Article
Psychiatry
Joanna M. Blodgett, Chantelle C. Lachance, Brendon Stubbs, Melissa Co, Yu-Tzu Wu, Matthew Prina, Vivian W. L. Tsang, Theodore D. Cosco
Summary: The CES-D scale has a four-factor structure suitable for adolescents in Western countries, while different factor structures exist in Asian countries. The use of different analytical methods and consideration of cultural differences impact the generalizability of the results.
Article
Psychology, Multidisciplinary
Cyrille Kossigan Kokou-Kpolou, Steven Kator Iorfa, Sunyoung Park, Doris Chinelo Chinweuba, Jude Mary Cenat, JohnBosco Chika Chukwuorji
Summary: This study examined the validity and gender invariance of the CESD-20-R among 502 Nigerian university students. The results showed good internal consistency reliability of the scale with gender differences, particularly in the self-destructive component related to suicidal ideation. The study suggests that while the CESD-20-R can be successfully used for gender comparisons, caution is needed in interpreting specific items.
CURRENT PSYCHOLOGY
(2022)
Article
Immunology
Wonsuk Choi, Robert Stewart, Hee-Ju Kang, Ju-Wan Kim, Hee Kyung Kim, Ho-Cheol Kang, Ju-Yeon Lee, Sung-Wan Kim, Jae-Min Kim
Summary: This study investigated the individual and interactive effects of systemic inflammation and life stressors on treatment responses in patients with depressive disorders. The results showed that higher baseline serum hsCRP levels and number of stressful life events had significant interactive effects on short- and long-term non-remission in patients receiving pharmacotherapy, suggesting a potential predictor for treatment responses.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Psychiatry
Abdelfettah El-Ammari, Hicham El Malki, Salma Ghofrane Moutawakkil, Jaouad El Hilaly, Fatima El Houari, Samir El Gnaoui, Mohammed El Amine Ragala, Karima El Rhazi, Btissame Zarrouq
Summary: This study validated the CES-D scale in the Moroccan dialectal Arabic context and demonstrated its reliability and validity for measuring depression severity in individuals with substance use disorder.
Review
Biochemistry & Molecular Biology
Xiangming Ji, Hongwei Yao, Maureen Meister, Douglas S. Gardenhire, Huanbiao Mo
Summary: COPD is a leading cause of death worldwide, characterized by emphysema and chronic bronchitis, with smoking as a significant risk factor in developed countries. Chronic inflammation contributes to disease progression and comorbidities. Tocotrienols show potential as anti-inflammatory agents in COPD management.
Review
Biochemistry & Molecular Biology
Peter J. Barnes
Summary: Patients with COPD exhibit increased oxidative stress in their lungs, which can be caused by external factors such as smoking and air pollution, as well as internal factors such as inflammation. Oxidative stress plays a major role in driving the pathology of COPD, leading to chronic inflammation, cellular senescence, impaired autophagy, and reduced repair mechanisms. Antioxidants may be effective in modifying the disease progression of COPD.
Article
Chemistry, Medicinal
Per G. G. Farup, Havard Hamarsland, Knut Sindre Molmen, Stian Ellefsen, Knut Hestad
Summary: This study compared the metabolism of the kynurenine pathway (KP) in healthy individuals and individuals with obesity, depression, and chronic obstructive pulmonary disease (COPD). The results showed that the KP was upregulated in the disease groups, and there were significant differences in the metabolites produced. In the obesity group, body mass index (BMI), smoking, diabetes, and C-reactive protein were important predictors of the differences. However, these factors were not related to the differences in the depression and COPD groups.
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoming Li, Xiang Zhang, Xiaozhi Hou, Xin Bing, Fangyuan Zhu, Xinhao Wu, Na Guo, Hui Zhao, Fenglei Xu, Ming Xia
Summary: This study found that DEC1 expression was increased in rat models of OSA-associated PAH. In vitro experiments showed that DEC1 overexpression exacerbated oxidative stress and inflammatory responses, and promoted cell proliferation in PASMCs. These results suggest that hypoxia-induced DEC1 inhibits PPARγ, which is an important mechanism in the development of PAH.
Article
Multidisciplinary Sciences
Makoto Yoshida, Tetsuya Hiramoto, Atsushi Moriwaki, Hisayuki Osoreda, Tomoaki Iwanaga, Hiromasa Inoue
Summary: This study aimed to investigate the comprehensive effect of extrapulmonary comorbidities on physical activity in Japanese patients with chronic obstructive pulmonary disease. The results showed that factors such as lung function, muscle function, depressive symptoms, and nutritional state were associated with decreased physical activity level.
Article
Environmental Sciences
Tsukasa Kato
Summary: The original four-factor model of the CES-D scale showed the best fit in this study. There were significant differences in subscale scores between Whites and Asians, with Indians scoring the highest in all subscales. Overall, Whites had lower CES-D scores compared to Asians.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Takahiro Kawasaki, Fuminori Sugihara, Kiyoharu Fukushima, Takanori Matsuki, Hiroshi Nabeshima, Tomohisa Machida, Yuichi Mitsui, Saki Fujimura, Rio Sagawa, Lee Gaheun, Kanako Kuniyoshi, Hiroki Tanaka, Masashi Narazaki, Atsushi Kumanogoh, Shizuo Akira, Takashi Satoh
Summary: The study demonstrates that FCHSD1 plays a crucial role in the pathogenesis of emphysema by inhibiting nuclear translocation of NRF2 and subsequently down-regulating SIRT1 levels, promoting the development of the disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychology, Educational
Patricia J. Kimong, Bradley T. Erford, Daniel A. DeCino
Summary: This study reviewed 19 English version scholarly works and 11 other language translation articles on the Center for Epidemiologic Studies Depression Scale - Revised (CESD-R) from 2004-2018. The study found that the scale demonstrated robust convergent, factorial, and diagnostic validity. The implications of these findings for counseling practice and research were discussed.
MEASUREMENT AND EVALUATION IN COUNSELING AND DEVELOPMENT
(2023)
Article
Public, Environmental & Occupational Health
Claire Song, Anne Gadermann, Bruno Zumbo, Chris Richardson
Summary: This study examined the differential item functioning of the CES-D scale between Chinese and White adolescents in Canada. It found non-uniform differential item functioning for item 7 in the CES-D scale. The study highlights the importance of considering cultural differences in the expression and experience of depression among adolescents.
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2022)
Article
Medicine, General & Internal
Carlos Roncero, Joselin Perez, Jesus Molina, Jose Antonio Quintano, Ana Isabel Campuzano, Javier Perez, Marc Miravitlles
Summary: This study aims to investigate the prevalence of suicidal ideation in patients with chronic obstructive pulmonary disease (COPD) and its association with demographic and clinical variables. The study found that suicidal ideation is common in COPD patients, especially in women. Severe depression is significantly associated with the occurrence of suicidal ideation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Sabina Antonela Antoniu, Ioana Buculei, Florin Mihaltan, Radu Crisan Dabija, Antigona Carmen Trofor
Summary: The article discusses the clinical data of main studies evaluating smoking cessation therapies for COPD patients, starting from seminal studies like the Lung Health Study to more recent ones. Despite the high impact on disease progression and demonstrated benefits of pharmacological therapies, smoking cessation remains challenging in COPD. Potential approaches to increase success rates include prolonging treatment duration, combination therapy, or sequential pharmacotherapy.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Review
Oncology
Teodora Alexa, Sabina A. Antoniu, Ioana Alexa, Adina Ilie, Mihai Marinca, Bogdan Gafton, Ramona Stefaniu
Summary: Checkpoint inhibitors have been shown to be efficacious and well tolerated in elderly patients with advanced non-small cell lung cancer. Clinical studies have demonstrated the effectiveness and safety of these compounds in this age group, making them a suitable treatment option for elderly patients with impaired functional status.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Review
Infectious Diseases
Radu Crisan Dabija, Ileana Antohe, Antigona Trofor, Sabina A. Antoniu
Summary: In severe SARS-COV-2 pneumonia, corticosteroids may be effective, but it is unclear if they can be safely used in patients with comorbid cardiovascular disease or how the ideal duration of therapy should be determined.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Bogdan Huzum, Sabina Antoniu, Raluca Dragomir
Summary: The study reviewed the scientific rationale for using denosumab in treating FD, as well as the efficacy and safety of this therapy for the condition, along with other treatment options. Denosumab shows potential as a therapeutic agent against FD, and a synergistic approach involving theranostics may enhance its therapeutic potential.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2022)
Article
Respiratory System
Elena Cojocaru, Cristian Cojocaru, Sabina Antonela Antoniu, Celina Silvia Stafie, Armand Rajnoveanu, Ruxandra-Mioara Rajnoveanu
Summary: Nebulized interferon-beta is being investigated as a potential therapy for SARS-COV2, as it has shown to accelerate disease recovery in phase II studies. Further clinical research is needed to determine its efficacy in severe cases of COVID-19, optimal treatment duration, and its suitability for home use, as well as potential combined regimens with antivirals or compounds to enhance interferon production.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Health Care Sciences & Services
Teodora Stratulat Alexa, Ioana Alexa, Sabina Antoniu
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Health Care Sciences & Services
Marina Ruxandra Otelea, Mihaela Trenchea, Agripina Rascu, Sabina Antoniu, Corina Zugravu, Stefan Busnatu, Anca Angela Simionescu, Oana Cristina Arghir
Summary: This study aimed to define smoking combined with obstructive sleep apnea (OSA) as a phenotype (SOSA) and demonstrate the detrimental effects of continued smoking on OSA. The findings indicated that smokers had an earlier onset of OSA and more severe daytime sleepiness. Chronic obstructive pulmonary disease (COPD) was more prevalent among smokers, and smoking significantly influenced the severity of OSA.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Vasile-Liviu Drug, Sabina Antoniu, Oana-Bogdana Barboi, Oana Cristina Arghir, Ion Bancila, Simona Bataga, Ciprian Brisc, Cristina Cijevschi-Prelipcean, Mihai Ciocirlan, Irina Ciortescu, Liliana David, Oana Claudia Deleanu, Mircea Diculescu, Anca Dimitriu, Daniela Dobru, Eugen Dumitru, Dan Ionut Gheonea, Cristian Gheorghe, Adrian Goldis, Mariana Jinga, Milena Man, Bogdan Mateescu, Mircea Manuc, Catalina Mihai, Florin Mihaltan, Traian Mihaescu, Laurentiu Nedelcu, Lucian Negreanu, Carmen-Monica Pop, Ruxandra Rajnoveanu, Adrian Saftoiu, Andrada Seicean, Ioan Sporea, Carol Stanciu, Teodora Surdea-Blaga, Marcel Tantau, Doina Todea, Anca-Victorita Trifan, Ruxandra Ulmeanu, Diana-Elena Iov, Dan-Lucian Dumitrascu
Summary: This article presents a guideline developed by the Romanian Societies of Gastroenterology and Neurogastroenterology, in association with the Romanian Society of Pneumology, regarding respiratory conditions associated with Gastroesophageal Reflux Disease (GERD). The experts used the Delphi methodology to review the literature and formulated 22 recommendations for the diagnosis and treatment of GERD-induced respiratory symptoms. The guideline emphasizes the potential link between GERD and bronchial asthma and chronic cough, and recommends proton pump inhibitors and laparoscopic Nissen fundoplication as therapeutic options.
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2022)
Review
Immunology
Alina Delia Popa, Armand Iustinian Enache, Iolanda Valentina Popa, Sabina Antonela Antoniu, Raluca Alina Dragomir, Alexandru Burlacu
Summary: Our paper aims to review the central attitudes associated with the hesitancy toward COVID-19 vaccination specific to Eastern European countries. The main determinants identified are public confidence in the vaccines' safety and efficacy, vaccine literacy, and public trust in the government and the medical system. Specific factors predicting the willingness to vaccinate in Eastern Europe have also been highlighted. Incorporating these attitudes into local public health programs can help reduce the spread and impact of COVID-19 in Eastern Europe and beyond.
Review
Oncology
Teodora Alexa-Stratulat, Mariana Pavel-Tanasa, Vlad-Andrei Cianga, Sabina Antoniu
Summary: This review discusses the role of cell senescence in non-small cell lung cancer (NSCLC) and its impact on treatment outcomes. While cell senescence has anti-tumor effects, upregulation of senescence can promote tumor metastasis and poor response to therapy. Little is known about potential approaches to mitigate the unfavorable consequences of senescence in NSCLC. Further investigation into the relationship between immune senescence and NSCLC, as well as the feasibility of immunotherapeutic approaches, is crucial for improving disease outcomes.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Review
Respiratory System
Ruxandra Ulmeanu, Ruxandra-Mioara Rajnoveanu, Sabina-Antonela Antoniu, Lavinia Davidescu, Milena-Adina Man, Ana-Florica Chis, Nicoleta-Stefania Motoc, Armand-Gabriel Rajnoveanu
Summary: The review found that when asthma and bronchiectasis coexist, patients have poorer clinical outcomes, higher disease severity, increased exacerbation rates, higher hospitalization trends, and greater risk for pulmonary complications.
EURASIAN JOURNAL OF PULMONOLOGY
(2022)
Article
Health Care Sciences & Services
Alina Delia Popa, Sabina Antonela Antoniu, Armand Iustinian Enache, Iolanda Valentina Popa, Raluca Alina Dragomir, Alexandru Burlacu
Summary: The article proposes the first validated Romanian questionnaire to assess people's level of education and attitudes towards general measures to protect against COVID-19 infection. Through factor analysis and internal fidelity assessment, three factors were identified and a predictive model for vaccination was developed. The implementation of the questionnaire can help identify areas in need of intervention and prevent a sixth wave of the COVID-19 pandemic in Romania.
Article
Medicine, General & Internal
Cristina Capsa, Laura Aifer Calustian, Sabina Antonela Antoniu, Eugen Bratucu, Laurentiu Simion, Virgiliu-Mihail Prunoiu
Summary: This case report presents a rare case of DLBCL of the uterine cervix, highlighting the diagnostic and therapeutic strategies. Treatment with CHOP polychemotherapy and radiotherapy was effective in achieving tumor regression and normal cervical size restoration.
MEDICINA-LITHUANIA
(2022)
Review
Medicine, General & Internal
Cristiana Libu, Marina Ruxandra Otelea, Ioan Anton Arghir, Agripina Rascu, Sabina Antonela Antoniu, Oana Cristina Arghir
Summary: Occupational chronic obstructive pulmonary disease (oCOPD) accounts for 15-20% of the global burden of this disease. Early detection and limiting occupational exposure are crucial.
MEDICINA-LITHUANIA
(2021)
Review
Medicine, General & Internal
Sabina Antonela Antoniu, Lucian Vasile Boiculese, Virgiliu Prunoiu
Summary: This review discusses the relevance of physical frailty in advanced COPD and its potential utility as an outcome measure in palliative care. The relationship between frailty traits and mortality and morbidity in advanced COPD is supported by available data.
MEDICINA-LITHUANIA
(2021)
