Article
Infectious Diseases
Qiong-yu Wang, Lin Yuan, Jia-yi Lin, Zhi-qiang Zhuo, Yong-mei Wang, Si-si Li, Min Zhang, Xing-dong Wu
Summary: This study aimed to investigate the clinical characteristics of severe influenza virus-associated pneumonia complicated with bacterial infection in children. The results showed that severe influenza virus-associated pneumonia complicated with bacterial infection was more common in children aged ≤ 5 years, and younger patients with underlying diseases were more susceptible to bacterial infection, especially gram-negative bacteria. Timely administration of neuraminidase inhibitors and antibiotics against susceptible bacteria is likely to help improve cure rates.
BMC INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Abderrahman Bimouhen, Zakia Regragui, Fatima El Falaki, Hassan Ihazmade, Samira Benkerroum, Imad Cherkaoui, Ahmed Rguig, Hind Ezzine, Touria Benamar, Soumia Triki, Youssef Bakri, Hicham Oumzil
Summary: The study found that RSV was the most common virus among III and SARI patients in Morocco, particularly in children under 5 years of age. Influenza viruses were also common and frequently detected in adults. Other respiratory viruses did not display clear seasonal patterns.
JOURNAL OF GLOBAL HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Gayan Bamunuarachchi, Samuel Pushparaj, Lin Liu
Summary: Influenza virus infection through seasonal epidemics and occasional pandemics has been a major public health concern for decades. Incomplete protection from vaccination and increased antiviral resistance due to frequent mutations of influenza viruses have led to a continuous need for new therapeutic options. The functional significance of host protein and influenza virus interactions has been established, but relatively less is known about the interaction of host noncoding RNAs, including microRNAs and long noncoding RNAs, with influenza viruses.
Article
Biochemistry & Molecular Biology
Yuki Furuse
Summary: Recent studies have shown the importance of RNA modifications in cellular functions, but information about RNA modifications in viral RNA is limited. Influenza A virus infection affects the expression levels of host factors for RNA modifications, some of which may have a proviral effect. This novel aspect of host-virus interactions could lead to the discovery of previously unrecognized viral pathogenicity mechanisms and aid in the development of new antiviral drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Tomoko Sumitomo, Masanobu Nakata, Satoshi Nagase, Yuki Takahara, Mariko Honda-Ogawa, Yasushi Mori, Yukako Akamatsu, Masaya Yamaguchi, Shigefumi Okamoto, Shigetada Kawabata
Summary: Influenza A virus infection increases susceptibility to secondary bacterial pneumonia, with GP96 on infected cell surfaces mediating interactions with Streptococcus pneumoniae, leading to increased bacterial adherence and translocation. Inhibition of GP96 enhances pneumococcal clearance and reduces lung pathology in infected mice, suggesting a potential therapeutic target for inhibiting bacterial colonization in an IAV-infected respiratory tract.
Article
Virology
Pinar Yazici ozkaya, Ese Eda Turanli, Hamdi Metin, Ayca Aydin Uysal, Candan cicek, Bulent Karapinar
Summary: This study aimed to identify the clinical features and mortality associated with severe influenza A and B virus infections in children admitted to the pediatric intensive care unit (PICU) between 2012 and 2019. The study found that although the proportion of influenza A cases admitted to the PICU was higher, the percentage of cases requiring PICU admission was nearly two times higher in influenza B cases. Additionally, there was no statistically significant difference in disease severity and complications in patients with influenza A and influenza B.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Yiguo Zhou, Juan Du, Jing-Qin Wu, Quan-Rong Zhu, Ming-Zhu Xie, Lin-Yi Chen, Ya-Qiong Liu, Wei Li, Ting-Fa Zhou, Qing-Bin Lu
Summary: This study compared the diversity and composition of lung bacteria in severe pneumonia patients who were influenza virus positive (IFVP) and influenza virus negative (IFVN). The results showed slightly higher microbial diversity in the IFVP group, with the dominant bacterial genera being Streptococcus, Klebsiella, Escherichia-Shigella in the IFVN group and Acinetobacter, Streptococcus, Staphylococcus in the IFVP group. The study also found a higher abundance of Klebsiella in the IFVN group. Therefore, individuals with severe pneumonia infected with influenza virus are more susceptible to certain bacteria, especially Acinetobacter baumannii, and further investigation is needed to understand the interaction between influenza virus and Acinetobacter baumannii in the progression of pneumonia.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Multidisciplinary Sciences
Helen E. Rich, Danielle Antos, Collin C. McCourt, Wen Quan Zheng, Louis J. Devito, Kevin J. McHugh, Radha Gopal, Jieru Wang, John F. Alcorn
Summary: The study found that IFN lambda 3(-/-) mice and control mice did not show significant differences in total IFN lambda levels during influenza/Staphylococcus aureus super-infection, suggesting a functional redundancy between IFN lambda subtypes. The results also indicate that influenza viral burden, rather than changes in cellular inflammation or viral load, correlates significantly with susceptibility to bacterial super-infection, highlighting the importance of IFN lambda in pulmonary pathogen defense.
Article
Infectious Diseases
Liang Chen, Xiudi Han, YanLi Li, Chunxiao Zhang, Xiqian Xing
Summary: This study aimed to compare the clinical characteristics and severity between adults with respiratory syncytial virus (RSV-p) and influenza-related pneumonia (Flu-p). The findings showed that severe outcomes, such as invasive ventilation, ICU admission, and 30-day mortality, were significantly higher in FluA-p compared to RSV-p, while FluB-p was comparable to RSV-p in terms of risk.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Nanoscience & Nanotechnology
Gefei Li, Wenxiao Ma, Juan Mo, Boyang Cheng, Shin-ichiro Shoda, Demin Zhou, Xin-Shan Ye
Summary: Rapid diagnosis and vaccine development are crucial to combat virus threats, facilitated by the development of rapid virus enrichment and purification techniques. The use of synthetic glycoclusters and reversible linkers to selectively capture viruses has shown promising results in improving clinical sensitivity and simplifying vaccine production processes. This innovative glycobead platform not only allows for sensitive virus detection, but also enables continuous one-step purification for future vaccine production.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Plant Sciences
Yuan-zhen Hao, Li-feng Cen, Ting Wang, Tong Yi, Xun-long Shi, Hui-juan Duan, Zhi Dai, Hai-yan Zhu, Jian-guo Tang
Summary: This study investigated the therapeutic effect of 999 XiaoErGanMao granules (XEGMG) on lung and intestine injury in H1N1 influenza virus-infected mice. The results showed that XEGMG can mitigate body weight loss, reduce lung index and pathological damage, and decrease the release of inflammatory cytokines. XEGMG can also protect goblet cells in the colon, maintain intestinal barrier, and regulate the major flora.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiao Huang, Feng Lu, Huanhuan Tian, Haoran Hu, Fangyu Ning, Quanmei Shang, Dong Hao, Weiwei Zhu, Guiqing Kong, Xiaohong Ma, Jiali Feng, Tao Wang, Xiaozhi Wang
Summary: Plasma levels of syndecan-1 and hyaluronan are positively correlated with disease severity in patients with influenza A (H1N1). Elevated syndecan-1 levels may have a potential role in systemic organ dysfunction and could serve as an indicator of disease severity and mortality in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Min Dou, Wenjun Song, Yongping Lin, Qigao Chen, Chang Lu, Zhongmin Liu
Summary: The study analyzed clinical characteristics and viral genes in patients with severe pneumonia due to H1N1 influenza virus in Guangzhou in 2019. Risk factors for severe disease were identified as chronic lung disease and cardiovascular disease, with a significant rate of secondary infections in critically ill patients. Furthermore, serum IL-8 levels were significantly higher in critically ill patients compared to nonsevere patients and healthy controls.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Daniel Reynolds, Cristina Vazquez Guillamet, Aaron Day, Nicholas Borcherding, Rodrigo Vazquez Guillamet, Jose Alberto Choreno-Parra, Stacey L. House, Jane A. O'Halloran, Joaquin Zuniga, Ali H. Ellebedy, Derek E. Byers, Philip A. Mudd
Summary: Severe cases of seasonal influenza or SARS-CoV-2 infection are associated with an influx of nonclassical monocytes, activated T cells, and plasmablast B cells into the lower airways, along with significantly elevated levels of 28 out of 35 measured cytokines. IP-10 concentration is the only cytokine that correlates between blood and bronchoalveolar lavage during severe infection.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Engineering, Multidisciplinary
Marina Kljakovic-Gaspic Batinjan, Tea Petrovic, Frano Vuckovic, Irzal Hadzibegovic, Barbara Radovani, Ivana Jurin, Lovorka Derek, Eva Huljev, Alemka Markotic, Ivica Luksic, Irena Trbojevic-Akmacic, Gordan Lauc, Ivan Gudelj, Rok Civljak
Summary: This study analyzed and compared the IgG glycosylation characteristics of patients with influenza, COVID-19, and healthy controls. The results showed significant decreases in IgG galactosylation, sialylation, and bisecting GlcNAc in deceased COVID-19 patients, while IgG fucosylation increased. Influenza patients and COVID-19 survivors had stable IgG glycosylation. The similarities in IgG glycosylation changes between COVID-19 survivors and influenza patients may indicate different immune responses to enveloped viruses.
