate the efficacy of PRP in osteoarthritis of the thumb basal joint and STT joint.
Review
Clinical Neurology
Jose I. Acosta Julbe, Jacob C. Mandell, Joerg Ermann, Zacharia Isaac, Julia R. Gottreich, Jay M. Zampini, Miriam DeFilipp, Michael N. Andrew, Jeffrey N. Katz
Summary: This study aimed to identify and describe the factors associated with patient-reported response after lumbar intra-articular facet joint injections or medial branch blocks. Facet joint osteoarthritis is a common cause of chronic low back pain. The success of these approaches is variable, prompting interest in identifying patient characteristics associated with response.
Article
Biology
Bruno Macedo de Sousa, Antonio Lopez-Valverde, Francisco Caramelo, Maria Joao Rodrigues, Nansi Lopez-Valverde
Summary: This study compared the efficacy on temporomandibular joint (TMJ) pain of intra-articular injections of betamethasone, sodium hyaluronate, and platelet-rich plasma. The findings showed that both platelet-rich plasma and sodium hyaluronate led to significant pain relief after treatment, while betamethasone was less effective.
Review
Orthopedics
Michael McLarnon, Neil Heron
Summary: IA-PRP injections show superior outcomes compared to CS injections in symptomatic management of knee OA, with better pain management, less joint stiffness, and improved participation in exercise/sporting activity at 12 months follow-up. Triple IA-PRP injections, separated by a week, are more effective than a single IA-PRP injection.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Diego De Nordenflycht, Anais Ayala, Luis Orellana, Ricardo de Souza Tesch
Summary: A scoping review was conducted to identify the evidence regarding intra-articular injections in the inferior joint space (IJS) of the temporomandibular joint (TMJ). The review found that intra-articular injections for the IJS of the TMJ can relieve TMJ pain, increase mouth opening, and improve TMJ dysfunction. Image-guided injection techniques appear to be more effective than anatomical techniques for needle location in the IJS.
JOURNAL OF ORAL REHABILITATION
(2023)
Review
Medicine, General & Internal
Maciej Checinski, Kamila Checinska, Natalia Turosz, Maciej Sikora, Dariusz Chlubek
Summary: This systematic review and meta-analysis aimed to validate the hypothesis that intra-articular injections into the inferior temporomandibular joint compartment are more efficient than analogous superior compartment interventions. The results showed a significant advantage of inferior over superior compartment temporomandibular joint intra-articular injections in improving articular pain, decreasing the Helkimo index, and increasing maximum mouth opening. However, further research is needed to overcome limitations such as the small number of eligible studies and discrepancies in substances used.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jae Gyoon Kim, Kang-Il Kim, Ki-Bong Park, Yong-Geun Park, Ji Hoon Bae, Young-Jin Seo, Jong-Keun Seon, Oog Jin Shon, Ji Hyun Ahn, Lih Wang, Joon-Ho Wang, Eui Sung Choi, Jeong-Ku Ha, Hyuk-Soo Han, Sang Won Moon
Summary: This study assessed the safety and effectiveness of the highly cross-linked hyaluronic acid-LBSA0103 in patients with knee osteoarthritis in South Korea. The results showed that LBSA0103 was well tolerated and had a consistent therapeutic effect.
Article
Orthopedics
Laura Elisa Streck, Sebastian Braun, Kimi Spilo, Cosima Sue Boettner, Marco Brenneis, Friedrich Boettner
Summary: This retrospective study evaluated 682 cases of intra-articular corticosteroid injections (ICSI) for hip osteoarthritis. The results showed that 0.6% of patients developed rapidly progressive osteoarthritis (RPIO) following the injections, but there was minimal risk for septic arthritis or periprosthetic joint infections (PJI), even in patients with multiple injections or injections within 3 months prior to total hip arthroplasty (THA).
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Multidisciplinary Sciences
Nathalie Accart, Janet Dawson, Michael Obrecht, Christian Lambert, Manuela Flueckiger, Julie Kreider, Shinji Hatakeyama, Peter J. Richards, Nicolau Beckmann
Summary: This study aimed to assess the impact of repeated intra-articular injections of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) on the development of gout in rats. Translational imaging was used to evaluate the extent of damage in different areas of the knee joint. The findings showed that MSU/LPS injections led to joint swelling, thickening of the synovial membrane, fibrosis of the infrapatellar fat pad, cartilage invasion by inflammatory cells, and increased sensitivity to mechanical stimulus. Magnetic resonance imaging (MRI) revealed changes in synovial fluid volume, decreased fat volume and fibrosis formation in the infrapatellar fat pad, and alterations in the femoral cartilage. These observations suggest that repeated intra-articular MSU/LPS injections can induce pathology in multiple tissues and may offer insights into the development of degenerative joint disease.
SCIENTIFIC REPORTS
(2022)
Article
Rehabilitation
Terin T. Sytsma, Rozalina G. McCoy, Karen M. Fischer, Kelly R. Dean, Laura S. Greenlund
Summary: This study examined the odds of influenza in patients who received intra-articular corticosteroid (IACS) treatment compared to matched controls. The results showed that patients receiving IACS during influenza season had higher odds of influenza, but vaccination seemed to mitigate this risk.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Orthopedics
Robert A. Burnett, Syed Khalid, Anne DeBenedetti, E. Bailey Terhune, Morgan L. Angotti, Craig J. Della Valle
Summary: Intra-articular corticosteroid injections in non-osteoarthritic knees may increase the risk of subsequent total knee arthroplasty (TKA) at 5 years. CSI may not be as benign as previously thought.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
