Article
Clinical Neurology
Nana Feng, Jundong Yang, Huajun Xu, Chujun Zhang, Fan Wang, Xiaolin Wu, Meizhen Gu
Summary: This study evaluated the associations between sleep architecture and metabolic parameters in 2,308 patients with suspected OSA, finding weak correlations between sleep quality and metabolic parameters such as weight, blood sugar, and cholesterol. The clinical impact of sleep structure on metabolism appears to be negligible, highlighting the need for further prospective studies to confirm these findings.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Hiwa Mohammadi, Ardalan Aarabi, Mohammad Rezaei, Habibolah Khazaie, Serge Brand
Summary: The study found that individuals with OSAS have significantly lower spindle density in N3 and shorter spindle duration in N2 compared to healthy controls. Furthermore, individuals with mild OSAS showed sleep spindle characteristics more similar to healthy controls, unlike those with moderate and severe OSAS.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Filip Franciszek Karuga, Julia Jaromirska, Mikolaj Malicki, Marcin Sochal, Bartosz Szmyd, Piotr Bialasiewicz, Dominik Strzelecki, Agata Gabryelska
Summary: Obstructive sleep apnea (OSA) is a common sleep disorder characterized by recurrent apneas and/or hypopneas due to upper airway obstruction. OSA patients are prone to developing metabolic complications, including metabolic syndrome and type 2 diabetes mellitus. This review discusses the role of microRNAs (miRNAs) in the development of OSA-associated metabolic complications and their potential as biomarkers for predicting these complications.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Wenxin Liu, Qingqing Du, Hong Zhang, Dingding Han
Summary: Obstructive sleep apnea syndrome (OSAS) in children is a significant public health issue that affects the physical and mental growth. OSAS alters the composition of the gut microbiome, affecting sleep patterns and leading to comorbidities such as obesity, hypertension, and cardiovascular disease.
Article
Endocrinology & Metabolism
Juan Wang, Haobo Xu, Jiansong Yuan, Chao Guo, Fenghuan Hu, Weixian Yang, Lei Song, Xiaoliang Luo, Rong Liu, Jingang Cui, Shengwen Liu, Yushi Chun, Shubin Qiao
Summary: The study revealed an independent association between obstructive sleep apnea (OSA) and metabolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), including obesity, elevated blood pressure, and high triglycerides. Further clinical trials are needed to determine if treating OSA can improve metabolic abnormalities and long-term outcomes in HCM patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Dimitrios G. Raptis, George D. Vavougios, Dimitra Siachpazidou, Chaido Pastaka, Georgia Xiromerisiou, Konstantinos Gourgoulianis, Foteini Malli
Summary: Genetic factors play a crucial role in the pathophysiology of OSAHS, with analysis of four SNPs associated with the syndrome revealing significant variance in certain polymorphisms among patients. In silico analysis identified a transcriptomic network of 274 genes involving cancer-associated gene signatures and adipogenesis pathway, shedding light on the regulatory mechanism and pathophysiology of OSAHS.
Review
Biochemistry & Molecular Biology
Zhikui Wei, You Chen, Raghu P. Upender
Summary: This review summarizes the role of adipokines in sleep physiology and sleep disorders. It is found that adipokines have multifaceted roles in sleep physiology and that sleep disturbances can affect adipokine functions, potentially contributing to systemic metabolic derangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Jonathan D. Santoro, Justin Del Rosario, Beth Osterbauer, Emily S. Gillett, Debra M. Don
Summary: An analysis of sleep positions in children with both Down syndrome and obstructive sleep apnea found a preference for lateral sleeping positions, potentially optimizing airflow but not correlated with the severity of OSA.
Article
Physiology
Xiaoming Li, Xuejian Liu, Qiu Meng, Xinhao Wu, Xin Bing, Na Guo, Xuening Zhao, Xiaozhi Hou, Baowei Wang, Ming Xia, Hui Li
Summary: This study found that circadian clock disruptions, especially Dec1, are linked to the development of OSA and MetS. The expression of Dec1 has a significant impact on various components of MetS, such as hyperglycemia, hypertension, hyperlipidemia, and obesity, and is closely related to oxidative and inflammatory indicators.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Eunhye Bae, Nakwon Kwak, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Jaeyoung Cho
Summary: This study assessed mortality in patients with chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), and overlap syndrome, and found that patients with overlap syndrome had increased mortality, although not higher than those with COPD alone. In predicting mortality, measurement of hypoxemic load was found to be more accurate than the apnea-hypopnea index.
Article
Medicine, Research & Experimental
Lucia Pinilla, Ivan D. Benitez, Fernando Santamaria-Martos, Adriano Targa, Anna Moncusi-Moix, Mireia Dalmases, Olga Minguez, Maria Aguila, Mariona Jove, Joaquim Sol, Reinald Pamplona, Ferran Barbe, Manuel Sanchez-de-la-Torre
Summary: The study investigated the plasma metabolome and lipidome of patients with suspected OSA to identify potential biomarkers for diagnosis and understand the underlying mechanisms of the disease. Results showed a plasma profile comprising 33 metabolites in OSA patients, with a specific 4-metabolite signature providing high accuracy for OSA detection. CPAP treatment led to changes in 5 plasma metabolites affected by OSA, indicating a potential for personalized OSA management using blood-based biomarkers and suggesting adaptive mechanisms in response to OSA-induced hypoxia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Physiology
Yufei Chen, Lijia Chen, Lingxia Ye, Jiabin Jin, Yingkai Sun, Ling Zhang, Shaoqian Zhao, Yifei Zhang, Weiqing Wang, Weiqiong Gu, Jie Hong
Summary: Obesity is a significant risk factor for metabolic syndrome and obstructive sleep apnea (OSA). Bariatric surgery is effective in reducing weight and obesity-related comorbidities. This study found that metabolic syndrome does not increase the risk for OSA in obese patients and both metabolically healthy and unhealthy obese patients can benefit equally from laparoscopic sleeve gastrectomy in terms of weight loss and OSA remission.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Czerwaty, Karolina Dzaman, Krystyna Maria Sobczyk, Katarzyna Irmina Sikorska
Summary: This systematic review aims to define the significance of the coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), known as overlap syndrome (OS), based on the current state of knowledge. After searching multiple databases, 38 eligible studies were included in this review, covering a total population of 27,064 participants. The paper summarizes the most important and up-to-date information regarding OS, including its prevalence, impact of age/gender/body mass index, polysomnography findings, pulmonary function, comorbidities, prediction of OSA in COPD patients, and treatment options for this syndrome.
Review
Physiology
Fatima O. Martins, Silvia V. Conde
Summary: The relationship between obstructive sleep apnea (OSA) and endocrine and metabolic disease is bidirectional, with OSA contributing to and exacerbating obesity, metabolic syndrome, type 2 diabetes, and endocrine disturbances, while endocrine and metabolic diseases are also considered major risk factors for the development of OSA. Various factors including sympathetic activation, deregulation of the hypothalamus-pituitary axis, insulin resistance, and inflammation of adipose tissue are postulated to contribute to dysmetabolic states in OSA. Sex hormones and gender differences play a significant role in the link between OSA and dysmetabolism.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Otorhinolaryngology
Christine H. Heubi, Philip Knollman, Susan Wiley, Sally R. Shott, David F. Smith, Stacey L. Ishman, Jareen Meinzen-Derr
Summary: In children with Down syndrome, 32.5% had sleep efficiency <80%; 75.6% had an elevated arousal index; and 15.9% had total sleep time <360 minutes. More than a third of the patients had >= 3 markers of poor sleep architecture. There was no difference in children with or without obstructive sleep apnea.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)