Article
Engineering, Environmental
Xia Li, Jianpeng Li, Sijia Hao, Ailing Han, Yayu Yang, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: A enzyme mimic material inspired by serine proteases was developed to degrade DEHP, which was then immobilized onto RC membranes for continuous recycling degradation. This biocatalytic membrane showed effective DEHP degradation and good stability, offering a promising biomaterial for water decontamination and liquid food depollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Gang Li, Chen -Yang Zhao, Qian Wu, Zhen Kang, Jia-Tai Zhang, Si-Yuan Guan, Hong-Wei Jin, Yun-Bo Zhang, Xiao-Lin Na
Summary: This study investigated the effect of DEHP on hepatic cholesterol metabolism and revealed the mechanisms underlying DEHP-induced hepatotoxicity. The results showed that DEHP increased levels of total cholesterol, high-density lipoprotein, and alanine transaminase in the serum, and altered oxidative stress response and cholesterol metabolism pathway in the liver.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Shuang Ding, Wen Qi, Qi Xu, Tianyang Zhao, Xu Li, Jianli Yin, Ruxuan Zhang, Chuanyi Huo, Liting Zhou, Lin Ye
Summary: The study revealed that DEHP exposure may affect lipid metabolism in adolescents by regulating the expression of lipid metabolism-related genes, particularly showing significant associations with compounds like MECPP, MCMHP, and n-ary DEHP levels.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biodiversity Conservation
Xianxu Li, Qian Wang, Can Wang, Zhongkang Yang, Jinhua Wang, Lusheng Zhu, Dexin Zhang, Jun Wang
Summary: This study investigated the acute and chronic toxicity of DEHP on zebrafish, focusing on oxidative damage, neurotoxicity, and DNA damage in the liver. The results showed that DEHP enhanced oxidative stress, lipid peroxidation, and cytotoxicity in zebrafish liver, leading to DNA damage. The severity of the effects was positively correlated with the concentration of DEHP.
ECOLOGICAL INDICATORS
(2022)
Review
Environmental Sciences
Luis Daniel Martinez-Razo, Alejandra Martinez-Ibarra, Edgar Ricardo Vazquez-Martinez, Marco Cerbon
Summary: DEHP, considered an endocrine disruptor chemical (EDC), is widely used in the plastic industry and can have negative effects on placental development and function, potentially impacting fetal growth. Research indicates that DEHP and MEHP can impair key processes in placental development and affect various placental functions. Clinical evidence also supports the connection between DEHP exposure and adverse pregnancy outcomes and pathologies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
David Hala, Lene H. Petersen, Duane B. Huggett, Michelle A. Puchowicz, Henri Brunengraber, Guo-Fang Zhang
Summary: DEHP, a common plasticizer, is a metabolic disrupter that affects the production and sequestration of CoA, an essential cofactor for oxidative and biosynthetic reactions. Exposure to DEHP led to significantly increased hepatic levels of free CoA and various CoA esters, particularly the physiological CoA ester of malonyl-CoA and the DEHP-derived CoA ester of 3-keto-2-ethylhexanoyl-CoA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Xia Wang, Dinggang Li, Xiangqin Zheng, Yifan Hong, Jie Zhao, Wei Deng, Mingxin Wang, Lianju Shen, Chunlan Long, Guanghui Wei, Shengde Wu
Summary: This study investigates the molecular mechanism of testicular damage caused by Di-(2-ethylhexyl) phthalate (DEHP). The findings suggest that DEHP exposure leads to histopathological alterations in prepubertal testes and significant changes in lipid metabolism and ferroptosis.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Heng Shi, Xin-Hai Zhao, Qin Peng, Xian-Ling Zhou, Si-Si Liu, Chuan-Chuan Sun, Qiu-Yu Cao, Shi-Ping Zhu, Sheng-Yun Sun
Summary: This study revealed that green tea polyphenols can alleviate DEHP-induced liver dysfunction, blood lipid dysregulation, fatty liver disease, and partial liver fibrosis in mice, and regulate immune cell infiltration. Additionally, an important miRNA-mRNA-protein molecular regulatory axis involved in mediating the therapeutic effects of GTPs on DEHP-induced liver damage was elucidated.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kuo-Cheng Lan, Te- Weng, Wei-Che Chiang, Chen-Yuan Chiu, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: DEHP and its metabolite MEHP have been found to inhibit myogenesis in vitro, suggesting their potential role as environmental risk factors affecting muscle differentiation.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Rui-jing Liu, Yong-jian He, Huan Liu, Dong-dong Zheng, Shao-wen Huang, Chun-hong Liu
Summary: Lycium barbarum polysaccharide (LBP) showed protective effects against DEHP-induced liver toxicity in rats by attenuating oxidative stress and down-regulating detoxification enzymes expression. This suggests that LBP could be a potential natural ingredient for auxiliary therapeutic use in health food.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Applied
Yuting Liang, Zhi Jiang, Wenfeng Shangguan
Summary: This study investigated the photocatalytic reaction behavior of DEHP over surface platinized TiO2, with the oxidation state of platinum found to be crucial in determining the photocatalytic activity. Platinized titania with oxidized Pt species showed higher photocatalytic activity compared to metallic Pt. Photocatalysis coupled with thermal catalysis can enhance the degradation of DEHP, and Pt oxide, particularly PtO, can improve the photocatalytic oxidation efficiency by promoting the separation efficiency of photo generated carriers.
Article
Engineering, Environmental
Huijun Li, Zhen Zhen, Dayi Zhang, Yongxiang Huang, Guiqiong Yang, Changhong Yang, Weilong Wu, Zhong Lin, Yan-Qiu Liang
Summary: In this study, the effects of straw carbonization returning on sea rice yield and DEHP degradation were investigated. It was found that straw carbonization returning significantly improved soil nutrients and reduced salt stress, leading to an increase in sea rice yield. DEHP degradation efficiency was enhanced, mainly attributed to factors such as high pH value, high soil organic matter, and enriched potential DEHP degraders. The results provide important insights into sea rice yield improvement and DEHP degradation mechanisms in coastal paddy soil through straw carbonization returning.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Immunology
Yu-Ri Kim, Mee Kyung Sang
Summary: In this study, the effects of di-(2-ethylhexyl) phthalate (DEHP) on the growth, metabolism, and virulence of Acidovorax citrulli were investigated. DEHP exposure did not affect the bacterial population, lipid peroxidation, membrane permeability, and nucleic acid leakage. However, it increased palmitoleic acid content, TCA cycle-related enzyme activity, and the content of certain metabolites. DEHP exposure also resulted in differential gene expression, with some genes related to translation, flagellum-dependent cell motility, and flagellum assembly being downregulated. Swimming activity and expression of pathogenicity genes were decreased in DEHP-exposed A. citrulli. These findings suggest that DEHP accumulation in soil could potentially impact the metabolism and virulence traits of A. citrulli.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biology
Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito-Matsuoka, Takahiro Arima, Yasuhisa Matsui
Summary: Maternal exposure to DEHP induces DNA hypermethylation of spermatogenesis-related gene promoters in fetal testicular germ cells in F1 mice, leading to downregulation of gene expression in spermatogonia and subsequent defects in spermatogenesis.
Article
Food Science & Technology
Yue-Qiang Huang, Yi-Xi Tang, Bai-Hao Qiu, Milton Talukder, Xue-Nan Li, Jin-Long Li
Summary: DEHP exposure can cause liver damage in quails, resulting in lipid metabolism disorders and inflammatory response.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Reproductive Biology
Sumitaka Kobayashi, Fumihiro Sata, Chihiro Miyashita, Atsuko Ikeda-Araki, Houman Goudarzi, Tamie Nakajima, Reiko Kishi
Summary: This study investigated how the interaction between mono-(2-ethylhexyl) phthalate (MEHP) and maternal genotypes associated with nuclear receptors affect fatty acid levels during pregnancy. The results showed that the interaction between MEHP and maternal genotypes PPARGC1A (rs8192678) and LXRB (rs2303044) can decrease fatty acid levels in pregnant Japanese individuals.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Hazuki Tamada, Takeshi Ebara, Taro Matsuki, Sayaka Kato, Hirotaka Sato, Yuki Ito, Shinji Saitoh, Michihiro Kamijima, Mayumi Sugiura-Ogasawara
Summary: The consumption of processed food during pregnancy is associated with pregnancy outcomes, and frequent consumption of ready-meals and frozen meals may increase the risk of stillbirth.
Article
Environmental Sciences
Shota Yamada, Takeshi Ebara, Toru Uehara, Taro Matsuki, Shingo Kimura, Yuya Satsukawa, Akira Yoshihara, Kazuji Aoki, Atsushi Inada, Michihiro Kamijima
Summary: This study aimed to identify effective measurement angles for pelvic incidence (PI) classification and develop a quick, noninvasive assessment tool. The results revealed that the HKL angle can accurately distinguish the size of PI and a reliable tool was designed for practical application.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Toshio Masumoto, Hiroki Amano, Shinji Otani, Michihiro Kamijima, Shin Yamazaki, Yayoi Kobayashi, Youichi Kurozawa
Summary: Cadmium, a heavy metal, has toxic effects on the human body. This study found that prenatal exposure to cadmium affects the mental development of children, but the effect decreases with age.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Yu Taniguchi, Shin Yamazaki, Shoji F. Nakayama, Makiko Sekiyama, Takehiro Michikawa, Tomohiko Isobe, Miyuki Iwai-Shimada, Yayoi Kobayashi, Mai Takagi, Michihiro Kamijima
Summary: This study summarizes the statistical data of complete blood count and chemistry panel from pregnant women enrolled in the Japan Environment and Children's Study (JECS). The results provide the mean values and standard deviations of various parameters during different trimesters of pregnancy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Toxicology
Tamie Nakajima, Hailan Wang, Yuan Yuan, Yuki Ito, Hisao Naito, Yoshiyuki Kawamoto, Kozue Takeda, Kiyoshi Sakai, Na Zhao, Hongling Li, Xinxiang Qiu, Lihua Xia, Jiabin Chen, Qifeng Wu, Laiyu Li, Hanlin Huang, Yukie Yanagiba, Hiroshi Yatsuya, Michihiro Kamijima
Summary: The study suggests that occupational exposure to TCE may lead to TCE-HS, and autoantibodies to CYP2E1 are primarily involved in the pathogenesis of this disorder.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Hazuki Tamada, Yuki Ito, Takeshi Ebara, Sayaka Kato, Kayo Kaneko, Taro Matsuki, Mayumi Sugiura-Ogasawara, Shinji Saitoh, Michihiro Kamijima
Summary: The composition of human gut microbiota has a long-term impact on human health and disease. This study validated two methods for stool specimen collection and storage, and found them to be useful in large-scale epidemiological studies. However, these methods may alter the relative abundances of certain bacteria.
Article
Pediatrics
Aya Yoshida, Kayo Kaneko, Kohei Aoyama, Naoya Yamaguchi, Atsushi Suzuki, Sayaka Kato, Takeshi Ebara, Mayumi Sugiura-Ogasawara, Michihiro Kamijima, Shinji Saitoh
Summary: Later-borns tend to be shorter than first-borns in childhood and adulthood, and this study aimed to investigate the relationship between birth order and growth during the first 4 years of life. The study found that birth order was significantly associated with postnatal growth, with later-borns having lower length Z-scores and higher odds of short stature compared to first-borns having no sibling. This suggests that birth order may be a predisposing factor for short stature in early childhood.
Article
Environmental Sciences
Yukiko Nishihama, Shoji F. Nakayama, Tomohiko Isobe, Michihiro Kamijima
Summary: This study aimed to examine the association between NEO exposure and child development. The results showed no statistically significant association between maternal urinary NEO concentrations during pregnancy and child development delays. Objective assessment of child development in different populations may be warranted to confirm these findings.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Junji Miyazaki, Satoyo Ikehara, Kanami Tanigawa, Takashi Kimura, Kimiko Ueda, Keiichi Ozono, Tadashi Kimura, Yayoi Kobayashi, Shin Yamazaki, Michihiro Kamijima, Tomotaka Sobue, H. Iso
Summary: This study examined the associations between prenatal exposure to metallic elements (mercury, selenium, and manganese) and the risk of allergic diseases in early childhood. The findings suggest that prenatal selenium exposure may be beneficial in reducing the risk of atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases, particularly with lower prenatal mercury exposure.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Tomoyuki Tsuchiyama, Yuki Ito, Masaru Taniguchi, Miki Katsuhara, Hitoshi Miyazaki, Michihiro Kamijima
Summary: High urinary levels of dialkylphosphates (DAPs) have been associated with adverse health outcomes. This study analyzed the levels of organophosphate pesticides (OPs) and DAPs in different food items. Certain fruits had high levels of DAPs, while vegetables showed positive associations with OPs and DAPs. This suggests that dietary habits and intake of preformed DAPs should be considered when interpreting urinary DAP biomonitoring data.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Neeranuch Suwannarin, Tomohiko Isobe, Yukiko Nishihama, Yuki Ito, Michihiro Kamijima, Takeshi Ebara, Mayumi Sugiura-Ogasawara, Naomi Nishikawa, Kunihiko Nakai, Yumina Minamikawa, Shoji F. Nakayama
Summary: The study aimed to evaluate the utility of urinary biomarkers for the exposure to low doses of neonicotinoid insecticides during pregnancy. The results showed that a single measurement of urinary NEO concentrations may not be an appropriate method of characterizing overall exposure, except for N-dm-ACE.
ENVIRONMENTAL RESEARCH
(2024)
Article
Public, Environmental & Occupational Health
Hiroaki Ono, Yasuki Hori, Mafu Tsunemi, Ippei Matsuzaki, Kazuki Hayashi, Michihiro Kamijima, Takeshi Ebara
Summary: An ergonomic motion tracking system for endoscopy suite (EMTES) was developed and found to be reliable in calculating occlusion, precision, and accuracy for upper and lower limb movements in endoscopists.
JOURNAL OF OCCUPATIONAL HEALTH
(2022)